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1 r to and following isovolumic haemodilution, whereby 20% of whole blood was removed and replaced with
2 the complete metabolome (11 385 components), whereby 76.8% was found compliant with the criteria for
4 movement can occur during CO-CO collisions, whereby a bump is followed by a move similar to a "do-si
6 be understood as a transfer of information, whereby a focal individual learns about the world by gai
7 e to an innate growth bistability phenomenon whereby a fraction of the drug-exposed population enters
8 gether, these data suggest a novel mechanism whereby a functional interaction between TRPV4 and Rac1
9 tood feature of this process is "zippering," whereby a fusion point moves directionally along an orga
10 t, or through a population coding mechanism, whereby a group of neurons, each with local effects, act
14 ransitional objects with a layered structure whereby a metal-rich core is enclosed by a silicate mant
15 e MEK inhibitor SL327, revealing a mechanism whereby a neurofibromin/Ras/MEK pathway regulates a crit
16 be mediated by target protection mechanisms, whereby a protein binds to the drug target and protects
17 ng an olfactory delayed match to sample task whereby a sample odor specifies the association between
18 ld form the basis for an integrated process, whereby a single hospital visit results in a bespoke ort
19 es of TPC2 and they establish a new paradigm whereby a single ion channel mediates distinct, function
20 a derived haplotype, MYBPC3(Delta25/)(-52), whereby a small subset of individuals bear both MYBPC3(D
21 ire the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism
22 ise model for MCD/C5 and PENLs pathogenesis, whereby acquisition of founder mutations in activated B
23 s provide a cellular and molecular mechanism whereby activation of OXTRs exerts anxiolytic effects.
25 ta establish a potential molecular mechanism whereby adversity during puberty can enact lasting trans
26 d their MSC niche, and a molecular mechanism whereby AML impairs normal hematopoiesis by remodeling t
27 d receptor (AMPAR) abundance and properties, whereby AMPARs are inserted into synapses during long-te
28 utilised the concept of in situ vaccination whereby an ICD inducing drug is injected locally to gene
30 analyzing the Ni-spiked compact COx samples, whereby an increase of the Ni content in the clay fracti
31 e oxygen vacancies (V(O)) in these materials whereby an increased concentration of V(O) sites correla
32 iorecognition elements for in vitro sensing, whereby an indicator of the differential binding affinit
33 ssential that there are inherited mechanisms whereby an individual can navigate-first, to the terminu
34 nsplantation provide a window of opportunity whereby aneuploid cells rise in frequency, only to decli
35 moted K/BxN serum-induced arthritis in mice, whereby ankle swelling was partially TLR4 dependent.
36 utionary trade-off in resistance management, whereby attempts to reduce selection for specialist resi
37 results support an attentional drag theory, whereby attentional engagement is prolonged when feature
38 alling mechanism for the plant hormone auxin whereby auxin directly affects the activity of the atypi
39 sensing is a bacterial communication process whereby bacteria produce, release, and detect extracellu
40 al bodies (BBs) nucleate and position cilia, whereby BB-associated striated fibers (SFs) promote BB a
41 in vivo environments remains unpredictable, whereby biocompatibility testing usually occurs in serum
42 ally different types of inclusions in NAFLD, whereby both gained significantly in number in advanced
43 ble, skin aging is a degenerative phenomenon whereby both intrinsic and environmental factors conspir
44 sal status was defined using age as a proxy, whereby breast cancer cases or deaths at age 50 years or
45 n vitro findings are consistent with a model whereby brief exposure of Cdon mutant embryos to ethanol
46 k between excitatory and inhibitory synapses whereby Ca(2+)-entering through postsynaptic NMDARs prom
47 followed an established age-infection curve, whereby calves (5 years) exhibited the highest FECs and
48 ese interactions suggest an inhibition model whereby CAP/KAc-actin serves as a bridge between INF2 DI
50 linical specimens, we identified a mechanism whereby CD8+ T cell activation in response to programmed
52 nt-based modelling of bacterial tit-for-tat, whereby cells stab rivals with poisoned needles (the typ
53 ork identifies a mechanism of cell migration whereby cellular mechanical forces dissociate extracellu
54 ctrolyte inductive effect has been proposed, whereby changes in bonding within the solid-electrolyte
56 These findings indicate a cascade effect whereby cMyBP-C dephosphorylation causes contractile def
57 contrast with the current model of scarring, whereby collagen deposition is exclusively attributed to
59 ated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables
60 ts may generate important carryover effects, whereby conditions experienced during one life-history s
61 refore a reversible pluripotent intermediate whereby control over both pluripotency progression and m
62 ne diseases by inducing infectious tolerance whereby conventional B cells acquire regulatory function
63 ine an essential step in Hedgehog signaling, whereby coreceptors activate SHH by chaperoning it from
64 egree of structural and functional homology, whereby CTIP2 or SATB2 of either species is sufficient t
65 The CTLA4 checkpoint serves as an exemplar, whereby CTLA4 activity is blocked by antibodies in cance
66 ochemically recurrent prostate cancer (PCa), whereby cycling treatment on and off can reduce cumulati
68 erto unrecognized signal transduction system whereby cytoplasmic sentinel lectins detect membrane dam
69 erization pathway within a cellular setting, whereby cytosine-guanosine binding appeared to disrupt t
71 r, few reports have described the mechanisms whereby (D)CDX-modified liposomes traverse the blood-bra
72 r negative other-regarding preference (ORP), whereby decisions affected the reward received by anothe
73 ction mechanisms under anaerobic conditions, whereby decreased decomposition of litter C was compensa
74 F3A is required for skin barrier homeostasis whereby decreased KIF3A skin expression causes disrupted
75 ncept of PITRM1-linked neurological syndrome whereby defects of mitochondrial presequence processing
76 owing key operations: a) pattern separation, whereby dense combinatorial representations of odors are
78 psules 1 and 2 enabled the design of systems whereby different cargoes could be moved between cages u
79 ies and validates a cell-intrinsic mechanism whereby differential protein phosphorylation causes spli
81 those used in the past, to propose a pathway whereby dosimetry helps the field by optimizing the biol
82 ing species exerted strong priority effects, whereby dynamics of late successional taxa were strongly
83 quantify a distribution of mitigation effort whereby each country is economically better off than und
84 e disorders feature a reciprocal interaction whereby each disease impacts the severity of the other.
85 tabolites were detected in examined samples, whereby each sample was contaminated between 13 and 55 n
86 the "reaction axis", which is the direction whereby electronic reorganization converts reactants' to
88 Our findings define molecular mechanisms whereby EMC1 dysfunction causes disease phenotypes throu
89 f ERG oncogene addiction in prostate cancer, whereby ERG facilitates AR signaling by maintaining core
91 aspect of Candida-streptococcal interaction whereby extracellular glucans may selectively favor S. m
93 tive abilities of the early mammalian embryo whereby fate decisions are coordinated at the population
95 nt contradiction by a depositional mechanism whereby fibers are preferentially removed from suspensio
96 es a novel mechanism of mechanotransduction, whereby force-induced membrane deformation activates int
97 e drug therapies, BMD targets can be reached whereby further improvements in BMD are not associated w
98 udy, we sought to determine the mechanism(s) whereby GCs influence the fibrotic response and mechanis
100 60% of traits exhibit co-gradient variation whereby genetic differences and plasticity-induced diffe
101 Concurrently we discovered a novel mechanism whereby gH/gL antibodies stabilize the complex and inhib
102 observations show a systems level phenomenon whereby global cell shape affects subcellular organizati
104 ecture.(1) Gravitropism is a dynamic process whereby gravistimulation induces the asymmetric distribu
106 ematopoietic transition (EHT) is the process whereby haemogenic endothelium differentiates into haema
107 Chirality-induced spin selectivity (CISS), whereby helical molecules polarize the spin of electrica
108 I3, revealing an intricate control mechanism whereby heteromerization of ORAI channels mediates grade
110 idential racial segregation via "redlining," whereby HOLC designated and colored in red areas they de
111 mediated immune regulation in the intestine, whereby homeostatic expression of ERbeta normally functi
112 to study the secondary metabolite formation, whereby HPCCC showed a superior separation capacity to f
113 To address this, we have devised a strategy whereby human endothelial and smooth muscle cells derive
114 ion of human prospermatogonial specification whereby human primordial germ cell (PGC)-like cells diff
115 models support a hypothesized effect pathway whereby IL-pat leads to intuitions of order which, in tu
116 our results provide evidence for a mechanism whereby imagined movements can directly affect motor per
117 , we use the model to investigate mechanisms whereby immune checkpoint therapy for cancer paradoxical
119 el for translational regulation is presented whereby in the absence of ligand the riboswitch is large
121 nificant for males when examined separately, whereby increased sleep difficulties were associated wit
124 ons are often seen as social feedback rules, whereby individuals copy the decisions they observe othe
125 sorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms i
126 natal immune system as compared with adults, whereby infants respond to microorganisms through biased
127 general feature of mammalian neural systems, whereby inhibitory interneurons act not simply to preven
129 Human dynein is regulated by autoinhibition, whereby intermolecular contacts limit motor activity.
130 mechanism of inducible antibiotic resistance whereby isolates that appear to be carbapenem susceptibl
131 he regulation of myogenesis and muscle mass, whereby it acts to maintain muscle mitochondrial functio
132 establishes a novel function for lactate whereby it is utilized in a new histone modification, hi
133 sly unknown role for platelet-derived PDGFB, whereby it promotes and maintains vascular integrity in
135 nthine phase undergoes an inverse transition whereby it transforms into the less-symmetric parallel-s
136 ion is a common feature of visual processing whereby large stimuli are less effective at driving neur
138 DNA, suggesting a 'kinetic gating' mechanism whereby lesion discrimination relied on efficient openin
140 present a fundamental challenge to proposals whereby linguistic computations, such as inhibiting irre
141 y immunity genes and suggest a working model whereby loss of CAMTA123 repression leads to the inducti
142 ranscription factor, and propose a mechanism whereby loss of phenotypic inheritance causes increased
143 l signaling axis in the endolysosomal system whereby LRRK2-mediated Rab10 phosphorylation stalls vesi
144 injury and fibrosis and fit with a mechanism whereby lung lymphatic network expansion reduces lymph s
145 the major problems of contemporary medicine, whereby many men with clinically insignificant disease a
146 We therefore describe a drug-able pathway whereby MDM2 ubiquitinates and degrades KRT10, increasin
147 s show a strong apoptotic cellular response, whereby mechanical stimulation causes those cells near t
148 n can be governed by microbial interactions, whereby metal-reducing bacteria are able to reduce solub
149 underlying partially reinforced fear (PRF), whereby mice received tone-shock pairings on half of con
150 chastic effects of microbiota perturbations, whereby microbial transmission through host interactions
152 , suggested a novel mechanism of cooperation whereby Mir142 loss-of-function counteracts aberrant sil
153 ct between respiration and oxidative stress, whereby mitochondrial oxidant levels do not rise with in
154 rized by exactly two 'universality classes', whereby models of the same class predict, under asymptot
157 roblem using an inorganic chemical approach, whereby multiple modes of protein-protein interactions a
159 r lncRNA OIP5-AS1 in myogenesis, the process whereby myoblasts differentiate into myotubes during mus
160 up endogenous structural proteomics approach whereby near-atomic-resolution cryo electron microscopy
161 rlier in development, suggesting a mechanism whereby neural circuits begin as flexible systems that d
162 oted in cognitive effectiveness (SAFTE(tm)), whereby night shift nurses experienced substantial decli
163 ve found evidence for a 'metallicity floor', whereby no globular clusters are found with chemical (me
164 riation the majority seem to be hyperplastic whereby non-native individuals express phenotypes that e
165 eaction can be further coupled to a reaction whereby nonsymbiotic haemoglobin oxidizes NO to nitrate.
166 gression and implicate a molecular mechanism whereby nuclear MET promotes aberrant Wnt/beta-catenin s
167 nstrated a previously unrecognized mechanism whereby nuclear PXN enhances angiogenesis by transcripti
168 clusion also manifests a "butterfly effect", whereby numerous metabolic changes and interdependent cr
170 ults may suffer from reverse causality bias, whereby obesity status influenced the biomarker concentr
171 of action independent of the etiology of VC, whereby (OEG(2))(2)-IP4 disrupts the nucleation and grow
173 ciation between the two processing pathways, whereby one can be impaired while the other develops typ
174 an undergo post-transcriptional surveillance whereby only a subset of the non-coding transcripts is a
175 to modulate the emission from a QCL device, whereby optically-generated acoustic phonon pulses are u
176 rageness" effect found in social psychology, whereby otherwise attractive, intercategory faces dimini
177 , we highlight microbial metabolite mimicry, whereby parent metabolites have weak interactions with t
178 iation between experience and reportability, whereby participants appear able to encode stimuli into
179 le the implementation of precision medicine, whereby patient management is tailored to the individual
181 vention followed by clinical practice change whereby patients with high-risk myocardium were identifi
183 lial remodeling involves ratcheting behavior whereby periodic contractility produces transient change
184 riments, we identified a molecular mechanism whereby PGE(2) promotes Yap dephosphorylation, nuclear t
185 ays in vitro suggest negative cooperativity, whereby phosphorylation in one protomer of the dimer inh
187 se inhibitors leads to endocrine-resistance, whereby physiologic levels of estrogen kill breast cance
188 findings reveal a novel virulence mechanism whereby plant pathogens target host RNA Pol IV for UPS-d
189 striking parallels with plant vernalisation, whereby plants remain dormant through the winter before
190 ear extinction is an active learning process whereby previously established conditioned responses to
191 oming these challenges and detail techniques whereby promising combination regimens can be identified
193 rotein exchange modulates adhesive function, whereby proteins are "locked in" to hyperadhesive desmos
194 sed risk for a highly vulnerable population, whereby pubertal programming of the PVN results in aberr
197 quality to observe the quantum Hall effect, whereby rhombohedral graphite exhibits phase transitions
198 A twostep pre-soaking stage was developed whereby rice was first incubated, at ambient temperature
199 vel form of regulation of protein synthesis, whereby RNA structures within the 5'-UTR regulate transl
200 some cases, bacteria show evolved trade-ups, whereby selection causes multiple fitness components to
202 nded in the structure-function relationship, whereby sequence determines structure that determines fu
203 insights into the CD40 signaling mechanisms whereby Ser-11 phosphorylation controls RING domain-depe
204 revealed that the lipovelutibol D framework, whereby serine is substituted for alanine in the fifth p
205 ammatory infiltrations, and oral microbiome, whereby several master inflammatory pathways constitute
207 ultiplication and propagation of aggregates, whereby short-lived oligomeric intermediates cause neuro
209 another foraging strategy, "shelling" [17], whereby some dolphins in this population feed on prey tr
210 ase states, revealing specific genes/operons whereby Spn adapts to and influences host sites in vivo.
211 cuitry, as well as address mounting evidence whereby stress hormones interact with endogenous BDNF-Tr
212 oid secretion, demonstrating a feedback loop whereby stressful stimuli activate RFRP neurons, which i
213 ranching morphogenesis in the mammary gland, whereby stromal ACKR2 modulates levels of the shared lig
215 levant as we approach the postmicrobiome era whereby studying the spatial structure of the pathogen a
216 multiparameter optimization in drug design, whereby substantial improvements in a variety of pharmac
217 reveals a previously unrecognized mechanism whereby such antibodies might impact HIV transmission an
219 orate a complex model for HIV-1 acquisition, whereby susceptibility is partly heritable and moderated
220 Further, we characterize a new mechanism whereby sustained stimulation by a major proinflammatory
224 time, to our knowledge, the dynamic behavior whereby Tfh cells migrate in human GC and highlight the
225 al denervation is an endovascular procedure, whereby the ablation of renal nerves results in reduced
226 uced electron transfer (PET) is a phenomenon whereby the absorption of light by a chemical species pr
227 a compact circuit in the vertebrate retina, whereby the AII amacrine cell (AII AC) provides inhibiti
228 athway and establish a classification system whereby the associations between TERT mutations and thei
229 rs under which this can be performed safely, whereby the BBB is disrupted to the point of being perme
231 2a, resulting in opening of the active site, whereby the beta-lactam antibiotic now is enabled to bin
232 lock-in effect" in barium block experiments, whereby the binding of external K(+) impedes the forward
233 ansition in IDPs termed "templated folding," whereby the binding partner dictates distinct structural
234 onal theory calculations support a mechanism whereby the borepin initially rearranges to a boranorcar
236 es proceeds through a cap-dependent pathway, whereby the cap-binding complex, eIF4F, anchors the prei
237 D462-E4 TCR binds over the F'-pocket of MR1, whereby the complementarity-determining region (CDR) 3be
238 the causal relationship, or 'codependency', whereby the composition of one guild affects the composi
239 l dimension of adolescent brain development, whereby the coupling between structural and functional c
241 strate a novel gene-environment interaction, whereby the effect of diabetes on PD risk appears to dep
242 based on their characteristic length scale, whereby the enabling feature of each technology is organ
243 liminary studies allude to a catalytic cycle whereby the excited state of the organophotocatalyst is
244 nd colleagues report a fascinating phenotype whereby the extracellular signal-regulated kinase (ERK)
245 isplays another unprecedented constellation, whereby the F0-F1-F2 adopts a new cloverleaf-like arrang
247 nt of RNA G-quadruplexes with two G-quartets whereby the folding potential is strongly influenced by
249 nts were offered facilitated cascade testing whereby the genetics team identified and contacted ARRs
250 r HCV's effect on intracellular desmosterol, whereby the HCV NS3-4A protease controls activity of 24-
252 ematopoiesis is reprogrammed upon infection, whereby the HSC compartment turns over substantially fas
255 ing over 4-7 y, identified a sex-interaction whereby the inverse Mg-CAD association was much stronger
256 s angle-resolved photoelectron spectroscopy, whereby the kinetic energy and angle of photoelectrons e
257 ivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center d
259 nt on murine tibiae to test this hypothesis, whereby the mechanoresponse was quantified experimentall
260 ajor depressive disorder, but the mechanisms whereby the microbiota modulates mood remain poorly unde
261 r vegetables, a hydroxylated SB was observed whereby the N-acyl chains showed a high occurrence of ve
262 One consisted of electrophilic substitution, whereby the nitrosonium ion (NO(+)) was the reactive ele
264 K(-2), respectively, when doped with N-DMBI, whereby the PFs recorded for N-N and A-N are among the h
265 ute an example of preventative medicine use, whereby the phytochemical compounds within plants reduce
266 a novel mechanism of cardiac autoregulation, whereby the previously implied increased propensity for
267 s, ratios, reaction times, and temperatures, whereby the reagents are passed through a copper coil re
268 r results support a unique disease mechanism whereby the reorganization of sub-TAD genome architectur
269 model for outward rectification is proposed whereby the reversal potential determines ion occupancy,
270 Here, we identified the molecular mechanism whereby the RQ mutation increases basal kinase activity
271 separations provided all four stereoisomers, whereby the S-configuration on both generally exerted th
272 an elaborate system for antigenic variation, whereby the sequence of the surface-bound lipoprotein Vl
273 main, specifically interacts with UDP-GlcUA, whereby the side chain of Arg259 H-bonds and forms a sal
274 novel pathway for neural control of movement whereby the somatosensory cortex directly influences mot
275 ogether, these data suggest a two-step model whereby the strength of self-peptide-induced TCR signal
276 Delay discounting describes the phenomenon whereby the subjective value of a reward declines as the
277 ptide selectivity via an indirect mechanism, whereby the TCR sensed the first residue of the peptide
278 en MoSe(2) and CrBr(3) in photoluminescence, whereby the valley polarization of the MoSe(2) trion sta
280 pe 2 diabetes (T2D) is a progressive disease whereby there is often deterioration in glucose control
281 er subtypes, and review potential mechanisms whereby these factors may influence breast carcinogenesi
282 ls drive allergic asthma, yet the mechanisms whereby tissue-resident memory Th2 (Th2 Trm) cells and c
284 owing AngII infusion, suggesting a mechanism whereby TNFR1 activation contributes to hypertension via
285 regulation incorporates a feedback mechanism whereby transcribed RNAs initially stimulate but then ul
286 different 5' Untranslated Regions (5'UTRs), whereby translation of a subset of these isoforms is sti
288 lomere length suggests an alternative method whereby tumor cells escape the critical shortening of te
289 novel autocrine signaling axis in OCCC cells whereby tumor-cell-produced interleukin-6 (IL-6) regulat
290 concentration differences among plant parts whereby twigs had the highest and most variable NSC conc
291 l oligonucleotide-templated reaction (EOTR), whereby two PNA probes - functionalized with an aniline
292 ction using an optogenetic competition assay whereby two targeted light beams independently activate
294 ey undergo ubiquitination, yet the mechanism whereby ubiquitination activates the adaptors and how th
296 pitation, leading to stromatolite formation, whereby viruses directly or indirectly impact microbial
298 s were made in the absence of applied force, whereby we infer that the initial assembly stage of FAs
300 roductive strategy to most eutherian mammals whereby young are born at a highly altricial stage of de