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1 8 weeks induced extensive hepatic fibrosis, whereupon 1D11 dosing was initiated and maintained for 8
2 ication is frequently not achieved with MTD, whereupon a de facto goal of longer-term tumor control i
3 ase E1 to an A/T-rich origin of replication, whereupon a dihexamer forms, resulting in DNA replicatio
4 ors on the cell surface and is internalized, whereupon a pH drop in the endosome (pH approximately 5.
5 e migration of the endo oxo out of the cone, whereupon a second silylation affords the stable U(IV) c
7 nd by triggering RIPK3-mediated necroptosis, whereupon a third T3SS effector, EspL, acts to inactivat
8 to relatively common anionic phospholipids, whereupon a two-dimensional search is initiated by the C
10 , little change was observed until ~15 mass% whereupon an exponential increase in rate occurred until
11 lceramide in live cells or in mouse tissues, whereupon an HPLC assay enabled detection and quantifica
12 ifferent time points for 14 days post injury whereupon animals were killed and cerebral tissue analyz
14 e membrane to the inner part of the cytosol, whereupon another diffusion-trapping mechanism involving
15 -6 days until the development of TIC and MR, whereupon biplane videofluoroscopy and transesophageal e
16 l effect on proMMP-2 activation was observed whereupon blocking ERK1/2 phosphorylation promoted proMM
18 iferative basal cells of mammalian epidermis whereupon cell division, transmembrane planar cell polar
19 niform stimuli trigger a symmetric response, whereupon cells stop and round up; then localized patche
20 lasmic reticulum to the trans-Golgi network, whereupon Cer is converted to sphingomyelin (SM) and oth
21 ected to non-surgical periodontal treatment, whereupon changes in salivary CSF-1, IL-34, and MMP-8 le
24 he Arg(234)-Glu(446) salt bridge is released whereupon conformational changes occur that activate the
25 pillomavirus virion uncoats in the endosome, whereupon conformational changes result in a dissociatio
26 d strategy is described for their synthesis, whereupon cross-conjugated ketones are dibromo-olefinate
27 xin internalization into acidified vesicles, whereupon cryptic segments from within the 1,050-aa tran
28 for ACKR3, was confirmed by binding studies, whereupon CXCR3, CXCR4, and ACKR3 small-molecule ligands
29 until replacement of the final alpha-helix, whereupon cyclopropanation and branching activity compet
30 d of the peptide cation and reagent dianion, whereupon dehydration of the complex via collision-induc
31 domain-general decision-making architecture, whereupon domain-specific information is converted into
32 domain-general decision-making architecture, whereupon domain-specific information is likely converte
33 sm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along microtubule
34 ability of mitotic kinetochores to biorient, whereupon each sister kinetochore forms microtubule (MT)
35 ral specificity to DNA junctions as a dimer, whereupon each subunit cleaves a phosphodiester bond of
36 urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversibl
37 was applied underwater to various substrates whereupon electrostatic complexation, phase inversion, a
39 itical role in bringing Gab2 to FcepsilonRI, whereupon Gab2 becomes tyrosyl-phosphorylated in a Syk-d
40 bitat lead to extinction of the specialists, whereupon generalists invade from the uniform habitat, a
41 ng of the human papillomavirus (HPV) capsid, whereupon host cyclophilins facilitate the release of mo
42 This run-down was prevented by okadaic acid, whereupon ICl,CaMK remained near its maximum value for >
43 omes of hematopoietic and parenchymal cells, whereupon IgG is diverted from degradation in lysosomes
44 LM) images NPCs at protein-level resolution, whereupon image analysis software studies NPC variabilit
45 . aureus to facilitate bacterial attachment, whereupon infected or sterile catheters were stereotacti
46 e then exposed to an N-heterocyclic carbene, whereupon intramolecular Stetter reaction proceeded smoo
47 mice unless the mice were stratified by age, whereupon inverse correlations between memory and Abeta(
48 mine, and N-glycolylglucosamine 6-phosphate, whereupon irreversible de-N-glycolylation of the latter
49 recruited by DNA-binding activator proteins, whereupon it alters chromatin structure to increase prei
50 water from humid air to a saturation point, whereupon it automatically and continually releases fres
51 alize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits DN
52 es phosphorylated in a lck-dependent manner, whereupon it can directly recruit p85 adaptor subunits o
56 s the star to evolve back into a cool giant, whereupon it experiences renewed mass ejection before re
57 tivation by post-translational modification, whereupon it facilitates translation of specific subsets
58 by increases in the cellular AMP:ATP ratio, whereupon it functions to help preserve cellular energy.
59 after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse gene fami
60 lls and released from apoptotic tumor cells, whereupon it interacts with the complement C5a receptor
61 and bystander cells uptake the released Tat whereupon it is endocytosed and internalized into endoly
62 that is induced upon bacterial colonization whereupon it is expressed in the ileum and colon, region
63 consumption may peak between 2015 and 2020, whereupon it is likely to drop by up to 40% until 2050.
65 es in the nucleus after rapamycin treatment, whereupon it primes the phosphorylation of the RNA polym
66 DC subsets efficiently internalize CLEC12A, whereupon it quickly translocates to the early endosomes
67 ium or H2 as the sample was heated to 523 K, whereupon it reacted with oxygen of the support to give
69 d/hook-type proteins before hook completion, whereupon it switches specificity to recognize filament-
70 on with receptor I, which phosphorylates it, whereupon it translocates into the nucleus presumably to
71 solar irradiation during an induction phase, whereupon it undergoes an in-situ restructuring process
72 This intermediate is prone to air oxidation whereupon it undergoes oxidative decarboxylation to yiel
73 erefore subjected ribose to these conditions whereupon it was partially converted to 2-deoxyribose.
74 damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to mit
75 hR recruit the P-TEFb to the cyp1a1 promoter whereupon its kinase subunit phosphorylates the RNA PII
76 generated an average charge state of 5.88+; whereupon, liquid chromatography/electrospray ionization
77 nation removes the repressive DNA structure, whereupon long K48-linked ubiquitin chains are conjugate
78 e transcription factor IRF3 to the promoter, whereupon MafB acted as a transcriptional antagonist, im
79 bridges (as many as 18 for specific binding) whereupon many of the unmasked charged groups hydrate an
83 s triggers the cells to reactivate the virus whereupon most are killed by CTL(IEs) before they can re
84 ctivated with 10 ng/ml LPS for various times whereupon N-acetylcysteine (30 mM) and alpha-tocopherol
85 h as angiotensin II into cellular responses, whereupon Na(+) and Ca(2+) influx and depolarization of
86 ed lysosomes independently of SG condensates whereupon NUFIP2 contributed to mTOR inactivation via th
87 es, NHP-O-B-glucoside and NHP glucose ester, whereupon only NHP-O-B-glucoside formation requires a fu
88 idents of discordance between the two tests, whereupon PCR shows positive results when culture indica
89 ve these chemicals until embryonic day 12.5, whereupon placental samples were collected and compared
90 ited to separate and purify target analytes, whereupon plutonium and neptunium were simultaneously is
91 by rnc) cleaves the pnp untranslated leader, whereupon PNPase represses its own translation by an unk
92 h MPO and PON1 interact during inflammation, whereupon PON1 binding partially inhibits MPO activity,
94 the intact propionic acid proved unworkable, whereupon protected propionate (-CO(2)(t)Bu) and several
95 a GFP plasmid inside the PFC nanoemulsions, whereupon protein expression is achieved selectively whe
97 (2-aminophenyl)naphthalene in CH(3)CN-D(2)O, whereupon regiospecific incorporation of deuterium takes
99 fp1's relocation to the nascent transcripts, whereupon Sfp1 accompanies these mRNAs to the cytoplasm
100 romotes a spread AEC2 KRT17+ basaloid state, whereupon sFRP2 then activates a mature cytokeratin 5+ (
101 FcgammaRIIb to promote SHIP phosphorylation, whereupon SHIP binds to Shc and dissociates from Fcgamma
102 e sites, BRG1 and SIRT1 physically interact, whereupon SIRT1 deacetylates BRG1 at lysine residues 102
103 xylates, with 3-cyanochromones is described, whereupon spirochromenofuran derivatives 5 or 6 were obt
104 d with corticotropin releasing factor (CRF), whereupon SSTR2 exits the compartment on syntaxin-6-posi
105 n=50) or a severe AMI (anterior AMI; n=50), whereupon surviving animals (n=36 moderate, n=33 severe)
106 umpy forms" until entry into the tsetse fly, whereupon TbPTP1 is inactivated and major changes in par
108 olved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine i
109 using the polarizable continuum model (PCM), whereupon the activation of the C-CN bond was found to b
110 (TTF*+) or dicationic (TTF2+) counterparts, whereupon the alpha-CD ring, moves along the dumbbell to
111 Nonspecific ligands rapidly dissociate, whereupon the antibody isomerizes to a nonbinding isomer
112 chanism is a weak base "ion-trapping" effect whereupon the basic drug is concentrated in the acidic f
114 ent network that eventually fills the gland, whereupon the buds shrink in size and become mitotically
116 expansion of the ductal cells as a monolayer whereupon the cells were overlaid with a thin layer of M
117 sine, is then added to the reaction mixture, whereupon the DNA molecules bind electrostatically to th
118 0.06), through the spin transition of iron, whereupon the elastic moduli exhibited up to 25% softeni
119 e CE instrument and homogenizes the eluates, whereupon the eluted blood compounds are automatically i
120 of an intrahelical, fully base-paired oxoG, whereupon the enzyme promotes extrusion of the target nu
121 dc42 localizes the exocyst to primary cilia, whereupon the exocyst targets and docks vesicles carryin
122 localizes the exocyst to the primary cilium, whereupon the exocyst then targets and docks vesicles ca
124 obalamin-colchicine prodrug by cancer cells, whereupon the hydrazone linker undergoes hydrolysis in t
125 plethora of real-world medical data exists, whereupon the increase in data volume comes at the expen
126 on sampling-leads to a randomized algorithm whereupon the kernel induces a probability distribution
127 ome fixed when environment variation is low, whereupon the mean fitness in the population is higher t
128 transiently translocated into the ER lumen, whereupon the NST domain is glycosylated to yield an ina
129 host plasma membrane and enters the cytosol, whereupon the P8 shell disassembles and the polymerase c
130 DMB were soaked in nicotinate mononucleotide whereupon the physiological reaction occurred in the cry
131 ypeptide that is imported into mitochondria, whereupon the pre-sequence is proteolytically removed to
132 naffected until [Zn] increased to 20 microM, whereupon the radius of gyration, RG, values increased f
133 r specifically binds methyl epoxyfarnesoate, whereupon the receptor homodimerizes and changes tertiar
134 iably deprotonated at physiological pH also, whereupon the resultant thiolate nucleophile may play an
135 ith a time constant of approximately 500 fs, whereupon the retinal rapidly twists and encounters a se
136 ites and cis-regulatory motifs is a frontier whereupon the rules governing protein-DNA binding are be
137 ugh the RAC1-NADPH oxidase 1 enzyme complex, whereupon the senescent cells express an antifibrosis ge
138 lar matrix of continuous or discrete values, whereupon the software is designed to rapidly visualise
139 pplied strain until a mechanical yield point whereupon the stress cannot increase anymore, afterward
140 portal that is embedded in the capsid wall, whereupon the structure of the portal and its interactio
141 pattern by 96 hours postfertilization (hpf), whereupon the temporal pattern of neuroD expression in c
142 ion by recruiting Csk to active Src kinases, whereupon their activities and consequent c-myc inductio
143 equired for maintaining the tumor phenotype, whereupon there is a switch from a gene expression progr
144 ss activated to differentiate to adipocytes, whereupon these cells reduce expression of several prote
145 until induced during regeneration or aging, whereupon they become Notch1-dependent and fail to fully
147 ficient at capturing microbes when immature, whereupon they can transform into potent antigen-present
148 activated by an associated tyrosine kinase, whereupon they dissociate from the receptor and dimerize
149 d into a mammalian skin by a sandfly vector, whereupon they encounter increased temperature and toxic
150 nt female changes in habitat use across time whereupon they increasingly relied on steeper post-glaci
151 ent to the plasma membrane by GTP-bound RAS, whereupon they initiate signaling through the MAP kinase
152 d Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells
153 ith temperature up to 15 C in E. verrucosus, whereupon they leveled off (except for lactate dehydroge
155 the chromosomes reached the cell periphery, whereupon they often somersaulted and returned to the ce
156 ken end until they encounter a chi sequence, whereupon they produce a 3' single-stranded DNA tail ont
157 d antigens in the CNS via molecular mimicry, whereupon they produce high levels of GM-CSF, IFNgamma a
158 eria until the insect tissues are exhausted, whereupon they reassociate and leave the cadaver in sear
159 y activation of endogenous adenylyl cyclase, whereupon they receive stimulation from adjacent PE via
160 r onto the biomolecule-containing particles, whereupon they were sampled into the inlet of our spectr
161 ity to efficiently infect immature human DC, whereupon those DC were observed to undergo rapid activa
162 by piperidine and piperazine substitutions, whereupon three compounds were identified as promising c
163 cells are pivotal in the reaction to injury, whereupon, under ideal conditions, repair and resolution
164 ural descriptors updated from this analysis, whereupon we identified and confirmed the first intrinsi