ライフサイエンスコーパス: whole blood

1 encounter during infection, in tumors and in whole blood.

2 y and quantitatively even when challenged in whole blood.

3 fluids, including urine, saliva, serum, and whole blood.

4 154-induced expression of CD69 on B cells in whole blood.

5 from hundreds of different microorganisms in whole blood.

6 RNAs (lncRNAs), LINC02555 and AC079630.4, in whole blood.

7 for protein biomarker detection in a drop of whole blood.

8 orks well both in standard conditions and in whole blood.

9 selective electrochemical output directly in whole blood.

10 f sepsis-causing Candida species directly in whole blood.

11 of inhibitory substances, such as serum and whole blood.

12 glucose in real samples using only 3 muL of whole blood.

13 capture CD4(+) T cells from a 30 muL drop of whole blood.

14 refore proposed to be released from cells in whole blood.

15 is assay on type 1 fibrillar collagen, using whole blood.

16 ssayed in buffer as well as 5% diluted human whole blood.

17 n-binding adhesin, increases GBS survival in whole blood.

18 cial cell from a mixture cell sample such as whole blood.

19 cular interaction led to improved potency in whole blood.

20 in vivo half-life and suboptimal potency in whole blood.

21 in clot formation in real time using flowing whole blood.

22 human CF vs. non-CF samples from airway and whole blood.

23 les from model organisms and patient-derived whole blood.

24 ns, as demonstrated in spiked milk and human whole blood.

25 measurements performed directly in undiluted whole blood.

26 3.9 muL plasma) was achieved for a sample of whole blood (30% hematocrit) in 10 min.

27 In mouse whole blood, ~44 eoxPL molecular species formed within m

28 After a simple 1:1 dilution of plasma and whole blood, a quantitative detection with good recoveri

29 e multiethnic DNA methylation data sets from whole blood, a total of 567 SZ cases and 594 nonpsychiat

30 Decreased TNF-alpha production in whole blood after ex vivo LPS stimulation indicates supp

31 ompared altered transcripts in the liver and whole blood after exposure to environmentally relevant c

32 Finally, blood-derived macrophages, whole blood and brain tissue from patients with C9-ALS/F

33 onfirmed that monocytes rapidly expose TF in whole blood and further demonstrate that platelet P-sele

34 nt prediction scores of gene expression from whole blood and liver tissue and assessed them for assoc

35 (TWAS) based on imputed gene expression from whole blood and liver.

36 the quantification of formaldehyde in human whole blood and of creatinine in saliva, and also for th

37 IFN-gamma and TNF-alpha ELISpot assays on whole blood and PBMCs were undertaken in control, critic

38 diabetes, we observed a correlation between whole blood and plasma mtDNA levels, indicating that the

39 orter (mtsA) are crucial for GBS survival in whole blood and plasma, (ii) gene W903_1820, encoding a

40 way gene aroA is essential for GBS growth in whole blood and plasma, and (iv) deletion of srr1, encod

41 41 genes that are required for GBS growth in whole blood and plasma, respectively.

42 common set of 29 genes was required in both whole blood and plasma.

43 nes required for bacterial survival in human whole blood and plasma.

44 9)O , HNO, and OH, but can detect ONOO(-) in whole blood and plasma.

45 han 30 min, including direct measurements in whole blood and saliva samples.

46 ls on pDCs, and IFN-responsive biomarkers in whole blood and skin biopsies were measured.

47 imultaneously analysed the transcriptomes of whole blood and spleen over 12 days of erythrocytic stag

48 creased stability in DBS and DUS compared to whole blood and urine at all storage temperatures and ti

49 Subjects provided whole blood and urine, which were processed and stored a

50 cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls

51 (TBP) panel using 379 retrospective, remnant whole-blood and synovial fluid specimens previously subm

52 ntrations in the gold standard (i.e., venous whole blood) and that DBS is a suitable tool for assessi

53 We evaluated whether basophil activation in whole blood, and plasma levels of peanut-specific immuno

54 oRNAs (miRNAs) in serum, plasma, exosome and whole blood are dysregulated in various types of disease

55 ncept application, we isolated bacteria from whole blood as demanded for rapid sepsis diagnosis where

56 ventional malaria RDTs and requires 5 muL of whole blood as sample.

57 Here we conduct RNA-sequencing on whole blood as well as on ventricular and lumbar cerebro

58 A whole-blood assay was used to interrogate in vitro cytok

59 ith high potency on enzymatic, NanoBRET, and whole blood assays, improved metabolic stability, and pr

60 l diagnosis of sepsis starting directly from whole blood, assays based on target-specific polymerase

61 these changes might be related to phenotype, whole blood at 30 days was challenged with lipopolysacch

62 Blood transfusion (whole blood at a target volume of 20 mL per kg) was admi

63 Complete (>=90%) CD40 receptor occupancy on whole blood B cells was observed at plasma concentration

64 LP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshir

65 e potential to be broadly utilized for other whole blood biomolecule analyses in POC testing applicat

66 Interestingly, whole blood, but not plasma clots from SCD patients, was

67 s also measured in the presence of serum and whole blood by MIC and minimal bactericidal concentratio

68 In whole blood, CC exposure induced a time- and concentrati

69 Sickle trait whole blood clots demonstrated an intermediate phenotype

70 Human whole blood clots were mounted in a flow system and visu

71 s shown by in vitro fluorogenic activity and whole blood clotting assays.

72 We performed RNA sequencing on whole blood collected from 88 individuals at the time of

73 Whole blood collected from EHS mice showed markedly atte

74 Whole blood, collected after 30 days of recovery from EH

75 Whole blood concentrations of 13.5 umol/L (95% credible

76 f two datasets (murine splenocytes and human whole blood) confirmed its accuracy in identifying even

77 owed an anti-inflammatory phenotype in human whole blood, confirming their cellular target engagement

78 In addition, incubating IdeS in whole blood containing 5B9 or HIT plasma samples led to

79 gregometry), conventional coagulation tests, whole blood counts, and platelet flow cytometry were per

80 All venous and fingerprick whole blood CrAg LFA tests were positive among 30 hospit

81 9 cells with parasite antigen stimulation in whole-blood cultures.

82 Blood cell populations and ex vivo innate whole blood cytokine responses were measured at baseline

83 years) and tested for specificity in a large whole blood dataset (n = 1175, ages = 28 to 98 years).

84 Next-generation genetic sequencing of whole blood-derived DNA in humans showed that clonal exp

85 Whole-blood dihydroceramides and ceramides were decrease

86 and Nutrition (EPIC)-Norfolk cohort, we used whole blood DNA collected at baseline, up to 11 years be

87 Reduced whole blood DNA methylation at 21 CpG sites was signific

88 ormed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional d

89 first epigenome-wide methylation analysis of whole blood DNA samples from a cohort of septic and nons

90 Methylation in whole blood DNA was measured at [Formula: see text] usin

91 5-hydroxymethylating activity, resulting in whole-blood DNA hypermethylation.

92 ods to estimate the cell type proportions in whole blood DNAm samples are only appropriate for one te

93 2-year period, inter-donation intervals for whole blood donation can be safely reduced to meet blood

94 Participants were whole blood donors who agreed to continue trial particip

95 p to 40 mL/kg of cold-stored, uncrossmatched whole blood during initial hemostatic resuscitation.

96 ipheral blood lymphocyte subpopulations, and whole blood EBVd were determined at months 1, 3, and 6.

97 ed the ability of a (to our knowledge) novel whole blood ELISpot assay and compared it with a more tr

98 The whole blood ELISpot assay offers a significant advance i

99 However, the whole blood ELISpot assay revealed that nonmonocyte, mye

100 Whole blood ELISpot was easy to perform, and results wer

101 anization recommends transfusion of 20 ml of whole-blood equivalent per kilogram of body weight for a

102 immediate transfusion with 20 ml or 30 ml of whole-blood equivalent per kilogram of body weight, as d

103 l group), in which transfusion with 20 ml of whole-blood equivalent per kilogram was triggered by new

104 y statistics from the AFGen 2017 GWAS; (2) a whole blood EWAS (Epigenome-Wide Association Study) of A

105 uring, and after OIT, basophil activation in whole blood ex vivo in response to peanut stimulation, a

106 a significant reduction in %ML when added to whole blood ex-vivo.

107 200 cells/mm(3)), CrAg LFA testing of venous whole blood, fingerprick capillary blood, and urine had

108 An immune cell profiling was performed by whole blood flow cytometry: CD4(+) T cells, Th2 cells (C

109 It is calculated from whole blood folate (WBF), serum folate (SFOL), and hemat

110 ent of molecular diagnostics to be used with whole blood for detection of bloodstream microorganisms

111 m melatonin sampled every 2 hours along with whole blood for RNA isolation over 24 hours.

112 n CD1 mice made coagulopathic by exchange of whole blood for washed red cells.

113 We tested 24 prototype devices with whole blood from 10 volunteers, various input volumes (4

114 ere, we compared DNA methylation profiles in whole blood from 120 HIV-infected children on antiretrov

115 hanges in age-related microRNAs by analyzing whole blood from 1334 healthy individuals.

116 Here we obtained whole blood from 156 patients with sepsis and 82 healthy

117 Whole blood from 23 controls (HC) and 20 patients with d

118 AS of >415 thousand CpG methylation sites in whole blood from 4170 individuals and map 4.7 million ci

119 We stimulated whole blood from active TB patients and compared to LTBI

120 mpaired production of IFN-gamma and IL-10 by whole blood from beta-thalassaemia patients upon stimula

121 dulator of immune function, was increased in whole blood from beta-thalassaemia patients, either with

122 nd decreased bacterial clearance activity of whole blood from healthy controls and beta-thalassaemia,

123 tome in multiple sample types, including (i) whole blood from hematopoietic cell transplant (HCT) rec

124 In this study, whole blood from non-metastatic NSCLC patients was colle

125 We perform RNA sequencing in whole blood from the same individuals at ages 70 and 80

126 -NMR based metabolomic analysis of serum and whole-blood from luteinizing/follicle-stimulating (LH/FS

127 ll phenotypes (range 0.19 to 3.54 fold), and whole blood gene expression (stable for > 20 K genes)-wi

128 Both raw whole blood gene expression data and informative gene mo

129 When compared with whole blood gene expression data from seven external dat

130 sed techniques are more suitable to quantify whole-blood gene expression compared to microarrays, as

131 Multiple whole-blood gene-expression studies have defined sepsis-

132 paration-free point-of-care (POC) device for whole blood glucose colorimetric detection.

133 The whole blood group had faster time to resolution of base

134 3 (0-8); P = 0.03] were administered to the whole blood group versus component group.

135 moking-associated DNA methylation changes in whole blood have been reported by many Epigenome-Wide-As

136 measure (to within 1% Hct of nominal values) whole blood Hct in ~10-20 s after sample dispensing.

137 Whole blood IGRA accurately distinguished between conval

138 contributes significantly to GBS survival in whole blood, (iii) the shikimate pathway gene aroA is es

139 t activation.Objectives: This study compared whole-blood impedance platelet aggregation in children w

140 ased expression of S100A8 and S100A9 mRNA in whole blood in human TB progressors when compared with n

141 Transfusion of whole blood in pediatric trauma patients is feasible and

142 RNA-Seq of whole blood in the Huntington's disease subjects found t

143 vation by both species, we performed ex vivo whole-blood infection assays and confrontation assays wi

144 asma curve (SUV(AUC,PP)), and area under the whole-blood input curve (SUV(AUC,WB)); and SUV(BW) corre

145 Electrolyte analysis in whole blood is demonstrated without suffering from optic

146 sorting and flow stretching design in which whole blood is sorted and fluid elements are stretched u

147 The separation of plasma from whole blood is the first step in many diagnostic tests.

148 lated phenotypes and thrombosis potential in whole blood, isolated platelets, and animal models of ar

149 ukocytes decreased with stress, yet maternal whole blood leukocyte analysis indicated monocytosis and

150 tudy, we perform RNA sequencing (RNA-Seq) on whole blood leukocyte samples taken from 16 patients wit

151 Immunophenotyping of whole-blood leukocytes was performed in patients upon ho

152 In the porcine MI model, whole-blood levels of QSOX1 and PLBD1 related to neutrop

153 n profile by NanoString platform to identify whole blood markers that can distinguish active TB from

154 ing several benefits compared to traditional whole blood methods.

155 arette consumption variation was captured by whole blood methylation array data.

156 entrations in the fM range, from unprocessed whole blood minuscule samples of only a few microliters.

157 nificance than cell abundance changes to the whole blood miRNA profile.

158 Computational deconvolution of whole-blood miRNAs into blood cell types suggests that c

159 included securing adequate potency in human whole blood, navigation away from Ames mutagenic amine f

160 We compared transcriptomic profiles of whole blood obtained from Ugandan children with acute CM

161 ase correlations with gene expression in the whole blood of more than 500 subjects from 3 racial/ethn

162 oinflammatory cytokine production ex vivo in whole blood of patients with alcoholic hepatitis.

163 nce of red blood cell (RBC) deformability in whole blood on platelet margination is investigated usin

164 depleted sequencing libraries for RNA-Seq of whole blood, one of which is also designed to deplete hg

165 000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes using a commercial array.

166 ally expressed genes in 2 or more studies of whole blood or peripheral blood mononuclear cells with c

167 microarray or RNA sequencing measurements on whole blood or peripheral blood mononuclear cells.

168 Whole blood or plasma from healthy volunteers was incuba

169 se for bioanalysis in complex milieu such as whole blood or serum.

170 s-links in the insoluble matrix component of whole-blood or plasma-fibrin clots and in in vivo thromb

171 In whole blood, PAR1-AP-triggered TF exposure required P-se

172 t can help as an important functional add-on whole-blood phenotyping.

173 ns between MOFs and biological milieu, human whole blood plasma was selected as a model.

174 assess metabolite-corrected radioactivity in whole blood, plasma, and urine.

175 rning, a fasting blood sample was taken, and whole-blood platelet aggregation was measured.Measuremen

176 nd easy-to-use toy is sufficient to separate whole blood, producing a plasma yield rate and purity of

177 ble isotope (delta(13) C) analysis of thrush whole blood, provides favourable pre-migratory condition

178 background populations (i.e., MeHg in venous whole blood ranged from 0.2 to 3 mug/L with a median val

179 Whole blood recipients (2016-2019) were compared to a pr

180 of the IL-1 receptor antagonist anakinra to whole blood reduced staphylococcal killing, supporting a

181 riptome-wide association study (TWAS) with a whole blood reference panel identified two significant l

182 e developed UCNP-LF test was validated using whole blood reference panels containing samples at diffe

183 igher for InHg (1.9 and 1.1 mug/L in DBS and whole blood, respectively) than MeHg (0.3 and 0.2 mug/L

184 ely) than MeHg (0.3 and 0.2 mug/L in DBS and whole blood, respectively).

185 7-0.53) of hemaPEN, 3 mm DBS subpunches, and whole blood revealed a limited hct dependence (<=7% conc

186 o analysis of inflammatory disease patients' whole blood revealed strong correlation of type I IFN sc

187 We performed next generation sequencing on whole blood ribonucleic acid obtained within six hours o

188 Gene expression from whole blood RNA was assessed in the trial participants.

189 Whole blood RNA-Seq analysis demonstrates a distinct imm

190 Whole blood RNA-Seq was performed for 20 samples from ch

191 y cohort with acute MI (n=143) and performed whole-blood RNA profiling at different time points.

192 rval, 0.129-0.776; P = 0.012).Conclusions: A whole-blood RNA signature of PAH, which includes RNAs re

193 We generated whole-blood RNA-seq from 94 individuals with undiagnosed

194 ciples and the performance of the sensors in whole blood, saliva, urine or interstitial fluids in det

195 orting device to purify Candida species from whole blood sample for enhanced molecular diagnosis of b

196 f plasma as a dried plasma spot (DPS) from a whole blood sample in less than 6 min.

197 TM) Plasma Separation membrane to threat the whole blood sample, filter paper to load the reagents ne

198 tients and 46 healthy control subjects), and whole blood samples (n = 498) from the Unbiased Biomarke

199 Blood lead concentrations were measured in whole blood samples among 1,548 participants (91% of coh

200 sensors have a turnaround time of 6 min for whole blood samples and 3 min for plasma samples regardl

201 in cytokines in serum and in LPS-stimulated whole blood samples and leukocyte membrane fatty acid pr

202 Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a

203 We analyzed whole blood samples from M. tuberculosis-infected South

204 Whole blood samples from patients treated for symptomati

205 ried out a validation study using paired DBS-whole blood samples from venous and capillary sources fr

206 n profiles for cellular heterogeneity within whole blood samples had a detrimental effect on the clas

207 heir practical application in the testing of whole blood samples in the point-of-care settings.

208 mina 450 K DNA-methylation array was used on whole blood samples of 340 Ghanaian adults residing in t

209 Viral RNA was not detected by PCR in whole blood samples of females from any intravaginal exp

210 SClow/CCR3pos) as outcome was performed with whole blood samples stimulated with allergen extracts of

211 e used volume-controlled (40 muL) paired DBS-whole blood samples to develop an analytical method that

212 h well-oriented antibodies was premixed into whole blood samples to interact with lymphoma cancer cel

213 RNA expression in 1,090 whole blood samples was determined for 103 target genes

214 Whole blood samples were analysed by real-time PCR for B

215 then calculating hematocrit (Hct) values of whole blood samples with nominal content of 28%, 35%, 40

216 First, on testing of 2,754 contrived whole blood samples, with or without spiked microorganis

217 ive detection in spiked plasma as well as in whole blood samples.

218 mfalciparum lactate dehydrogenase (PfLDH) in whole blood samples.

219 f remission compared with non-remission from whole blood samples.

220 nsitive detection of protein biomarkers from whole blood samples.

221 were validated against actual cell counts in whole blood samples.

222 it-of-detection at 10 CFU/muL for 5% diluted whole blood samples.

223 MV-qPCR assay conducted on DNA isolated from whole blood samples.

224 dardized mean difference across 4 studies of whole-blood samples (n = 1567 cases, n = 954 controls),

225 sis.Methods: RNA sequencing was performed on whole-blood samples from 359 patients with idiopathic, h

226 us (EBOV) and other potential pathogens from whole-blood samples from 70 patients with suspected Ebol

227 U38, which identified U38 mRNA in all tested whole-blood samples from patients with concurrent HHV-6B

228 tion-real-time quantitative PCR (RT-qPCR) in whole-blood samples from subjects without HHV-6B plasma

229 Fingerstick whole-blood samples were collected from participants in

230 s performed using PBMC fraction from patient whole-blood samples.

231 we performed targeted proteomics (N=625) of whole blood sera from patients with American College of

232 Whole blood, serum, and urine aliquots were prepared and

233 Aliquots of whole blood, serum, and urine from clinically characteri

234 vels differing between cases and controls in whole blood (SH2B3, SPSB1, RP11-747H7.3, RP4-737E23.2) a

235 exchange transiently reversed resistance of whole blood sickle clots to fibrinolysis, in part by dec

236 A collection of 530 whole-blood specimens collected from patients being eval

237 those without asthma, quantified plasma and whole-blood sphingolipids, and assessed sphingolipid de

238 between nonallergic childhood asthma, lower whole-blood sphingolipids, and asthma-risk 17q21 genotyp

239 From 10 uL of whole blood spiked with NS1 antigen, our biosensor relia

240 s macaques with ART restored CD4+ T cells in whole blood, spleen, and bronchoalveolar lavage (BAL) fl

241 ulture offers a next-generation solution for whole blood stimulation and immunomonitoring with the po

242 t TruCulture, an immunomonitoring method for whole blood stimulation, could discriminate active disea

243 Ex vivo whole blood stimulations were performed with matched con

244 nt killing assays, peritoneal macrophage and whole blood stimulations, phagocytosis assays and an in

245 weight (SUV(BW)), lean body mass (SUV(LBM)), whole blood (SUV(WB)), parent plasma activity concentrat

246 Whole-blood TBR provided an excellent correlation with K

247 cant associations in T cells, monocytes, and whole blood that replicated findings from a past methyla

248 Upon perfusing the vascular lumen with whole blood, the microengineered capillary wall protecte

249 When applied to patient DNA extracted from whole blood, this new RPA assay was able to detect 100%

250 concentrations ranging from 100% (undiluted whole blood) to 12.5% (diluted concentrations).

251 We observed a distinct whole blood transcriptional profile, as well as differen

252 We integrated whole-blood transcriptome and CD4(+) T-cell epigenome pr

253 The whole blood transcriptomes of moderate-to-severe adult a

254 o human immune responses to CPS, we profiled whole-blood transcriptomes by RNA-seq before and during

255 Metabolomic data were integrated with whole blood transcriptomic data for each participant at

256 We examined if a whole blood transcriptomic signature measured soon after

257 Whole blood transcriptomics provides a unique opportunit

258 By integrating whole-blood transcriptomics, flow-cytometric analysis, a

259 rf2-related and erythropoiesis signatures by whole-blood transcriptomics.

260 Compared to component transfusion, whole blood transfusion results in faster resolution of

261 Our findings suggest that whole blood transfusion was associated with improved sur

262 void and treat anemia and the reemergence of whole blood transfusion.

263 ation test was performed using the patient's whole blood treated with the reagent above, which showed

264 However, whole blood trough concentrations commonly utilized in T

265 just calcineurin inhibitor dose according to whole blood trough level, even though it overestimates t

266 ome-Wide Association Study) of AF; and (3) a whole blood TWAS (Transcriptome-Wide Association Study)

267 of TBI on gene expression changes in murine whole blood using RNAseq analysis, gene ontology and net

268 in the saliva of gB vaccinees, though not in whole blood, vaginal fluid, or urine.

269 D was not directly related to alterations in whole blood viscosity and the shear stimulus.

270 ion reduced Hct by 18 +/- 2% (P < 0.001) and whole blood viscosity by 22 +/- 5% (P < 0.001).

271 Whole blood VL was determined by real-time polymerase ch

272 device allows bedside plasma separation from whole blood, volume metering, depletion of albumin, prot

273 The post-transfusion INR was decreased in whole blood vs component cohort [median (IQR) 1.4 (1.3-1

274 sources (venous vs capillary) and matrices (whole blood vs DBS).

275 good recoveries of 79% in plasma and 74% in whole blood was achieved.

276 ned at 8 time points over an 8-h period, and whole blood was counted on a NaI gamma-counter.

277 hen (paracetamol) in plasma and finger-prick whole blood was fabricated.

278 For Allo-CFC, normal whole blood was incubated with third-party peripheral bl

279 DNA from whole blood was interrogated using the MethylationEPIC o

280 Also, when whole blood was perfused in von Willebrand factor-coated

281 fter isovolumic haemodilution, where ~20% of whole blood was removed and replaced with 5% human serum

282 ing isovolumic haemodilution, whereby 20% of whole blood was removed and replaced with 5% human serum

283 Whole blood was stimulated using the QuantiFERON-TB Gold

284 unt, <=200/mul) receiving CD4 count testing, whole blood was tested for CrAg by CryptoPS and the IMMY

285 Whole blood (WB) and platelet-rich plasma (PRP) were per

286 Whole blood (WB) is the most common DNA source of many m

287 was added to platelet-poor plasma (PPP) and whole blood (WB), as well as purified and fluorescently

288 ls of betahydroxybutyrate (BHB) in serum and whole-blood (WB) of prolactinomas (0.481 +/- 0.211/0.329

289 s, glia, bulk brain, T cells, monocytes, and whole blood were enriched for genes supported by genome-

290 Twenty-eight children who received whole blood were matched to 28 children who received com

291 (sepsis-2 definition), BC and PCR/ESI-MS on whole blood were positive in 14.6% and 25.6% of cases, r

292 nduced activation in platelet-rich plasma or whole blood whereas LPS(SM) and LPS(RS) inhibited platel

293 intra-sample cellular heterogeneity, such as whole blood which is a convolution of DNAm profiles acro

294 lly relevant concentrations within 13 min in whole blood, which is faster than other approaches requi

295 Exogenous stimulation of whole blood with bacterial LPS emulated some but not all

296 nt of blood sugar levels in a single drop of whole blood with excellent recovery is presented.

297 latform capable of isolating rare cells from whole blood with high purity.

298 e concept with samples in buffer and diluted whole blood with limits of detection of 0.793 pM and 1.5

299 carcinoembryonic antigen (CEA) in 30 muL of whole blood with the assistance of a portable Raman read

300 When stimulating either human or mouse whole blood with thrombin, we saw a significant decrease