ライフサイエンスコーパス: whole-genome

1 for genetic generalized epilepsy across the whole genome.

2 ains and losses at the same areas across the whole genome.

3 scribed spacer regions, and for 4 others the whole genomes.

4 The isolates were sequenced (whole genome, 16S, rpoB) by the Centers for Disease Cont

5 ances of two commercially available kits for Whole Genome Amplification (WGA), PicoPLEX and RepliG we

6 Whole-genome analysis showed that O-glycosylated protein

7 e safety assessment of microbial strains via whole-genome analysis was proposed.

8 Whole genome and exome sequencing followed by Sanger con

9 le myeloma evolution in a large cohort of 89 whole genomes and 973 exomes.

10 sing 84,729,690 somatic mutations from 4,645 whole-genome and 19,184 exome sequences that encompass m

11 evaluate novel CHD gene candidates, based on whole-genome and iPSC RNA sequencing of a HLHS family-tr

12 This is particularly challenging when large whole-genome and metagenome databases are involved.

13 noncoding variants in cancer by integrating whole-genome and transcriptome sequencing data from a si

14 l relapses, and 11 longitudinal pairs) using whole-genome and whole-exome sequencing reveals that chr

15 This whole-genome approach introduces potential candidate gen

16 on in read-level CpG methylation patterns in whole genome bisulfite sequencing data.

17 Analysis of both human and mouse whole genome bisulfite sequencing datasets reveals read-

18 ead-level CpG methylation patterns in tissue whole genome bisulfite sequencing libraries reflect cell

19 Unbiased omics profiling, such as whole genome bisulfite sequencing, reduced representatio

20 les, retaining half of each male's semen for whole genome bisulfite sequencing.

21 e leverage whole-genome sequencing (WGS) and whole-genome bisulfite sequencing (WGBS) data on populat

22 By studying whole-exome sequencing and whole-genome bisulfite sequencing of cell free DNA (cfDN

23 romatin immunoprecipitation with sequencing, whole-genome bisulfite sequencing, and chromosome confor

24 od based on summarizing sequenced reads from whole-genome clinical samples and cataloging them in "In

25 ogical advances have enabled the analysis of whole genomes, comprising thousands of tumours across po

26 e Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome

27 he genetic basis for phenotypic evolution as whole genomes continue to populate the tree of life.

28 rted tumor fractions from these samples with whole-genome copy-number variant (CNV), whole-exome sequ

29 LITAF-deficient cells, a second, subsequent whole-genome CRISPR-Cas9 screen identified the LITAF-lik

30 the ever-increasing quality and quantity of whole-genome data, evolutionary insight into origins of

31 rocesses, we studied 3,000 tumor-normal-pair whole-genome datasets from 42 different human cancer typ

32 Whole-genome deep sequencing-based analysis has revealed

33 ioral and physiological differences, but the whole-genome divergence between them was unexplored.

34 Whole-genome doubling (WGD) is a prevalent event in canc

35 st recurrent losses probably occurred before whole-genome doubling, that was found as a clonal event

36 Although whole genome duplication (WGD) has been suggested to fac

37 A recent whole genome duplication in the Maleae/Pyreae tribe (wit

38 Genetic redundancy resulting from whole genome duplication is thought to facilitate evolut

39 Whole-genome duplication and tandem duplication events h

40 dosage balance operate immediately following whole-genome duplication and that duplicate gene retenti

41 Among the genes retained from this whole-genome duplication are homologues of genes that re

42 We also provide evidence for a whole-genome duplication event in the lineage leading to

43 er lily transcriptomes reveal a Nymphaealean whole-genome duplication event, which is shared by Nymph

44 nalysis with yeast paralogs derived from the whole-genome duplication event.

45 The prevalence and recurrence of whole-genome duplication in plants and its major role in

46 MSH5B and MSH4D following hybridization and whole-genome duplication may have occurred due to gene r

47 We uncovered a whole-genome duplication that occurred in the Jurassic,

48 Finally, we confirmed an ancient whole-genome duplication that took place in a common anc

49 Due to a teleost-specific whole-genome duplication, A. burtoni possess two androge

50 cots are sister lineages and showed that two whole-genome duplications occurred in the Trochodendrale

51 y vertebrate evolution was shaped by ancient whole-genome duplications, the number, timing and mechan

52 Employing whole-genome, exome, transcriptome, and methylation sequ

53 T)], TERT mRNA expression by RNA-sequencing, whole-genome/exome sequencing, and clinical covariates i

54 Time-resolved whole genome expression profiling revealed that RNLs and

55 research is the first study to characterize whole-genome expression in fibroblast cells obtained fro

56 The genes most positively weighted on the whole-genome expression map colocated with schizotypy-re

57 d game theoretic centrality to rank genes on whole genomes from 756 multiplex autism families.

58 eassuring de facto positive controls for our whole-genome gene expression discovery approach.

59 nd model organisms including body images and whole-genome gene expression profiles.

60 We generated whole-exome sequencing and whole-genome genotyping data to identify rare, pathogeni

61 an lung fibroblast), and (iii) budding yeast whole-genome Hi-C data at a single restriction cut site

62 hoblastoid cell line), (ii) 40-kb resolution whole-genome Hi-C data from IMR90 (human lung fibroblast

63 closely related to cheese sauce isolates by whole-genome high-quality single-nucleotide polymorphism

64 Here we analyse a sampling of 102 whole genomes including >2.6 million protein sequences.

65 lity of the new implementation by building a whole-genome index of the 5008 haplotypes of the 1000 Ge

66 Surveillance of RVA at whole genome level will enhance further assessment of va

67 ntire protocol from tissue reception through whole-genome library generation can be accomplished in a

68 identification of disease-relevant STRs from whole-genome long-read sequencing data on patients with

69 ip strength in men, suggesting blood-derived whole genomes may also provide a biologic measure of age

70 The web application includes >80 whole-genome metabolic reconstructions of diverse organi

71 MP) using methylation profiles only, and (3) whole-genome/methylome prediction (WGMP) with combining

72 ations including common oncogenic mutations, whole genome mutations and copy number variations betwee

73 4 microbiopsies), whole-exome (n = 655), and whole-genome (n = 88) sequencing.

74 By sequencing the whole genome of MERS-CoV from persistently infected bat

75 Here, we compare whole genomes of 11 wild-caught individuals of the bdell

76 We retrospectively sequenced the whole genomes of 145 M. abscessus isolates from 62 patie

77 a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of

78 Here, we sequenced the whole genomes of 24 individual pigs representing 22 bree

79 We sequenced and compared the whole genomes of 40 individual mosquitoes from two locat

80 Here we sequenced whole genomes of 632 colonies derived from single bronch

81 ely sampled organisms using the sequences of whole genome, of whole transcriptome, and of whole prote

82 m 1,188 donors of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Ca

83 Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Ca

84 Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Ca

85 d 993 tumors from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium with previously identif

86 Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium(2) of the International

87 part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole

88 part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole

89 part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium.

90 nome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and un

91 et from the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) project to demonstrate that-in add

92 Whole genome phylogeny showed that most of the strains a

93 ompared in terms of prediction accuracy: (1) whole-genome prediction (WGP) using SNP marker informati

94 e on Arabidopsis thaliana mutation, studying whole genome profiles of mutation accumulation (MA) line

95 lution test alternative to MAPREC, producing whole-genome profiles to evaluate OPV production consist

96 Using whole-genome quantitative gene expression as a model, he

97 We compare the method via simulation to a whole-genome regression approach (LEMMA) for estimating

98 odeling approach, and a separate analysis of whole-genome replication profiling, here we show that th

99 The whole genome resequencing analyses have now been extende

100 This work demonstrates the utility of whole genome resequencing as a cost effective, direct, a

101 reference genome for blackcaps and obtained whole genome resequencing data from individuals across i

102 The region was discovered through whole genome resequencing focused on chicken chromosome

103 Using whole-genome resequencing data, we identified variants i

104 ical traits and 136,429 SNP markers from the whole-genome resequencing platform.

105 on de novo genome assemblies and additional whole-genome resequencing, we use phylogenomic and popul

106 Whole-genome RNA-sequencing analysis of embryonic day (E

107 We performed a high-throughput whole-genome RNAi screen to identify novel inhibitors of

108 in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences.

109 he first case of SNP variations in the mouse whole genome scale.

110 We performed whole genome sequence (WGS) analysis of lung function an

111 Whole genome sequence (WGS) data could transform our abi

112 Whole genome sequence analysis was performed on a subset

113 cal Genome Reference Bank (MGRB), comprising whole genome sequence and phenotype of 2570 elderly Aust

114 likely-gene-disrupting variants encoded from whole genome sequence data to ASD; however, this previou

115 expensive to obtain genotype data and indeed whole genome sequence data, the question then becomes to

116 Recent studies have uncovered whole genome sequence of SARS-CoV-2 (causing COVID-2019)

117 The combination of near to real-time whole-genome sequence analysis and epidemiology resulted

118 Whole-genome sequence analysis demonstrated the Houston

119 The growth of ESBL-E was quantified and a whole-genome sequence analysis was performed.

120 ol on microbial strain safety assessment via whole-genome sequence analysis.

121 We sought to comprehensively investigate whole-genome sequence and RNA sequence from human bronch

122 Examining whole-genome sequence data describing a chronic case of

123 We analyzed whole-genome sequence data from 165 primary membranoprol

124 in the rhesus macaque (Macaca mulatta) using whole-genome sequence data from 32 individuals in four l

125 Finally, we integrate this information with whole-genome sequence data from 375 individual mosquitoe

126 g of a rapid-flowering mutant was done using whole-genome sequence data from bulked DNA from a segreg

127 ces per submission and the analysis of a new whole-genome sequence will take approximately 1 min.

128 d with conventional RT-PCR based methods and whole genome sequenced using the Illumina MiSeq platform

129 However, working with whole genomes sequenced over several years in different

130 Applying SigProfilerSimulator to 2144 whole-genome sequenced cancers reveals: (i) that most do

131 lating agents, as well as in whole-exome and whole-genome-sequenced tumors identified signatures high

132 The increasing availability of cancer whole genome sequences and functional genomics data from

133 ived from comprehensive sets of AMR genes or whole genome sequences and may not be suitable for use w

134 tic resistance genes from various formats of whole genome sequences based on the CARD or ResFinder da

135 investigations with analysis of mumps virus whole genome sequences from 201 infected individuals, fo

136 Using 76 whole genome sequences representing 21 orders spanning m

137 The availability of whole genome sequences was expected to supply essentiall

138 The comparison of whole-genome sequences across 10 additional Formica spec

139 Here we analyse high-coverage whole-genome sequences from 97,691 participants of diver

140 Here we analyse whole-genome sequences of males from native populations

141 However, experimentally determining the whole-genome sequences of many diverse organisms was pra

142 Whole-genome sequences of seven phage susceptible A. bau

143 We used whole-genome sequences to compare genomes from periods b

144 into lineages and sublineages based on their whole-genome sequences, but little is known about the im

145 nomic links using Mycobacterium tuberculosis whole-genome sequences.

146 Whole genome sequencing (30X) and digital droplet PCR (d

147 ility, Multilocus Sequence Typing (MLST) and Whole Genome Sequencing (WGS) analysis.

148 Bulk whole genome sequencing (WGS) enables the analysis of tu

149 We present SNVs discovered by whole genome sequencing (WGS) of three Moroccans.

150 present here an unbiased approach combining whole genome sequencing (WGS) with patient-induced pluri

151 Whole genome sequencing (WGS), on the other hand, allows

152 ethods, but there are plans for implementing whole genome sequencing (WGS).

153 rsity and characterization were performed by whole genome sequencing (WGS).

154 Whole genome sequencing alerted us to the existence of g

155 st-line approach, followed by a more refined whole genome sequencing analysis.

156 n testing for five lipid traits in two UK10K whole genome sequencing cohorts, hypothesizing that cis-

157 Surveillance strategies based on whole genome sequencing could help with the early identi

158 Whole genome sequencing coupled with an outbreak-strain-

159 Whole genome sequencing data did not identify a strain g

160 q and RNA-seq, and then integrate these with whole genome sequencing data from 232 OCs.

161 Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38

162 Whole genome sequencing data from cases and controls wer

163 Using the GTEx whole genome sequencing data, we identify 20,545 high-qu

164 o accurately assemble organelle genomes from whole genome sequencing data.

165 We performed whole genome sequencing for two American minks with Moyl

166 Whole genome sequencing in multiplex families, proband-p

167 noma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors with matching trans

168 Here we have performed whole genome sequencing of consecutive M. tuberculosis i

169 SWGA enables the successful whole genome sequencing of samples with low parasite den

170 Whole genome sequencing of select transformants demonstr

171 MIC, pDST and whole genome sequencing of the pncA, rpsA and panD genes

172 We performed whole genome sequencing on isolates from early pediatric

173 Whole genome sequencing revealed differences in putative

174 Here we use C. elegans whole genome sequencing to systematically quantify the c

175 Whole genome sequencing was performed on 20 matched bloo

176 and detect potential transmission clusters, whole genome sequencing was performed on nasopharyngeal

177 Long-read whole genome sequencing was performed using Pacific Bios

178 ive RT-PCR primers/probe were developed, and whole genome sequencing was performed.

179 Whole genome sequencing was used to uncover a frame-shif

180 ingle nucleotide polymorphisms identified by whole genome sequencing were used to design a specific p

181 itulates mutational signatures identified by whole genome sequencing, and will ultimately allow the s

182 th genomic data from whole exome sequencing, whole genome sequencing, and/or array-based imputation.

183 31 patients were examined by culture, qPCR, whole genome sequencing, serotyping, and reverse transcr

184 By parent-offspring whole genome sequencing, we estimate a mutation rate (3.

185 Using whole genome sequencing, we identified a heterozygous fr

186 Using clinical whole genome sequencing, we show that AR binding sites h

187 r the solubility limit were then analyzed by whole genome sequencing, which revealed prevalent point

188 were not randomized and received ultra-rapid whole-genome sequencing (urWGS).

189 the same wards within 7 days were chosen for whole-genome sequencing (WGS) and a phylogenetic analysi

190 the genomic landscape of myeloma using deep whole-genome sequencing (WGS) and develop a model that i

191 We performed whole-genome sequencing (WGS) and pan-genome analysis on

192 Here, we leverage whole-genome sequencing (WGS) and whole-genome bisulfite

193 Whole-genome sequencing (WGS) can support surveillance b

194 Whole-genome sequencing (WGS) data from 853 rhesus macaq

195 Whole-genome sequencing (WGS) is now routinely performed

196 Here we perform whole-genome sequencing (WGS) of 103 UM from all sites o

197 We undertook whole-genome sequencing (WGS) of 660 pneumococcal isolat

198 Whole-genome sequencing (WGS) of cfDNA allowed ultra-sen

199 (SV) in neuroblastoma using a combination of whole-genome sequencing (WGS) of tumor-normal pairs (n =

200 l serotyping results by latex agglutination, whole-genome sequencing (WGS) with PneumoCaT, and DNA mi

201 ver, new sequencing approaches, particularly whole-genome sequencing (WGS), have dramatically changed

202 comparative genomic hybridization (CGH) and whole-genome sequencing (WGS), have greatly advanced the

203 issue samples based on low-coverage clinical whole-genome sequencing (WGS).

204 ariation to whole-exome sequencing (WES) and whole-genome sequencing (WGS).

205 CR) was performed for specific pathogens and whole-genome sequencing (WGS).

206 edium-throughput genotyping (31,811 SNPs) or whole-genome sequencing (WGS, 8.7 million SNPs).

207 ebsiella oxytoca infection was identified by whole-genome sequencing (WGS; later found to be part of

208 However, the wide adoption of whole-genome sequencing also poses new challenges for pu

209 Here we performed whole-genome sequencing analyses of 426 individuals-comp

210 region on canine chromosome 33, followed by whole-genome sequencing analysis that revealed a long in

211 ased caution to address systematic biases in whole-genome sequencing and alignment.

212 lts were confirmed using pathogen isolation, whole-genome sequencing and antibiotic susceptibility te

213 estion, fluorescence-activated cell sorting, whole-genome sequencing and data analysis.

214 lysis provides results on the integration of whole-genome sequencing and deep phenotyping for clinica

215 Through a combination of whole-genome sequencing and transcriptomics, we showed t

216 Whole-exome and whole-genome sequencing are becoming financially feasibl

217 However, the increasing application of whole-genome sequencing as a diagnostic tool is leading

218 t suspected, adopting whole-exome sequencing/whole-genome sequencing as a first-line test should be c

219 Whole-genome sequencing confirmed distinct species ident

220 Genetic variants were examined using whole-genome sequencing data among survivors of African

221 Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a c

222 Short-read whole-genome sequencing data are often applied to large-

223 Our interrogation of the whole-genome sequencing data for 215 breast tumors catal

224 Using public whole-genome sequencing data from 2,606 samples from dif

225 f Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 3

226 Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 3

227 We analyze whole-genome sequencing data from 268 patients to catalo

228 We applied SBMClone to single-cell whole-genome sequencing data from two breast cancer pati

229 ural variant caller utilizing low-depth (8X) whole-genome sequencing data generated by Oxford Nanopor

230 hen using dense imputation from multi-ethnic whole-genome sequencing data in admixed Hispanics/Latino

231 high sequence and structural diversity from whole-genome sequencing data remains highly challenging.

232 lassifiers have successfully been applied to whole-genome sequencing data to identify genetic determi

233 Using matched whole-genome sequencing data, we associated several cate

234 and 60-80% of indels detected in human brain whole-genome sequencing data.

235 of structural variant (SV) breakpoints from whole-genome sequencing data.

236 ross 2,658 tumors from 38 cancer types using whole-genome sequencing data.

237 A key goal of whole-genome sequencing for studies of human genetics is

238 r dysenteric diarrhea and endorse the use of whole-genome sequencing for sustained surveillance of NT

239 This study used imputed whole-genome sequencing from the Trans-Omics for Precisi

240 Whole-genome sequencing has enhanced surveillance and fa

241 As access to whole-genome sequencing has grown, greater amounts of mo

242 re we address these challenges by performing whole-genome sequencing in a large PID cohort of 1,318 p

243 Whole-genome sequencing in one affected dog and its obli

244 d MFRP and PRSS56 testing in 20 families and whole-genome sequencing in one family.

245 Through whole-genome sequencing of 13 melanoma metastases sample

246 Therefore, whole-genome sequencing of 756 child-parent trios of Eur

247 Shallow whole-genome sequencing of 777 biopsies, sampled from 88

248 We conducted whole-genome sequencing of all 1,575 available GAS macro

249 We performed whole-genome sequencing of the SKBR3 breast cancer cell

250 dilution AST with seven antibiotics and for whole-genome sequencing of up to 5,000 isolates.

251 Using whole-genome sequencing of zebrafish mutants isolated in

252 We performed whole-genome sequencing on food and clinical isolates.

253 f this intervention in a model that compared whole-genome sequencing plus current practice versus cur

254 Whole-genome sequencing projects are increasingly popula

255 ly longer sequence reads, which when used in whole-genome sequencing projects have yielded better rep

256 al resistance (AMR), classic genotyping, and whole-genome sequencing results.

257 Whole-genome sequencing reveals the absence of off-targe

258 VAPOR retrieved references for 257 real whole-genome sequencing samples with a mean of >99.8% id

259 In this study, we used whole-genome sequencing to analyze a large collection of

260 We performed whole-exome and shallow whole-genome sequencing to identify genes and pathways p

261 ediated by foldback inversions combined with whole-genome sequencing to study their formation.

262 ARO colonization on NF admission, we applied whole-genome sequencing to track the spread of 4 ARO spe

263 Methods: Within a prospective multicenter whole-genome sequencing trial (NCT01855477), 69 mPC pati

264 g genomic data, particularly when annotating whole-genome sequencing variants against a huge database

265 Using whole-genome sequencing we now identified a single rare

266 lerated short-read aligner, can compute WGS (whole-genome sequencing) alignments ten times faster tha

267 landers with genetic information (imputed or whole-genome sequencing).

268 54 y [range 20 to 89+]; 70.6% European) had whole-genome sequencing, and were deeply phenotyped usin

269 crobial resistance determination, such as by whole-genome sequencing, are required.

270 It highlights the role of whole-genome sequencing, expanded phenotypic drug suscep

271 ction and characterizing the viral load, RSV whole-genome sequencing, host immune response, and trans

272 e generated and analyzed, and how SARS-CoV-2 whole-genome sequencing, in combination with epidemiolog

273 using a combination of short- and long-read whole-genome sequencing, we found no significant associa

274 semble methods using both real and synthetic whole-genome sequencing, whole-exome sequencing, and dee

275 tions, and duplications were genotyped using whole-genome sequencing-based data.

276 Cultured isolates underwent whole-genome sequencing.

277 g with K1 open reading frame Sanger and KSHV whole-genome sequencing.

278 ncluding multilocus typing of five genes and whole-genome sequencing.

279 genetic test with whole-exome sequencing or whole-genome sequencing.

280 e readily selected, from single mutations to whole-genome sequencing.

281 sequencing panels as well as whole-exome and whole-genome sequencing.

282 ated sources in NYS were characterized using whole-genome sequencing.

283 Established methods for whole-genome-sequencing (WGS) technology allow for the d

284 Thus, using a cohort-based whole-genome-sequencing approach in the diagnosis of PID

285 Here, we applied whole-genome shotgun sequencing of microbial DNA extract

286 sualize not only single genomic loci but the whole genome simultaneously.

287 We also used whole-genome single-cell DNA sequencing to reveal that g

288 Using whole-genome single-molecule real-time (SMRT) sequencing

289 ng advanced assays, such as eCLIP, Hi-C, and whole-genome STARR-seq on a number of data-rich ENCODE c

290 The current study explored the whole genome to identify SNPs, genes, and pathways that

291 r that visualizes all the obtained data from whole genome to single-nucleotide resolution.

292 ventricular cardiomyocytes and interrogated whole genome transcriptional responses.

293 Furthermore, whole-genome transcriptome analysis examined deregulated

294 paraffin-embedded (FFPE) tissues to provide whole-genome transcriptome analysis.

295 hetic pathway genes are impacted by a recent whole-genome triplication event.

296 maximum number of sequence variants for the whole genome was 58 nucleotides (0.7%) compared to the p

297 of pairwise nucleotide differences among the whole genomes was found to be 788.690 with a diversity i

298 The strain's whole-genome was sequenced through several next-generati

299 neuroblastoma pathogenesis, here we analyze whole-genome, whole-exome and/or transcriptome data from

300 Here we produced and analysed whole-genome, whole-transcriptome and DNA methylation da