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1 s, indicate that later replacements were not wholesale.
2 Thus, therapeutic manipulation rather than wholesale ablation of pericytes can be exploited to prim
6 rsement rates; medication costs included the wholesale acquisition cost for sacubitril/valsartan and
8 btained from published national sources; the wholesale acquisition cost of sacubitril-valsartan was $
9 termediate value at the current undiscounted wholesale acquisition cost price at an EF of 60% or less
10 ds over time in average wholesale prices and wholesale acquisition cost unit prices and the correlati
13 The ASPs of biosimilars were calculated from wholesale acquisition costs from a representative distri
14 K9 inhibitor costs of $14,350 (based on mean wholesale acquisition costs of evolocumab and alirocumab
19 prevents hindbrain segmentation and causes a wholesale anterior homeotic transformation of r2-r6, to
22 ivation produces content-limited rather than wholesale changes in a memory and its associations and e
24 ays orchestrate such control and bring about wholesale changes in the gene expression profiles of cel
27 a suggests that the developmental window for wholesale circuit plasticity may extend into adulthood f
29 neuroimaging biomarkers, however, require a wholesale commitment to a precision psychiatry approach
30 , realizing this future is contingent upon a wholesale commitment to studying population mental healt
34 child-appropriate formulations [CAFs]) using wholesale data from the IQVIA-Multinational Integrated D
35 This helps to explain how T. brucei escapes 'wholesale deamination' of its genome while harbouring bo
36 1 phosphorylation was not a consequence of a wholesale defect in mammalian target of rapamycin functi
37 progenitors to adult hepatocytes involves a wholesale depletion of canonical cofactor required for S
38 dorsal-ventral patterning network led to the wholesale deployment of the cuticle biosynthesis pathway
39 ng view is that axonal retraction involves a wholesale depolymerization of microtubules and microfila
42 ave suggested that birds lack a mechanism of wholesale dosage compensation for the Z sex chromosome.
43 based on Medicare reimbursement and average wholesale drug price data and using disease prevalences
44 al study examines within-class changes in US wholesale drug prices for brand-name medications from 20
46 g that loss of these proteins does not cause wholesale dysregulation of the endo-lysosomal system.
49 minimizing emissions and levelized cost when wholesale electricity prices are below 4.5 and 5.2 US ce
52 of produce should be prevented in retail and wholesale establishments, in packing sheds, and on farms
53 frequency sea level fluctuations resulted in wholesale extinction or major innovation within evolutio
54 cifically discuss volcanic scenarios without wholesale failure, where stress oscillations may generat
56 containing millions of clones, enabling the wholesale identification of novel secreted proteins with
57 hus, in contrast to the view that there is a wholesale immune activation during sepsis, one immediate
59 Remarkably, heterotrophic plants exhibited wholesale loss of many organelle-targeted aaRS and other
65 ed for widespread closure of Chinese wet and wholesale markets due to numerous zoonotic disease outbr
66 2014 to unify all trades in the agricultural wholesale markets of the state to be carried out within
68 t this response could suppress infection via wholesale microbial community changes to further benefit
70 endent cis-regulation is chiefly executed by wholesale modulation of accessibility at regulatory DNA
72 sidered both institutional costs and average wholesale price (AWP) and performed probabilistic sensit
74 ices measured by transaction prices, average wholesale price (AWP), and national drug acquisition ave
75 of treatment was calculated based on average wholesale price collected from the 2021 Micromedex Red B
76 nstallation cost of solar photovoltaic (PV), wholesale price of agave ethanol, and cost of agave cult
77 ts of SBP treatment were determined from the wholesale price of drugs and from disbursements by the H
78 and returns as a result of variations in the wholesale price of electricity and installation cost of
79 thin complex health systems and reducing the wholesale price of medicines might not always or immedia
82 o of non-communicable disease medicines at a wholesale price of US$1 per treatment per month in low-i
87 medication costs were estimated by using net wholesale prices (clopidogrel=$4.62/d; prasugrel=$5.45/d
88 in outcomes were trends over time in average wholesale prices and wholesale acquisition cost unit pri
90 from PubMed literature searches and average wholesale prices of medications; all costs were discount
91 Costs of study drugs were estimated from wholesale prices with adjustment for discounts and rebat
94 ariation and abundance profiles of genes and wholesale primary and secondary metabolic pathways betwe
96 in, indicating that m-calpain does not cause wholesale proteolysis of other sarcomeric and actin cyto
98 the wt interface, but rather, results from a wholesale reconfiguration of many of the original bindin
100 ering of low-symmetry MOC assemblies without wholesale redesign of the ligand framework, and fundamen
101 features of STAT5 behavior, most notably the wholesale redistribution that occurs when NK cells shift
104 ually all TE lineages makes it unlikely that wholesale removal of TEs is responsible for the compact
105 e evolution of newly emergent Y chromosomes, wholesale renovation is the paramount theme in the conti
106 ) some environmental perturbations can cause wholesale reorganization of ecosystems because they exce
110 emeal remodeling of lysosomal components and wholesale repair and discuss their implications in physi
111 For transportation fuels in particular, wholesale replacement of a fuel is logistically problema
112 e renewal of constituents but the continuous wholesale replacement of myelin membranes; and (2) the s
115 e show how an introduced prey has led to the wholesale restructuring of an island food web, including
116 m lysosomes via nanoscale damage rather than wholesale rupture and that nucleation of cytosolic tau c
117 and without any theory collected facts on a wholesale scale." He also wrote, "How odd it is that any
118 Molecular Cell, Hogues et al. demonstrate a wholesale shift in the key regulatory protein involved i
119 e use can prevent ecosystems from undergoing wholesale state transitions, highlighting the importance
120 ositioning of amino acid side-chains without wholesale structural alteration in the polypeptide appea
121 , proteobacteria, and actinobacteria exhibit wholesale substitution of aminoadenine for adenine, ther
122 e are currently insufficient data to warrant wholesale switching to novel lipid emulsions or the glob
123 ver, they are usually nonselective and cause wholesale T cell depletion leaving the individual in a s
125 dependently of dimerization, suggesting that wholesale topological inversion is an unlikely event in
127 es of the steroid hormone ecdysone drive the wholesale transformation of the larva into an adult.
128 dinates developmental transitions, including wholesale transformation of the larva into the adult dur
129 itant with mass coral mortality, we document wholesale transformation of the symbiont assemblages in
133 ent, with different models predicting either wholesale (up to 99%) decarbonation of the subducting sl