ライフサイエンスコーパス: wholly

1 ith the ZNF831 p.R1393Q variant partially or wholly abolishing these functional phenotypes.

2 Veto-induced B-cell tolerance could be wholly abrogated by treatment with the toll-like recepto

3 er the KCNQ3-Y67F or KCNQ3-Y349F mutants and wholly absent in the KCNQ3-Y67F/Y349F double mutant.

4 years), but this finding could be largely or wholly accounted for by the association of cholesterol w

5 lymorphisms flanking the OPN3 and CHML genes wholly accounted for the original linkage in the Danish

6 lthough increases in IgG(4) levels cannot be wholly accounted for within the allergen-specific fracti

7 It appears that a wholly acellular pertussis vaccine series is significant

8 We argue that it is difficult to wholly align these associations with standard concepts o

9 andeiraea simplicifolia lectin I (BS-I), the wholly alpha-gal-specific BS-I isolectin B4, and elicite

10 he absence of lateralization in partially or wholly androgen-insensitive mice suggests that androgen

11 xtant variation and also provide support for wholly apomictic reproduction within the most common clo

12 al, and behavioral adaptations to suit their wholly aquatic lifestyle.

13 Here, we report a wholly artificial compound that acts on small molecules

14 Here, we report on a wholly artificial small-molecule robotic arm capable of

15 functional tetherin derivatives, including a wholly artificial tetherin molecule.

16 imbalances, a complexity predicted to emerge wholly as a single-cell division event.

17 %, suggesting that improvements could not be wholly ascribed to better clinic record keeping.

18 paired LV systolic performance and cannot be wholly ascribed to changes in LV preload or compliance.

19 he observation that endogenous Spi-1 mRNA is wholly associated with polysomes in MEL cells, suggests

20 Hospitalisations wholly attributable to alcohol consumption decreased by

21 h a reduction in deaths and hospitalisations wholly attributable to alcohol consumption in the four m

22 Study outcomes, wholly attributable to alcohol consumption, were defined

23 n (95% CI -18.4 to -8.3; p=0.0004) in deaths wholly attributable to alcohol consumption.

24 deaths, and reductions in hospitalisations, wholly attributable to alcohol consumption.

25 cted in the first hour after reperfusion was wholly attributable to C5a.

26 ve high mortality that does not appear to be wholly attributable to cryptococcal disease.

27 The difference in older patients was almost wholly attributable to increasing periprocedural stroke

28 impairments in Alzheimer's disease were not wholly attributable to simple auditory perceptual or tas

29 It wholly automated four widely used downstream analyses fo

30 in the H5 HA identified here would render a wholly avian H5N1 virus transmissible.

31 ral RNA segments demonstrated that these are wholly avian influenza viruses of the North American lin

32 icity in mice compared to those containing a wholly avian polymerase complex.

33 cropollutants, such as pesticides, is almost wholly based on single-species responses to individual c

34 uction for TGF-beta signaling to T cells can wholly be explained by its role in induction of Foxp3, a

35 ughput into a single extremely versatile and wholly biocompatible technology.

36 All effects on the CR were wholly blocked by propranolol.

37 Loss of UNC5B partially or wholly blocked the ability of Notch activation to regula

38 l cancer, and that this is driven largely or wholly by calcium.

39 o the unchanged inter-subunit bridges formed wholly by RNA, the bridges involving proteins undergo la

40 modal devices is difficult to be implemented wholly by traditional manufacturing techniques for at-ho

41 of the ER and often surrounded, partially or wholly, by a network of ER-bound NS5A protein.

42 ve phaeochromocytoma (PC12) cells, which was wholly Ca2+ dependent, but unaffected by Cd2+ (200 micro

43 We use a simplified model, which can be wholly calibrated from standard chronic bioassay data.

44 erence and the world outside of it cannot be wholly captured by our words, we hope nonetheless to pre

45 nding to DC-SIGN and MDDCs is largely if not wholly carbohydrate dependent.

46 reased, the response to elevated [CO(2)] was wholly caused by increased light-use efficiency.

47 bviating the condition of solution averaging wholly changes expectations of the magnitudes and etiolo

48 manner, which necessitates a long, slow and wholly chemical breakdown.

49 ation, although the precise mechanism is not wholly clear.

50 ndons, but the underlying mechanisms are not wholly clear.

51 However, the data are not wholly compatible with a strict multiple system account.

52 dues) and SspB (1462 aa residues) are almost wholly conserved (98% identical) in the C-terminal regio

53 ovule homologues indicate that they are not wholly conserved between angiosperms and Ginkgo biloba.

54 Thus, our metafluid is wholly consistent with equilibrium thermal physics, desp

55 me inhibition assays using TLM analogues are wholly consistent with our structural observations.

56 This result is wholly consistent with previous work showing higher over

57 m the soma at the same level as the branches wholly contained in sublamina b, thereby forming an annu

58 erminal domain such that each active site is wholly contained within a single subunit.

59 ns, the core Cdc13 ssDNA-binding activity is wholly contained within a single tight-binding oligosacc

60 of Ca(2+) with actin, while type 2 sites are wholly contained within gelsolin.

61 e that these organisms might be partially or wholly controlled by augmenting host responses.

62 osed impact site and that postimpact basalts wholly cover it.

63 s that are now occupied by plant communities wholly created by humans, in which diversity may reflect

64 s were established in primary cultures under wholly defined (serum-free) conditions that we developed

65 Using a wholly defined spike-in data set and one from a diabetes

66 We have generated a wholly defined spike-in dataset for Agilent microarrays

67 Our previous wholly defined spike-in datasets, the Golden and Platinu

68 ved or novel substrate specificities are not wholly defined.

69 ed cancer immunotherapy but their success is wholly dependent on amplifying an existing immune respon

70 reconstitution, demonstrates that ILC2s are wholly dependent on Bcl11b for their development.

71 Furthermore, stimulation is wholly dependent on functional ATP-binding pockets in bo

72 e that induced by A1 receptor stimulation is wholly dependent on KATP channel opening.

73 work, efficiency is highly variable and not wholly dependent on mutation position.

74 benthic communities in the ocean are almost wholly dependent on near-surface pelagic ecosystems for

75 They are wholly dependent on NMDAR neurotransmission, with little

76 itness, but that the 'sign' of the effect is wholly dependent on the environment.

77 Moreover, we suggest that odor perception is wholly dependent on the integrity of this memory system

78 e believed to be obligate biotrophs that are wholly dependent on the plant partner for their carbon s

79 response upon re-encounter with antigen) is wholly dependent on the presence of T(H) cells during, b

80 aling upstream of LET-60 RAS in a manner not wholly dependent on the ubiquitin-ligase domain.

81 protein (MAP) kinases ERK1 and ERK2 and was wholly dependent upon extracellular calcium ions.

82 ethanesulfonate-induced alkylation damage is wholly dependent upon glycosylase-mediated initiation of

83 s for words and show that visual recognition wholly depends on attention even for highly familiar and

84 uggests that temperature compensation is not wholly determined by the intrinsic properties of the cen

85 er space", with sensory and cognitive worlds wholly different from our own.

86 lly recognize and bind to each other using a wholly different logic, "socket-plug" complementarity, a

87 d 36 CVD-related proteins, respectively, are wholly disordered.

88 c infection with large doses of virus, it is wholly disposable in both control of virus replication a

89 he biosyntheses of their bicyclic nuclei are wholly dissimilar.

90 he subtypes of dyslexia might have partly or wholly distinct genetic causes.

91 that reversibly transform between multiple, wholly distinct shapes: four different letters and every

92 nd reading ability appeared to be largely or wholly distinct, suggesting that the correlation between

93 sequences, design and biochemical testing of wholly DNA sensor constructs, and translation to a funct

94 PCR products are prepared in wholly double-stranded homoduplex form for a baseline me

95 At -60 mV, EPSCs were wholly due to CNQX-sensitive, non-NMDA glutamate recepto

96 fited from surveillance, the program was not wholly effective in cancer prevention.

97 also indicated, but these approaches are not wholly effective.

98 ading module gave polyketide products almost wholly either acetate derived or propionate derived, res

99 tical scenario in which dementia risk can be wholly eliminated by removing risk factors, which should

100 he results we describe are consistent with a wholly empirical explanation of color contrast effects.

101 tures of different shapes is determined by a wholly empirical strategy of visual processing.

102 as substrates for secretion seems not to be wholly encoded within the Yop peptide sequence.

103 , this evidence questions existing models of wholly endogenous demographic boom-bust.

104 s, confers transforming activity while it is wholly endoplasmic reticulum-retained in U87 cells.

105 ASCO wholly endorses the Bone Health and Bone-Targeted Therap

106 alternative to conventional open surgical or wholly endovascular repairs of thoracoabdominal aneurysm

107 hich the developing spore (the forespore) is wholly engulfed by the adjacent mother cell.

108 urge in critically ill patients, but few are wholly equipped to manage this new disease.

109 irds, H5N2, H5N8, and H5N1, representing the wholly Eurasian lineage H5N8 and two novel reassortant v

110 in which patients with brain metastases were wholly excluded (7.5% v 6.2%, P = .42).

111 finding suggests that when animal foods are wholly excluded from the diet, the endogenous production

112 onally excluded in 2,263 trials (73.5%), and wholly excluded in 308 trials (10.0%).

113 ded (ie, excluded in some circumstances), or wholly excluded.

114 ndividual drivers alone were insufficient to wholly explain national differences, whereas interacting

115 Competition for FABPs may in part or wholly explain the increased circulating levels of endoc

116 isk of death from CHD and stroke that is not wholly explained by antipsychotic medication, smoking, o

117 core excluded volume theory, nor can they be wholly explained by interactions between the head groups

118 ent evidence that the threshold model is not wholly explained by sensory (feedforward) information bu

119 p in survival from prostate cancer cannot be wholly explained by socio-economic differentials in earl

120 the effect of the glycation index on risk is wholly explained by the associated level of A1C.

121 ther influences, i.e. their activity was not wholly explicable in terms of saccade parameters.

122 ed with the realization that strange beasts, wholly extinct, were once populating Earth's ancient oce

123 However, many envelope assembly factors are wholly extracytoplasmic.

124 species, life-history strategies range from wholly freshwater-resident populations, to migratory and

125 ail and confirmed that the projection arises wholly from pyramidal cells.

126 behavior measured by all informants, that is wholly genetic in origin.

127 en recovered from Canadian pigs, including a wholly human H1N2 virus and human-swine reassortants.

128 In contrast, a wholly human H3N2 virus was isolated from a single baby

129 rt, we identified a novel influenza virus of wholly human origin that has been circulating undetected

130 Since wholly human seasonal H3N2 viruses in the United States

131 hogenicities and replication kinetics of the wholly human virus and a triple-reassortant virus in 7-w

132 Genetic differences between this wholly human virus and the triple-reassortant viruses ma

133 pulmonary lesions, while infection with the wholly human virus induced only mild pulmonary changes.

134 Our results demonstrate that the wholly human virus replicated to significantly lower tit

135 ine virus into the genetic background of the wholly human virus resulted in a significant increase in

136 2-associated responses, which are largely or wholly IL-4 dependent, such as the production of IgG1 or

137 ila and human, including Parkin S65, did not wholly impair Parkin translocation to mitochondria.

138 icit water were significantly different than wholly implicit solvent calculations with the calculated

139 by a set of DNA cassettes that are prepared wholly in vitro.

140 centred on maximum-grade adverse events, is wholly inadequate for characterising the tolerability of

141 that the common use of sand or dust proxy is wholly inadequate for the prediction of the behaviour of

142 t of bitter phytonutrients for health may be wholly incompatible with consumer acceptance.

143 rimental vicinal proton couplings, which are wholly inconsistent with the trans conformation.

144 A fourth option, a 'do-nothing' approach, is wholly inconsistent with the well-established scientific

145 ch suggest that the present findings are not wholly inconsistent with those of the earlier study.

146 ual cell's decision to die or survive is not wholly independent but depends, at least in part, on fee

147 at the replicative capacity of Ad5 dl1520 is wholly independent of host cell p53 status, as is the re

148 bability distributions suggests they are not wholly independent processes.

149 where agriculture is thought to have arisen wholly independently.

150 We also show that other colors are less or wholly ineffective.

151 properties of the mirror system are neither wholly innate [14] nor fixed once acquired; instead they

152 summarize variability in the population are wholly insufficient for modeling intraindividual persona

153 They have been construed as wholly intolerant of oxygen, a feature that was original

154 angiogenin, only six residues appeared to be wholly intolerant to substitution: two histidine residue

155 a chemically similar elastomer prepared from wholly isotropic precursors.

156 ecessary kinetic studies, catalysis being a "wholly kinetic phenomenon" as J.

157 etastatic D2.A1 organoids were spherical and wholly lacked E-cad expression.

158 ns exist, and mechanistic details are almost wholly lacking.

159 um levels; this effect was partially but not wholly mediated through relapse prevention.

160 m closed-system extraction to degassing of a wholly molten body, show that significant open-system si

161 One mutation, L376W, leads to a wholly monomeric variant that shows full activity.

162 the initial stages of motor learning are not wholly motor but rather involve plasticity in somatic an

163 rom macrophages, in which case the effect is wholly MyD88 dependent but only partially TLR9 dependent

164 here the friction's nonlinearity seems to be wholly negligible.

165 offers a preclinical proof-of-concept for a wholly new approach to chemoprevention in carriers of BR

166 f thermodynamic conditions, toward realizing wholly new electronic properties.

167 Overall, our results identify a wholly new facet to the multifunctionality of MDSC in dr

168 als readily undergo capture by Ni complexes, wholly new feedstocks for cross-coupling have been reali

169 ecently, in the 1990s, the introduction of a wholly new form of noninvasive cross-sectional imaging,

170 nder-exploited for the scalable synthesis of wholly new materials by chemically transforming the poly

171 of materials that often display modified or wholly new properties compared to their molecular compon

172 his MRI approach may provide the basis for a wholly new strategy to evaluate Alzheimer's disease susc

173 strategies that support human navigation in wholly novel environments.

174 The results demonstrate a wholly novel mechanism by which T-helper (T(H) ) polariz

175 cies is defined as a taxonomic species based wholly on morphology, but often morphospecies consist of

176 both homo and heterosequence nucleopeptides wholly on solid support with high yield and purity.

177 target genes by Bck2 depends partly, but not wholly, on SBF and MBF.

178 these observations is that Rab27a functions wholly or in part as the melanosome receptor for myosin

179 f secondary metabolites that are synthesized wholly or in part by nonribosomal peptide synthetases.

180 thetic ganglion neuronal cell number are due wholly or in part to the division of neuronal cells with

181 y neurological diseases are being associated wholly or in part with functional changes within specifi

182 ins from some B. thuringiensis serovars were wholly or largely assigned to a single ST, for example,

183 t this reduced paternal inheritance might be wholly or partially due to postfertilization events.

184 ented legislation prohibiting smoking in all wholly or partially enclosed public spaces.

185 ITY CRITERIA: Published 1950-2009; conducted wholly or partially in England; original data on inciden

186 A subset of these are located wholly or partially in looped regions in the Y3 and Y4 R

187 ibility that zeta-globin production might be wholly or partially redundant in embryos in which the ad

188 ining hepatitis C virus (HCV)-like IRESs, is wholly or partially resistant to inhibition by eIF2 phos

189 ested in combination with D371A and found to wholly or partially revert these phenotypes.

190 nce evolution, while those whose history was wholly or partially within the dinoflagellate plastid ge

191 Respondents preferred to be wholly or partly involved in the decision-making process

192 sceptibility to diacetyl chloramphenicol was wholly or partly the consequence of intrinsic carboxyles

193 istent with its roles in RNA replication, is wholly or predominantly on the cytoplasmic face of the E

194 on in the absence of detergent and, thus, is wholly or predominantly on the cytoplasmic face of the v

195 monium fluoride quantitatively generates the wholly organic 81-atom-loop trefoil knot.

196 s represents one of the hardest and stiffest wholly organic materials known.

197 dium ethylenediaminetetraacetate affords the wholly organic molecular link.

198 the removal of the ion template, result in a wholly organic molecular material that forms as stacks a

199 gy, and subsequent demetalation afforded the wholly organic Solomon link.

200 on typical EF tasks by children inside, and wholly outside schooled worlds.

201 ARMO BioSciences, a wholly owned subsidiary of Eli Lilly and Company.

202 Lilly and Company and ImClone Systems LLC, a wholly owned subsidiary of Eli Lilly and Company.

203 Oncoethix GmbH (a wholly owned subsidiary of Merck Sharp & Dohme Corp).

204 Oncoethix GmbH, a wholly owned subsidiary of Merck Sharp & Dohme Corp.

205 Millennium Pharmaceuticals, a wholly owned subsidiary of Takeda Pharmaceutical Company

206 Millennium Pharmaceuticals (a wholly owned subsidiary of Takeda Pharmaceutical Company

207 Millennium Pharmaceuticals, Inc, a wholly owned subsidiary of Takeda Pharmaceutical Company

208 Millennium Pharmaceuticals, a wholly owned subsidiary of Takeda Pharmaceutical Interna

209 etics Inc, Millennium Pharmaceuticals Inc, a wholly owned subsidiary of Takeda Pharmacuetical Company

210 ng not present to the senses or never before wholly perceived in reality"; imagination combines "crea

211 f strategies used by individual women is not wholly predictable from prepregnant indexes.

212 Although not wholly predictive of clinical success, in vitro and in v

213 ects of team strategy, with no single metric wholly predictive of success.

214 torage, so they can no longer be regarded as wholly pristine.

215 mmense number of sequence combinations makes wholly random sampling unfeasible, two key simplificatio

216 scription elongation and termination using a wholly recombinant archaeal RNAP and synthetic nucleic a

217 information of RNAPs at high-resolution and wholly recombinant archaeal transcription systems, we ar

218 and interaction with the archaeal RNAP in a wholly recombinant in vitro transcription system.

219 ile the dark-state eta(1)-SO(2) structure is wholly recovered by heating the crystal to room temperat

220 information captured by each measure was not wholly redundant.

221 onal properties of developing tendon are not wholly reflected by protein expression and tissue morpho

222 reward-related impairments, yet it cannot be wholly related to one or the other process and their cor

223 d via the bite of the tsetse fly where it is wholly reliant on glycolysis for the production of ATP.

224 ling is the generation of a basal epithelium wholly replacing the epidermis of the wound.

225 ch ensures that the genome is accurately and wholly replicated, is established during G1, before the

226 , by making versions of Chordin partially or wholly resistant to Tld cleavage and introducing them in

227 from an anarchic, cycling piwi-1+ population wholly responsible for production of all temporary and d

228 revealed that PKR contributes to but is not wholly responsible for reovirus-induced host shutoff.

229 the notion that a Th2 response is partly or wholly responsible for the inability of Th1-mediated imm

230 ardiovascular risk factors do not seem to be wholly responsible for the increased cardiovascular risk

231 ing that the IL-2 production failure was not wholly responsible for the proliferation defect.

232 ive-immunity trade-off is partially, but not wholly responsible for these effects.

233 onkeys by this time, with ocean barriers not wholly restricting their northward movements, requiring

234 Kraepelin's pivotal distinction was neither wholly right nor wholly wrong: the 2 major psychoses sho

235 These data identify a wholly RNA driven reaction that may offer novel opportun

236 from the wild-type crystal structure was not wholly satisfactory, as errors accumulated with successi

237 f land within Chelicerata and the absence of wholly secondarily marine arachnid orders.

238 Two were wholly separate from the health care system.

239 withdrawal-induced cell death, again by two wholly separate signaling mechanisms, PKA-dependent for

240 s for narrowing the field in such cases, yet wholly simulated mechanisms must be interpreted with gre

241 ' and stated categorically that 'no organism wholly soft can be preserved'.

242 FA profile in visceral fat, but possibly not wholly sufficient in reverting the metabolic effects ind

243 st time that synthetic alpha-Syn fibrils are wholly sufficient to initiate PD-like LBs/LNs and to tra

244 However, current evidence does not wholly support this conclusion.

245 provide the only experimental approach that wholly supports all the critical aspects of LCR activity

246 omic force microscopy (AFM) show that ADH-41 wholly suppresses the aggregation of Abeta at a substoic

247 A wholly synthetic 20-mer peptide containing cysteine 106

248 The operation of this wholly synthetic and stripped-down system compares to th

249 But efforts to produce wholly synthetic catalytic peptides have typically resul

250 as recombinant DNA from all domains of life, wholly synthetic DNA sequences, and engineered gene expr

251 A wholly synthetic interferon, interferon alfacon-1 or con

252 edersen half a century ago, the chemistry of wholly synthetic macrocycles for structure-specific, hig

253 The realization of the Borromean link in a wholly synthetic molecular form is reported.

254 Here we describe a wholly synthetic molecular system that converts an exter

255 Wholly synthetic molecules involving both mechanical bon

256 can be unraveled through the application of wholly synthetic networks with well-defined chemistries

257 Herein, we describe a wholly synthetic small-molecule system that, under the i

258 Developing 'wholly synthetic' macromolecular analogues that can mimi

259 Here, we report on wholly synthetic, water-soluble, and chiral tubules that

260 o the offspring before gestation or if it is wholly the gestational exposure that affects offspring b

261 progression of cells from G1 into S phase is wholly to activate an E2F-1-like activity through phosph

262 s living in darkness, I attribute their loss wholly to disuse"[1].

263 privilege in the CNS is often mis-attributed wholly to the blood-brain barrier.

264 nesis and that this effect can be attributed wholly to the high-dose insulin in SEB-1 cells.

265 ss are those that accrue unexpectedly or are wholly unanticipated.

266 otype-initiated investigations in uncovering wholly uncharacterized antimicrobials.

267 Coarctation stenting was performed wholly under rtMRI guidance in 13 swine.

268 me and apply a free energy framework to more wholly understand why cells ingress.

269 ons show behavior-related differences is not wholly understood.

270 specific aspects of social phenotype remain wholly undescribed.

271 ST in social interaction in primates remains wholly unexamined.

272 vs. mismatched (different-identity) pairs of wholly unfamiliar faces.

273 d in the first symmetry-breaking step remain wholly unknown in the most obviously chiral animals, the

274 rences for groups of a given size are almost wholly unknown.

275 nal role(s) of cyanobacterial LDs are almost wholly unknown.

276 ars of work, many thousands of patients, and wholly unreasonable delay in approval of a treatment who

277 luconeogenesis and, outside the cell, exerts wholly unrelated cytokine properties.

278 MOG-specific T cells were not wholly unresponsive though, as they did secrete IL-10 af

279 The patient was wholly unresponsive to sulfonylurea therapy (up to 1.14

280 therapy based on differences in biology are wholly untapped.

281 This region includes c-myc and is wholly within 8q24.

282 nce interval (CI; -3.9 to -0.04 letters) lay wholly within both upper and lower margins of the permit

283 ly some monoclonal antibodies, with epitopes wholly within domain 1 of ICAM-3, were able to block bin

284 ) antiport in the transporters-are contained wholly within each subunit of the homodimer.

285 eletion interval spans 600-1,100 kb and lies wholly within the 1.3-Mb region identified by recombinat

286 cts of the E. coli 16S gene were then placed wholly within the IVS sequence, and the 16S gene was del

287 oteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tum

288 eneration, because they evolved from a state wholly without sex chromosomes (rather than after a larg

289 tal distinction was neither wholly right nor wholly wrong: the 2 major psychoses show both distinctiv