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3 gamma-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer's d
4 regulators are transposable elements (TEs), whose aberrant usage could contribute to oncogenic trans
5 tal Retardation Protein (FMRPO), the protein whose absence causes FXS, differentially modulates HCN c
7 ew optical biometers, formulas, and methods (whose accuracies have yet to be completely tested) have
9 stance by increasing the expression of genes whose action diminishes the efficacy of anti-cancer drug
10 s with ubiquitin-specific protease 8 (USP8), whose activating mutations underlie human tumorigenesis.
12 kin is exclusively innervated by GRP fibers, whose activation via optogeneics and chemogenetics in th
13 wo interaction layers by connecting proteins whose activities are affected by cancer drivers to prote
14 07) sequesters KATms from diverse substrates whose activities are down-regulated by acylation but are
15 se of covalently reactive beta5i inhibitors, whose activity against the constitutive proteasome (c-20
16 rvations inform the development of catalysts whose activity can be tuned by an external force that is
17 a significant proportion of amygdala neurons whose activity correlated with both expected rewards for
18 loci that produce functional RNAs from those whose activity is attributable to the act of transcripti
19 are governed by the master regulator tra-1, whose activity is controlled by chromosomal sex and is n
20 their counterparts in somatosensory cortex, whose activity is driven primarily by afferent inputs ra
21 ring its affinity for the phosphatase Cdc14, whose activity is essential for mitotic exit and complet
23 he data indicate that olig2(+) cells are ENs whose activity is modulated with locomotion, suiting the
24 er of PFAS compounds, including alternatives whose activity on hPXR has not been experimentally teste
25 s, we identified splicing factor RNP-6/PUF60 whose activity suppresses immunity, but promotes longevi
26 inputs from context-responding vCA1 neurons, whose activity was required for contextual fear learning
29 ishable by other diagnostic codes from those whose admissions will not have a sepsis code, their heal
30 form affords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer ch
31 several avenues for experimental approaches whose aim is to reduce the fibrotic response that the ty
32 ensity conditioning, as well as for patients whose allograft came from a matched sibling versus an un
33 pha and found the presence of hexagonal nets whose arm lengths were similar to those of the hexagonal
34 white matter development between individuals whose autism severity increased, remained stable, or dec
35 pha,beta-unsaturated hydrazones is presented whose behavior and reactivity are governed by various ty
36 le paclitaxel-based microtubule stabilisers, whose binding is induced by photoisomerisation to their
37 , transcription factors (TF) were identified whose binding sites were enriched or depleted in mutatio
38 hosphorylation are rheostats in immune cells whose bioenergetics have functional outputs in terms of
39 n transient Neoproterozoic weathering events whose biogeochemical consequences were sustained by a se
40 es of designed analogues of disorazole B(1), whose biological evaluation led to the identification of
41 This results in a complex range of isoforms whose biological relevance largely remains to be determi
42 mocitrate] species designated FeMo-cofactor, whose biosynthesis and insertion requires the action of
44 and orthotopically sutured to the recipient, whose bladder above the ureteral opening level was remov
45 No increased risks were observed in women whose BMI normalized from childhood to adulthood: RR was
47 en controlled for tissue type, than patients whose cancers were not driven by ecDNA-based oncogene am
48 ch are capable of sequestering an enzyme and whose catalytic efficiency can be manipulated by the mol
49 etic variants, each with very small effects, whose causal effects could not be individually identifie
50 terus is provided by spinal afferent nerves, whose cell bodies lie predominantly in thoracolumbar dor
52 nd a nonoverlapping set of brain connections whose changes after ECT can track patients' verbal memor
53 (GBMD) is a large and complex coastal system whose channel network is vulnerable to morphological cha
54 vel, several studies report that adolescents whose childhood ADHD symptoms have remitted are indistin
55 tals (LCs) are omnipresent in living matter, whose chirality is an elegant and distinct feature in ce
57 fection and room air oxygen saturation <=94% whose clinicians requested remdesivir through the compas
58 crowded cellular spaces with liquid-like KGs whose coalescence was restricted by keratin filament bun
59 ng remarkably strong, hierarchical clusters, whose cohesion derives from grain size rather than miner
61 intermediate beta-glucose 1,6-bisphosphate, whose concentration depends on the beta-glucose 1-phosph
63 alized patients (excluding those in the ICU) whose condition reached the alert threshold at hospitals
64 tend to coalesce to form a localized wrinkle whose configuration depends on the initial wrinkle geome
65 ting protein-based mechanisms of inheritance whose conformational changes lead to the acquisition of
66 of the assembly of the pterosaur body plan, whose conquest of aerial space represents a remarkable m
67 ll-type-specifying transcriptional circuits, whose constituent genes featured exceptionally high rate
68 delling to demonstrate that inhibitor pairs, whose constituents adopt distinct mechanisms of haematin
69 tain appreciable levels of other flavonoids, whose content increases under post-harvest heat treatmen
70 , as the LHb receives many excitatory inputs whose contributions to cocaine aversion remain uncharact
71 hlin of visual neuroscientist Horace Barlow, whose contributions to the understanding of brain functi
73 In this study, we report two cases of GPA whose corneal ECD decreased significantly after phacoemu
75 addition of low-risk vaccination programmes whose coverage encompassed children and young adults (ag
76 h rate nearly equal to that of young drivers whose crash rate is the highest among all age groups.
77 dentate spikes (DSs), and a novel event type whose current source density (CSD) signature resembled t
78 cally encoded cytochrome P411 enzymes (P450s whose Cys axial ligand to the heme iron has been replace
80 ere that loss of the MutLalpha subunit MLH1, whose defect is responsible for ~50% of dMMR cancers, re
81 egress requires two proteins, NPC1 and NPC2, whose defects are responsible for Niemann-Pick disease t
83 important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-
84 lectively enriched in either population, but whose developmental functions are unknown in these neuro
86 lly resonated with those clinical scientists whose disenchantment with traditional categorical and di
87 all, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an
88 hundreds of cell lines has identified genes whose disruption leads to fitness defects, a critical st
90 inguished wild from cultivated genotypes and whose divergence may be a consequence of domestication.
92 ent bronchoscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 45
93 exacerbation, the proportion of participants whose dose of inhaled corticosteroid was reduced, or the
94 anine residues that form an aromatic pathway whose dynamic rearrangements enable H(+) movement outsid
95 determines an optimal subset of model states whose dynamics should be corrected by the ANN by examini
96 mitigating role and mechanism of TDP-43 NBs, whose dysfunction may be involved in ALS pathogenesis.
97 lpha-binding and -activating (GBA) motif and whose dysregulation underlies human diseases, including
98 Notably, these mutations include mutations whose effect had previously been incorrectly predicted u
99 strongest enhancer of the pkd2 phenotype but whose effect was found to be independent of the canonica
100 pansion and dilution is relevant for systems whose elements must assess their inputs and outputs from
101 Last, we find that engineered waterways, whose emissions are currently not reported in inventorie
102 hen shattered, thereby producing micronuclei whose encapsulated ecDNAs are substrates for chromothrip
103 we report a new substrate, hydrofurimazine, whose enhanced aqueous solubility allows delivery of hig
105 onella may be a bile acid-sensitive bacteria whose enrichment is enabled by aldafermin-mediated suppr
106 s a homotypic receptor of the Ig-superfamily whose exact role in immune modulation has remained elusi
108 , by trial-and-error, the same motor routine whose execution resulted in the precise timing of their
110 e markers, in contrast with sulfonated HMOs, whose expression correlated with suppression of two majo
111 sons, CRISPR hits were overlapped with genes whose expression correlates with susceptibility to this
112 he nuclear lamina filament Lamin B2 (Lmnb2), whose expression decreases in mice after birth, is essen
113 sed of a discrete set of Myc-activated genes whose expression increased in the presence of active bet
114 evelopmental trajectories of leaf allometry, whose expression is contingent heavily upon the environm
116 BV posttranscriptional regulator protein SM, whose expression is limited to the replicative cycle.
117 tified a core set of brain endothelial genes whose expression is regulated by neuronal activity.
118 ly unknown-as evidenced by the many proteins whose expression is regulated in response to nitrogen av
119 PC2 as a ubiquitous stress-sensitive protein whose expression is up-regulated in response to cell str
120 ectionally from active regulatory sequences, whose expression levels correlate with enhancer activity
122 es, including attack by arthropod herbivores whose feeding activity is often stimulated by rising tem
125 ents a multilayered biomolecular condensate, whose formation by liquid-liquid phase separation (LLPS)
127 e-senescent cells was G:C->T:A transversion, whose frequency was intensified in the treated immortali
128 both c-KIT and to the RasGAP, neurofibromin, whose function is completely dependent on this interacti
133 ructures of organic and inorganic components whose function relies on molecular heterogeneity at the
135 ationally classified into molecular subtypes whose functional relevance remains to be comprehensively
136 protein ubiquitous in Gram-negative bacteria whose gene frequently occurs in clusters of copper resis
137 lated functions, and operons are gene blocks whose genes are co-transcribed on a single mRNA molecule
139 ntified cell surface markers, CD69 and CD36, whose genes were differentially expressed between these
140 ential GRNs in cancer versus normal tissues, whose genes with largest network degrees have been repor
141 underpinnings of EoE, highlighting 13 genes whose genotype-dependent expression expands our etiologi
142 evance to the crystal engineering community, whose goal is the design of solids with bespoke properti
143 of gonorrhea, is an exclusive human pathogen whose growing antibiotic resistance is causing worldwide
144 ead to the synthesis of other porous liquids whose guest-uptake properties may be tailored to fulfil
145 family of uranium-oxysulfate cluster anions whose hierarchical assembly in water is controlled by tw
147 bond formed by a serine or threonine residue whose hydroxyl side chain H-bonds to an over-coordinated
148 ey contain poly-histidine chains (poly-His), whose imidazole groups generate (14) N-quadrupolar-peaks
149 iral load, with a greater effect in patients whose immune response had not yet been initiated or who
150 fect of diet composition on wild adult birds whose immune systems are presumably fully developed and
151 Cigarette smoke is the first complex odor whose in vivo receptor response pattern has been measure
152 rid PKS module harboring KR1 was engineered, whose individual catalytic domains have been crystallogr
154 vation tests, revealed 19 new cases of genes whose integrity is regulated by IGEs (including dut, ecc
155 reflected by the formation of compartments, whose interactions form a characteristic checkerboard pa
156 , the dielectric properties of a water model whose intermolecular electrostatic interactions are enti
158 report on the formation of polymer hexosomes whose inverted cylinders orient in an unusual manner, fo
159 e PC involves unidentified molecular details whose involvement in RAG-RSS dynamics are crucial to qua
160 ifies a sub-network consisting of nine genes whose joint activity positively correlates with increasi
161 rate, and persistent mark of nucleus rupture whose kinetics are partially dictated by membrane reseal
162 e identified several drosophila CYPs (dCYPs) whose knockdown reduced PCB 28-derived OH-metabolites an
164 hese benefits are most prominent in patients whose left ventricular end-diastolic dimension Z score b
165 ontains a disordered C-terminal domain (CTD) whose length enigmatically correlates with genome size.
166 s around a thin (<130 nm) MukBEF axial core, whose length is ~1,100 times shorter than the chromosoma
167 y in KPC/Cdh11(+/-) and KPC/Cdh11(-/-) mice, whose lesions also contained fewer FOXP3(+) cells in the
168 of the DLC1 mutants indicated 7 of 9 mutants whose lesions were located in the Rho-GAP domain were de
169 typic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosi
171 een printing, and electron-beam lithography, whose limitations have hampered rapid innovations and br
172 ing via newly formed soil carbonate minerals whose long-term fate requires assessment through field t
175 inuclear u(3)-oxo-bridged Mn(III)-based SMM, whose magnetic anisotropy is closely related to the Jahn
176 oduce inter- or intra-researcher differences whose magnitude has not been previously quantified in th
177 ce a new automated image processing pipeline whose main novelties include an innovative module for ce
178 ning and the International Seabed Authority, whose mandates include regulation of all mineral-related
179 ribe here probably the first molecule (RBM3) whose manipulation affects translation specifically in s
180 llular structures known as perineuronal nets whose maturation is associated with the end of early cri
181 tested psychophysically in human observers, whose measured differences in the diameters of each ento
182 fied a third onset-hastening modifier signal whose mechanism of action remains uncertain but does not
183 crisis, we need to discover novel analgesics whose mechanisms do not involve the mu opioid receptor b
184 -binding site and three other phospho-sites, whose mechanisms in inhibiting binding are not understoo
185 cularly troublesome when evaluating grasses, whose members represent our most agriculturally signific
186 ALN(-) with ALN(-) immune patterns was found whose members were more similar to those of the ALN(-) o
187 38,000 idle wells, and ~63,000 active wells, whose methane (CH(4)) emissions remain largely unquantif
188 hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing
191 eaction affords aldehyde end-capped polymers whose molecular weight can be tuned by varying the ratio
192 ere stronger among boys, as well as children whose mother had a lower education level or smoked durin
193 nd/or at preschool age, 4.5 y (n = 273), and whose mothers had a 2-h 75-g oral-glucose-tolerance test
194 mized clinical trial, we found that children whose mothers had been treated with the drug had higher
195 GT is the holoparasite Lophophytum mirabile, whose mtDNA has lost most native genes but contains inta
196 We also examined the behavior of 337 genes whose much higher levels of expression in symbiotic than
198 (Tyr) locus as an experimental model, a gene whose mutations are associated with albinism, we describ
200 neuroticism lived shorter lives, individuals whose neuroticism was characterized by worry and vulnera
201 in both regions were identified as neurons, whose numbers remained stable over time, suggesting that
202 kly IB4+ and IB4- neurons cultured from rats whose OIHP was reversed in vivo Thus, in vivo administra
203 he case of the amyloid beta (Abeta) peptide, whose oligomers are associated with Alzheimer's disease.
204 adult Drosophila melanogaster central brain whose optogenetic activation increased, and genetic inac
205 RNA isoforms during neocortical neurogenesis whose orthologs include risk genes for neurodevelopmenta
206 and their interaction forms a control system whose output is adjusted adaptively to minimize timing e
207 1 binds putative enhancers of Atf4 and Hsps, whose overexpression largely recapitulated the Myt-mutan
209 ory failure requiring oxygen supplementation whose Pao(2) increased >=20% with prone positioning, and
210 modes (basic food, other food and non-food), whose parameters are probabilistically estimated using a
212 uring rheumatoid arthritis and osteoporosis, whose pathogenesis is associated with a Th17/Treg imbala
213 e cells in vLGN displayed gamma oscillations whose phase and strength varied with stimulus pattern, a
214 es are relevant aquatic organic contaminants whose photochemical transformation is affected by dissol
216 e can help delineate many neuron populations whose physiological properties can be readily related to
217 activation and platelet aggregation in mice whose platelets express only talin-1(R35E, R118E) are ev
219 For little brown bats (Myotis lucifugus), whose populations have experienced declines of over 90%
221 mutations that affect non-hotspot residues, whose potential functional contributions to disease are
223 ethods disclosed a set of metabolic pathways whose presence and/or expression correlates with strain
224 ith possible clinical utility, many of which whose presence in blood is likely linked to specific cel
226 Elastic energy stored in bent filaments, whose presence was confirmed by cryo-electron tomography
227 l depletion with anti-CD20 to retain B cells whose presence were required to achieve EAE recovery.
229 1,002 coronary heart disease (CHD) patients, whose primary objective is to compare the effect of 2 he
231 the gene encoding amyloid precursor protein, whose processing can result in formation of beta-amyloid
233 ion of capsid proteins and other late genes, whose production is transcriptionally controlled by a co
235 ular masterpieces devised by expert chemists whose properties are now being exploited far beyond trad
237 ure of the insulating ground state of VO(2), whose properties have been an issue for accurate predict
238 ic hydroxyapatites are confounding materials whose properties remain uncertain, even after years of s
239 gorithms, we are able to generate assemblies whose protein annotations are statistically enriched for
240 REBPs), membrane-bound transcription factors whose proteolytic activation requires the cholesterol-se
241 le but still highly stable in aqueous media, whose proteolytic degradation could be used in these wir
244 ar PLD activity, yielded a panel of optoPLDs whose range of catalytic activities enables mimicry of e
245 n profile: the long noncoding RNA ephemeron, whose rapid upregulation is crucial for the transition o
246 e rational design of photoswitchable systems whose reactivity can be controlled via host-guest intera
247 ic cleavage of the RNA model substrate HPNP, whose reactivity is 30-fold larger with respect to the u
249 as not been observed in the piriform cortex, whose responses to odorants are sparsely distributed acr
250 his goal is the connectivity of the network, whose role in altering gene expression remains unclear.
251 evated liver transaminase levels in subjects whose samples were RDT positive compared to RDT negative
252 ially colocalized with nuclear paraspeckles, whose scaffolding lncRNA NEAT1 is dramatically upregulat
253 sult in two healthy datasets and in patients whose scans suffered signal loss due to intracortical el
255 rnate retinal loci at further eccentricities whose separation is below the upper disparity limit.SIGN
256 y structured loop in the glutaminase domain, whose sequence is present in eukaryotic enzymes but abse
257 ma) is an intracellular transcription factor whose signaling activation by the selective agonist piog
258 re critical mediators of platelet activation whose signaling can be modulated by members of the regul
261 "stony" corals are major habitat engineers, whose skeletons form the framework for the highly divers
263 ed MuPyV resistant to a monoclonal Ab (mAb), whose specificity overlapped the endogenous anti-VP1 res
264 CLCN6 associated with neurological diseases, whose spectrum of clinical features depends on the diffe
266 Analysis of a zebrafish mutant, spondo, whose spine is dysmorphic, prompted us to reconstruct pa
267 rding to a sequential learning algorithm and whose spread was linked to the range of past measurement
268 eme to Pb(4)S(3)I(2) colloidal nanocrystals, whose structure matches the one that has been published
269 with four other archaeal filamentous viruses whose structures we have previously determined, and show
270 a long-lived partially folded intermediates, whose structures, potentially toxic oligomerization, and
271 s are governed by the conformation landscape whose study requires characterization of the ground and
273 diversity of angiosperms than those beetles whose symbionts solely supplement polygalacturonase.
275 M sleep consists of alternating brain states whose temporal dynamics determine whether conscious expe
276 Barabasi-Albert and Watts-Strogatz networks whose temporal dynamics follow a fractional order state
277 and cadherin-23 (CDH23), form the tip-links, whose tension gates the hair cell mechanoelectrical tran
278 research may reveal NMJ targets and pathways whose therapeutic modulation will help slow the progress
279 egulator of pathological cardiac hypertrophy whose therapeutic targeting in heart disease has been el
280 literature on chiral pai-conjugated systems whose thin films have been characterized by ECD and/or C
281 s a true tumor-specific cell surface antigen whose tissue specificity enables the development of nove
282 ly suggest a trade-off mechanism for females whose total reproductive investment is governed by pre-b
283 ation was lost in the Deltakatms strain, and whose transcript levels increased in M. smegmatis biofil
284 fined functional states during movie viewing whose transitions are temporally aligned to specific fea
286 ay measurements to identify gene transcripts whose translation was up-regulated in response to the st
287 % to 18%) and were observed only in patients whose tumors harbored FGFR1-3 point mutations or fusions
288 expression in human PanINs and that patients whose tumors have low HPK1 and high AXL expression level
289 dding CDKIs to endocrine therapy in patients whose tumours might have differing degrees of endocrine
291 sly received long-term insulin treatment and whose type 2 diabetes was inadequately controlled (glyca
292 otic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with h
294 of root canal infections and identified taxa whose virulence properties should be further explored.
295 osoma vivax is a related, livestock pathogen whose VSG lack structures that facilitate gene conversio
296 mpare clinical outcomes between participants whose weaning trials were retrospectively determined to
297 a weighted network, the gene proximity map, whose weights are based on the contact frequencies betwe
298 enzymes and the ribosomal methyltransferases whose widespread presence severely compromises all amino
299 assembly integral membrane protein (VMA21), whose X-linked mutations lead to autophagic myopathy.