ライフサイエンスコーパス: wide

1 extensive transcriptional readthrough genome-wide.

2 of 6.4 nm are demonstrated on stripes >80 nm wide.

3 se regions and their interactions with brain-wide activity drive action selection is less understood.

4 tation-based method for measuring the genome-wide activity of Cas9 in vitro.

5 etabolites should be investigated metabolome-wide after "Sweating".

6 Genome-wide analyses also revealed that wild-type AID localized

7 fic metrics and answer scales for consortium-wide analyses as well as for comparison of data across i

8 Our genome-wide analyses identified one novel gene (NDUFB9) associa

9 relevant for future population-scale genome-wide analyses of blueberry.

10 We performed a transcriptome-wide analysis during in vitro mucociliary differentiatio

11 The PRP was constructed from a genome-wide analysis of BBxgenotype interaction predicting time

12 study presents the first large-scale, exome-wide analysis of rare variants in AMD.

13 tion than would be expected given the genome-wide ancestry frequencies.

14 Each patch of the SU is 50-200 m wide and long and consists of 5-10 m of south-dipping la

15 takes advantage of the newly emerged, genome-wide and tissue-specific expression quantitative trait l

16 Small- and wide-angle X-ray scattering examines the packing of PE c

17 canning calorimetry (DSC), grazing-incidence wide-angle X-ray scattering, and microscopy can be relat

18 Here we report a genome-wide annotation of transcriptional regulators in A. fumi

19 non-invasive anti-tumor tool, which may have wide application for tumors located in deeper tissues.

20 Genome-wide approaches including polygenic risk scores (PRSs) a

21 ever, unbiased methods to profile GxE genome-wide are nascent and, as we show, cannot accommodate gen

22 , this approach should be generalizable to a wide array of bacteria and find application in medical,

23 ages of T lymphocytes and higher levels of a wide array of inflammatory mediators in their MEE compar

24 er subfamily of Class B GPCRs that control a wide array of physiological processes and are implicated

25 Using this approach, a wide array of polycyclizations are achieved, including v

26 The 51 surgeons interviewed identified a wide array of potential benefits and disadvantages of ov

27 e mammalian lung epithelium is composed of a wide array of specialized cells that have adapted to sur

28 satile donors that play important roles in a wide array of subdisciplines of inorganic chemistry incl

29 We demonstrate that a wide array of substituents is tolerated with this novel

30 n between brain structural development and a wide array of these factors by leveraging data from the

31 Here, we perform genome-wide assessment of chromatin accessibility of the human

32 n summary statistics from the largest genome-wide association analysis of MD (n = 135,458 cases, n =

33 life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expre

34 Previous genome-wide association studies (GWAS) have identified 14 singl

35 Genome-wide association studies (GWAS) have identified over 400

36 nmeasured geographical confounding on genome-wide association studies (GWAS) of complex human traits

37 tive polygenic risk scores (PRS) from genome-wide association studies (GWASs) including 55,105 CRC-af

38 s of findings from a meta-analysis of genome-wide association studies (meta-GWASs) of the broad depre

39 ibility genes identified using public genome-wide association studies data were particularly enriched

40 Genome-wide association studies have identified noncoding varia

41 Genome-wide association studies have revolutionized our underst

42 In recent years, genome-wide association studies have shed light on the genetics

43 Genome-wide association studies have shown many variants are fo

44 Epigenome-wide association studies identified the cg00574958 DNA m

45 Data from genome-wide association studies in up to 215,551 participants f

46 us is the 3rd strongest risk locus in genome-wide association studies of Parkinson disease (PD).

47 lygenic risk score (PRS) derived from genome-wide association studies of posttraumatic stress disorde

48 ng molecular mechanisms, we performed genome-wide association studies of the urinary concentrations o

49 nts for brain disorders identified by genome-wide association studies reside in the noncoding genome,

50 tion to perform cell type-specific methylome-wide association studies within subpopulations of neuron

51 Rationale: GWAS (Genome-Wide Association Studies) have identified hundreds of ge

52 can be used to interpret results from genome-wide association studies, and we discuss current challen

53 aluated heritability enrichment in 64 genome-wide association studies, emphasizing schizophrenia.

54 sociated with type 2 diabetes risk in genome-wide association studies.

55 meta-analyses with 2 independent EoE genome-wide association studies.

56 within a PD risk locus identified by genome-wide association studies.

57 ocus on individual common variants in genome-wide association studies.

58 models using summary statistics from genome-wide association studies.

59 use organs with body mass index (BMI) genome-wide association study (GWAS) data from >457,000 individ

60 Our genome-wide association study (GWAS) identified one novel genom

61 A recent genome-wide association study (GWAS) of 59 cerebrospinal fluid

62 We carried out a genome-wide association study (GWAS) using a panel of 5130 clon

63 We performed a genome-wide association study and analysed the most recent Park

64 ften pose a challenge for traditional genome-wide association study approaches in defining a clear ge

65 A genome wide association study demonstrated that both dietary an

66 We performed a genome-wide association study in Arabidopsis (Arabidopsis thali

67 mary statistics from a European-based genome-wide association study perform poorly in Mexican America

68 In addition, we used a genome-wide association study to identify loci that are associa

69 e area measurements were submitted to genome-wide association testing, followed by polygenic risk sco

70 Here, we used genome-wide association to identify loss-of-function (LOF) muta

71 d, influences chromatin accessibility genome-wide at cellularization, suggesting both are pioneer fac

72 Optically active defects in wide band gap materials, for instance, are critical cons

73 ng good mobility have been big challenges in wide band gap materials.

74 d offline analysis of missense variants by a wide biological community.

75 s (lowest 6(th) percentile of the population-wide BMI spectrum) in a uniquely phenotyped Estonian coh

76 P1 HA-elicited mAbs exhibited a wide breadth of HA recognition, ranging from narrowly re

77 sheet up to hundreds of micrometres long and wide but only about four nanometres thick-in which warp

78 ods enable mapping RBP targets transcriptome-wide, but methodological differences present challenges

79 ently available that has investigated genome-wide changes in gene expression during the normal physio

80 Thus, ANP32E dramatically influences genome-wide chromatin accessibility through subtle refinement o

81 Genome-wide chromatin interaction mapping, using Hi-C, reveals

82 easure neural activity across this brainstem-wide circuit are lacking.

83 Genome-wide CNV breakpoint association showed not only signific

84 tructural systems biology enables a proteome-wide, computational assessment of changes to atomic-leve

85 e, but concurrently increased sensory, brain-wide connectivity.

86 IGH and MYD88(L265P) mutation and the genome-wide copy number aberration (CNA) profiles of individual

87 Using a training-testing approach, epigenome-wide CpGs associated with asthma were identified.

88 Here we performed genome-wide CRISPR screens in Vero-E6 cells with SARS-CoV-2, Mi

89 The genome-wide cross-trait analysis features in several analytic a

90 hromosome-autonomous signaling and a nucleus-wide crossover-counting mechanism partitions holocentric

91 o there is no comprehensive survey of genome-wide CTCF binding patterns across different human cancer

92 ded from two national registries with genome-wide data and two local cohorts, and further incorporate

93 tory of these movements, we generated genome-wide data for 11 ancient individuals from the island of

94 We assembled genome-wide data on 89 individuals dating from ~9,000-500 years

95 predicted their population trends from a UK-wide dataset.

96 We highlight organism-wide differences in mitochondrial proteins including con

97 edian value larger than one, although with a wide dispersion.

98 Due to the wide distribution of these compounds in both the ambient

99 Genome-wide DNA methylation and gene expression are commonly al

100 We tested for RDCs by our genome-wide DSB identification approach that captures DSBs via

101 m allows continuous stimulus sampling over a wide dynamic range.

102 t by the lack of small genetic switches with wide dynamic ranges that control transgene expression wi

103 high-throughput analysis of nuclease genome-wide effects by sequencing' (CHANGE-seq), a scalable, au

104 ion analyses were performed to infer phenome-wide effects of free testosterone on 461 outcomes in 161

105 present a framework to estimate the economy-wide energy requirements and carbon emissions associated

106 omic approaches to generate the first genome-wide estimates of genetic diversity within dwarf lemurs.

107 l biopsy (55.3%, n = 302/546) or lumpectomy (wide excision) (38.5%, n = 210/546).

108 We collected genome-wide exon data for 110 (~80%) species in the group and a

109 ressed these questions in a series of genome-wide experiments coupled to a novel bioinformatic analys

110 use chromatin immunoprecipitation and genome-wide expression analyses to study a possible role of Rme

111 previous findings, demonstrated that genome-wide expression in our new murine model more closely app

112 nly modest (1.4-7.8%) perturbation in genome-wide expression was observed.

113 d-like structures through application of the wide family of click transformations.

114 aphic analysis of the diffraction pattern in wide-field imaging.

115 position based on an optical microscope with wide-field interferometric detection of absorption-induc

116 retrieve this near-field information through wide-field optics in a spatially resolved manner, and th

117 une cells and inhibitory checkpoints, genome-wide frequencies of copy number alterations, mutational

118 first model ever reported that covers such a wide frequency range and includes both interfacial and p

119 eracusis as increased loudness growth over a wide-frequency range, decreased tolerance to loud sounds

120 Cellular integrity, migration, and genome-wide gene expression changes were examined in 16HBE14o-

121 rols detained intron splicing to tune system-wide gene expression, providing a means to couple nutrie

122 Here, we integrate estimates of genome-wide genetic variation with demographic and niche modeli

123 We used an individual-level, population-wide health database to examine associations between ant

124 e gene regulatory processes including genome-wide histone modification, transcriptional regulation, a

125 e range of possible outcomes is sufficiently wide, however, to even include some possibility that Jos

126 esults suggest a general strategy for genome-wide identification and characterization of silencer ele

127 l, M&M does not meet expectations for system-wide improvement.

128 The Chesapeake Basin-wide Index of Biotic Integrity, a benthic macroinvertebr

129 hildren for influenza can produce population-wide indirect effects.

130 y systems for precision nanomedicine attract wide interest across areas of molecular cell biology, ph

131 Cobalt sulfide has interwoven surfaces with wide internal spaces that can accommodate sodium polysul

132 Such taxation is an effective population-wide intervention.

133 chromatography (UHPLC) analysis to integrate wide-isolation quantitative strategies for high-resoluti

134 G epitope recognition at a global, allergome-wide level during allergen-specific immunotherapy (AIT).

135 n targets of mHAAs and mHAMs at the proteome-wide level, which highlights their different toxicity pa

136 monohaloacetamides (mHAMs), at the proteome-wide level.

137 4.8 nm) for the detection of NH(4)(+) with a wide linear range of 0.1-11.5 mM (R(2) = 0.996) and high

138 ity towards the co-enzyme NADH, delivering a wide linear range of 20-960 muM and a high sensitivity o

139 versity analysis revealed significant genome-wide losses of variation among the three stages and supp

140 Integrated analysis of transcriptome-wide m(6)A-seq and mRNA-seq analysis identified the glut

141 for statistically enriched dots on a genome-wide map.

142 Here, we integrate genome-wide measures of mRNA expression, miRNA expression, DNA

143 tiation, and support a model in which genome-wide methylation changes are transduced to differentiati

144 that could have a role in the altered genome-wide methylation profile: the long noncoding RNA ephemer

145 recently published approaches, making genome-wide multilocus analysis of longitudinal traits possible

146 mance of the community, indicating ecosystem-wide multitrophic complementarity, which is potentially

147 Here, through a genome-wide mutant screen of human antigen-presenting cells, we

148 only the I-PI transition engages a brainstem-wide network, and that rLFPs during the PI-E2 transition

149 veness contrasts strongly with intense brain-wide neural network dynamics.

150 Thereafter, the patient underwent a wide orbital exenteration with reconstruction using a te

151 is screen utilized the most extensive genome-wide ORF collection to date, covering 90% of human, nonr

152 ility in organic and aqueous solvents over a wide pH range (pH 1-14), including in the presence of 5

153 genome assembly that combines the chromosome-wide phasing and scaffolding capabilities of single-cell

154 This nation-wide population-based study aimed to report postoperativ

155 e and complexity for a given material in the wide pressure-volume-temperature domain even if its typi

156 Using genome-wide profiling of the H3K27ac histone modification, we i

157 cky Mountains to perform the first community-wide quantification of the drivers of bee phenology.

158 hemical genomic method for the transcriptome-wide quantitative mapping of ac(4)C at single-nucleotide

159 ogation of chromatin architecture and genome-wide RALY-binding pattern reveal insights into its coope

160 Distribution between two phases covered a wide range from being primarily in gas-phase (TEP, TnBP)

161 s have daily rhythms in behaviors and show a wide range of activity patterns.

162 A wide range of acyl fluorides were obtained in moderate t

163 troscopy to track disease progression over a wide range of ages in participants with DMD.

164 d material, has recently been explored for a wide range of ambient applications.

165 l at predicting population dynamics across a wide range of animal taxa.

166 addressing ground-state spins would enable a wide range of applications in quantum information scienc

167 to the well-established GaAs platform for a wide range of applications relying on coherent Bosons in

168 ewed, as these play an important role in the wide range of applications towards which polypeptides ha

169 be adapted for studying cellular forces in a wide range of applications.

170 that this technique will be applicable to a wide range of biological samples and will help to improv

171 simple, scalable, and can be applicable to a wide range of biomass ashes in a closed 'emission-captur

172 e currently the focus of investigation for a wide range of biomedical applications that fall into the

173 nsions and conduction velocity (CV) across a wide range of both stable and unstable VTs delineated by

174 tures optimised for precision-targeting of a wide range of cancers.

175 ctions between disordered proteins involve a wide range of changes in the structure and dynamics of t

176 le completion was generally similar across a wide range of characteristics, younger, healthier, Hispa

177 light (400 nm) and achieves borylation of a wide range of chloroarenes with B(2)pin(2) at room tempe

178 fluorine response factors are obtained for a wide range of compounds, highlighting good efficiency of

179 g type of therapeutic for the treatment of a wide range of conditions, including cancer, but they als

180 traction in a single extraction method for a wide range of DBPs, producing the lowest method detectio

181 ow that the identification is accurate for a wide range of different interfering background structure

182 roteins facilitates promiscuous binding to a wide range of different molecular targets, consistent wi

183 robiome and health are rapidly emerging in a wide range of diseases.

184 our method on lymphatic valves displaying a wide range of dysfunction, from fully competent to compl

185 are addressing the current obstacles with a wide range of engineering strategies in order to improve

186 The wide range of environmental conditions and processes inv

187 and phylogenetic diversity in response to a wide range of environmental variables.

188 sed test SFselect was applied to idfentify a wide range of events of selection (old and recent), and

189 structural basis for the interpretation of a wide range of existing data and the design of further ex

190 lso scored by 53 general endoscopists with a wide range of experience from 4 countries to benchmark C

191 cterial type VII secretion systems secrete a wide range of extracellular proteins that play important

192 The robust method is tolerant of a wide range of functionalities, including rarely reported

193 This opens a wide range of future applications including protein-liga

194 , whereas CF(3) radical addition furnishes a wide range of gem-difluoroalkenes through beta-fluoride

195 lecular markers are essential for studying a wide range of genetic parameters in Lilium species.

196 hagic Escherichia coli that is tolerant to a wide range of glycoforms.

197 are ubiquitous human pathogens that cause a wide range of health complications.

198 viruses.IMPORTANCE Influenza virus infects a wide range of hosts, resulting in illnesses that vary fr

199 Abdominal pain in adults represents a wide range of illnesses, often warranting immediate inte

200 r success, these treatments commonly evoke a wide range of immune-related adverse events (irAEs) that

201 eplication of the genome and the repair of a wide range of lesions.

202 broad sensitivity OFF-RGCs that respond to a wide range of light decrements.

203 s MRI and to validate this approach across a wide range of lung diseases.

204 Datasets of a wide range of markers highlight a decline in capillary a

205 flexible platform that can be extended to a wide range of materials for improved biological performa

206 ganic molecule or metal cation, generating a wide range of materials with tailored properties.

207 ter an initial thermal oxidation, supports a wide range of metal and metal oxide active phases.

208 highly dynamic organelles that can exhibit a wide range of morphologies.

209 allow capturing the electronic dynamics of a wide range of nanoscale materials with ultimate spatiote

210 n of ethylene, propylene, and butenes into a wide range of oligomers that are highly sought-after in

211 o a new class of tunable metamaterial over a wide range of operating frequencies.

212 ound to vary between 300 and 1800 K nm for a wide range of particle compositions.

213 tes are fascinating materials that exhibit a wide range of physical properties, including giant Rashb

214 ord the producing bacteria protection from a wide range of physical, chemical, and biological stresse

215 n, and it is chemically complex-reflecting a wide range of physiological states and functions.

216 ught to systematically screen and validate a wide range of potential modifiable factors for depressio

217 ariability in growing season rainfall over a wide range of precipitation amounts, from extreme wet to

218 ptimal choice of sorter and parameters for a wide range of probes and brain regions.

219 The software can handle a wide range of problems that interest biomechanists, incl

220 g in size and shape were investigated over a wide range of relative humidities (0-90%) and temperatur

221 that intervention strategies should target a wide range of relevant factors, including ACEs, socioeco

222 ironment and can reach polar latitudes via a wide range of routes, such as some persistent organic po

223 il formation is central to the etiology of a wide range of serious human diseases, such as Alzheimer'

224 from infected and uninfected subjects, and a wide range of serum/plasma antibody levels was delineate

225 r phosphotyrosine motifs and is present in a wide range of signaling pathways across different evolut

226 Here we analyze butterfly wings across a wide range of simulated environmental conditions, and fi

227 ome inequality affects the distribution of a wide range of social and economic outcomes.

228 have been implicated in the regulation of a wide range of social behaviors across taxa.

229 are a conserved structural fold but act on a wide range of substrates to catalyze reactions involved

230 ems such as pollen paper opens the door to a wide range of sustainable, eco-friendly, and biocompatib

231 Finally, the striatum and thalamus showed a wide range of synapse densities.

232 ith continuous information transfer across a wide range of the spatial frequency spectrum, with impro

233 We cover a wide range of transition-metal-catalyzed, template-direc

234 cohort, we signifies that MOVICS can serve a wide range of users and assist cancer therapy by moving

235 was more frequently cost-effective across a wide range of willingness-to-pay thresholds.

236 e in vivo studies of cell-cycle control in a wide-range of developmental contexts.

237 ability and scalp potentials, we conducted a wide-ranging exploratory data analysis (EDA), pooling ou

238 The results have wide-ranging implications for global ecology and for ant

239 Our results have wide-ranging implications for optimising antitrypanosoma

240 Rapid climate change has wide-ranging implications for the Arctic region, includi

241 The biological carbon pump (BCP) comprises wide-ranging processes that set carbon supply, consumpti

242 nternational Humic Substance Society (IHSS), wide-ranging values exist in the literature.

243 largely manifested as differences in genome-wide recombination rate rather than remodeling of the lo

244 transcription factor availability via genome-wide redistribution and couples BRAF to tumorigenesis.

245 The analysis of a wide representation of heterologous plant species corrob

246 al recent deep learning techniques including wide residual networks, dropouts and dilated convolution

247 Low-level class-wide resistance, which often goes undetected in the clin

248 In the absence of population-wide restrictions, isolation of infected individuals is

249 ean domain, and reflects the transition from wide rift to continental breakup.

250 et effects in KID-KCs, as detected by genome-wide RNA sequencing.

251 ated during development, we performed genome-wide RNA tomography sequencing on zebrafish, chicken, mo

252 However, the genome-wide role of CSB/Rad26 in TC-NER, particularly in the co

253 ls to study DSB repair at a local and genome-wide scale.

254 markers for cancers by performing a phenome-wide scan (PheWAS).

255 biquitous and inexpensive reagents, boasts a wide scope, and can be made highly atom economic, makes

256 The wide scopes of MBH adducts and indolizines were investig

257 conjugating enzyme E2 variant 1) in a genome-wide screen designed to identify novel effectors of the

258 A previous genome-wide screen revealed that depletion of 14 RNA splicing f

259 llowed by polygenic risk scoring and phenome-wide screening, to identify genetic comorbidities.

260 Here, using genome-wide screening, we find that SAT1 selectively controls n

261 erent patients with VRL had no common genome-wide signatures.

262 ated with the reproductive subtype at genome-wide significance (PRDM2/KAZN, P = 2.2 x 10-10; IQCA1, P

263 as well as aggressiveness; 183 reach genome-wide significance.

264 weighted polygenic scores using known genome-wide significant associations for T2D, fasting glucose,

265 The authors identified novel genome-wide significant associations near genes involved with g

266 ion studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's di

267 X, based on the number of independent genome-wide-significant loci across all diseases (for example,

268 eloped a nucleotide resolution transcriptome-wide, single molecule SM-PAT-seq method.

269 set of five putative MDD biomarkers, genome-wide SNP data, and 27 clinical, demographic and lifestyl

270 a (Amygdalus, Prunus and Cerasus) for genome-wide SNP identification and to assess genetic diversity

271 Genome-wide spatial transcriptomics analysis provides an unprec

272 This wide spectrum of disorders, which include dyskeratosis c

273 o confine acoustic waves in an all-angle and wide spectrum range due to tremendous impedance mismatch

274 devegetation simulations, that represent the wide-spread exposure of bare soil in the 1930s, suggest

275 nents of a touch sensor operational across a wide temperature range, including freezing conditions, i

276 rs with the tools to analyze proteins over a wide temperature range, paving the way toward T-dependen

277 ls and compare them in the context of genome-wide transcriptional landscapes.

278 In genome-wide transcriptional studies, we found that ZIKV infecti

279 Genome-wide transcriptomic analyses have revealed abundant expr

280 ia has been increased in recent years by the wide use of antibiotics in human populations and in live

281 There is wide variability among emergency medical systems (EMS) w

282 following hepatopancreatic procedures with a wide variation in the rates of TO among hospitals.

283 Napping could be beneficial but there was wide variation regarding nap duration and timing, and we

284 t capable after training of discriminating a wide variety of analytes.

285 s and other transitions may be inherent in a wide variety of animals.

286 including cyclic and acyclic alcohols and a wide variety of arylacetonitriles bearing different func

287 synthesis of 35 different ketones bearing a wide variety of functional groups with an average yield

288 y and architecture of biofilms produced by a wide variety of microorganisms.

289 s applicable to high resolution imaging of a wide variety of non-volatile and semi-volatile molecules

290 ystems and are important for understanding a wide variety of phenomena in physics.

291 an important role in cellular responses to a wide variety of physiological and pathological condition

292 Urban areas exist in a wide variety of population sizes, from small towns to hu

293 Recent studies have unveiled a wide variety of regulatory mechanisms including autoregu

294 NA-based junctions has been reported using a wide variety of set-ups(2-4), but experiments so far hav

295 ent nonplanar framework and are soluble in a wide variety of solvents.

296 ample of a versatile microbe that exhibits a wide variety of states is the bacterium Bacillus subtili

297 The hippocampal CA1 field integrates a wide variety of subcortical and cortical inputs, but its

298 the effectiveness of this framework across a wide variety of tasks and computational paradigms, rangi

299 Application to kinetic analysis of a wide variety of transformations (acylation, S(N)Ar, sily

300 sage of Pol II through +1 nucleosomes genome-wide would obligate H2A.Z turnover, we propose that glob