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1 ) of 88 degrees C (+45 degrees C relative to wild type).
2 hat of heteromeric GlyRs (0.96; cf. 0.99 for wild type).
3 tant, NRAS-mutant, NF1-deficient, and triple wild-type).
4 t C/P efficiency of CSTF2D50A was lower than wild type.
5 ncy of root hair formation compared with the wild type.
6 ficantly less stable and infectious than the wild type.
7 G and fusion (F) protein levels than for the wild type.
8 pta and more nuclei per compartment than the wild type.
9 te influx in cadt1 was 2.4 times that of the wild-type.
10 lated in overexpressing fruits compared with wild-type.
11 instead of localising at myofibre ends as in wild-type.
12 nt reduction in MNRR1 levels compared to the wild type (0% heteroplasmy) (CL9), we evaluated the effe
13 ation (half-widths: 0.25 +/- 0.08 ms, n = 19 wild-type, 0.60 +/- 0.17 ms, n = 21 Kv3.3KO, p = 0.0001)
14 ecombinant virus lacking these miRNAs to the wild type (17syn+), we found that during acute infection
15 rent contraction kinetics in knockout versus wild-type; (2) Aberrant activation of the glucose/lipid
16 In the test sample of 49 gliomas (nine IDH wild type, 21 IDH mutant/1p19q intact, and 19 IDH mutant
17 antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c
18 hanced by about 2 and 8 K when compared with wild-type A(1)-receptor and A(1)R-Y288A(7.53) (a folding
20 rectly injecting adenoviruses expressing CaM-wild type, a loss-of-function CaM mutation, CaM (1-4), a
21 , recombinant RSV strains harboring either a wild-type A2 strain G gene (one stop codon preceding a w
24 direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thali
28 n of the ACKR2-V41A receptor compared to the wild type allele by measuring its ligand binding affinit
33 bining infection studies of L. monocytogenes wild type and isogenic mutants together with biochemical
36 te hippocampal and cortical slices from male wild-type and amyloid precursor protein (APP) knock-out
38 tly, equally inhibits ring-stage survival of wild-type and artemisinin-resistant parasites harboring
39 d the immune response were analyzed by using wild-type and B-cell-deficient (muMT) mice and transfer
41 e, a differential study was carried out with wild-type and CT-1 null mice in fed (ad libitum) and foo
42 day 5 postinfection (d p.i.), although both wild-type and DUBmut virus infections resulted in simila
45 combination strategies that can target BRCA wild-type and homologous recombination (HR) DNA repair-p
47 mice displayed increased weight relative to wild-type and increased food intake at 20 months of age,
49 tal periodontitis was induced for 30 days in wild-type and Msx2 knock-in Swiss mice using Porphyromon
53 mutation caused a splicing defect, we tested wild-type and mutant mRNA substrates, containing 333 nt
57 sphorylation of AGO2(Y393) disrupts both the wild-type and oncogenic KRAS-AGO2 interaction, albeit un
58 he onset of rapid cell rearrangement in both wild-type and snail twist mutant embryos, where our theo
59 ated Vi (165 kDa) induced a response in both wild-type and T cell-deficient mice, suggesting that it
62 carried out parallel CRISPR-Cas9 screens in wild-type and TP53 knockout human retinal pigment epithe
64 ange mass spectrometry (HXMS) are applied to wild-type and VWD variants of the single A1, A2, and A3
66 the dentate gyrus, which was not the case in wild-type animals, and worsens impairment in spatial lea
67 report describes the effects of full-length, wild-type APC (fl-APC) on cell-cell adhesion genes and p
68 n tested the impact of expressing either the wild type APH-1B or the APH-1B T27I variant on gamma-sec
70 rt a novel transgenic mouse expressing human wild-type asyn under control of the noradrenergic-specif
71 ities in mice intranasally challenged with a wild-type B anthracis strain or with an isogenic mutant
76 he protective efficacy of BCG-disA-OE versus wild-type BCG and measured lung weights, pathology score
78 ty of homomeric GlyRs (to 0.16; cf. 0.99 for wild type) but reduced only marginally that of heteromer
79 within the primordia of tt7-2 compared with wild-type, but not in the tt4 mutant, consistent with op
80 P mice (CD31(+) CD45(-) GFP(+) cells), or in wild type C57BL/6 mice (CD31(+) CD45(-) endoglin(+) cell
82 we used streptozotocin to induce diabetes in wild-type C57BL/6 and knockout mice lacking the genes en
84 ilateral superior cervical ganglionectomy in wild-type C57BL/6 mice, we showed that sympathetic nerve
85 de in cells that potently block infection by wild-type capsid, demonstrating that HIV-1 can use disti
86 transformation of AA to HMD (via 6-ACA), the wild type CAR was combined with the L342E variant and tw
87 3D genome folding using Hi-C experiments on wild type cells and ataxia telangiectasia mutated (ATM)
89 orthogonal methods we validated that PIK3CA wild-type cells adopt MAPK-dependent circuitries in brea
90 e activator aphB, and ompR overexpression in wild-type cells also repressed virulence through aphB We
93 tation to indole caused a bipartite response-wild-type cells were attracted to regions of high indole
96 vioral effects without necessarily restoring wild-type circuit states, while highlighting the potenti
97 ted using tissue-specific GA inactivation in wild-type (Col-0) or rescue of GA-deficient dwarf mutant
98 re abundant and myofiber size was larger for wild-type compared with Icam1(-/-) mice during 28 days o
101 ty of the other four containing at least one wild-type copy of Ppal15kDa was compromised at varying l
104 lone should be offered to patients with BRAF wild-type cutaneous melanoma, while those three regimens
106 activity in a manner indistinguishable from wild-type D2R, indicating that arrestin recruitment can
107 tent neutralizing antibody responses to both wild-type (D614) and D614G mutant(2) SARS-CoV-2 as well
108 nches light-induced rhodopsin signaling like wild type, demonstrating that in vivo monomeric arrestin
109 assembly of equimolar mixtures of mutant and wild-type desmin generated chimeric filaments of seeming
111 the aortas of young and aged normolipidemic wild type, disease-free mice and found that aging led to
112 ation between mutated DNA from patients over wild-type DNA from healthy volunteers was obtained thus
113 molecule intermolecular FRET measurements of wild-type E-cadherin and cis-interaction mutants combine
118 r cell death can have the opposite effect on wild-type epithelia by inducing, via a non-autonomous IL
119 ions induce distinct expression changes from wild-type ETV6 and enhance cell motility and invasivenes
120 indicate that the dominant structure in the wild type exhibits a triplet involving the unpaired nucl
124 D8s; however, gB-CD8s primed by a concurrent wild-type flank infection infiltrated the TG and were re
127 A2 strain G gene (one stop codon preceding a wild-type gene end signal), an A4G gene end signal prece
131 FX6(HA) reporter allele by gene targeting in wild-type H9 cells to precisely define RFX6 expression a
132 he frequency of homozygous TSG disruption in wild-type hosts compared to those with an inherited driv
133 chanically evoked currents is similar to the wild type; however, the proportions of rapidly adapting
134 f megakaryocyte-associated genes compared to wild-type HSPCs, and we provide early validation of G6B
135 d a DNase I cleavage assay we found that the wild type hTERT core promoter folds into a stacked, thre
140 for RSV-driven AHR, since reconstitution of wild-type ILC2 rescued RSV-driven AHR in IL-13-deficient
141 3% enzymatic activity when compared with the wild-type immunotoxin in an adenosine diphosphate-ribosy
144 rand invasion occurs in uls1Delta cells with wild-type kinetics, arguing that global histone depletio
146 rom nonfailing and HF hearts, 4 mouse lines: wild-type, KO (CaMKIIdelta-knockout), CaMKIIdeltaC trans
147 r in mitochondria from YAC128 mice and their wild-type littermates as well as in mitochondria from po
148 1 deletion (EC-AGO1-knockout [KO]) and their wild-type littermates to a fast food-mimicking, high-fat
149 e inside the airway of Dp16 mice compared to wild-type littermates, showing the potential risk of upp
153 action to a live human host, a behavior that wild-type males never display, suggesting that male mosq
157 resistant to growth of various cancers than wild-type mice and are more responsive to anti-PD-1 immu
158 ntotemporal dementia (FTD) as well as in the wild-type mice and tau knock-out and P301L tau mouse mod
159 pts were expressed at very low levels in the wild-type mice and were significantly upregulated in the
160 S100-knockout mice weighed 21% more than wild-type mice at age 8 weeks and a higher proportion de
162 thermore, melanopsin-activated astrocytes in wild-type mice enhanced the firing rate of cortical neur
164 mized female GPR30(-/-) , ERalpha(-/-) , and wild-type mice injected intramuscularly with the potent
165 jection of two antisense oligonucleotides in wild-type mice leads to a dose-dependent increase in pro
171 serotypes were injected intrathymically into wild-type mice, and gene transfer efficiency was monitor
172 C/MS, in normal small intestines of C57BL/6J wild-type mice, and in normal and tumour samples from Ap
175 histone mark H3K9me3 in mdx mice compared to wild-type mice, indicating a chromatin conformation less
176 el intensity and subcellular distribution in wild-type mice, knockout mice, and receptor-positive and
179 ponses that were comparable in magnitudes to wild-type mice, suggesting that this B cell response was
191 erebral infiltration of ACE10 as compared to wild-type monocytes (~3-fold increase; P < 0.05) led to
192 mutant superoxide dismutase-1 (mutSOD1) kill wild-type motor neurons (MNs) by an unknown mechanism.
193 the causative bacterial species in different wild-type mouse backgrounds as well as in knockout, tran
194 uces ECM and integrin alpha5 proteins in K41 wild-type mouse embryo fibroblasts (MEFs), CRT null MEFs
195 xposure to all-trans retinoic acid (ATRA) on wild-type NK and CD38KO NK cell function and highlighted
196 yzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricu
200 based on their mode of action and effects in wild-type or in other neurodegenerative disease models m
201 s identified by pigment presence or absence (wild-type or knock-out lineages, respectively) followed
205 ransfer (FRET) to determine the influence of wild-type or S34F-substituted U2AF1 on the conformationa
206 (39 muW/cm(2)), which is higher than that of wild-type P. aeruginosa and even the strongly electrogen
207 eomic comparison of TbDYRK null mutants with wild-type parasites identified molecules that operate on
208 r levels of alkylation-induced DNA breaks as wild type, PARP-1 activation is undetectable in AAG-defi
210 by using cyanide to block Pi assimilation in wild-type plants and a vacuolar Pi transport mutant, and
211 tants were not affected compared to stressed wild-type plants, suggesting that alterations in PA leve
216 ue is essential for the proximal activity of wild-type PLCgamma1, but we provide evidence that activa
217 on of InsP(8) levels through transfection of wild-type PPIP5K1; transfection of kinase-dead PPIP5K1 w
219 tructural analyses of the PIs complexed with wild-type Protease (PR(WT)) and highly-multi-PI-resistan
222 enerate a similar inflammatory response to a wild-type rabbit strain and, therefore, validated this m
223 We measured airway inflammation and AHR in wild-type, RAGE(-/-) , TLR4(-/-) and TLR4(-/-) RAGE(-/-)
225 agonists have no effect on dopamine (DA) in wild type rats, we used the methylzoxymethanol acetate (
226 genomic databases showed that patients with wild-type RBM10 and p53 survive longer than do those wit
227 tal defect, completely rescued in irradiated wild-type recipients of PDIA6-deficient bone marrow cell
228 nd in naive BALB/c mice compared to that for wild-type RSV, the r2stop+A4G RSV was better able to inf
231 ultaneously to the S protein and neutralized wild-type SARS-CoV-2 virus in a synergistic manner.
232 to 25 degrees introduces variability in the wild-type seam cell lineage, with a proportion of animal
235 Adult rat ventricular myocytes expressing wild-type SERCA2b or a redox-insensitive mutant in which
236 the SFTSV-A46 mutant replicated similarly to wild-type SFTSV (SFTSV-WT), it showed weaker pathogenic
237 Consistently, the application of auxin to wild-type shoots induced a steeper GSA and auxin transpo
240 s able to tolerate 100 mM serine whereas the wild type strain was already inhibited by 1 mM of the am
241 per(Bd-Kah) element isolated from the Kahuku wild-type strain was highly degenerate and appeared to h
245 e until a reference genome of autotetraploid wild type sugarcane specie, Saccharum spontaneum is avai
246 into the plant tissue are as virulent as the wild type, suggesting that this is due to alterations in
249 lipoxygenase mutant, lox10, colonized by the wild-type T. virens (TvWT) lacked ISR response against C
250 Here we show that, when challenged with wild-type temperate phages (which can become lysogenic),
251 Idelta-knockout), CaMKIIdeltaC transgenic in wild-type (TG), or KO background, and wild-type mice exp
252 attainment of structural information on the wild-type TM287/288 expressed in cellular membranes with
257 SF3B1 mutations, we also detected nine SF3B1 wild-type tumors (including five lung adenocarcinomas).
258 ficantly outcompeted during cochallenge with wild-type UMH9 in the kidneys and spleen after inoculati
259 ch postulates that reexposure to circulating wild-type varicella delays the onset of herpes zoster, p
262 hogenesis of the DUBmut virus to that of the wild-type virus and found that the DUBmut-infected mice
264 ylation and grew to 2-log-higher titers than wild-type virus in human Caco-2 cells and simian Vero ce
267 Several pathways activated by heat stress in wild type were induced to a lesser extent in Mgat4d[-/-]
268 nzyme showed no loss in activity compared to wild type, while displaying a T(m) of 88 degrees C (+45
269 er times to respiratory arrest compared with wild type, without altering blood chemistry or displayin
274 tation increased chromosome instability in a wild-type (WT) background, suggesting that such mutants
278 r that, AnxA1, Fpr2/3 knockout (KO) mice and wild-type (WT) controls were infected intranasally with
280 essed in HuH7 cells were less sensitive than wild-type (WT) enzyme to degradation evoked by DPTA, sug
281 ER+, PR+ T47D breast cancer cells expressing wild-type (WT) ER or an activating ESR1 mutation, Y537S-
282 tions in the expression of the corresponding wild-type (WT) gene, due to either variations in copy nu
283 ative damage were greater in Taz(KD) than in wild-type (WT) hearts, but there were no differences in
284 ere, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable
285 ction with Citrobacter rodentium compared to wild-type (WT) mice evidenced by more severe intestinal
287 from about 4 postnatal weeks, SOD1-G93A and wild-type (WT) mice were evaluated in the rotarod test,
296 d IgG binding to red blood cells (RBCs) from wild-type (WT), alpha1,3-galactosyltransferase gene-knoc
300 OV-neutralizing and binding antibodies using wild-type Zaire EBOV (ZEBOV) or pseudovirion assays were