ライフサイエンスコーパス: window of opportunity

1 impressionable period often regarded as the window of opportunity.

2 in the youngest patient implies a potential window of opportunity.

3 d if the CCR5 peptide is absent during their window of opportunity.

4 that interact within specific developmental windows of opportunity.

5 rs and will be key to understanding critical windows of opportunity.

6 pies during this diagnostic and therapeutic "window of opportunity."

7 lly in a nonthreatening way; (2) identify 'a window of opportunity'; (3) deliver sustainable and avai

8 nt age in 2022, it is imperative to take the window of opportunity afforded by China's economic growt

9 suggest that antiretroviral treatment in the window of opportunity after exposure to HIV could preven

10 ntial therapeutic value within a therapeutic window of opportunity after SEB encounter.

11 carcinogenesis pathway supports a potential window of opportunity among the target population.

12 t application of biologic therapy within the window of opportunity and aid in the monitoring of respo

13 py may paradoxically limit their therapeutic window of opportunity and clinical activity.

14 ming of intervention to target any potential window of opportunity, and potential mechanisms for diet

15 l, learning lessons from experience, seizing windows of opportunity, and ensuring sensitivity to cont

16 The outcomes suggest a window of opportunity at a young age for intervention to

17 in ABC skill gains and identify higher-skill windows of opportunity based on specific climate conditi

18 nfection period, however, presents a unique "window of opportunity," because there are a limited numb

19 and multilateral agencies should seize this window of opportunity before it closes.

20 y is important as many couples have a narrow window of opportunity before the age-related effects of

21 de in clinical trials, we conducted a pilot, window-of-opportunity clinical study in 17 patients with

22 NSCC who received erlotinib monotherapy in a window-of-opportunity clinical trial (patients scheduled

23 the knowledge base to be acquired before the window of opportunity closes for feasible management.

24 Here, in window-of-opportunity cohorts A (4 weeks of anti-PD-1) a

25 s, while dysregulation during this critical 'window of opportunity' could have lifelong impacts on th

26 g evidence that communities can seize on the window of opportunity created by climate-induced shocks

27 -1 transmission could potentially narrow the window of opportunity during which a vaccine is able to

28 during infection defined an extremely narrow window of opportunity during which anti-TNF therapeutics

29 malaria parasite, the merozoite, has a small window of opportunity during which it must successfully

30 n multiple sclerosis lesions may determine a window of opportunity during which oligodendrocyte precu

31 ue that adolescence represents an additional window of opportunity during which substantial life cycl

32 e is appealing, because it might allow for a window of opportunity during which treatment regimens ca

33 c vegetation modelling, we identify two key 'windows of opportunity' during the Ordovician and Jurass

34 in determining the critical periods (i.e., a window of opportunity) during perimenopause for restorin

35 nitiate antirheumatic therapy, a therapeutic window of opportunity early in the course of RA associat

36 te of what the concept of intervening in the window of opportunity entails.

37 dalar structure and function, there exists a window of opportunity even after stress to mitigate its

38 ity of information to address whether such a window of opportunity exists for progesterone and its re

39 n of pancreatic cancer suggests that a large window of opportunity exists for the early detection of

40 y, we sought to identify whether a temporal "window of opportunity" exists during which cells of the

41 ce or repress exon 3 occurs during a limited window of opportunity following transcription, indicatin

42 port, chiral nanomaterials are opening a new window of opportunities for the design of advanced funct

43 ur in vitro and in vivo data not only open a window of opportunities for the development of novel can

44 The window of opportunity for a HIV-1 vaccine is from the ti

45 This confirms that the window of opportunity for a protective effect might be f

46 therapeutic strategy still might represent a window of opportunity for a subpopulation of patients wi

47 Levodopa has a short half-life and a limited window of opportunity for absorption in the proximal sma

48 tudy of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge

49 ve yet to be done, but it is likely that the window of opportunity for altering the course of brain d

50 sion to new joints, and identifies a rolling window of opportunity for altering the natural history o

51 These data imply a window of opportunity for anti-K-ras therapies after tum

52 ss how the current situation offers a unique window of opportunity for assessing the effects of de-es

53 This provides a window of opportunity for athletes to exploit with relat

54 Studies suggest a window of opportunity for biologically based diagnostics

55 ltured Rosa cells RG-II domains have a brief window of opportunity for boron-bridging intraprotoplasm

56 e prostasin, resulting in an extremely brief window of opportunity for both active matriptase and act

57 he link between HBV and HCC risk, creating a window of opportunity for cancer prevention in HBV carri

58 Large-pore ion channels present a window of opportunity for cell-specific intracellular dr

59 over a period of 10 to 15 years, providing a window of opportunity for chemoprevention and early inte

60 ement characteristics: The gate opens a time-window of opportunity for competence transitions during

61 ects of ZIKV can be reduced using a seasonal window of opportunity for conception that may minimize m

62 vasculature, reducing hypoxia and creating a window of opportunity for concurrent chemotherapy; thus,

63 change and land and sea use are closing the window of opportunity for connectivity conservation.

64 function of drug dose, establishes either a window of opportunity for containing tumors or the inevi

65 Our findings highlight the rapidly closing window of opportunity for controlling the outbreak and a

66 This prolonged course of disease provides a window of opportunity for diagnosis before symptoms occu

67 e their oncologic knowledge to determine the window of opportunity for each surgical procedure, based

68 c cancer progression and define a broad time window of opportunity for early detection to prevent dea

69 plant loss or death due to CLAD might open a window of opportunity for early diagnosis and treatment

70 t midlife, we suggest there exists a sizable window of opportunity for early interventions to counter

71 transmission and immune defense, implying a window of opportunity for early interventions, whereas t

72 clues through the course of hATTR-CA offer a window of opportunity for early treatment onset to cease

73 ganglion cell loss alone, it also suggests a window of opportunity for effective neuroprotection.

74 the periweaning period was associated with a window of opportunity for enhanced pT(reg) cell generati

75 he TDP may represent an as yet unappreciated window of opportunity for extracellular cues to influenc

76 ts, where early vernal species have a narrow window of opportunity for growth before late spring spec

77 uman immune system in BLT mice may provide a window of opportunity for HTLV-1 replication and the sel

78 These results suggest that the window of opportunity for human DNA ligase I may extend

79 A window of opportunity for immune responses to extinguish

80 cates prenatal life and early childhood as a window of opportunity for improving lung health in adult

81 with the possible existence of a therapeutic window of opportunity for intervening to promote recover

82 function in ACHM with age suggests that the window of opportunity for intervention by gene therapy i

83 to the early recovery period as a potential window of opportunity for intervention to alter patient

84 There appears to be an early and brief window of opportunity for intervention to mitigate the p

85 Importantly, it represents a window of opportunity for intervention, as remaining at

86 r HIV-exposed infants, but there is a narrow window of opportunity for intervention.

87 sed attention on the period -9 to 24 mo as a window of opportunity for interventions against stunting

88 easures during early childhood, suggesting a window of opportunity for interventions targeting these

89 We show that the window of opportunity for invasion of drug resistant str

90 of hypomethylation (e.g. in tumor cells), a window of opportunity for L1 derepression arises, and ad

91 progression, and suggest that a substantial window of opportunity for locus coeruleus/ norepinephrin

92 scillation upstates are thought to provide a window of opportunity for memory consolidation, particul

93 nsertional activity in males by exploiting a window of opportunity for mobilization created by the ac

94 Because of the limited window of opportunity for mtDNA transfer to the germline

95 f allergen-specific IgE, which can provide a window of opportunity for novel therapeutic intervention

96 The existence of a second window of opportunity for nutritional interventions duri

97 To estimate the window of opportunity for ovarian cancer screening, we d

98 Early and accurate diagnosis offers a window of opportunity for parental counseling and manage

99 gene-encoded determinants that minimize the window of opportunity for PFI to bind provide a growth a

100 ate formation of free radicals may provide a window of opportunity for pharmacological rescue immedia

101 ng rapid eye movement sleep provide a unique window of opportunity for plasticity in neuronal represe

102 s and G1 phase is crucial for establishing a window of opportunity for pluripotency exit and the init

103 imizing the treatment regimen may extend the window of opportunity for preventing perinatal HIV infec

104 They also imply that there is a window of opportunity for prevention of AHT, and potenti

105 gest pre- and perinatal life as an important window of opportunity for prevention of asthma and inhal

106 overall a relatively early phase, there is a window of opportunity for prevention that should not be

107 period appears to provide us with a crucial window of opportunity for prevention.

108 dilated cardiomyopathy in DMD and identify a window of opportunity for preventive interventions.

109 GA pathology develops, provides an extended window of opportunity for proof-of-concept evaluation of

110 As a result, the window of opportunity for realizing the benefits of a bi

111 le pausing of polymerase provides a temporal window of opportunity for recruitment of factors to modu

112 m pregnancy to 24 months of age is a crucial window of opportunity for reducing undernutrition and it

113 y analyses suggested that the most important window of opportunity for regular yogurt consumption to

114 ns the promoter of bound RepA and provides a window of opportunity for repA transcription.

115 This diversity provides a window of opportunity for research on genes and gene-env

116 ehabilitation while not missing the critical window of opportunity for successful transplantation whe

117 rly peripheral nerve regeneration offering a window of opportunity for surgical intervention where ea

118 usion and metabolism mismatch may open a new window of opportunity for surgical intervention.

119 ure chop accumulation and thereby provides a window of opportunity for the cell to re-establish homeo

120 ndicates that pubertal development reopens a window of opportunity for the HPA axis to recalibrate ba

121 icular subpopulation apparently represents a window of opportunity for the initiation of potentially

122 Temporarily inhibiting p53 function offers a window of opportunity for the memory CD8 T cells to repa

123 We here identify a precise window of opportunity for the treatment of complex spina

124 Our findings suggest that the best window of opportunity for therapeutic approaches is befo

125 t autoantibodies, which opens an interesting window of opportunity for therapeutic intervention.

126 d emphasizes the concept of a "developmental window of opportunity for therapeutic mitigation" in wha

127 woody vegetation due to drought may create a window of opportunity for these invaders.

128 ur results could point to a limited temporal window of opportunity for this therapeutic intervention.

129 election criteria are underway to expand the window of opportunity for thrombolysis.

130 ly detection of LOS may provide clinicians a window of opportunity for timely initiation of individua

131 potentially at preclinical stages, offers a window of opportunity for tolerogenic therapy.

132 Delayed treatment protocols may extend the window of opportunity for treatment of spinal cord injur

133 A window of opportunity for treatment was detected because

134 second decade of life, suggesting an optimal window of opportunity for treatment within the first 3 d

135 Pregnancy represents a window of opportunity for vaccination due to established

136 delayed in several countries, pointing to a window of opportunity for vaccination in a future pandem

137 demonstrate that by utilizing rapamycin, the window of opportunity for veto-based induction of tolera

138 ue in the mouse intoxication models revealed windows of opportunity for antibody therapeutic treatmen

139 least in part in ASD neurons, and may reveal windows of opportunity for biotherapeutics to target the

140 Research has elucidated two distinct windows of opportunity for clinical use of hypothermia.

141 The findings indicate that the windows of opportunity for enhancing growth after spinal

142 y model in which core promoters define broad windows of opportunity for expression, by defining a ran

143 ritorial conflicts thus provide intermittent windows of opportunity for host reproduction.

144 conception and post-delivery represent early windows of opportunity for improving long-term health, e

145 vant for precision health, may help identify windows of opportunity for intervention, and may inform

146 Research aims to define the temporal windows of opportunity for interventions, test the safet

147 sions into an extended open state may create windows of opportunity for protein factors involved in D

148 lic awareness and electoral periods can open windows of opportunity for reframing agendas and promoti

149 ld be particularly beneficial when temporary windows of opportunity for safe access can be granted in

150 driven excitability changes provide temporal windows of opportunity for single pyramidal cells to sup

151 rely on alternating waves of inhibition and windows of opportunity for spiking.

152 dothelial cell cycle states provide distinct windows of opportunity for the molecular induction of ar

153 ulation of anti-TNF therapy identified clear windows of opportunity for this intervention as well as

154 ring medical attention thus represent unique windows of opportunity for trafficked persons to receive

155 cuss the emerging therapies, and examine the windows of opportunity for treating AKI.

156 ury evolves after hypoxia-ischemia, offering windows of opportunity for treatment and insights into t

157 that a patient is screened within a certain "window of opportunity" for intervention when early cance

158 nds and that fast elongation compresses the "window of opportunity" for recognition of upstream splic

159 This delay provides a critical "window of opportunity" for recruitment of lineage-specif

160 The totality of data indicates that the "window of opportunity" for reducing coronary heart disea

161 To understand if these processes act as "windows of opportunity" for changes in cell identity, we

162 This suggests the existence of temporal "windows of opportunity" for tumours of different types i

163 an important complementary concept, next to windows of opportunity, for sustainability science resea

164 also indicated that there was a therapeutic window of opportunity from P4 through P8 defined by the

165 While such a window of opportunity has been described for estrogen, t

166 A window of opportunity has been suggested for reducing th

167 unctional neurosurgical techniques, a unique window of opportunity has recently arisen to target pote

168 A 'critical window of opportunity' has been proposed for the efficac

169 We explored the window of opportunity hypothesis in relation to cognitiv

170 ent conflicting data can be explained by the window of opportunity hypothesis suggesting that the neu

171 Moreover, they lend credence to the "window of opportunity" hypothesis during which hormone r

172 This has led to the 'Window of Opportunity' hypothesis, which states that est

173 Arapaima management is a superb window of opportunity in harmonizing the co-delivery of

174 ur results support the concept of a critical window of opportunity in sepsis resuscitation.

175 gies that act to recapitulate the early life window of opportunity in stemming the FA epidemic.

176 ould be evaluated as adjuncts to broaden the window of opportunity in the treatment of the reperfusio

177 prediagnostic phase of the disease offers a window of opportunity in which disease-modifying therapi

178 est that early-phase CDI provides a possible window of opportunity in which MIF targeting, potentiall

179 early postnatal period represents a critical window of opportunity in which parallel development of t

180 Instead, there may be a tumor stage-specific window-of-opportunity in which conserving STMN1 expressi

181 d (ii) that climate-related shocks can offer windows of opportunity in which latent local adaptive ca

182 There are windows of opportunity in which vaccination would be ben

183 with its control by vaccination offering a "window of opportunity" in which infection may occur.

184 and mutational processes that can determine "windows of opportunity" in time to detect rapidly progre

185 The concept of a 'window of opportunity' in treating a disease assumes the

186 This short window of opportunity is applicable to HIV infections an

187 in this activity, suggesting that a temporal window of opportunity is missed after zen knockdown.

188 The window of opportunity is still open, but we need to reco

189 ble but requires early consideration, as the window of opportunity may be short.

190 pus erythematosus has shown that the optimal window of opportunity may even extend into asymptomatic

191 Using these values, our model predicts a window of opportunity of 2.9 years, indicating that one

192 on of ictus patients, offering a therapeutic window of opportunity of great interest for patient reco

193 These "windows of opportunity" offer a chance to identify both

194 rt longitudinal studies helping to untangle 'windows of opportunity' or reverse causation with vascul

195 or anastrozole 1 mg oral daily on days 1-14 (window-of-opportunity phase) via an interactive web-base

196 central Ki67 scores at baseline and week 2 (window-of-opportunity phase).

197 reserved into adult life such that a lengthy window of opportunity should exist for intervention with

198 (ER), CDK4/6 and PI3K pathways and based on window of opportunity studies showing that metformin sup

199 TOT-HER3 is a window-of-opportunity study designed to assess the biolo

200 tinct recruitment mechanisms, this creates a window of opportunity that could be exploited for the de

201 mmation in different tissues and highlight a window of opportunity that might exist for early-life pr

202 to changes in age structures with an assumed window of opportunity that opens when falling birth rate

203 rodevelopmental outcomes before the critical window of opportunity that precedes the divergence of gr

204 STATEMENT Critical periods are developmental windows of opportunity that ensure the proper wiring of

205 of this model revealed two time-constrained windows of opportunity that must be met for the complete

206 fe; thresholds are set within this neonatal "window of opportunity" that govern how the immune system

207 These findings may be reminiscent of the "Window of Opportunity" theory, which suggests that estro

208 Although there is a window of opportunity to change the gambling policy syst

209 rentiate enantiomers by DECS opens up a vast window of opportunity to characterize the class effects

210 onset renal cystic disease, which provides a window of opportunity to conduct unilateral nephrectomy

211 These findings open a window of opportunity to consider T-cell targeting as a

212 lly induce endothelial leakiness, creating a window of opportunity to control drug delivery across th

213 hich raises the question of what is the real window of opportunity to detect high-grade serous perito

214 during periods of organ failure to permit a window of opportunity to diagnose and treat underlying d

215 There is a window of opportunity to dilute the legacy of historical

216 of viral Ag thus affords persisting virus a window of opportunity to escape from immune surveillance

217 rmath of mass shootings is often viewed as a window of opportunity to garner support for gun control

218 This provides a long window of opportunity to get ahead of the pathobiologica

219 rns, along the care continuum, may present a window of opportunity to identify individuals at risk fo

220 e first 2 years after treatment, providing a window of opportunity to identify patients with molecula

221 in response to immunotherapy also presents a window of opportunity to illuminate mechanisms of resist

222 The preschool years offer a unique window of opportunity to instill healthy life-style beha

223 sizes of putative MS risk factors, a limited window of opportunity to intervene, and the relatively l

224 experimental evidence reveals only a narrow window of opportunity to invade the mesenchyme of the me

225 t well characterized and represents a unique window of opportunity to investigate human neural and co

226 his case, a strong summer La Nina provided a window of opportunity to issue a much more confident for

227 need to leverage the COVID-19 pandemic as a window of opportunity to make health financing policies

228 linical treatments, eventually expanding the window of opportunity to optimally enhance cognition and

229 early microbiome environment and presents a window of opportunity to optimise protection from rotavi

230 nce represents a potentially underrecognized window of opportunity to optimize bone mass.

231 only marginally increased hence unveiling a window of opportunity to pharmacologically augment S100A

232 nd the possibility of a prodrome indicates a window of opportunity to potentially reverse early disea

233 degenerative retinal disease, there may be a window of opportunity to preserve daylight vision, as th

234 aking childhood and adolescence an important window of opportunity to prevent atherosclerotic cardiov

235 rioperative period has gained attention as a window of opportunity to prevent cancer recurrence.

236 The data further suggest a short window of opportunity to prevent the loss of CD4(+) T ce

237 Alarmingly, policymakers face a narrowing window of opportunity to prevent the worst impacts, nece

238 opocule, namely, (13)C(16)O(18)O, provides a window of opportunity to probe directly the effective te

239 indicating that midlife might offer another window of opportunity to promote healthy aging.

240 a child's life from 2-5 years of age offer a window of opportunity to promote nurturing and caring en

241 This study examined whether puberty opens a window of opportunity to recalibrate the HPA axis toward

242 gan failures, thus providing patients with a window of opportunity to recover from potentially life-e

243 This suggests a window of opportunity to repair ischemic MR after which

244 te the adaptive role of reconsolidation as a window of opportunity to rewrite emotional memories, and

245 Findings open a novel window of opportunity to study alteration of GABAA-/GABA

246 di is a small town in Brazil that provides a window of opportunity to study the influence of sleep pa

247 emerging class of regulatory RNA and offer a window of opportunity to target epigenetic modifications

248 ly before age 20 years highlights the unique window of opportunity to target prevention efforts among

249 term graft outcome but importantly provide a window of opportunity to therapeutically intervene to pr

250 tion of rapamycin significantly extended the window of opportunity to veto based deletion by preventi

251 g process in brain can provide insights into windows of opportunities to promote healthy brain aging.

252 This could potentially provide windows of opportunity to address the effects of ELA thr

253 ries, TEs can exploit specific developmental windows of opportunity to evade host silencing and incre

254 ing levels of dd-cfDNA over time may provide windows of opportunity to intervene early and before irr

255 ualization of immunosuppression and identify windows of opportunity to intervene early and before the

256 regional climate extremes and hence utilise windows of opportunity to issue trustworthy and actionab

257 ty of the disease but also providing several windows of opportunity to prompt or rewire a proficient

258 r women in midlife and highlight therapeutic windows of opportunity to reduce the risk of late-onset

259 sts of activity during REM sleep may provide windows of opportunity to synchronize the hippocampal tr

260 It further offers a unique "window of opportunity" to explore mechanisms and identif

261 (early G1 versus late G1) provide different "windows of opportunity" to enable the differential expre

262 n of different factors (eg, early diagnosis, window of opportunity, treat-to-target strategy, advent

263 We conducted a prospective window-of-opportunity trial (NCT03995706) at the Univers

264 We conducted a surgical window-of-opportunity trial of the MDM2 inhibitor navtem

265 We conducted a window-of-opportunity trial, evaluating evolocumab's BBB

266 We address this using a uniquely designed window-of-opportunity trial, in which 35 inoperable EAC

267 f tissue from the central nervous system via window of opportunity trials

268 Master protocols and window-of-opportunity trials provide platforms to rapidl

269 Window-of-opportunity trials, during which patients rece

270 We discuss how neoadjuvant 'window-of-opportunity' trials are being leveraged to pro

271 The window of opportunity was tested by delaying angiotensin

272 The window-of-opportunity was <3 hours after CC injection.

273 represents an early cardiovascular moment or window of opportunity when CVH should be measured, monit

274 ruption and loss of life, especially during "windows of opportunity" when noteworthy events in the Ea

275 education of the immune system during this "window of opportunity," when microbial colonization has

276 lowing bone marrow transplantation provide a window of opportunity whereby aneuploid cells rise in fr

277 Using this window of opportunity will require early diagnostic and

278 QMSI was applied in a preoperative window-of-opportunity (WoO) study of the inhibitor of ap

279 erspective, has usually focused on shocks as windows of opportunity (WoO) where alternatives can brea