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2 is subfamily include a divergent DNA-binding winged helix, a leucine zipper, a zinc finger, and a pol
3 In comparison, weaker interaction of FOXA1 winged helix, and the NH(2)-terminal domains was documen
4 d-forming N-terminal domain, which reveals a winged-helix architecture, with additional structural el
5 itself to one Cul3 molecule and binds to the winged-helix B domain at the C terminus of the second Cu
6 ic residue predicted to be at the tip of the winged helix beta-hairpin), showed a decrease in DNA bin
8 are critical for the development of forkhead-winged helix box transcription factor 3(+) regulatory T
9 he chicken homolog of FoxD3, a member of the winged-helix class of transcription factors, and analyze
11 e that deleted the Foxm1b exons encoding the winged helix DNA binding and transcriptional activation
13 -mediated phosphorylation of a serine in the winged helix DNA binding motif curtails FoxO1 nucleosome
14 family of TFs, defined by a highly conserved winged helix DNA-binding domain (DBD), has diverged into
15 cription factors that shares homology in the winged helix DNA-binding domain and the members of which
16 cription factors that shares homology in the winged helix DNA-binding domain and whose members play e
17 U_0916 protein identified two domains, one a winged helix DNA-binding domain common for transcription
19 The 95 amino acid residue protein contains a winged helix DNA-binding domain with an extended C-termi
21 monomeric subunits are predicted to adopt a winged helix DNA-binding motif which dimerizes through f
23 scriptional regulators comprises a subset of winged helix DNA-binding proteins and includes numerous
26 (Fox) proteins share the Forkhead domain, a winged-helix DNA binding module, which is conserved amon
28 tional regulators belonging to the family of winged-helix DNA binding proteins known as the Fox famil
31 monomer comprises two domains: an N-terminal winged-helix DNA-binding domain and a C-terminal PLP-bin
36 crystal structure of Vfr shows that it is a winged-helix DNA-binding protein like its homologue cycl
37 homologous to the winged helix-turn-helix ('winged helix') DNA-binding/transcription activation doma
38 y unrecognized domains in ASXL1: a forkhead (winged-helix) DNA-binding domain and a deubiquitinase ad
40 domains in Uaf30 that include an N-terminal winged helix domain and a disordered tethering domain as
41 C-terminus of Cac1, including the structured winged helix domain and glutamate/aspartate-rich domain,
42 uch a region consists of a zinc domain and a winged helix domain and plays an important role in enzym
43 unds binding to a protein pocket between the winged helix domain and topoisomerase-primase domain, re
48 NA in a manner similar to RecQ1, whereas the winged helix domain may assume alternative conformations
49 erminal domain near Pol I wall or the tandem winged helix domain of A49 at a partially overlapping lo
50 of these complexes were mapped to the second winged helix domain of human ESCRT-II subunit VPS25 and
52 merization domain on the Pol II lobe and the winged helix domain of the TFIIF small subunit Tfg2 abov
53 ding is mediated principally by a C-terminal winged helix domain that inserts deeply into the major a
54 Qin (amino acids 246-451, extending from the winged helix domain to the C-terminus) and identified am
57 an N-terminal AAA(+) domain and a C-terminal winged-helix domain (WHD), but use remarkably few base-s
59 r on the proposed recognition surface of the winged-helix domain and around the PRPP binding site at
61 cQ has evolved an SSB-Ct binding site on its winged-helix domain as an adaptation that aids its cellu
63 s indicate that ORC encircles DNA, using its winged-helix domain face to engage the mini-chromosome m
64 in the RecQ variants indicate a role for the winged-helix domain in helicase activity beyond SSB prot
66 rates that the helix-turn-helix motif in the winged-helix domain mediates the interaction with this s
67 Here, we report a cocrystal structure of the winged-helix domain of human RNA polymerase II-associati
69 th tubulin monomers via the carboxy-terminal winged-helix domain of Ska1, providing the structural ba
70 e conserved aromatic residue in the extended winged-helix domain of TFEalpha interacts with promoter
71 A-dependent conformational rearrangements: a winged-helix domain pivots approximately 90 degrees to c
73 for membrane localization of ToxR is for its winged-helix domain to co-operate with TcpP to activate
74 alpha/beta fold, a short helical motif and a winged-helix domain, resulting in the burial of the casp
75 s, a RecQ-specific zinc-binding domain and a winged-helix domain, the latter implicated in DNA strand
76 between RecQ and SSB is mediated by the RecQ winged-helix domain, which binds the nine C-terminal-mos
83 ithin the ATPase, Topoisomerase/Primase, and Winged helix domains, including four that encode protein
87 n factors (HNF-3gamma and RFX1) and from the winged-helix domains found within the RAP30 subunit of T
88 wo-layered notched ring in which a collar of winged-helix domains from the Orc1-5 subunits sits atop
89 stallography, we show that Cdt1 contains two winged-helix domains in the C-terminal half of the prote
91 th the N-terminal OB fold and the C-terminal winged-helix domains of Stn1 can bind to the Pol12 subun
93 dynamic movements of the ORC1 AAA+ and ORC2 winged-helix domains that likely impact DNA incorporatio
96 es and show here for the first time that the winged helix factor Foxa3 promotes adipocyte differentia
97 e result of increase binding of the forkhead winged helix factor FoxD1 to a TGF-beta-responsive eleme
98 l lines of evidence suggest that the related winged-helix factor Pintallavis functions as the ortholo
102 data suggested that a member of the Forkhead/winged helix family of transcription factors mediated th
103 hat the Foxk1 gene, a member of the forkhead/winged helix family of transcription factors, is express
110 jI gene, which encodes a novel member of the winged-helix family of transcriptional regulators and al
113 vitro, and reveals how subtle changes in the winged-helix fold can modulate the functional properties
116 ted domain-swapping interactions between the winged-helix folds and AAA+ modules of neighbouring prot
117 on factors, binds DNA via a highly conserved winged-helix "forkhead box" motif used by other regulato
119 cis-element upstream of Tbx1 that recognized winged helix/forkhead box (Fox)-containing transcription
122 Because HILS1 also belongs to the large winged helix/forkhead protein superfamily, HILS1 may als
127 whether NKX2.1 interacts with members of the winged-helix/forkhead family of FOXA transcription facto
129 -function mutations in Whn (Hfh11, Foxn1), a winged-helix/forkhead transcription factor, cause the nu
130 ed by an unidentified member of the forkhead/winged helix (Fox) family of transcription factors.
133 us aureus CzrA and cyanobacterial SmtB, are "winged" helix homodimeric DNA-binding proteins that bind
136 helix proteins via the versatile use of the winged helix motif as a homo- or heterodimerization scaf
143 nucleic acid binding surfaces of the RRM and winged-helix motifs, although present in the RNA binding
146 involves the first FF motif of p190A and the winged helix/PCI domain of eIF3A, is enhanced by serum s
147 lpha1 and alpha3 in both subunits, a mode of winged helix protein dimerization that is reminiscent of
149 e data suggest that the winged region of the winged helix protein participates in DNA binding and act
150 This, in turn, suggests that Cnr is also a winged helix protein, a possibility that is supported by
151 or the nuclear transcription factor Forkhead winged helix protein-3 and able to inhibit naive T cell
152 nd a concomitant down-regulation of Forkhead/winged-helix protein 3 (Foxp3), TGFbeta, and IL-10 expre
153 We propose that MarR also belongs to the winged-helix protein family and has a similar mode of DN
155 om phage to man, the DNA-binding activity of winged helix proteins can be regulated by other winged h
157 ged helix proteins can be regulated by other winged helix proteins via the versatile use of the winge
159 criptional regulator SarA protein family are winged-helix proteins that are involved in gene regulati
160 SarS, and MarR, we further classified these winged-helix proteins to three subfamilies, SarA, SarS,
162 ain, and the C-terminal part, which includes winged-helix, ratchet, and oligonucleotide/oligosacchari
163 ution x-ray crystal structure of the dimeric winged helix SarA protein, which differs from the publis
165 ologous regions of both proteins fold into a winged-helix structure, which specifically binds to the
170 ors, namely Kite dimers (Kleisin interacting winged-helix tandem elements), interact with Smc-kleisin
171 t the C-terminal, DNA-binding domain (tandem-winged helix), the heterodimerization, and the linker do
174 ro, as demonstrated by cytokine and forkhead/winged helix transcription factor (FoxP3) gene and prote
175 beta induce naive T cells to become forkhead/winged helix transcription factor (Foxp3) positive regul
176 of the T(reg) cell lineage factor, Forkhead/winged helix transcription factor (Foxp3), and tolerance
184 a 35,000-fold higher expression of forkhead/winged helix transcription factor forkhead box (FOXF1) n
185 ed genome-wide binding sites of the forkhead/winged helix transcription factor Foxa1, which functions
186 l YAC-based Foxa3Cre transgene to delete the winged helix transcription factor Foxa2 (formerly HNF-3b
187 tro analysis has suggested that the forkhead/winged helix transcription factor Foxa2 (formerly HNF-3b
189 nd cell type-specific gene ablation that the winged helix transcription factor Foxa2 is required for
193 We show in both mouse and zebrafish that the winged helix transcription factor Foxg1 is expressed in
197 duction in the CD4(+)CD25(+)CD62L(+)forkhead/winged helix transcription factor gene (Foxp3(+)) compar
198 cell-specific transcription factor forkhead/winged helix transcription factor gene (FOXP3) in CD4+CD
199 tabolite NAD induce death in murine forkhead/winged helix transcription factor gene-expressing CD4+CD
200 ed mice possess increased levels of forkhead/winged helix transcription factor gene-expressing CD4+CD
201 khead Box C1 (FOXC1) gene encodes a forkhead/winged helix transcription factor involved in embryonic
202 generation of allospecific CD4CD25 forkhead/winged helix transcription factor P3 (FOXP3) T-regulator
203 L, however, significantly increased forkhead/winged helix transcription factor P3 (FOXP3) Tregs, wher
206 ances is restrained by CD4(+)CD25(+)forkhead/winged helix transcription factor(+) regulatory T cells.
207 hymic mice depleted of CD4(+)CD25(+)forkhead/winged helix transcription factor(+) regulatory T cells.
208 D25+ glucocorticoid-inducible TNFR+-Forkhead/winged helix transcription factor+ populations and effic
209 ported that expression of the human forkhead/winged helix transcription factor, CHES1 (checkpoint sup
214 opulation does acquire the X-linked forkhead/winged helix transcription factor, FoxP3, which is assoc
217 we demonstrate novel roles for the forkhead/winged helix transcription factors Foxa1 and Foxa2 in th
218 -beta and -gamma) constitute a sub-family of winged helix transcription factors with multiple roles i
219 2/Mfh1 genes encode closely related forkhead/winged helix transcription factors with overlapping expr
222 onditional deletion of the gene encoding the winged-helix transcription factor Foxa2 (Forkhead box a2
223 over a dramatic and unpredicted role for the winged-helix transcription factor Foxa2 (formerly HNF-3
224 In this study, we elucidate the roles of the winged-helix transcription factor Foxa2 in ventral CNS d
225 teracts with and inhibits DNA binding by the winged-helix transcription factor FoxH1 (FAST), a critic
233 differ significantly from those of bona fide winged-helix transcription factors (HNF-3gamma and RFX1)
234 Members in the superfamily of the forkhead/winged-helix transcription factors are known to play a c
236 ist), a novel member of the Foxi-subclass of winged-helix transcription factors that is involved in t
237 RovA, a member of the MarR/SlyA family of winged-helix transcription factors, regulates expression
239 ell phenotypes, suppressor ability, forkhead winged/helix transcription factor box P3 (FOXP3) gene, a
241 family of prokaryotic metalloregulators are winged-helix transcriptional repressors that collectivel
242 Although the RepA and DnaD NTD both contain winged helix-turn-helices, the DnaD NTD self-assembles i
243 Its cytoplasmic domain is homologous to the winged helix-turn-helix ('winged helix') DNA-binding/tra
244 domains represent a growing subfamily of the winged helix-turn-helix (HTH) domain family whose member
246 n1 (Stn1C) was found to comprise two related winged helix-turn-helix (WH) motifs, one of which is mos
247 n factor complexes and contain an N terminal winged helix-turn-helix (wHTH) DNA binding domain (DBD).
249 yclases, FhlA) domain that binds BCAAs and a winged helix-turn-helix (wHTH) domain that binds to DNA,
250 in ligase of Escherichia coli belongs to the winged helix-turn-helix (wHTH) family of transcriptional
254 at least two receiver domains, an OmpR-class winged helix-turn-helix DNA binding domain, and a histid
257 -terminal regulatory domain and a C-terminal winged helix-turn-helix DNA-binding domain, with phospho
258 ding, while the N-terminal domains contain a winged helix-turn-helix DNA-binding motif and are arrang
259 is composed of three domains: an N-terminal winged helix-turn-helix domain (WH), a GAF-like domain,
260 R on a conserved arginine residue within the winged helix-turn-helix domain is necessary for modulati
261 al domain is fused to a C-terminal MarR-like winged helix-turn-helix domain that is expected to be in
262 family nucleases, are replaced by an unusual winged helix-turn-helix domain, where the "wing" is cont
264 s overall fold resembles closely that of the winged helix-turn-helix family of DNA-binding proteins.
267 (chxR), whose amino acid sequence contains a winged helix-turn-helix motif similar to the DNA-binding
268 e N-terminal DNA-binding domain contains the winged helix-turn-helix motif, and the C-terminal presum
271 Z adopts a unique fold in which three tandem winged helix-turn-helix motifs scaffold a positively cha
272 onal changes needed to allow the DNA-binding winged helix-turn-helix motifs to interact with the cons
275 tion crystal structure of apo-MtaN reveals a winged helix-turn-helix protein with a protruding 8-turn
276 in the modes of DNA binding is evident with winged helix-turn-helix proteins, raising doubts that me
278 of the yeast transcription factor Mbp1 is a winged helix-turn-helix structure, with an extended DNA
280 posed of an N-terminal DNA binding domain of winged helix-turn-helix topology and a C-terminal dimeri
283 ovel 7 kDa T7 protein, Gp5.7, which adopts a winged helix-turn-helix-like structure and specifically
285 The structure reveals the presence of a winged-helix-turn-helix DNA binding motif, but the locat
288 tudies show that RacA contains an N-terminal winged-helix-turn-helix module connected by a disordered
289 RctB contains at least three DNA binding winged-helix-turn-helix motifs, and mutations within any
293 We have localized the position of the TFE winged helix (WH) and Zinc ribbon (ZR) domains on the RN
294 FIIE-like factors, which is characterised by winged helix (WH) domain expansion in eukaryotes and los
295 we identify and determine the structure of a winged helix (WH) domain from human MUS81, which binds D
296 e present a model for the interaction of the winged helix (WH) domain of ORC2 with DNA that differs f
298 Deleting or mutating K99 of the N-terminal winged helix (WH) motif in ASH2L abrogates H2Bub-depende
299 at both the DNA substrate and the C-terminal winged-helix (WH) domain influence the orientation but t
300 Helicase activity, as well as the conserved winged-helix (WH) motif and the helicase and RNase D C-t