ライフサイエンスコーパス: wingless

1 s a niche expressing the ligands Serrate and Wingless.

2 capsule selector genes such as cut, Lim1 and wingless.

3 glycan/HSPG-binding morphogens, Hedgehog and Wingless.

4 ped human medulloblastomas (50 MBSHH, 28 Wnt/Wingless, 44 Group 3 and 94 Group 4) and their conservat

5 Wingless, a Drosophila Wnt homolog, has been reported to

6 Finally, removal of one copy of wingless, a gene required for normal trichome patterning

7 eal an intertissue signaling system in which Wingless acts as an effector of MED13 in heart and muscl

8 kers, and female alates (winged) and queens (wingless), AK cDNA was obtained from the red imported fi

9 Additionally, in response to Wingless, all prospective wing cells produce an unidenti

10 ing, we identified a 120 kb insertion in the wingless allele.

11 at and Dachsous, organized by the morphogens Wingless and Decapentaplegic, suppress Warts by acting v

12 of sloppy-paired and paired with respect to wingless and engrailed at the parasegment boundary is co

13 We show that escort cells produce both Wingless and Hedgehog ligands for the FSC lineage, and t

14 mechanism distinct from that induced by Wnt/Wingless and highlight the essential non-metabolic funct

15 tion and development via cross-talk with the wingless and Int (Wnt)/beta-catenin signaling pathway.

16 Wingless and INT-1 (WNT)/beta-catenin signaling is reduc

17 ith cell cycle control and activation of the Wingless and integration site (Wnt)/beta-catenin pathway

18 The wingless and integration site growth factor-5a (Wnt5a) i

19 Wingless and Myc are induced by tissue damage and are im

20 These results indicate that STAT, Wingless and Myc are major parallel regulators of cell c

21 porcupine gene is required for secretion of wingless and other Wnt proteins, and sporadic mutations

22 genes (Abd-A, EF1alpha-F1, EF1alpha-F2, and Wingless) and one mitochondrial gene (COI) sampled from

23 ess signaling molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a pr

24 ate-gene approaches have implicated the JNK, Wingless, and Hippo pathways in regeneration.

25 iquitous: the most basal living insects, the wingless Archaeognatha, possess glomerular antennal lobe

26 The wingless arthropods evolved a highly textured, hierarchi

27 pective wing cells survive in the absence of Wingless as long as they are not surrounded by Wingless-

28 -binding protein that is secreted along with Wingless at the neuromuscular junction.

29 unction of Evenness Interrupted (Evi)/Wls, a Wingless-binding protein that is secreted along with Win

30 asitic morphological characters such as tiny wingless body, head with strong chewing mouthparts, robu

31 are highly modified parasites (including the wingless Braulidae) of bees and other insects.

32 stigated the olfactory system of the primary wingless bristletail Lepismachilis y-signata (Archaeogna

33 In Drosophila, the ligand Wingless causes the C terminus of its Frizzled2 receptor

34 activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been de

35 and is required for only a limited number of Wingless-dependent processes.

36 Wingless downregulates the activity of the serine/threon

37 We find that for nearly all Wingless-driven developmental processes, a three- to fou

38 miR-310/13) cluster as a novel antagonist of Wingless (Drosophila Wnt) pathway activity in a function

39 Interestingly, several members of the WNT (Wingless)-DVL signaling cascade, including phospho-GSK3b

40 are required for full function, to maintain wingless expression and parasegment boundaries throughou

41 evolved from simpler schemes by co-option of Wingless expression at new sites.

42 e two groups of vg-dependent tissues in the "wingless" first thoracic segment (T1).

43 rtebrate fauna, in particular to the endemic wingless flies Anatalanta aptera and Calycopteryx mosele

44 gs that rely solely on the membrane-tethered Wingless for Wnt signaling, suggesting that a Wnt gradie

45 stasis experiments further demonstrated that Wingless functions downstream of MED13 within a muscle-r

46 genome engineering to replace the endogenous wingless gene, which encodes the main Drosophila Wnt, wi

47 c interactions were detected with the Notch, Wingless, Hedgehog or Dpp pathways, nor did Fas2 inhibit

48 d by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle.

49 that encode secreted proteins and found that Wingless inhibition also caused obesity.

50 In turn, Wingless-INT (Wnt) 3 (Wnt3) ubiquitination is decreased,

51 cell proliferation, survival, and canonical wingless-int (WNT) activity are not mTOR dependent, but

52 Environmental Wingless-INT (WNT) levels can control the G1 length dist

53 hreonine protein kinase AKT-beta-catenin and Wingless-Int (Wnt)-beta-catenin signaling pathways.

54 nic hedgehog, fibroblast growth factors, and wingless-int (Wnt)/beta-catenin.

55 clear beta-catenin zone, which is induced by wingless-int (Wnt)7a protein diffusing in from posterior

56 addition of roof plate-specific spondin 1, a wingless-int agonist, Ring/Dense colony-forming cells ca

57 y Wnt target genes, that remove surface Wnt (wingless-int) receptors.

58 Regional expression of Wingless/Int (Wnt) genes plays a central role in regulat

59 h cells provide a crucial niche by secreting Wingless/Int (Wnt) ligands.

60 In early Caenorhabditis elegans embryos, the Wingless/int (Wnt)- and Src-signaling pathways function

61 ibromin assists in mediating output from the Wingless/Int signaling pathway, and dysfunction of the e

62 phoproteins (DVL1-3), key regulators of Wnt (Wingless/Int) signalling pathways important for axon gui

63 They are bound and activated by the Wingless/Int-1 lipoglycoprotein (WNT) family of secreted

64 signaling induced by 19 mammalian, secreted Wingless/Int-1 lipoglycoproteins (WNTs).

65 cardiomyocyte proliferation with emphasis on wingless/int-1 protein signaling, crosstalk between the

66 cyte proliferation, with a specific focus on wingless/int-1 protein signaling.

67 FZDs coordinate wingless/Int-1 signaling and SMO mediates Hedgehog signa

68 The Wingless/Int1 (Wnt) signaling system plays multiple, ess

69 Because canonical Wnt (Wingless/Int1) signals critically regulate renewal versu

70 The leukotriene (LT) and wingless/integrase (Wnt) pathways have been implicated i

71 The Wingless/integrase-1 (Wnt) family of protein ligands and

72 Although wingless integrated MMTV (Wnt)/beta-catenin signaling pl

73 factor-beta (Tgfbeta), sonic hedgehog (Shh), wingless-integrated site (Wnt)/beta-catenin, bone morpho

74 We also show that beta-catenin siRNA and the Wingless/integrated (Wnt) inhibitor pyrvinium block the

75 Wingless/integrated (Wnt) signaling has emerged as a maj

76 Focusing on the role of Wnt3a (wingless/integrated 3a), this study was aimed to assess

77 ch are adenosine A(2A) receptors (A2ARs) and Wingless/Integrated-beta-catenin pathways.

78 3' UTRs and experimentally verified secreted wingless-interacting molecule (swim) as an authentic tar

79 tterning signals that operate locally (e.g., Wingless/Ints [Wnts], Bone Morphogenetic Proteins [BMPs]

80 We suggest therefore that the spread of Wingless is dispensable for patterning and growth even t

81 Our data also suggested that Wingless is not required during the early stages of disc

82 Sand dwellers show rapid deployment of Wingless, later foxg1 expression and a larger pallium.

83 ow that when making targeted jumps, juvenile wingless mantises first rotated their abdomen about the

84 Interestingly, wingless maternal parasitoids produced more winged proge

85 f MED13 in heart and muscle and suggest that Wingless-mediated cross-talk between striated muscle and

86 We show that wing spots are induced by the Wingless morphogen, which is expressed at many discrete

87 in vivo morphology of overgrowth clones and wingless mutants via perturbations solely on planar diff

88 he Antarctic midge, Belgica antarctica, is a wingless, non-biting midge endemic to Antarctica.

89 CtBP can both repress and activate Wingless nuclear targets in Drosophila.

90 ressors drive shifts in fecundity and winged/wingless offspring production, and how secondary symbion

91 results from the bidirectional influence of wingless on both presynaptic and postsynaptic structures

92 lost and cannot be restored by activation of Wingless or Myc.

93 basal Axin levels must be controlled for Wnt/Wingless pathway activation, and how Axin stability is r

94 Finally, as observed previously for Wingless pathway components, Tnks activity in absorptive

95 n the adult intestine, where activity of the Wingless pathway is graded and peaks at each compartment

96 erky and Ebd1 interact directly with the Wnt/Wingless pathway transcriptional co-activators beta-cate

97 e downstream transcriptional effector of the Wingless pathway, also evoked an obese phenotype in flie

98 is conferred by a pathway consisting of Wnt (Wingless) pathway components, including posterior pharyn

99 Manipulation of the Hedgehog and Wingless pathways in cichlid and zebrafish embryos is su

100 These include sonic hedgehog, wingless, planar cell polarity and fibroblast growth fac

101 plore the influence of symbionts across wing/wingless polyphenism as well as symbiont interaction wit

102 Cells flanking the source of Wingless produce a negative signal (encoded by notum) th

103 Accordingly, in Drosophila, the morphogen Wingless produced in the wing's prospective distal regio

104 cell proliferation and tissue growth through wingless production when apoptosis is inhibited by p35.

105 ic plasticity, producing winged (rather than wingless) progeny that may be better able to escape dang

106 tion is induced by Hedgehog and inhibited by Wingless, providing a sensitive system in which to ident

107 exuals to workers) and the individual level (wingless queens evolve in ants), and other consequences

108 marrow microenvironment that dysregulate the wingless related integration site network, a central pat

109 The cortical hem, a source of Wingless-related (WNT) and bone morphogenetic protein (B

110 Gene deletion of intermediates of Wingless-related integration (Wnt) signaling causes hear

111 h homolog protein 1 but higher expression of wingless-related integration site (WNT) family pathway c

112 lum (ER) chaperone protein for the canonical Wingless-related integration site (WNT) signaling recept

113 SIP), follistatin (FST), ecodysplasin (EDA), wingless-related integration site (Wnt), and beta-carote

114 a network of fibroblast growth factor (FGF), wingless-related integration site (WNT), and bone morpho

115 Wingless-related integration site (WNT)/beta-catenin sig

116 on and subsequent increased transcription of Wingless-related integration site target genes.

117 naptic adhesion complexes and canonical Wnt (Wingless-related integration site) signal transduction.

118 tous polyposis coli), thereby affecting Wnt (Wingless-related integration site) signaling and regulat

119 ranscriptional coactivator in canonical Wnt (wingless-related integration site) signaling.

120 Putative driver mutations affecting WNT (wingless-related integration site), JAK-STAT (Janus kina

121 rious signaling pathways, including the Wnt (wingless-related integration site)/beta-catenin pathway.

122 thalamic axons, which secrete the morphogen Wingless-related MMTV (mouse mammary tumor virus) integr

123 is work, we show that the timed secretion of Wingless-related MMTV (mouse mammary tumor virus) integr

124 Wingless-related MMTV integration site 1 (WNT1)/beta-cat

125 (2.5-fold), GABA A receptor (2.9-fold), and wingless-related MMTV integration site 7B (2.8-fold).

126 kkopf 3 (DKK3), a secreted modulator of WNT (Wingless-related MMTV integration site)/beta-catenin sig

127 Dickkopf-1 (DKK1), an antagonist of the wingless-related mouse mammary tumor virus (WNT) signali

128 Wingless-related proteins (WNTs) regulate extension of t

129 naling pathways involving hedgehog proteins, wingless-related proteins and fibroblast growth factors

130 velopment, the secretion of Drosophila Wnt1, Wingless, requires the function of Evenness Interrupted

131 ngless as long as they are not surrounded by Wingless-responding cells.

132 Ebd1 is expressed in only a subset of Wingless responsive cell types, and is required for only

133 ere significantly up-regulated in winged and wingless S. avenae small RNA libraries, respectively.

134 es indicated that mutant LRP5 led to reduced wingless signal activation.

135 tors essential for wing development (such as Wingless signal and apterous), and has nubbin enhancer a

136 Wnt/Wingless signal transduction directs fundamental develop

137 During metazoan development, the Wnt/Wingless signal transduction pathway is activated repeti

138 Wingless signaling acts to balance the proportion of hin

139 Further, in embryos lacking the Wingless signaling component zw3, the same full apical e

140 Wnt/wingless signaling contributes to the development of neu

141 Importantly, cby(1/1) flies did not show Wingless signaling defects.

142 Finally, Gsb has been shown to antagonize Wingless signaling during embryonic fate specification,

143 contrast, perturbation of Decapentaplegic or Wingless signaling failed to affect Rbf niche cell expre

144 identified DIAP1 as a positive regulator of Wingless signaling in a Drosophila S2 cell-based RNAi sc

145 estigated, and found, a role for Dot1 in Wnt/Wingless signaling in an in vivo model system.

146 tive signal (encoded by notum) that inhibits Wingless signaling in nearby cells.

147 dgehog ligands for the FSC lineage, and that Wingless signaling is specific for the FSC niche whereas

148 Therefore, relative differences in Wingless signaling lead to competitive cell interactions

149 The Wingless signaling pathway controls various developmenta

150 The wingless signaling pathway establishes a midline anterio

151 anscriptional activity downstream of the Wnt/Wingless signaling pathway has been observed in many hum

152 ogy of PCLD to deregulation of the canonical wingless signaling pathway.

153 y Dot1 and its associated factors to the Wnt/Wingless signaling pathway.

154 mplex and mediate the same context-dependent Wingless signaling responses.

155 ivity, promotes contextual regulation of Wnt/Wingless signaling responses.

156 , postsynaptic response, and anterograde Wnt/Wingless signaling, all of which modulate NMJ growth thr

157 ndent on hid but independent of Myc, Yorkie, Wingless signaling, and of ribosome biogenesis.

158 atenin degradation and prevent inappropriate Wingless signaling, but its effects on the Hedgehog path

159 As Axin is a rate-limiting factor in Wingless signaling, its regulation is essential.

160 ompensation rescues both Decapentaplegic and Wingless signaling, suggesting a universal role of this

161 ment boundaries during GBE is independent of Wingless signaling, suggesting pair-rule gene control.

162 hat Notum could amplify local differences in Wingless signaling, thus serving as an early trigger of

163 NRF1), in promoting contextual regulation of Wingless signaling.

164 ating role in both physiological and ectopic Wingless signaling.

165 umor suppressor, a negative regulator of Wnt/Wingless signaling.

166 Because WNT (wingless) signaling-induced activation of the transcript

167 -related protein 1 levels and increased WNT (wingless) signaling.

168 l co-activators facilitate cell-specific Wnt/Wingless signalling responses by modulating beta-catenin

169 nts that cannot dimerize are able to promote Wingless signalling, but are defective in repressing Win

170 engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases.

171 and Pygopus, a nuclear protein required for Wingless signalling, support a model where monomeric CtB

172 a genetic screen for components that promote Wingless signalling, we identified Earthbound 1 (Ebd1),

173 l where CtBP is a gene-specific regulator of Wingless signalling, with some targets requiring CtBP di

174 strength and timing of opposing Hedgehog and Wingless signals establish evolutionary divergence in do

175 t that competing ventral Hedgehog and dorsal Wingless signals mediate evolutionary diversification of

176 sulting in expression of foxg1 before dorsal Wingless signals, and a larger subpallium.

177 cumulate beta-Catenin and ectopically induce Wingless target genes.

178 sults in decreased expression of a subset of Wingless target genes.

179 kuld, are essential for the transcription of Wingless target genes.

180 dependent role of ISWI-ACF1 in repression of Wingless targets is also observed.

181 ro-dimerization and consequent repression of Wingless targets.

182 signalling, but are defective in repressing Wingless targets.

183 cts downstream of Pygopus in activating some Wingless targets.

184 s a similar reduction in expression of these Wingless targets.

185 levels and a reduction in expression of many Wingless targets.

186 and increased and disorganized expression of wingless, the central component of the Wnt signaling pat

187 us, cells influence each other's response to Wingless through at least two modes of lateral inhibitio

188 t the microRNA, miR-965, acts via string and wingless to control histoblast proliferation and migrati

189 otein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and t

190 the developmental fate of their embryos from wingless to winged morphs.

191 how that, in the prospective wing, prolonged wingless transcription followed by memory of earlier sig

192 Here, we show that, in parallel, Wingless triggers two nonautonomous inhibitory programs

193 omeobox (Hox)-Fibroblast growth factor (Fgf)-Wingless type MMTV integration site family (Wnt) genetic

194 Elements of the sonic hedgehog pathway and Wingless type MMTV integration site family were validate

195 eted Frizzled-related protein 1 (SFRP1) is a Wingless-type (Wnt) antagonist that has been associated

196 s of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway.

197 1/2) activation in conjunction with elevated wingless-type (Wnt) signaling.

198 demonstrate a critical paracrine role of the wingless-type (WNT)/beta-catenin pathway in estrogen/pro

199 Aberrant activation of Wingless-type (Wnt)/beta-catenin signaling is widespread

200 eak, including fibroblast growth factors and wingless-type family members (Wnt).

201 nd wnt/beta-catenin (where wnt refers to the wingless-type mammary tumor virus integration site famil

202 Whereas the roles of the canonical wingless-type MMTV (mouse mammary tumor virus) integrati

203 We identified 3 main clusters of HCCs: the wingless-type MMTV integration site (32 of 89; 36%), int

204 e site was rescued by local treatment with a Wingless-type MMTV integration site (Wnt) antagonist, Di

205 croenvironment converging to dysregulate the Wingless-type MMTV integration site (Wnt)/beta-catenin s

206 The vital role of Wingless-type MMTV integration site (Wnt)/beta-catenin s

207 Aberrant activation of canonical Wingless-type MMTV integration site family (Wnt) signali

208 The wingless-type MMTV integration site family (WNT)/beta-ca

209 Wingless-type MMTV integration site family (WNT)16 is a

210 n which we identified causative mutations in wingless-type MMTV integration site family 1 (WNT1).

211 hogens of the bone morphogenetic protein and wingless-type MMTV integration site family member (Wnt)

212 , while defects in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT

213 ironment that includes the Wnt family member wingless-type MMTV integration site family member 16B (W

214 on of a truncated protein, which retains the Wingless-type MMTV integration site family member-ligand

215 WNT10A (Wingless-type MMTV integration site family, member 10A)

216 KD1), which is a repressor of canonical WNT (wingless-type MMTV integration site) signaling.

217 ) compartment where they become inducible by wingless-type mouse mammary tumor virus integration site

218 y modulating the balance between mesenchymal Wingless-type Mouse Mammary Tumor Virus integration site

219 astoma as four molecular subtypes, including wingless-type murine mammary tumor virus integration sit

220 ated protein 4) as a facilitator of the WNT (Wingless-type) antagonist sclerostin and found mutations

221 ion, emphasizing that workers are not simply wingless versions of queens.

222 For example, the Wnt ligand Wingless (Wg) activates the naked cuticle (nkd) gene in

223 Epidermal growth factor receptor (EGFR) and wingless (wg) alleles also modify the ago apoptotic phen

224 mbined gradients of two secreted morphogens, Wingless (Wg) and Decapentaplegic (Dpp).

225 velopment is that secreted molecules such as Wingless (Wg) and Hedgehog (Hh) generate pattern by indu

226 intestinal stem cells (ISCs) by stimulating Wingless (Wg) and JAK/STAT pathway activities, whereas c

227 ine and Raspberry increase the activities of Wingless (Wg) and the EGF-ligand Spitz (Spi), respective

228 n of multiple genes, including the WNT genes wingless (wg) and Wnt6.

229 signaling proteins such as Hedgehog (Hh) and Wingless (Wg) depend on heparan sulfate proteoglycans (H

230 nkd) gene limits signaling by the Wnt ligand Wingless (Wg) during embryo segmentation.

231 sophila wing disc, wherein apically secreted Wingless (Wg) encounters its receptor, DFrizzled2 (DFz2)

232 d (Fz)-containing myoblast cytonemes take up Wingless (Wg) from the disc, and Delta (Dl)-containing m

233 s discovered the link between the Drosophila wingless (Wg) gene and the vertebrate oncogene int-1, th

234 P results in more than two-fold induction of wingless (wg) gene expression along with robust inductio

235 Dlp), cognate receptor Frizzled-2 (Frz2) and Wingless (Wg) ligand.

236 gaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 microm away, raising t

237 The mechanisms by which the Wingless (Wg) morphogen modulates the activity of the tr

238 cific and segment-specific regulation of the Wingless (Wg) morphogen underlies the development of sex

239 Hth expression is the result of Wingless (Wg) pathway activity at the eye margins and re

240 s to investigate the regulating mechanism of Wingless (Wg) pathway in tumor invasion.

241 al margins is blocked by the activity of the Wingless (Wg) pathway.

242 Spatial and temporal control of Notch and Wingless (Wg) pathways during development is regulated a

243 In the Drosophila melanogaster ovary, Wingless (Wg) promotes proliferation of follicle stem ce

244 Lipid-modified Wnt/Wingless (Wg) proteins can signal to their target cells

245 F progression is due to ectopic induction of Wingless (Wg) signaling and Homothorax (Hth), the negati

246 iR-8 controls the activity of the long-range Wingless (Wg) signaling by regulating Swim expression in

247 Wnt/Wingless (Wg) signaling controls many aspects of animal

248 We show that reduced Wingless (Wg) signaling dominantly inhibits Stat92E acti

249 we describe genetic interactions between the Wingless (Wg) signaling pathway and a nonmuscle myosin h

250 Here we show that components of the Wingless (Wg) signaling pathway are expressed in prohemo

251 ophila wing discs, Dlp represses short-range Wingless (Wg) signaling, but activates long-range Wg sig

252 Armadillo (Arm) is crucial for transducing Wingless (Wg) signaling.

253 ologue of Sulfs, Sulf1, negatively regulates Wingless (Wg) signaling.

254 egulation of cell fate through modulation of Wingless (Wg) signaling.

255 ative cell proliferation in cooperation with Wingless (Wg) signaling.

256 n extracellular gradient of the Wnt1 homolog Wingless (Wg) was observed extending over several cells

257 Unexpectedly, we identified wingless (wg), a secreted morphogen that regulates synap

258 onizes the signaling of the prototypical Wnt Wingless (Wg), by releasing glypicans from the cell surf

259 L3E)] fed on sucrose alone showed suppressed Wingless (WG), Cut (CT) and Senseless (SENS) expression.

260 on/acylation in regulating the activities of Wingless (Wg), the main Drosophila Wnt member.

261 vi is required for the secretion of the Wnt, Wingless (Wg).

262 wingless (wg)/Wnt family are essential to development in

263 Previously, the Wingless (Wg)/Wnt pathway was shown to underlie the stru

264 In the fly epidermis, Wingless (Wg)/Wnt signaling directs cells to produce eit

265 Wingless (Wg)/Wnt signaling is essential for patterning

266 Wingless (Wg)/Wnt signaling is fundamental in metazoan d

267 Dpp antagonizes activity of wingless (Wg)/Wnt signaling, which positively regulates

268 Here, we study the role and regulation of Wingless (Wg)/Wnt signalling during intestinal regenerat

269 morphogens, Decapentaplegic (Dpp, a BMP) and Wingless (Wg, a Wnt).

270 These cells reside in domains of high Wingless (Wg, Drosophila Wnt-1) and STAT92E (sole Drosop

271 mporally with that of ac-sc in the notum, is Wingless (Wg; also known as Wnt).

272 Wnt signaling ligand discovered, Drosophila Wingless (Wg; Wnt1 in mammals), plays crucial roles in s

273 to asymmetric division additionally requires Wingless, which regulates Numb expression in the AMP lin

274 appaB ligand (RANKL), osteoprotegerin (OPG), wingless (WNT) 10b, dickkopf-related protein 1 (DKK-1),

275 sfrp5 and bmper, notable for roles in Wingless (Wnt) and bone morphogenetic protein (BMP) sign

276 -Linked (DDX3X) is frequently mutated in the Wingless (WNT) and Sonic hedghog (SHH) subtypes of medul

277 nce of joint shape, including members of the Wingless (Wnt) and the bone morphogenetic protein (BMP)

278 Positive signaling by the canonical wingless (Wnt) pathway is critical for the differentiati

279 entional DCs via activation of the canonical Wingless (Wnt) pathway.

280 supports normal PAEC function by recruiting Wingless (Wnt) signaling pathways to promote proliferati

281 n Akt/glycogen synthase kinase-3 (GSK-3) and wingless (Wnt) signaling pathways, which have been assoc

282 rise frequently as a consequence of aberrant wingless (Wnt) signalling.

283 n kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal st

284 naling pathways, including Hedgehog (Hh) and Wingless (Wnt), and oriented cell divisions, all of whic

285 ry pathways, including Sonic hedgehog (Shh), Wingless (Wnt), retinoic acid receptor (RAR), and bone m

286 four molecular subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group

287 cally distinct subgroups of medulloblastoma: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group

288 In this review, we summarize how the wingless (Wnt), transforming growth factor-beta, and bon

289 ecutively and interdependently activates the wingless (Wnt)-beta-catenin (betaC) and Wnt-planar cell

290 for glycogen synthase kinase 3 and upstream wingless (Wnt)-frizzled (Fz) signaling pathways in mood

291 Survival in patients with non-wingless (WNT)/non-SHH disease with CMB/LCA was not impr

292 TP53 mutations are enriched in wingless (WNT; 16%) and sonic hedgehog (SHH; 21%) medull

293 5-year EFS and OS differed between low-risk (wingless [WNT], n = 4; both 100%), high-risk ( MYCC/ MYC

294 The secreted Wingless/Wnt molecule is a potent regulator of synaptic

295 High dietary sugar increased canonical Wingless/Wnt pathway activity, which upregulated insulin

296 ntify a presynaptic effector molecule of the Wingless/Wnt signal, Cortactin.

297 Proper regulation of the Wingless/Wnt signaling pathway is essential for normal d

298 al of intestinal stem cells is controlled by Wingless/Wnt-beta catenin signaling in both Drosophila a

299 zing centers correspond precisely with WntA, wingless, Wnt6, and Wnt10 expression patterns, thus sugg

300 marked divergence between winged queens and wingless workers, but morphological specializations for