ライフサイエンスコーパス: with high specificity

1 could potentially be used for genome editing with high specificity.

2 dephosphorylate ~15000 different substrates with high specificity.

3 h is a rapid isothermal amplification method with high specificity.

4 hich exhibits excellent DNA binding affinity with high specificity.

5 xpression on B cells captured seroconversion with high specificity.

6 xpressing high levels of novel genetic tools with high specificity.

7 lls/serum while binding to cells of interest with high specificity.

8 sters, sulfate esters, and carboxylic acids, with high specificity.

9 ase spatiotemporally at the site of interest with high specificity.

10 A installation in endogenous RNA transcripts with high specificity.

11 ctosidase genes into endogenous genomic loci with high specificity.

12 sport the ammonium and methylammonium cation with high specificity.

13 kewise can be targeted to uncover inhibitors with high specificity.

14 dentify RNA editing events from RNA-Seq data with high specificity.

15 Ab bridging assays combine good sensitivity with high specificity.

16 iple corresponding novel spatial experiences with high specificity.

17 is STR to bind to an unknown nuclear protein with high specificity.

18 adults using point-of-care ultrasonography, with high specificity.

19 rtunities for generation of neuroprotectants with high specificity.

20 ts could detect as low as 5 fg of target DNA with high specificity.

21 ism for forming protein dimers and oligomers with high specificity.

22 detect 8-OHdG in an artificial urine sample with high specificity.

23 The sensor responds with high specificity.

24 lin imaging compound), which binds to myelin with high specificity.

25 number of Alu and non-Alu RNA editing sites with high specificity.

26 eliver APEX2 to the human telomerase RNA hTR with high specificity.

27 protein is compatible to bind the human ACE2 with high specificity.

28 ck-out proteins within the secretory pathway with high specificity.

29 de-activated sugar to the macrolide scaffold with high specificity.

30 plex cellular conditions in individual cells with high specificity.

31 ften difficult for small molecules to target with high specificity.

32 mone (3R,7S)-jasmonoyl-l-isoleucine (JA-Ile) with high specificity.

33 e-fused recombinant proteins in living cells with high specificity.

34 recognize and incorporate correct substrates with high specificity.

35 otein-RNA interactions to organize complexes with high specificity.

36 he approach enabled rapid thrombin detection with high specificity.

37 can monitor T-cell activation and expansion with high specificity.

38 in obtaining a larger number of fingerprints with high specificity.

39 FNs can be designed to target a chosen locus with high specificity.

40 This probe photolabels PfCRT in situ with high specificity.

41 hallenging to build target prediction models with high specificity.

42 addition to that of numerous other proteases with high specificity.

43 ce data may identify patients at risk for HT with high specificity.

44 a-2 receptor (18 kDa) in rat liver membranes with high specificity.

45 acterization of analytes in complex mixtures with high specificity.

46 lar-massive hepatocellular carcinoma subtype with high specificity.

47 ty as well as mismatches along their lengths with high specificity.

48 mor vasculature or extravascular compartment with high specificity.

49 of diverse biochemical changes in organisms with high specificity.

50 tion technique must combine high sensitivity with high specificity.

51 idly inhibits the GTPase activity of dynamin with high specificity.

52 ts show that hUG binds Lip-1R on these cells with high specificity.

53 GT must recognize its heterocyclic substrate with high specificity.

54 ium intercalators target DNA base mismatches with high specificity.

55 only three of these 11 bases are recognized with high specificity.

56 opulations and can assign fragments >or=1 kb with high specificity.

57 egative test can exclude metastatic deposits with high specificity.

58 HCCH peptide, is capable of binding to zinc with high specificity.

59 We selected an RNA aptamer that binds to HSF with high specificity.

60 , as they can recognize target DNA sequences with high specificity.

61 ung adenocarcinomas from normal lung tissues with high specificity.

62 ytic immune cells, particularly macrophages, with high specificity.

63 omatostatin-expressing cortical interneurons with high specificity.

64 -appearing uninvolved large airway brushings with high specificity.

65 E545 K) and 0.1% for PIK3CA exon 20 (H1047R) with high specificity.

66 oxidation reaction was carried out by m-CPBA with high specificity.

67 marks contacts close to ligand binding sites with high specificity.

68 s further validated by detecting genomic DNA with high specificity.

69 s requires that they "recognize" one another with high specificity.

70 binding pocket and that FES binds to ERalpha with high specificity.

71 of protein complexes whose subunits interact with high specificity.

72 endomysial antibodies tests were associated with high specificity.

73 vides information about unlabeled live cells with high specificity.

74 l fatty tissue can show perivesical invasion with high specificity.

75 1C]ABP688, which binds to an allosteric site with high specificity.

76 demonstrate subpicomolar limit of detection with high specificity.

77 itors in the test group (20% of the dataset) with high specificity (86%) and sensitivity (78%).

78 redictive biomarker of in vivo drug response with high specificity (92%) and strong positive predicti

79 This process modifies with high specificity a conserved Pro, shares with the d

80 direct quantification of ribosomal proteins with high specificity, accuracy, and throughput.

81 RNA elements must bind an effector molecule with high specificity against a background of other cell

82 also detect the cDNA from SARS-CoV-2 (1 pg) with high specificity against SARS-CoV (2003).

83 -positive patients at risk for liver disease with high specificity, albeit with only moderate sensiti

84 ng protein kinases, designing drug compounds with high specificity among the kinases has proven diffi

85 tertiary structures to bind target molecules with high specificities and affinities.

86 The H3R and H4R activated Galphai with high specificity and a high potency.

87 biological molecules in the molecular crowd with high specificity and accuracy, uncovering unique pr

88 eic acid aptamers can bind to target ligands with high specificity and affinity and may offer therape

89 trimethylated lysine residues of histone H3 with high specificity and affinity and no lot-to-lot var

90 unodeficiency virus type 1 (HIV-1) integrase with high specificity and affinity but whose function in

91 ger (ZF) domains that recognize DNA triplets with high specificity and affinity can be used to create

92 dular subunits: an aptamer domain that binds with high specificity and affinity to a target ligand an

93 we selected a human Fab, designated KYK-2.0, with high specificity and affinity to human NKG2D.

94 combinant protein, we show that Pet54p binds with high specificity and affinity to the aI5beta intron

95 lity shift assays showed that AtWRKY30 binds with high specificity and affinity to the WRKY consensus

96 odies (mAbs) are a major class of medicines, with high specificity and affinity towards targets spann

97 Eight nanobodies, recognizing BBMV with high specificity and affinity, were retrieved after

98 selected for their ability to bind proteins with high specificity and affinity.

99 nobody that target their respective antigens with high specificity and affinity.

100 onal receptors capable of binding chaperones with high specificity and affinity.

101 nant tumor cells and tumor microenvironments with high specificity and affinity.

102 ons CLADE produced a new aptamer to thrombin with high specificity and affinity.

103 te receptor, yet only domain 11 binds IGF-II with high specificity and affinity.

104 VAR2CSA) binds to the placental receptor CSA with high specificity and affinity.

105 um metalloinsertors that bind DNA mismatches with high specificity and are preferentially cytotoxic t

106 nts of DSB hotspots - they bind DSB hotspots with high specificity and are required for DSB formation

107 The FYVE domain binds with high specificity and avidity to phosphatidylinosito

108 single apoferritin molecules in vitreous ice with high specificity and determines their orientation a

109 hytic renal mass 2 cm or greater in diameter with high specificity and diagnostic accuracy.

110 -2B RNAi eliminates neoblast gene expression with high specificity and discrimination from gene expre

111 chniques to manipulate microbial communities with high specificity and efficacy.

112 s may provide opportunities to target tumors with high specificity and efficacy.

113 ed gene editing in multiple human cell lines with high specificity and efficiencies of up to ~50%.

114 Isl1-Lhx3 drives MN differentiation with high specificity and efficiency in the spinal cord

115 hey have the potential to catalyze reactions with high specificity and efficiency without the use of

116 te the development of potent antiviral drugs with high specificity and efficiency.

117 netic particles through the host interaction with high specificity and efficiency.

118 iates targeted DNA integration in Drosophila with high specificity and efficiency.

119 on mechanism combines structural promiscuity with high specificity and enables discrimination between

120 baby hamster kidney cell extracts that bind with high specificity and high affinity to sequences wit

121 ase resolution for studying genome structure with high specificity and high genome coverage.

122 identified severe reactors and low threshold with high specificity and high sensitivity.

123 The BAT diagnosed PA with high specificity and identified severe reactors and

124 However, development of small molecules with high specificity and in vivo efficacy for mutagenic

125 metalloinsertors bind to DNA base mismatches with high specificity and inhibit cellular proliferation

126 Consolidation thus operates during sleep with high specificity and is subject to systematic influ

127 elevant drug that blocks phosphodiesterase 5 with high specificity and is used to treat erectile dysf

128 etry is a robust method to quantify analytes with high specificity and multiplexing ability, hence we

129 epressive Disorder, our method discriminated with high specificity and nearly perfect sensitivity the

130 engineered to detect diverse target proteins with high specificity and offer an attractive alternativ

131 a novel and viable way to detect biomarkers with high specificity and open the route to an original

132 Plasma miR371 expression predicts aGCM with high specificity and positive predictive value.

133 Responders could be identified with high specificity and positive-predictive value.

134 imals have been identified that target ASICs with high specificity and potency.

135 zation of these goals will require reactions with high specificity and precise control.

136 polar disorder patients and control subjects with high specificity and predictive value compared with

137 f of trial-adjudicated CVEs during follow-up with high specificity and predictive value, but imperfec

138 Swi2/Snf2 protein, binds HJ-like structures with high specificity and promotes their bidirectional b

139 (1) ASL binding occurs with high specificity and relatively high affinities at

140 sures the ex-vivo kinetics of sCD73 activity with high specificity and reproducibility and is suitabl

141 the sensitive enrichment of cTnI (<1 ng/mL) with high specificity and reproducibility, while simulta

142 detection of relatively low abundance miRNAs with high specificity and reproducibility.

143 rategy to study the surfaces of living cells with high specificity and resolution down to 10-20 nm.

144 e using 11C-BU99008 PET, a novel radioligand with high specificity and selectivity for imidazoline 2

145 ection methods that predicted liver necrosis with high specificity and selectivity in an independent

146 onitoring NQO1 activity in vitro and in vivo with high specificity and selectivity.

147 UMOD, MMP-7, SERPING1, TIMP1) classified AR with high specificity and sensitivity (area under ROC cu

148 and vaccenic acid (18:1n-7) predicted an LFD with high specificity and sensitivity (ROC curves: 0.99)

149 platform was able to detect each HBV marker with high specificity and sensitivity (with three orders

150 We report that zebrafish ORA1 recognizes with high specificity and sensitivity 4-hydroxyphenylace

151 ore assay that is capable of resolving 5 hmC with high specificity and sensitivity and demonstrate it

152 s assay can be used to immunophenotype NLHPL with high specificity and sensitivity and rapidly purify

153 inosis (BV); this subtype could be predicted with high specificity and sensitivity based on the Nugen

154 ntaminant nuts which could then be monitored with high specificity and sensitivity by selective react

155 Detecting target analytes with high specificity and sensitivity in any fluid is of

156 m the resulting catalog of TCRbeta sequences with high specificity and sensitivity in both the origin

157 The CRM genes could diagnose AR with high specificity and sensitivity in three additiona

158 Detection of SNPs with high specificity and sensitivity is essential for e

159 We developed an inhibition ELISA with high specificity and sensitivity that is applicable

160 The lack of high-throughput methods with high specificity and sensitivity to detect changes

161 vely diagnose acute cellular rejection (ACR) with high specificity and sensitivity would significantl

162 , rho L, between two LOD score profiles can, with high specificity and sensitivity, identify pairs of

163 ing and diagnosis of syphilis require assays with high specificity and sensitivity.

164 l function in photoreceptor cells is derived with high specificity and sensitivity.

165 alysis and validation resulted in a gold set with high specificity and sensitivity.

166 ins, i.e., human serum albumin and lysozyme, with high specificity and sensitivity.

167 multiplexed and quantitative miRNA analysis with high specificity and sensitivity.

168 ed nodes may identify the seizure onset zone with high specificity and sensitivity.

169 of genes in tens of thousands of individuals with high specificity and sensitivity.

170 This assay can detect and quantify HIV-1 RNA with high specificity and sensitivity.

171 y the size, content and location of variants with high specificity and sensitivity.

172 e detection of resectable pancreatic cancer, with high specificity and sensitivity.

173 in vivo investigation of biochemical changes with high specificity and sensitivity.

174 ent dyes can image hydrogen peroxide in vivo with high specificity and sensitivity.

175 relate with melanoma metastasis to the liver with high specificity and sensitivity.

176 ogical processes from normal liver processes with high specificity and sensitivity.

177 tates the detection of low abundance binders with high specificity and sensitivity.

178 y in silico, bound the minimal FLAG sequence with high specificity and sensitivity.

179 aortic PWV, and aortic bifurcation diameter with high specificity and sensitivity.

180 ish Ags in the form of peptide-MHC complexes with high specificity and sensitivity; however, how subt

181 te lattice within the tumor microenvironment with high specificity and soft-tissue contrast-to-backgr

182 uires the manipulation of cellular processes with high specificity and spatio-temporal precision.

183 GABA, dubbed GABA-Snifit, which senses GABA with high specificity and spatiotemporal resolution on t

184 ing, males respond to female-produced blends with high specificity and temporal resolution.

185 inhibit cytosolic sulfotransferases (SULTs) with high specificity and therapeutically relevant affin

186 toxins) that bind ion channels and receptors with high specificity and therefore are important pharma

187 These agents target cartilage with high specificity and this property is inherent to t

188 e that the BMP1 prodomain binds BMPs 2 and 4 with high specificity and with a KD of approximately 11

189 The final scaffolds bound b12 with high specificity and with affinity similar to that

190 e capable of detecting insulin and C-peptide with high specificity and with picomolar concentration d

191 d a limit of detection as low as 0.056 ng/mL with high specificity, and also showed excellent applica

192 UAAs are incorporated with high specificity, and functionally active transport

193 system detects single nucleotide mismatches with high specificity, and has a limit of detection of 1

194 ed, individual DNA cleavage events, rapidly, with high specificity, and in real-time are described.

195 c domains recombine user-defined DNA targets with high specificity, and that designed ZFRs integrate

196 dopsis thaliana were analyzed simultaneously with high specificity, and the sensitivity of the method

197 gh-affinity ligands recognizing biomolecules with high specificity are crucial for drug discovery and

198 mutants, we show that toxins and antitoxins with high specificity are frequently connected in sequen

199 roteins from complex cell and tissue lysates with high specificity as confirmed by SDS-PAGE analysis

200 The DR-TGD2C protein bound PtdOH with high specificity, as demonstrated by membrane lipid

201 STAGE tag analysis to identify enriched loci with high specificity, as verified by quantitative ChIP.

202 BoNTs bind with high specificity at neuromuscular junctions and the

203 with high sensitivity based on stiffness and with high specificity based on fluidity.

204 designed to target the abnormal fibroblasts with high specificity because many classes of chemothera

205 Gemin5 binds with high specificity, both in vitro and in vivo, to seq

206 ed process involving numerous factors acting with high specificity, both temporally and by location.

207 s simplex virus-1 (HSV) in corneal scrapings with high specificity but poorer sensitivity.Real time P

208 binds tightly to DNA to recognize promoters with high specificity but then releases these contacts d

209 We find these probes form bonds with DNA with high specificity but with varied stability in respo

210 rkers could predict severity of appendicitis with high specificities, but low sensitivities.

211 to be capable of detecting single molecules with high specificity, but achieving single-molecule sen

212 scopy (a time consuming and costly technique with high specificity, but low sensitivity), clinical us

213 to express a chimeric antigen receptor (CAR) with high specificity, but moderate affinity, for CEA an

214 can be identified by HLA class II tetramers with high specificity, but unexpected low sensitivity.

215 TFs target their DNA-recognition sequences with high specificity by binding with resident times of

216 uble- and single-stranded regions are coated with high specificity by telomere end-binding proteins,

217 y phosphorylated at the plasma membrane, and with high specificity by the apically localized kinase L

218 without appendicitis and are distinguishable with high specificity by using a PSV greater than 10 cm/

219 dRNAs can be combined with high-specificity Cas9 variants, which often do not

220 ertainment and identification of myocarditis with high specificity challenging in clinical trials and

221 hat all complexes bind to the mismatch sites with high specificities; DNA binding affinities to oligo

222 tantly related species can detect constraint with high specificity due to the loss of conserved neutr

223 Here we show that an artificial aldolase with high specificity for acetone as the aldol donor can

224 y a remarkable decarboxylating monooxygenase with high specificity for arginine.

225 nit of the DDB heterodimeric protein complex with high specificity for binding to a variety of DNA he

226 thesis, and evaluation of fluorogenic probes with high specificity for BlaC, a biomarker expressed by

227 18-4a (NH(2)-WxEAAYQkFL-CONH(2)) [corrected] with high specificity for breast cancer cells and improv

228 nd Cas2 proteins catalyze spacer integration with high specificity for CRISPR repeat junctions.

229 ctrodes for the rapid detection of pathogens with high specificity for live cells.

230 making it challenging to produce antibodies with high specificity for NAT1 or NAT2.

231 itor variant (Ile-Lys-Pro-Arg-/-Ser-Ile-Pro) with high specificity for NSP4.

232 T-1032, a compound with high specificity for PDE5 over PDE6, had a similar

233 rotein (RPA), but unlike RPA, Teb1 binds DNA with high specificity for telomeric repeats.

234 edly rapid oxime reaction (>150 M(-1) s(-1)) with high specificity for the abasic (AP) site of DNA.

235 eishmania expresses a single acyltransferase with high specificity for the precursor dihydroxyacetone

236 s identify a class of G+U-rich RNA sequences with high specificity for this protein.

237 Using the first operating cut point with high specificity, for EyePACS-1, the sensitivity wa

238 are then captured by a thiol-affinity resin with high specificity (>97%).

239 phopeptide enrichment from a complex mixture with high specificity (>99%), which could almost be cons

240 EHI_182030 (10 pg/mL, corresponding 453 fM) with high specificity has been achieved, employing the n

241 eneralizable strategies that accomplish this with high specificity have been slow to emerge.

242 ells upon chemical or mechanical stimulation with high specificity, high sensitivity and wide dynamic

243 of technologies to isolate these tumor cells with high specificity; however, there are limited techni

244 as distinguish non-COVID related pneumonias with high specificity in diverse patient populations.

245 s regulate AMPAR trafficking and degradation with high specificity in response to differing neuronal

246 GagDeltap6 binds to Psi RNA with high specificity in vitro and also selectively pack

247 system is quantitative, reversible and works with high specificity in vitro and in vivo in living bac

248 cleaves a semi-palindromic 15-bp target site with high specificity in vivo and in vitro.

249 logues were shown to target carrier proteins with high specificity in vivo and undergo chemoselective

250 Cas12a can bind and cut dsDNA targets with high specificity in vivo, making it an ideal candid

251 ogical probes that inactivate individual SHs with high specificity in vivo.

252 cterial TetR fold to bind aromatic isoprenes with high specificity, including CoQ intermediates that

253 romophores having a metalloporphyrin moiety, with high specificity into the interior core of the bund

254 The HA complex recognizes E-cadherin with high specificity involving extensive intermolecular

255 thin the right upper quadrant of the abdomen with high specificity, irrespective of gestational age.

256 ment of ultrasensitive analytical techniques with high specificities is required to analyze the cell

257 many small molecules in a single measurement with high specificity is a significant improvement over

258 a single aaRS binds distinct anticodon loops with high specificity is not well understood.

259 cPMP by MoaC or its human homologue, MOCS1B, with high specificities (Km < 0.060 muM and 0.79 +/- 0.2

260 single molecules in a living bacterial cell with high specificity, millisecond time resolution, and

261 one (GSH) and hydrogen peroxide (H(2) O(2) ) with high specificity on a basis of domino reactions on

262 ata suggest that CheR methyltransferases act with high specificity on their cognate chemoreceptors.

263 se (GST, glutathione S-transferase) isoforms with high specificity or high promiscuity are compared.

264 achieved was 95-99% across alteration types, with high specificity (positive predictive value >99%).

265 amino acid side chains by targeted reagents with high specificity, probing structural changes at sel

266 zable technique to image endogenous proteins with high specificity, resolution, and contrast in singl

267 of the degree of processing it has undergone with high specificity, sensitivity and rapidity.

268 inct from Mk exosomes (MkExos), target HSPCs with high specificity since they have no effect on other

269 These enzymes are being engineered with high specificity such that off-target binding of ce

270 (HP100, 12 mum), followed by an endoprotease with high specificity (Tail21, 8 mum), and HP at 600 MPa

271 and their ability to bind long DNA sequences with high specificity, TALEs have been used in many appl

272 ells, we demonstrate labeling of fixed cells with high specificity that correlates well with fluoresc

273 Furthermore, we demonstrate with high specificity the same multiplexed detection usi

274 Human cytochrome P450 aromatase catalyzes with high specificity the synthesis of estrogens from an

275 ce methyltransferase DNMT1, which methylates with high specificity the unmethylated strand of a hemim

276 lation of B2.1, a dimeric peptide that binds with high specificity to b12 and competes with gp120 for

277 We show that although F3-Cis-Np bind with high specificity to both human ovarian tumor cells

278 b domains accounts for IgG's ability to bind with high specificity to essentially any antigen.

279 ndonucleases (HEs) cut long DNA target sites with high specificity to initiate and target the lateral

280 the assembly of nucleosomes, and DNA motifs with high specificity to nucleosomes have been identifie

281 is a calcium-independent lectin, which binds with high specificity to O-linked alpha1,4-GlcNAc-capped

282 ed on a murine precursor antibody that binds with high specificity to pGlu3-Abeta monomers, oligomers

283 idopsis thaliana) chloroplast psbA mRNA bind with high specificity to psbA mRNA in vivo.

284 UV-vis) of the protein showed that it bound with high specificity to the desired cofactors, suggesti

285 ineered zinc finger protein (Gq1) that binds with high specificity to the intramolecular G-quadruplex

286 TZF homologs tristetraprolin and ERF-2 bind with high specificity to UUAUUUAUU elements.

287 unctionalities in the side chains that react with high specificity toward thiol ligands.

288 n be used as a tool to monitor and quantify, with high specificity, tumor response in PSMA-positive p

289 GF captures blood circulating monocytes (MC) with high specificity under a range of shear stresses.

290 ing various substrates into desired products with high specificity under mild conditions, their effec

291 cilitates the detection of peritoneal tumors with high specificity upon intraperitoneal tumor targeti

292 the TTP family of proteins, TIS11d binds RNA with high specificity using a pair of CCCH-type tandem z

293 homogeneous solution at ambient temperatures with high specificity using a sophisticated biosensor.

294 yltransferase activity in Enterobacteriaceae with high specificity using the standard disk susceptibi

295 To develop a sequential, two-step assay with high specificity, we used PBMCs from kidney recipie

296 structural protein 3 (NS3):1406-1415 epitope with high specificity when presented by HLA-A2.

297 etween CEA protein and anti-CEA in real-time with high specificity, which revealed selective electric

298 mers were shown to detect various quinolones with high specificity, while specific binding activities

299 e to detect intracellular cancer RNA markers with high specificity within 30 minutes post treatment,

300 r phosphatases dephosphorylate their targets with high specificity, yet the structural and sequence d