ライフサイエンスコーパス: without altering

1 uences, for example to tune translation rate without altering a protein sequence.

2 hift of the ACh concentration-response curve without altering ACh efficacy.

3 in control versus 1/14 hearts at 100 nmol/L) without altering action potential duration or restitutio

4 ansients, and cocaine augments dopamine tone without altering activity of cholinergic interneurons.

5 ecifically diminished adhesion to E-cadherin without altering adhesion to fibronectin matrix proteins

6 uced lipid accumulation in human adipocytes, without altering adipocyte differentiation marker gene e

7 induced the anti-inflammatory cytokine IL-10 without altering AdipoR expression.

8 hosphorylation on both phosphorylation sites without altering Akt phosphorylation.

9 surface trafficking in hippocampal neurons, without altering AMPA receptor trafficking.

10 blocked neurodegeneration in TgF344-AD rats, without altering amyloid deposition or indicators of neu

11 regions of the MOR can modulate side effects without altering analgesia.

12 ory processes and abrogated neuropathic pain without altering anticancer properties of paclitaxel and

13 onociceptive synaptic long-term potentiation without altering antinociception.

14 tack behavior in total Avpr1b knockout mice, without altering anxiety-like behaviors.

15 tial memory deficits and synaptic depletion, without altering APP or Ass metabolism.

16 negative emotionality in unstressed animals without altering appetite.

17 the stability of the AR-FL and AR-V proteins without altering AR RNA splicing.

18 nd domain inhibits stimulation by Gbetagamma without altering basal activity or Galphaq response.

19 dent increase in lysosomal V-ATPase activity without altering basal activity.

20 leading to retraction of the apical dendrite without altering basolateral dendrite dynamics.

21 toward a less inflammatory phenotype in vivo without altering behavior.

22 h ENaC, decreases ENaC functional expression without altering beta-ENaC expression at the apical surf

23 decreases ENaC functional expression, again without altering beta-ENaC expression at the apical surf

24 xin-3alpha(A687T) enhanced binding to LRRTM2 without altering binding to postsynaptic neuroligin-1.

25 respiratory arrest compared with wild type, without altering blood chemistry or displaying hyperther

26 bilize the mouse carotid artery mechanically without altering blood dynamics, which dramatically enha

27 energy expenditure and promoted weight gain without altering blood glucose levels, silencing VMNCCKB

28 that AA-ORS treatment (1) increased Lgr5(+), without altering Bmi1 positive cells; (2) increased leve

29 ain fatty acids by 87 and 69%, respectively, without altering body weight, energy expenditure, respir

30 pal long-term potentiation (LTP) impairments without altering brain amyloid beta (Abeta) pathology.

31 -ATPase activity via increased maximal rate, without altering Ca(2+) affinity.

32 nction as measured by invasive hemodynamics, without altering Ca(2+) spark frequency.

33 airs diastolic function in the intact heart, without altering calcium sensitivity or cooperativity of

34 nt of TCPOBOP-induced proliferative response without altering CAR activation.

35 KD2 knockout elevated blood pressure in mice without altering cardiac function or kidney anatomy.

36 verexpression attenuated CB1R downregulation without altering CB1R desensitization.

37 l, while overexpression of NSun2 elevated it without altering CDK1 mRNA levels.

38 93b causes an accelerated expansion of HSCs, without altering cell cycle or survival, but by decelera

39 te the pace of downstream behavioral rhythms without altering central aspects of the clock mechanism.

40 simultaneous administration of DEANO or HU, without altering CFHb, in an NO pathway-mediated manner.

41 to Pt nanoparticles, the unique size control without altering chemical properties afforded by this ap

42 hannel structure and impairs channel opening without altering cilia localization and channel assembly

43 oblasts, drastically altered the RPM network without altering circulating CSF1 levels.

44 l self-administration for more than 2 months without altering cocaine self-administration.

45 thermal treatment (RCH: 20-30%, RCA: 44-55%) without altering color properties.

46 reduced aversion-resistant alcohol drinking, without altering consumption of quinine-free alcohol or

47 egulation of Nav1.5 specifically tunes INa,L without altering critical physiological components of th

48 (+) and CD4(-)CD8(-) lpr T cell accumulation without altering defective lpr apoptosis.

49 ent of plaque load and could be extinguished without altering deposited amyloid.

50 ity to oseltamivir by increasing NA activity without altering drug binding.

51 relate of arousal and cognition enhancement, without altering duration of time across all sleep/wake

52 sulin-independently decreasing blood glucose without altering energy balance.

53 effects of the HPT axis may favour longevity without altering energy metabolism.

54 induced activation of p38, a pro-death MAPK, without altering ERK and JNK.

55 e mutation that augments spontaneous release without altering evoked release, suggesting that aberran

56 leads to increased collagen internalization without altering expression of the endocytic collagen re

57 robust inhibition of the mutant GJB2 allele without altering expression of the wild-type allele.

58 rolled the location of attentional selection without altering feature discrimination.

59 romotes the expansion of adipose tissue mass without altering food intake or physical activities.

60 rient oxidation, and decreases body fat mass without altering food intake, lean body mass, body tempe

61 unction via a HIF2alpha-dependent mechanism, without altering Foxp3 expression.

62 e silencing and heterochromatin condensation without altering genome-wide DNA methylation patterns.

63 focal, specific, and sustained ENS ablation without altering GI transit or colonic contractility, al

64 ific fatty acid profile in broodstock diets, without altering gilthead seabream broodstock reproducti

65 NRCAM reduces numbers of inhibitory synapses without altering glutamatergic synaptic density.

66 y exacerbates cognitive deficits in APP/PS1, without altering gross motor function.

67 n) as a possible strategy to limit water use without altering growth.

68 ve chromatin compaction and gene repression, without altering H3K27me3 levels.

69 These changes occur without altering hair-bundle compliance or the number of

70 plitude at maximal activation (maximal Ih ), without altering HCN1 surface expression, in two classes

71 very of viral genomes to these core clusters without altering HCV RNA colocalization with NS5A.

72 cylglycerol, cholesterol and blood pressure, without altering heart rate; changes in the number and s

73 This resulted in a 34% increase in HCLs without altering hepatic ATP concentrations.

74 disrupts these gene-related folding features without altering higher-order chromatin structures.

75 ed BLA-evoked synaptic responses in the mPFC without altering hippocampus-evoked responses.

76 c function and myocardial strain in CKD mice without altering hypertension or degree of renal dysfunc

77 tive CD8(+) T cells overlapped significantly without altering immunodominance hierarchy.

78 denervated SCs can be efficaciously enhanced without altering innervated SCs.

79 ce during inspiration increased tidal volume without altering inspiratory duration, whereas expirator

80 ration and increased apoptosis in pregnancy, without altering insulin sensitivity, suggesting that ra

81 the localization of ASOs into autophagosomes without altering intracellular concentrations or traffic

82 ation selectively reduced HBV virion release without altering intracellular viral replication or the

83 on of mechanically induced myotonia occurred without altering intrinsic muscle excitability, such tha

84 dless of channel state (open or closed), and without altering its apparent Ca(2+) sensitivity.

85 decays, whereby a quark changes its flavour without altering its electric charge.

86 e radical lifetimes from 2 h to over 20 days without altering its electronic structure.

87 uld reduce the frequency of its normal-modes without altering its electrostatics.

88 was immobilized on octadecyl-activated resin without altering its fatty acid selectivity.

89 expression in terminals ( approximately 70%) without altering its function.

90 udal extent and area of the activated barrel without altering its identity.

91 as open in the dark and closed in the light, without altering its ion selectivity.

92 egrated on the surface of the test structure without altering its mechanical and geometrical properti

93 interfaces that integrate into brain tissue without altering its properties.

94 o 95.1% and from 88.9% to 95.1% (P < 0.001), without altering its sensitivity (97.7% vs 95.5%, P = 1.

95 he incorporation of various functional units without altering its supramolecular architecture.

96 on) to decrease alpha(IIb)beta(3) activation without altering its surface expression.

97 neutralization by MV polyclonal immune sera without altering its thermostability.

98 arted antimicrobial activity to the membrane without altering its transport properties.

99 Rs and reduction of pre-miRs and mature miRs without altering levels or cellular localisation of miR

100 utic option to abate allergic airway disease without altering life-saving autonomic hypoxic reflexes.

101 crease the ligand size by about 1.5 angstrom without altering ligand chemistry.

102 yacrylamide gels to alter substrate rigidity without altering ligand density, we show that fibrotic r

103 ting ketone levels by using a palatable diet without altering lipid levels.

104 urons decreases food intake and body weight, without altering locomotion and anxiety.

105 d end feet that wrapped around blood vessels without altering locomotion behaviors, suggesting struct

106 tidepressant effects in the forced swim test without altering locomotor activity.

107 al genome exhibited a decrease in aggression without altering male-male courtship.

108 me and urinary glucose excretion (P < 0.001) without altering MAP, HR, RBF, or CrCl.

109 3-OHB increased MVO(2) without altering MEE.

110 ology through posttranslational modification without altering microbial community composition.

111 n levels and impairs directed cell migration without altering microtubule organization and independen

112 both glycolytic and oxidative muscle fibers without altering mitochondrial copy number and the abund

113 rease in mtDNA levels (mutant and wild-type) without altering mitochondrial mass.

114 l behavioral measures of cocaine dependence, without altering motor performance or reinforcement by a

115 e effect of albumin on Klotho protein levels without altering mRNA levels, thus mainly abrogating the

116 required for efficient COX1 mRNA translation without altering mRNA levels, which results in a decreas

117 to control the force and motility of myosin without altering myosin's structure.

118 Suppressing excitability of newborn neurons without altering neurogenesis abolish the antidepressant

119 e impedance phase introduced by HCN channels without altering neuronal excitability and found that th

120 and formation of synapses at new locations, without altering neuronal morphology.

121 neutralization sensitivity to rhesus CD4-Ig without altering neutralization by human CD4-Ig, SIV neu

122 mice via excitatory chemogenetic receptors, without altering normal circuit anatomy, recapitulated s

123 razine has beneficial antidyskinetic effects without altering normal motor responses to L-DOPA.

124 neuropathic pain in male and female rodents without altering normal pain response.

125 of cytoplasmic constituents into the nucleus without altering nuclear efflux.

126 UA and XOR activity in obese wild-type mice without altering obesity-associated insulin resistance/d

127 astrocytic differentiation by cultured EZCs without altering oligodendroglial or neuronal differenti

128 ains, effectively depleting defined lineages without altering other cellular physiology.

129 on action potential burst duration in vitro, without altering other electrophysiological characterist

130 he formation of the larval stem cell niches, without altering other midgut cell types.

131 impair Na(V) -accessory protein interactions without altering other properties of channel function.

132 quency of MHC class II(+) pDCs in the spleen without altering overall pDC frequency, number, or matur

133 e expression of newly synthesized alpha2B-AR without altering overall receptor synthesis and internal

134 n secretion to IBMX and KCl were all reduced without altering oxygen consumption rate compared with s

135 yl-1-methylxanthine and KCl were all reduced without altering oxygen consumption rate compared with s

136 ilation (145 +/- 4 to 173 +/- 5 ml min(-1) ) without altering P aC O2 or pH and enhanced ventilatory

137 Applying IL-13 increased ASL pH to ~7.4 without altering paracellular HCO(3) (-) permeability, a

138 ly, significantly reduced complex stability, without altering peptide conformation or T cell recognit

139 This would allow preference evolution without altering perception of the wider environment.

140 ic climate change alters seasonal conditions without altering photoperiod and can thus create a cue-e

141 ion diminished morphine tolerance and reward without altering physical dependence, whereas the exon 4

142 Using ALOD4, we: (1) deplete ER cholesterol without altering PM or overall cellular cholesterol leve

143 nhibition of gamma-aminobutyric acid release without altering postsynaptic responses.

144 ancreatic cancer diminished liver metastasis without altering primary tumor size.

145 pha1 TM3-4 loop that affects GlyR physiology without altering protein expression at the whole-cell an

146 We found that imatinib blocked tolerance without altering receptor internalization induced by eit

147 iggers dephosphorylation and desensitization without altering receptor localization.

148 -34a overexpression decreased efferocytosis, without altering recognition of live, necrotic, or Ig-op

149 duced peripheral red blood cell (RBC) counts without altering relative abundances of erythroblast sub

150 y to dictate the number of vesicles released without altering release probability.

151 parallel-fiber synaptic transmission by ~50% without altering release probability.

152 ter determines vesicular release probability without altering release time course.

153 utation of which reduces recombination rates without altering replication fidelity.

154 perglycemia enhanced these vasoconstrictions without altering respective receptor mRNA expression.

155 r allografts and in human cells (53% vs. 0%) without altering RIP1 expression, and this process was i

156 ctility through a Ca(2+)-dependent mechanism without altering sarcoplasmic reticulum Ca(2+) load and

157 height, organ size and seed weight (7-25%), without altering seed quality traits like fatty acid com

158 induced the adaptation of efferent signals, without altering sensory signals.

159 r extent than synchronous ST-EPSC amplitudes without altering sEPSCs or thermal sensitivity.

160 impairment of long-term synaptic plasticity without altering short-term plasticity.

161 creased both instantaneous and long-term WUE without altering significantly the photosynthetic capaci

162 capacity and cytotoxicity of Tim-3(+) cells without altering Slamf6(+) numbers during lymphocytic ch

163 ed proteins that modulate peptide generation without altering source protein expression.

164 ons compromises spine head width and length, without altering spine dynamics.

165 Loss of lgc-46 prolongs evoked release, without altering spontaneous activity.

166 uced both synchronous and asynchronous EPSCs without altering spontaneous or thermal-evoked transmiss

167 By modulating substrate porosity without altering stiffness in polyacrylamide gels, we sh

168 dynamic volume in both WT and dimeric CaMKII without altering subunit stoichiometry or the net homo-F

169 ns cause large-scale transcriptional changes without altering susceptibility to other antibiotics, re

170 t AMPA-receptor-mediated, synaptic responses without altering synapse density.

171 erogeneous enhancement in HERV transcription without altering T cell recognition.

172 played a loss of T cell-suppression capacity without altering T(reg) cell proliferation and survival.

173 t allows for switching of the IgG subclasses without altering target binding specificity to generate

174 can be modulated chemically and genetically without altering the absolute amount of mature FXN prote

175 heroin infusions in a progressive ratio test without altering the acquisition or maintenance of heroi

176 enting translocation of AKT into lipid rafts without altering the activation of receptor-associated k

177 le is predicted to prevent protein secretion without altering the activity of LFNG, thus increasing t

178 ncreased the firing rate of VTA MC3R neurons without altering the activity of non-MC3R expressing VTA

179 ponse in the lung to environmental allergens without altering the adaptive immune response.

180 tion was found to affect the turnover number without altering the affinity for substrates, whereas th

181 ft of bound CaM to a lower FRET orientation (without altering the amount of CaM bound to RyR).

182 e innervation and restore cognitive function without altering the anxiogenic phenotype.

183 nipulated in parallel to tune pH-sensitivity without altering the aptamer sequence itself.

184 . perfringens invasion into ileum (P < 0.05) without altering the bacterial ileal luminal colonizatio

185 balanced defects in mitochondrial transport, without altering the balance between stationary and movi

186 approximately 0) devices from 14.7% to 16.9% without altering the bandgap of the perovskite material.

187 ved macrophages after crossing the BBB model without altering the BBB model integrity.

188 from spontaneously occurring sleep spindles without altering the behavioral state, when compared to

189 vivo induction of Treg cells promoted by PM without altering the capacity to induce functional aller

190 study single cell metabolic heat production without altering the cell behavior, but it is currently

191 have different neutron scattering properties without altering the chemical composition of the cells.

192 nanoparticles with adjustable release rates without altering the chemical structures of the polymer

193 ficient to suppress Myc transcription in cis without altering the chromatin organization of the locus

194 rotein-coupled signalling of angiotensin II, without altering the classical G protein-coupled pathway

195 a mechanical compression on individual cells without altering the composition of the matrix.

196 cifically study the function of LCs in vivo, without altering the DC subset composition in the skin,

197 ts of drugs can be conjugated to the surface without altering the dendrimer's performance, for exampl

198 viated pain affective-motivational behaviors without altering the detection of noxious stimuli, withd

199 of CCOs, greatly reduced enzymatic activity without altering the dioxygenase labeling pattern.

200 ne's effects in nicotine-experienced monkeys without altering the discriminative-stimulus properties

201 tion of synaptic vesicles in neuronal somata without altering the distribution of other organelles.

202 ytosine base to form 5 methyl cytosine (5mC) without altering the DNA sequences.

203 ver, we were able to minimize these effects, without altering the dose, with supportive measures, eg,

204 actions can alter the host response to drugs without altering the drug or the host.

205 The antibody does this without altering the dynamics of the spike motion betwee

206 w that these behavioral changes are achieved without altering the endogenous period of the master cir

207 and virulence and bacterial survival in vivo without altering the examined gallbladder pro- or anti-i

208 glucose concentration impaired SOCs function without altering the expression levels of STIM1, Orai1,

209 P increased the expression of GCL holoenzyme without altering the expression of its subunits or Nrf2

210 esion RNA synthesis by Escherichia coli RNAP without altering the fidelity of nucleotide incorporatio

211 anges in CFTR's transmembrane domains (TMDs) without altering the function of the nucleotide binding

212 g the genetic sequence) and gene regulation (without altering the genetic sequence).

213 le specific and robust target gene knockdown without altering the genome.

214 ibility to implement a variety of algorithms without altering the hardware.

215 eins and allows their unambiguous assignment without altering the identification of internal digestio

216 expressing neurons (1-10 Hz stimulus trains) without altering the incidence of synaptic response fail

217 inction of established taste aversion memory without altering the initial associative taste learning

218 ulation and eliminated synaptic facilitation without altering the initial probability of vesicle rele

219 s IRA maturation and its mitogenic potential without altering the insulin effects.

220 .73+/-9.34% of TCMPs crossed the epithelium, without altering the integrity of the cell layer.

221 setting panels away from the idealized sheet without altering the kinematic model used to simulate fo

222 rrents are dose-dependently inhibited by AMD without altering the kinetics of current decay at both 2

223 drogen diffusivity in alpha-Zr and Zircaloy, without altering the kinetics of long-range diffusion.

224 of GMP induced a marked increase in activity without altering the Km values for the substrates.

225 ganization of nonglassy nematic LC molecules without altering the LC directors.

226 nificantly increased the level of viral RNAs without altering the level of cccDNA.

227 eration, and mitigate severity of acute GVHD without altering the load or function of alloreactive im

228 tly accelerated the rate of TRPC4 activation without altering the maximal current density and this ef

229 d presents significant therapeutic potential without altering the mechanism of intracellular action o

230 r ATM kinase inhibition suppresses resection without altering the MH pattern of the A-EJ-mediated swi

231 (FACE) allows open-air elevation of [CO(2) ] without altering the microclimate.

232 ver, KIF3CC accelerates the catastrophe rate without altering the microtubule growth rate.

233 omophore interactions in covalent assemblies without altering the molecular geometry or solvent polar

234 cellulose biosynthesis in a bacterial model, without altering the morphology and the crystallinity of

235 ime could aid the addressee's understanding, without altering the movement's trajectory.

236 eases ICL-induced mutagenesis in human cells without altering the mutation spectra.

237 tivity and P50 phosphorylation in HC11 cells without altering the NF-kappaB2 pathway.

238 diate the allosteric effects of ATP binding, without altering the nucleotide-binding pattern.

239 enhances learning and increases SV pool size without altering the number of dopamine neurons, their a

240 d social interaction between unfamiliar rats without altering the number or pattern of ultrasonic voc

241 complished by increasing the kinetic on-rate without altering the off-rate and has a component that i

242 analyte ions could be formed simultaneously without altering the operational parameters of the ion s

243 approach to improve the shelf life of foods without altering the organoleptical characteristics and

244 ar coupling method, the rearrangement occurs without altering the original conformation.

245 y associated with key structural transitions without altering the overall conformation of the pre- an

246 on of chirality provides protease resistance without altering the overall mode of cellular entry, a p

247 undreds of lncRNAs and unstable transcripts, without altering the overall transcription rate in cells

248 umidity during production, use, and storage, without altering the oxidation state, for 6 months.

249 ion and simultaneously increased lesion size without altering the parasite burden.

250 ferometry (BSI), which can facilitate assays without altering the participating components.

251 ed the T(3) + IGF-1 reduction of BrdU uptake without altering the phosphorylation of ERK or Akt at bo

252 ses, and reduced atherosclerotic plaque size without altering the plasma lipid profiles in apolipopro

253 ectively interferes with PIN1 basal polarity without altering the polarity of apical proteins.

254 ce can achieve full 2pi phase shift coverage without altering the polarization if it is illuminated f

255 rcoded probes, at physiological temperature, without altering the probes themselves.

256 " altering the inputs to a cognitive process without altering the processing itself.

257 alose monomycolate across the inner membrane without altering the proton motive force.

258 te the distribution of NTFs along filaments, without altering the random distribution of CTFs.

259 lly decreased the capacity of the RRP, again without altering the rate of vesicle priming into the RR

260 f IRA and its associated mitogenic signaling without altering the signals emanating from IRB.

261 95 repressed IGF2R translation cooperatively without altering the stability of Igf2r mRNA.

262 romoter prevented glucose-induced mRNA decay without altering the start site of transcription.

263 28E variant increases the mobility of CaV1.2 without altering the steady-state maintenance of cluster

264 Mutagenesis of the +59 motif without altering the stem-loop structure resulted in red

265 ing affinity of alphaS for synaptic vesicles without altering the structural properties of the bound

266 ) host NCs results in a lattice contraction, without altering the structure and morphology, which has

267 ferences in brain size build memory capacity without altering the structure of the data being stored.

268 affect the extent of unconscious processing without altering the subjective awareness.

269 or drug conjugation would allow drug loading without altering the surface composition and therefore l

270 ure by changing the local chemical state and without altering the surface roughness by swift heavy io

271 even more strongly than NHCs to Au surfaces without altering the surface structure.

272 itions by adjusting driving field parameters without altering the target state or quantum evolution.

273 to the apical plasma membranes of RPT cells without altering the total cellular pool of AT2Rs and in

274 ifying genome organization and gene activity without altering the underlying DNA sequence.

275 gned by exchanging one amino acid at a time, without altering their alpha-helical structure, which is

276 al denaturation [DeltaCm (GndHCl) = 0.53 M], without altering their catalytic efficiency and stereose

277 lodextrin-metal organic frameworks (CD-MOFs) without altering their crystallinity.

278 f genes of interest in major immune lineages without altering their development or function.

279 lter spatial correlations in natural movies, without altering their edge structure.

280 ow, adipose tissue, and umbilical cord blood without altering their ex vivo characteristics.

281 anufacture of multi-VSTs from healthy donors without altering their phenotype or function and may ser

282 ase of the affinity of the produced MIP NPs, without altering their physical properties such as size,

283 ecular species to travel into or out of MOFs without altering their pristine physicochemical properti

284 he fusion proteins were loaded onto exosomes without altering their surface markers, particle size or

285 heir signal-to-noise ratio and dynamic range without altering their workflow and readout devices.

286 to an increase in new-born neuron production without altering those extra cells' morphological or fun

287 xosome cargo levels of chemokines and HMGB1, without altering total exosome secretion or GPVI cargo.

288 n levels of plasma platelet-derived exosomes without altering total levels of exosomes.

289 concentration in 1321N1 and C6 glioma cells without altering TRAP-6 and carbachol Ca(2+) responses.

290 lar GzmB strongly inhibits Treg suppression, without altering Treg viability.

291 lumab treatment inhibited osteoclastogenesis without altering tumor burden.

292 effects on the tumor-immune infiltrate, yet without altering tumor growth.

293 y as a tool to optimize the material bandgap without altering ultrafast photophysics is reported.

294 t fluid removal by UF attenuates sleep apnea without altering uremic status.

295 the expression of VEGFR2 in control tissue, without altering VEGFR1 and VEGF-B expression.

296 referentially eliminated breast cancer cells without altering viability of bone marrow stromal cells.

297 ly conjugated with GFP in the cytosol and ER without altering VLP formation or GFP fluorescence.

298 cells induces an increase in L-type current without altering voltage-dependent activation, thus refl

299 oclastogenesis in PAR1 KO cells to WT levels without altering WT responses.

300 maternal copy of SNORD116 could be achieved without altering ZNF274 protein levels.