ライフサイエンスコーパス: woodchuck

1 one liver sample from a liver tumor-positive woodchuck.

2 ovel Helicobacter sp. strain isolated from a woodchuck.

3 ted less frequently) compared with resolving woodchucks.

4 , were never in excess of those in resolving woodchucks.

5 till increased compared to that of resolving woodchucks.

6 and incomplete compared to that of resolved woodchucks.

7 proteasome, and studied their infectivity in woodchucks.

8 ce productive acute infection in naive adult woodchucks.

9 inst WHV replication in chronically infected woodchucks.

10 ings in the final stages of FIAU toxicity in woodchucks.

11 cing WHV-DNA levels in serum in WHV-infected woodchucks.

12 compared with normal liver from WHV-infected woodchucks.

13 om acute infection or in those of uninfected woodchucks.

14 he limit of detection in half of the treated woodchucks.

15 as the WHV PreC protein (WPreC) in infected woodchucks.

16 from X/c-myc bitransgenics and WHV-infected woodchucks.

17 and woodchuck hepatitis virus (WHV)-infected woodchucks.

18 ound in chronically infected chimpanzees and woodchucks.

19 ivers of WHV-infected control or ETV-treated woodchucks.

20 d during immune clearance in the ETV-treated woodchucks.

21 8-week-old weanlings (33% chronic) and adult woodchucks (0% chronic; i.e., all resolved).

22 rcent chronic of total infected) in neonatal woodchucks (1-3 days old).

23 from 20 (17 WHV-infected and 3 noninfected) woodchucks, 10 with WHV-associated hepatic tumors and 10

24 ectious virus (approximately 10(7.7)-10(9.5) woodchuck 50% infectious doses per milliliter [WID(50%)/

25 cytotoxic activities on both mouse L929B and woodchuck A2 cells in the presence of actinomycin D.

26 stained after treatment cessation, and these woodchucks also developed detectable anti-WHsAg antibodi

27 HV-infected hepatocytes from chronic carrier woodchucks also established a persistent infection in uP

28 inate overexpression of N-myc2 and IGF-II in woodchuck altered hepatic foci may allow cells which oth

29 yzed RNAs were from the liver of an infected woodchuck and from a liver cell line at 6 days after tra

30 ral nucleoside therapy has been shown in the woodchuck, and "proof of principal" has been established

31 ing HDV replication in hepatocytes of human, woodchuck, and mouse origin, no approximately 21-nt RNAs

32 and HCCs collected from three superinfected woodchucks, and (iii) finding WHVNY DNA replication inte

33 pression was inoculated into WHV-susceptible woodchucks, and a productive infection was demonstrated.

34 ication in transfected cells and in infected woodchucks, and as was previously reported, patients inf

35 (WHx) is required for infectivity of WHV in woodchucks, and the gene encodes a broadly acting transc

36 reporter genes first was evaluated in normal woodchucks, and then the immunogenicity of an analog woo

37 e liver of woodchuck hepatitis virus carrier woodchucks, and these genes continue to be overexpressed

38 g with potent antiviral efficacy, and in the woodchuck animal model it also decreased hepatitis B vir

39 cies from the serum and liver of an infected woodchuck as well as deltaAg species expressed in and se

40 re firmly establish chronic WHV infection in woodchucks as an accurate and predictive model for antiv

41 huck hepatitis virus (WHV)-infected neonatal woodchucks at 2 time points before the self-limited or c

42 A replication intermediates in three of four woodchucks at 2 weeks after adenovirus infection.

43 Woodchucks became seronegative for anti-WHs 3-6 years la

44 extracted from the liver of an HDV-infected woodchuck, behaved as if it contained a 5'-cap structure

45 Induction of hepatocellular carcinoma in woodchucks by woodchuck hepatitis virus is associated wi

46 It suggests the woodchuck can be a useful model for the study of the acq

47 Woodchuck cDNA and genomic DNA libraries were screened w

48 integrated viral DNA in the livers of three woodchucks chronically infected with the woodchuck hepat

49 Woodchucks chronically infected with the woodchuck hepat

50 Conventional vaccination of woodchucks chronically infected with the woodchuck hepat

51 irus (WHV), serve as a model for HBV because woodchucks chronically infected with WHV also develop he

52 aluated the antiviral efficacy of GS-9688 in woodchucks chronically infected with woodchuck hepatitis

53 o-5-methyl-beta-L-arabinofuranosyluracil) to woodchucks chronically infected with woodchuck hepatitis

54 e analogue with potent antiviral efficacy in woodchucks chronically infected with woodchuck hepatitis

55 Using woodchucks chronically infected with woodchuck hepatitis

56 udy, we asked how these losses compared when woodchucks chronically infected with woodchuck hepatitis

57 Laboratory reared woodchucks chronically infected with woodchuck hepatitis

58 We found that livers from woodchucks chronically infected with woodchuck hepatitis

59 pheral blood mononuclear cells isolated from woodchucks chronically infected with woodchuck hepatitis

60 When woodchucks chronically infected with woodchuck hepatitis

61 A woodchuck-derived hepatitis delta virus (HDV) inoculum w

62 In this report, we show that woodchucks diagnosed with HCC have dramatically higher l

63 e progressively severe, and all FIAU-treated woodchucks died or were euthanized 78 to 111 days after

64 pared to virions harvested from WHV-infected woodchucks during either (i) early chronic infection, wh

65 r tissues obtained from transiently infected woodchucks during the critical phase of the recovery per

66 The woodchucks experienced significant dose dependent decrea

67 Hepatic biopsies from woodchucks experimentally inoculated with WHV were exami

68 une response to WHxAg was documented in some woodchucks following acute WHV infection.

69 livers and HCCs from a panel of WHV carrier woodchucks for the presence of WHx by utilizing an immun

70 expansion could not be explored because the woodchuck genome has not yet been sequenced.

71 ion, half of the surgically treated infected woodchucks had developed self-limited infections, while

72 Resolving woodchucks had robust, acute-phase vCMI to WHV antigens

73 In order to determine if woodchucks harbor a Helicobacter sp. that might play a r

74 Woodchuck HBV mutants that lack HBx are unable to replic

75 he same was observed with the HBx protein of woodchuck HBV.

76 Both in human and woodchuck HCC cell lines, separate treatments with antis

77 The apparent absence of WHx in some woodchuck HCCs indicates that WHx may not be required to

78 we have developed the core protein from the woodchuck hepadnavirus (WHcAg) as a new particulate carr

79 variants of this epitope within a versatile woodchuck hepadnavirus core-based virus-like particle (W

80 cent studies on the X protein encoded by the woodchuck hepadnavirus have provided correlative evidenc

81 X/p53 complexes in vivo and in vitro in the woodchuck hepadnavirus system, combined with analogous d

82 an be made to replicate in woodchucks, using woodchuck hepatitis B virus as a helper virus.

83 odchucks undergoing clearance of a transient woodchuck hepatitis infection by determining the fate of

84 n of either normal saline (n = 30), AAV-BDNF-woodchuck hepatitis posttranscriptional regulatory eleme

85 The cis-acting element found in the woodchuck hepatitis virus (WHV) (the WHV posttranscripti

86 t were chronically infected with HBV-related woodchuck hepatitis virus (WHV) and already developed HC

87 but not other animal hepadnaviruses, such as woodchuck hepatitis virus (WHV) and duck hepatitis B vir

88 The woodchuck hepatitis virus (WHV) and its natural host, th

89 The woodchuck hepatitis virus (WHV) and its natural host, th

90 (HCC) associated with chronic infection with woodchuck hepatitis virus (WHV) and serve as a model of

91 g woodchuck hepatocytes were infectable with woodchuck hepatitis virus (WHV) and showed WHV replicati

92 demonstrated that the X-deficient mutants of woodchuck hepatitis virus (WHV) are not completely repli

93 When woodchucks chronically infected with woodchuck hepatitis virus (WHV) are superinfected with H

94 chucks were infected experimentally with the woodchuck hepatitis virus (WHV) at 3 days of age.

95 an initial experiment, groups of six chronic woodchuck hepatitis virus (WHV) carrier woodchucks recei

96 Woodchucks infected at birth with woodchuck hepatitis virus (WHV) cleared viremia and deve

97 rs from woodchucks chronically infected with woodchuck hepatitis virus (WHV) contained covalently clo

98 A small region in the capsid protein of woodchuck hepatitis virus (WHV) contains four hydrophobi

99 Integrations of woodchuck hepatitis virus (WHV) DNA and rearrangements o

100 WH44KA cells contain a single woodchuck hepatitis virus (WHV) DNA integration in the 3

101 We have recently described HBV and woodchuck hepatitis virus (WHV) dominant negative (DN) c

102 Woodchuck hepatitis virus (WHV) efficiently induces hepa

103 of woodchucks chronically infected with the woodchuck hepatitis virus (WHV) elicited differential T-

104 Woodchuck hepatitis virus (WHV) enhancer II (EnII) is lo

105 hucks that were experimentally infected with woodchuck hepatitis virus (WHV) for 4 weeks by intraperi

106 201 to 205 of the pre-S envelope protein of woodchuck hepatitis virus (WHV) form a conserved amino a

107 cil) to woodchucks chronically infected with woodchuck hepatitis virus (WHV) induces a transient decl

108 es of neonatal woodchucks with self-limiting woodchuck hepatitis virus (WHV) infection to those woodc

109 xamined and compared with other markers of a woodchuck hepatitis virus (WHV) infection using rabbit a

110 Liver tissue from woodchucks with chronic woodchuck hepatitis virus (WHV) infection was assayed fo

111 self-limited (resolved) and chronic neonatal woodchuck hepatitis virus (WHV) infection.

112 -mediated immunity (vCMI) following neonatal woodchuck hepatitis virus (WHV) infection.

113 ions of these cytokines during the course of woodchuck hepatitis virus (WHV) infection.

114 ocyte turnover during clearance of transient woodchuck hepatitis virus (WHV) infections.

115 Accordingly, several woodchuck hepatitis virus (WHV) inocula were characteriz

116 Woodchuck hepatitis virus (WHV) is prone to aberrant ass

117 Here, we found that the woodchuck hepatitis virus (WHV) precore/core gene produc

118 Woodchucks (Marmota monax) infected with the woodchuck hepatitis virus (WHV) represent the best anima

119 ks, and then the immunogenicity of an analog woodchuck hepatitis virus (WHV) surface antigen (WHsAg)

120 red by testing the ability of the virions of woodchuck hepatitis virus (WHV) to induce productive acu

121 reared woodchucks chronically infected with woodchuck hepatitis virus (WHV) were treated with N-nony

122 Woodchucks chronically infected with the woodchuck hepatitis virus (WHV) were treated with the an

123 The woodchuck hepatitis virus (WHV) X gene (WHx) is required

124 In this study, we generated a series of woodchuck hepatitis virus (WHV) X mutants, including mut

125 ubcellular distribution and the stability of woodchuck hepatitis virus (WHV) X protein (WHx) in prima

126 Woodchuck hepatitis virus (WHV), a close relative of hum

127 9688 in woodchucks chronically infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely

128 k (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely

129 nfection in an estimated 240 million people; woodchuck hepatitis virus (WHV), an HBV homologue, has b

130 nfected with a closely related hepadnavirus, woodchuck hepatitis virus (WHV), serve as a model for HB

131 Using woodchucks chronically infected with woodchuck hepatitis virus (WHV), we investigated the con

132 We find that the closely related woodchuck hepatitis virus (WHV), which has been shown to

133 cal biopsies of the liver were obtained from woodchuck hepatitis virus (WHV)-infected neonatal woodch

134 er tumors from X/c-myc bitransgenic mice and woodchuck hepatitis virus (WHV)-infected woodchucks.

135 was not demonstrated for HBV or HBV-related woodchuck hepatitis virus (WHV).

136 -transcriptional regulatory element from the woodchuck hepatitis virus (WPRE).

137 chuck ( Marmota monax ) harbors a DNA virus (Woodchuck hepatitis virus [WHV]) that is similar in stru

138 e cultures following in vitro infection with woodchuck hepatitis virus and treatment with inhibitors

139 ed from woodchucks chronically infected with woodchuck hepatitis virus and vaccinated with woodchuck

140 ree woodchucks chronically infected with the woodchuck hepatitis virus before and during 30 weeks of

141 We found that woodchuck hepatitis virus capsid protein undergoes struc

142 recancerous lesions observed in the liver of woodchuck hepatitis virus carrier woodchucks, and these

143 Analysis of several HBV/woodchuck hepatitis virus chimeras corroborated the find

144 ks (Marmota monax) chronically infected with woodchuck hepatitis virus contained at least 100,000 clo

145 replication, and intrahepatic expression of woodchuck hepatitis virus core antigen (WHcAg) in a dose

146 tory acting RNA element (WPRE), derived from woodchuck hepatitis virus in combination with an antibod

147 gulation was similarly observed during acute woodchuck hepatitis virus infection.

148 of hepatocellular carcinoma in woodchucks by woodchuck hepatitis virus is associated with the activat

149 A related element from woodchuck hepatitis virus is known as the woodchuck post

150 ciated virus-mouse phenylalanine hydroxylase-woodchuck hepatitis virus post-transcriptional response

151 th 4 erythroid enhancers with or without the woodchuck hepatitis virus postregulatory element (WPRE)

152 on than its sc counterpart, which lacked the woodchuck hepatitis virus posttranscriptional regulatory

153 The woodchuck hepatitis virus posttranscriptional regulatory

154 in nonhepatoma cells are not able to support woodchuck hepatitis virus replication.

155 oodchuck hepatitis virus and vaccinated with woodchuck hepatitis virus surface antigen could be induc

156 ed when woodchucks chronically infected with woodchuck hepatitis virus were treated with L-FMAU [1-(2

157 Cotranslation of woodchuck p53 with woodchuck hepatitis virus X antigen, followed by immunop

158 Expression of the woodchuck hepatitis virus X gene in alpha ML cells does

159 The expression and localization of the woodchuck hepatitis virus X-antigen (WHxAg) was examined

160 ), two hepadnaviruses (hepatitis B virus and woodchuck hepatitis virus), and an intron-retaining tran

161 that in the livers chronically infected with woodchuck hepatitis virus, (i) hepadnavirus superinfecti

162 h includes human Hepatitis B virus (HBV) and Woodchuck hepatitis virus.

163 cacy in woodchucks chronically infected with woodchuck hepatitis virus.

164 et-like region in the mammalian hepadnavirus woodchuck hepatitis virus.

165 ted with HBV and of woodchucks infected with woodchuck hepatitis virus.

166 woodchuck that was chronically infected with woodchuck hepatitis virus.

167 investigated the function of these genes in woodchuck hepatocarcinogenesis by using a woodchuck live

168 ased expression in 100% of primary human and woodchuck hepatocellular carcinomas surveyed.

169 We have therefore measured cccDNA levels in woodchuck hepatocyte cultures following in vitro infecti

170 4) to 8 X 10(4) molecules of WHx per primary woodchuck hepatocyte.

171 that wHDV infects not only cultured primary woodchuck hepatocytes (PWH) but also primary human hepat

172 ishes a persistent noncytotoxic infection of woodchuck hepatocytes in uPA/RAG-2 chimeric mouse livers

173 we developed a mouse model by transplanting woodchuck hepatocytes into the liver of mice that contai

174 Normal adult woodchuck hepatocytes proliferated and reconstituted up

175 uPA/RAG-2 mice containing woodchuck hepatocytes were infectable with woodchuck hep

176 The woodchuck hepatocytes were transplanted via intrasplenic

177 e cytoplasm but not in the nuclei of primary woodchuck hepatocytes.

178 Cell line WH44KA is a highly malignant woodchuck hepatoma cell line.

179 o maintain the malignant phenotype of WH44KA woodchuck hepatoma cells and provide a direct function f

180 The polypeptide encoded by each gene among woodchucks, humans and mice can differ: the human TNF, L

181 -alpha and LT-beta genes are identical among woodchucks, humans and mice, except that the human LT-be

182 i-gp130 monoclonal antibody, suggesting that woodchuck IL-6 activity is specifically mediated by sign

183 demonstrate biologic activity, we expressed woodchuck IL-6 and showed that the purified recombinant

184 To further understand woodchuck IL-6 biology, we cloned and characterized the

185 Cloning of the woodchuck IL-6 gene and demonstrating biologic activity

186 The woodchuck IL-6 gene encodes a polypeptide of 207 amino a

187 The complete woodchuck IL-6 gene is about 7 kb and consists of five e

188 The inhibitory effect of woodchuck IL-6 on M1 cells was blocked by an anti-gp130

189 ude higher than that in transiently infected woodchucks, implying that integration and other genomic

190 Half the woodchucks in each group then received four injections o

191 Woodchucks infected at birth with woodchuck hepatitis vi

192 Woodchucks infected with a closely related hepadnavirus,

193 panzees chronically infected with HBV and of woodchucks infected with woodchuck hepatitis virus.

194 Woodchuck is an important animal model for studying huma

195 The IL-6 gene organization of the woodchuck is similar to those of the human, rat, and mou

196 The woodchuck is used as an animal model for studying chroni

197 inst WHV replication in chronically infected woodchucks is described.

198 lysis were determined to be identical to the woodchuck isolate.

199 These included replication in woodchuck liver and also in mouse liver and skeletal mus

200 in woodchuck hepatocarcinogenesis by using a woodchuck liver epithelial cell line (WC-3).

201 chain reaction of total RNA from two normal woodchuck livers.

202 a study was undertaken to determine whether woodchucks' livers were infected with a Helicobacter sp.

203 pecifically expressed in the placenta of the woodchuck Marmota monax, at the level of cells fusing in

204 The Eastern woodchuck ( Marmota monax ) harbors a DNA virus (Woodchu

205 The Eastern woodchuck (Marmota monax) is naturally infected with woo

206 irus (WHV) and its natural host, the Eastern woodchuck (Marmota monax), have been established as a mo

207 irus (WHV) and its natural host, the Eastern woodchuck (Marmota monax), have been established as a pr

208 The model we have used is the woodchuck (Marmota monax), which shares similarities in

209 rmota Himalayana hepatovirus (MHHAV) in wild woodchucks (Marmota Himalayana) in China.

210 in hepatocellular carcinoma (HCC) of Eastern woodchucks (Marmota monax) chronically infected with WHV

211 dy suggested that the livers of 2.4-year-old woodchucks (Marmota monax) chronically infected with woo

212 Woodchucks (Marmota monax) have a high incidence of hepa

213 Woodchucks (Marmota monax) infected with the woodchuck h

214 Woodchucks (Marmota monax) that were chronically infecte

215 Chronic HDV infection in woodchucks may result from a delayed and weak immune res

216 Using the newly developed custom woodchuck microarray platform, we compared the intrahepa

217 tome, together with the generation of custom woodchuck microarrays.

218 ata establish the translational value of the woodchuck model and provide new insight into immune path

219 ties, and their therapeutic potential in the woodchuck model for human hepatitis B virus (HBV).

220 The woodchuck model has been important in the preclinical ev

221 HBV-infected hepatocytes and in vivo in the woodchuck model of CHB.

222 (N-nonyl-DNJ), had antiviral activity in the woodchuck model of chronic hepatitis B virus (HBV) infec

223 These studies further define the woodchuck model of HBV infection and should allow for th

224 The woodchuck model of hepatitis B virus (HBV) infection dis

225 The woodchuck model of viral-induced HCC has been used effec

226 her experimental antiviral agents in the WHV/woodchuck model system.

227 ead/superinfection (observed recently in the woodchuck model) are not due to the diminished infectivi

228 Underscoring the translational value of the woodchuck model, this study also determined that WHV-ind

229 With the woodchuck model, we demonstrated that the X-deficient mu

230 studies of human hepatitis B virus using the woodchuck model.

231 humans can be studied experimentally in the woodchuck model.

232 scans of 11C-choline were acquired using the woodchuck models of HCC.

233 the 3' untranslated region of exon 3 of the woodchuck N-myc1 gene.

234 with a retroviral vector overexpressing the woodchuck N-myc2 gene display a higher proliferation rat

235 on role in hepadnavirus-associated tumors in woodchucks or causes enterohepatic disease in cats.

236 with a monoclonal antibody (12.8.5) against woodchuck oval cells, suggesting a lineage relationship

237 Cotranslation of woodchuck p53 with woodchuck hepatitis virus X antigen,

238 om woodchuck hepatitis virus is known as the woodchuck posttranscriptional regulatory element (WPRE).

239 uck hepatitis virus (WHV) infection to those woodchucks progressing to persistent WHV infection.

240 onic woodchuck hepatitis virus (WHV) carrier woodchucks received daily doses of FIAU by intraperitone

241 WHV-infected woodchucks received eight weekly oral doses of vehicle,

242 consequences of prolonged virus suppression, woodchucks received ETV orally for 8 weeks and then week

243 All woodchucks receiving this inoculum became positive for H

244 on for 12 weeks using cyclosporine A in such woodchucks resulted in transient reactivation of WHV rep

245 in HBV-infected chimpanzees and WHV-infected woodchucks revealed multiple distinct phases of viral de

246 Testing of the mutants in susceptible woodchucks revealed that, as expected, viruses with lesi

247 Seven age-matched uninfected woodchucks served as controls.

248 umans treated with FIAU, suggesting that the woodchuck should be valuable in future investigations of

249 g in uninfected and WHV chronically infected woodchucks showed a significant increase of intrahepatic

250 (HDV) RNAs in the livers of two HDV-infected woodchucks showed that 96% of the antigenomic RNA but on

251 and genomic DNA libraries were screened with woodchuck-specific DNA probes to isolate the cDNA and ge

252 th 3 mg/kg GS-9688 was confirmed in a second woodchuck study.

253 estimated death rate of hepatocytes in these woodchucks, suggesting that death of infected cells was

254 decreased hepatitis B virus (HBV) cccDNA and woodchuck surface antigen.

255 Serum of 1 woodchuck that became positive for WHV DNA during immuno

256 HDV cDNA clone directly into the liver of a woodchuck that was chronically infected with woodchuck h

257 Almost all woodchucks that become chronic WHV carriers after experi

258 e same time point postinfection, livers from woodchucks that eventually progressed to chronic infecti

259 re related, because they were collected from woodchucks that originally were infected with standardiz

260 G with its lipid prodrug in vivo, we treated woodchucks that were experimentally infected with woodch

261 sustained antiviral response in WHV-infected woodchucks; the identification of a baseline intrahepati

262 In the woodchuck, there are four exons for TNF, four exons for

263 in clinical anti-HBV studies in WHV-infected woodchucks, thereby making interpretations of the potent

264 The bacterially expressed woodchuck TNF and LT-alpha proteins exhibited cytotoxic

265 The woodchuck TNF gene promoter contains consensus sequences

266 However, only woodchuck TNF showed cytotoxic activity on human HepG2 c

267 The cDNAs for woodchuck TNF, LT-alpha and LT-beta code for proteins of

268 cell response profile of chronic WHV carrier woodchucks to that seen in prophylactic vaccination and

269 sequencing, assembly, and annotation of the woodchuck transcriptome, together with the generation of

270 and, after 8 weeks, the mean body weights of woodchucks treated with FIAU were significantly lower th

271 igen load, but was significantly enhanced in woodchucks treated with L-FMAU and was broadened to incl

272 We cloned and characterized the woodchuck tumor necrosis factor (TNF) and lymphotoxin-al

273 f hepatocyte turnover in the livers of three woodchucks undergoing clearance of a transient woodchuck

274 erimentally, HDV can be made to replicate in woodchucks, using woodchuck hepatitis B virus as a helpe

275 Furthermore, chronic WHV infection in woodchucks usually leads to development of hepatocellula

276 Comparison of precancerous lesions in donor woodchucks versus recipient uPA/RAG-2 mice revealed an e

277 cy of integrated DNA in chronically infected woodchucks was found to be 1 or 2 orders of magnitude hi

278 The syndrome of delayed toxicity in woodchucks was similar to that observed previously in hu

279 ection and hepatocellular carcinoma (HCC) in woodchucks, we surveyed livers and HCCs from a panel of

280 Livers from uninfected and WHV-infected woodchucks were examined to determine if pgp was express

281 t, groups of nine WHV carriers or uninfected woodchucks were given 1.5 mg/kg/d of FIAU orally for 12

282 Neonatal woodchucks were infected experimentally with the woodchu

283 Neonatal woodchucks were more susceptible to chronic infection by

284 Virus titers in all four woodchucks were only transiently suppressed, suggesting

285 Six weeks after the superinfection, the woodchucks were sacrificed and tissues of the livers and

286 One week after surgery the WHV carrier woodchucks were superinfected with WHV-enveloped HDV (wH

287 Based on these results, woodchucks were treated with IL-12 in combination with a

288 Eight infected woodchucks were treated with lamivudine and four were in

289 Woodchucks were used to study the antiviral activity and

290 hepadnavirus core proteins derived from the woodchuck (WHcAg), ground squirrel (GScAg), and arctic s

291 Three woodchucks, which were chronically infected with the str

292 th declined about two- to threefold in those woodchucks, while mRNA levels for gamma interferon and t

293 Clonal amplification of hepatocytes from a woodchuck with hepatocellular carcinomas was demonstrate

294 growth advantage in hepatocarcinogenesis of woodchucks with chronic WHV infection.

295 Liver tissue from woodchucks with chronic woodchuck hepatitis virus (WHV)

296 CDI was performed in vivo in five woodchucks with natural hepatomas and in 12 rabbits befo

297 Thus, the EP-based vaccination of normal woodchucks with pDNA-WHsAg induced a skew in the Th1/Th2

298 n (WHx) in primary hepatocytes isolated from woodchucks with persistent WHV infection.

299 hepatic transcriptional profiles of neonatal woodchucks with self-limiting woodchuck hepatitis virus

300 ed these questions by asking if treatment of woodchucks with the nucleoside analog inhibitor of viral

301 re alpha-1,6-linked fucose, as compared with woodchucks without a diagnosis of HCC.