ライフサイエンスコーパス: worm

1 Caenorhabditis elegans became known as 'the worm'.

2 hole-Organ Magnetic Resonance Imaging Score (WORMS).

3 al development following pairing with a male worm.

4 red close proximity between bacteria and the worm.

5 al microtubules (PLMs)] on both sides of the worm.

6 th at the cellular level and inside the live worm.

7 artmentalized metabolic model of a parasitic worm.

8 laboratory animals, such as mouse, rat, and worm.

9 philus gyrociliatus, a meiobenthic segmented worm.

10 esent in many filariae-which is vital to the worm.

11 logical functions of these pheromones in the worm.

12 nd perturb chemotaxis phenotypes in filarial worms.

13 cts and increased pathogen susceptibility in worms.

14 between UNC-104 and SYD-2 in ptp-3 knockout worms.

15 intracellular environment in live C. elegans worms.

16 s nearly 90% lower in pigs that had expelled worms.

17 observed in m-tyrosine-treated tatn-1 mutant worms.

18 undred proteins in various organs within the worms.

19 awling speeds, and taxis towards neighboring worms.

20 DNA-binding protein of 43 kDa overexpressing worms.

21 lity impairment in D76N beta(2)-m expressing worms.

22 te, thorough, but temporary paralysis of the worms.

23 activation were hypertoxic in zip-3-deletion worms.

24 to flight due to damage caused by developing worms.

25 enerate within about a week, forming two new worms.

26 stigating the therapeutic potential of these worms.

27 l long-lived mutants, including daf-2 mutant worms.

28 antly reducing the burden of VRE in infected worms.

29 or blisters and burrows caused by polychaete worms.

30 n unc-64/syntaxin by generating knockin (KI) worms.

31 e against the microfilarial progeny of adult worms.

32 ified feeding using aggregating npr-1 mutant worms.

33 mechanical strain in Caenorhabditis elegans worms.

34 ies-level molecular identification for these worms.

35 models of autism and aggregation behavior in worms.

36 can form well-defined spheres (4 degrees C), worms (22 degrees C) or vesicles (50 degrees C) in aqueo

37 eavage and polyadenylation in C. elegans The worm 3' UTRome v2 represents the most comprehensive and

38 to the community the updated version of the worm 3' UTRome, which we named 3' UTRome v2.

39 This makes these worms a powerful model system for understanding the mole

40 Proportions of dead worms also did not differ between the 4 groups (P = .919

41 Proportions of dead worms also did not differ between the 4 groups (p=0.9198

42 Field worms also displayed elevated concentrations of n:3 acid

43 to 98% and 99% decreases in mean intestinal worm and egg burdens in immunized mice, respectively.

44 our additional model organisms - mouse, fly, worm and yeast - and identified 54 novel EMF proteins in

45 Enrichr for four model organisms: fish, fly, worm and yeast.

46 egenerative abilities and the parasitic tape worms and blood flukes that exert a massive impact on hu

47 (TOP2) physically interact in both mice and worms and colocalize on condensed chromosomes during mit

48 o map differences in gene expression in live worms and discovered that mutations in the co-chaperone

49 e loss of bioluminescence using N2 reference worms and eat-2 mutants, and found a nearly 100-fold inc

50 chemosensory signaling proteins in filarial worms and encourage a more thorough investigation of cla

51 dministration extends the lifespan of yeast, worms and flies, decelerates senescence of human cell cu

52 ecular mechanisms of neurite regeneration in worms and flies.

53 lifespan in yeast and organismal lifespan in worms and flies.

54 f phenotypic conservation between dystrophic worms and humans provides a unique opportunity to gain i

55 to induce pathogen avoidance in the treated worms and in four subsequent generations of progeny.

56 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory.

57 ht to be intermediate between cycloneuralian worms and lobopodians.

58 evealed that alphaKG extends the lifespan of worms and maintains the pluripotency of embryonic stem c

59 Ca(2+) influx and spastic paralysis of adult worms and rapid vacuolization of the worm surface.

60 markedly impaired survival in starved larval worms and recovery upon refeeding bacteria.

61 stinal Th2 responses against Trichuris muris worms and Schistosoma mansoni eggs do not develop in mic

62 ehensive set of regions in the human, mouse, worm, and fly genomes that have anomalous, unstructured,

63 ction tracks for human, mouse, chicken, fly, worm, and mosquito.

64 emonstrate that physical contact with a male worm, and not insemination, is sufficient to induce fema

65 300,000 samples from human, mouse, rat, fly, worm, and yeast-collected in this study.

66 calcium increased in the Antimycin A-treated worms, and its down-regulation rescued the muscle damage

67 cuolar proton pump subunits in hlh-30 mutant worms, and knockdown of vacuolar H+-ATPase 12 (vha-12) a

68 n all eukaryotes we tested, including fungi, worms, and mammals.

69 nvironmental allergens, infectious parasitic worms, and microbes.

70 and variably with schistosome cercarial and worm antigens.

71 AXS studies indicate that, on average, three worms are formed per vesicle.

72 These slender aquatic worms are observed to perform elongation-contraction and

73 Chaetognaths (arrow worms) are an enigmatic group of marine animals whose ph

74 Last, we could reverse this 'worm arrhythmia' by the benzothiazepine S107, establishi

75 of chemosensation in the migration of larval worms, arthropod and mammalian infectious stage Brugia p

76 oles and challenging them with parasitic gut worms as adults.

77 DA was superior to IA for inactivating adult worms at all time points.

78 DA was superior to IA for inactivating adult worms at all time points. Both treatments were well tole

79 arly, during large population swarming, only worms at the migrating front are in contact with bacteri

80 tis elegans, RNAi can be achieved by feeding worms bacteria carrying a plasmid expressing double-stra

81 s, which are secreted by mussels, sandcastle worms, barnacles, and caddisfly larvae, exhibit robust u

82 curate predictions about the dynamics of the worm behavior, and it can be used to characterize the fu

83 cantly associated with increase in cartilage WORMS (beta = 0.2; 95% CI: 0.02, 0.4; P = .007).

84 We find that many worm-bioactive small molecules (a.k.a. wactives) accumul

85 sea urchins and burrowing fauna (polychaete worms, bivalve mollusks) increased from N to S with decl

86 Conversely, worm burden was higher in Nmur1(-/-) mice than in contro

87 These worms burrow into bivalve shells, creating unsightly mud

88 sis nor learning disabilities induced in the worm, but is beneficial at low amplitudes to ensuring ho

89 discover that parasitic worms, but not commensal protists, stimulate tuft cells

90 repressing other cell fates in the nematode worm C. elegans.

91 The nematode worm Caenorhabditis elegans (C. elegans) is a versatile

92 hat multiple small RNA-seq datasets from the worm Caenorhabditis elegans had shorter forms of miRNAs

93 The model agrees with experiments in the worm Caenorhabditis elegans that show the following: Lif

94 as become well established that the nematode worm Caenorhabditis elegans triggers innate immune respo

95 (Arabidopsis thaliana), rice (Oryza sativa), worm (Caenorhabditis elegans), and human (Homo sapiens)

96 Genomic studies of filarial worms can improve our understanding of their biology and

97 A worm carrying a TRPV1 construct lacking the distal C-ter

98 nsic functional Notch signaling had impaired worm clearance, decreased intestinal type 2 inflammation

99 observed to boost the burrowing speed of the worm compared to swimming in water with the same stroke

100 C1 signaling and extends the lifespan of the worms, confirming an evolutionarily conserved and unexpe

101 s in nematode life cycles, and that filarial worms contain compact and highly diverged chemoreceptor

102 iation between urinary 2-MPC levels and both worm counts (p = 0.023) and the number of eggs per gram

103 were prepared from ~400 mum thick S. mansoni worm couples, comparing several microembedding approache

104 a was able to block Orsay virus infection in worm culture and vice versa, suggesting these two viruse

105 er of these kinases results in paralysis and worm death in a mammalian host.

106 Worms deficient in lysosomal lipase 2 (lipl-2), a lysoso

107 Worms deficient in tyrosine aminotransferase activity di

108 s sufficient to rescue starved hlh-30 mutant worms, demonstrating a critical need for TOR activation

109 In favorable conditions, worms develop rapidly and continuously through four larv

110 RNA-Seq analysis of F01D4.5 mutant worms disclosed a significant reduction in the expressio

111 us medinensis, the causative agent of Guinea worm disease in humans, is being reported with increasin

112 Here, we report that dys-1 worms display early pathogenesis, including dysregulated

113 d undergoes vertical transmission to progeny worms during serial passage in lab colonies.

114 he lumen of the small intestine, where adult worms dwell.

115 rograms are solely based on the detection of worm eggs in stool.

116 thin intestinal epithelial cells, with adult worms embedded in a partially intracellular niche in the

117 unfavorable through the second larval stage, worms enter dauer diapause, a state of global and revers

118 The global Guinea Worm Eradication Program (GWEP) has successfully reduced

119 ed at which a cell fate decision in nematode worms evolves is due to the number of genes that control

120 pain sensations in mammals, transgenic TRPV1 worms exhibit an aversive response to capsaicin.

121 protective function of TATN-1, tatn-1 mutant worms exhibited delayed development, marked reduction in

122 and cytokine production, leading to delayed worm expulsion during infection with the gastrointestina

123 was sufficient to restore IgE production and worm expulsion in inulin-fed mice.

124 Despite this, inulin prevented worm expulsion in normally resistant mice, instead resul

125 Without CGRP signaling, ILC2 responses and worm expulsion were enhanced.

126 ng and accelerates aging of long-lived daf-2 worms fed a high glucose diet.

127 n Anisakis spp. abundance (average number of worms/fish) over a 53 year period from 1962 to 2015 and

128 Based on data from worms, flies, and mice, we propose that the turnover of

129 ae behavior and enhanced the number of adult worms following murine infection.

130 e in reducing the Wolbachia load in filarial worms following oral administration to mice.

131 n laboratory model organisms - such as acoel worms, frogs, fish and mice - have revealed that chromat

132 metabolic measurements of single C. elegans worms from larval to adult stages.

133 we describe a new fossil polychaete (bristle worm) from the early Cambrian Canglangpu formation(7) th

134 umulated in earthworms [BSAF ~ 2.5-5.4 (g(dw,worm)/g(dw,soil))(-1)] but to a lesser extent than perfl

135 synthetic communities of previously-isolated worm gut commensals.

136 norhabditis elegans defined a characteristic worm gut microbiota significantly influenced by host gen

137 Enterobacter commensals are common in the worm gut, contributing to infection resistance.

138 s delta to survive harsh environments in the worm gut, could be applicable to bioengineering applicat

139 Dracunculus medinensis, or human Guinea worm (GW), causes a painful and debilitating infection.

140 in the requirement for H3K9me3 and the main worm H3K9me3 methyltransferases, SET-25 and SET-32.

141 54 (22.7%), and 20/125 (16.0%) living female worms had normal embryogenesis in the IVM annual, IVM se

142 154 (22.7%) and 20/125 (16.0%) living female worms had normal embryogenesis in the IVM annual, IVM se

143 au transgenic animals at greater levels than worms harboring either the Abeta1-42 or tau transgene al

144 Research on these worms has been constrained by a lack of genetic and geno

145 affold attachment factor B. phm-2(lf) mutant worms have an abnormal pharynx grinder, which allows liv

146 Branchiobdellidan worms have previously been shown to have positive effect

147 etween days 6 and 12 of adulthood, after the worms have reproduced, as individual proteins lose their

148 Although aquatic annelid worms have some of the fastest escape responses in natur

149 pparent cure of infection, though effects on worm health or behavior were not observed.

150 Experiments on mitochondrial DNA in worms highlight that cheating does not always pay off.

151 ration, we sequenced the genome of the acoel worm Hofstenia miamia, a highly regenerative member of t

152 This study shows that mutations of HRPU-2, a worm homolog of mammalian hnRNP U, result in dysfunction

153 regulated by cell-autonomous function of the worm homologs of a NMDAR subunit and CaMKII.

154 The new device, named "worm hospital" allows us to perform the entire nerve reg

155 euronal activity of a Caenorhabditis elegans worm in 3D using a time sequence of fluorescence images

156 ns of the protein myohemerythrin from peanut worm in aqueous ammonium acetate solutions from ~15 to 9

157 rgic disease [2.12 (1.48-3.02)]; frequent de-worming in the last 12 months [2.01 (1.30-3.11), >=2 ver

158 These animals do not differ from wild-type worms in histology, expression of key polarity genes, or

159 o Kenya Imarisha Afya (Swahili for Eradicate Worms in Kenya for Better Health [TUMIKIA]) trial, done

160 the proportion of fertile and viable female worms in onchocercomata excised at 36 months.

161 We demonstrate that adult Loa loa worms in subcutaneous tissues, circulating microfilariae

162 on to impede blood clot formation around the worms in vivo.

163 isters to Arthropoda and Onychophora (velvet worms) in the superphylum Panarthropoda by morphological

164 eters were optimized for labeling within the worms including the microfluidic flow system and hydroge

165 to suppress the phenotypes of paqr-2 mutant worms, including their characteristic membrane fluidity

166 induction collapsed in 8 days old transgenic worms, indicating the age dependency of disease outbreak

167 o helminth infection is critical in limiting worm-induced tissue damage and expelling parasites.

168 Schistosome worms infect over 200 million people worldwide.

169 the faecal microbiota of animals with heavy worm infection burdens was characterised by lower microb

170 ntify that control of chronic adult filarial worm infection is evident in IL-4Ralpha-deficient (IL-4R

171 oximal colon of pigs with a persistent adult worm infection that was nearly 90% lower in pigs that ha

172 o further clarify the epidemiology of guinea worm infections in dogs.

173 ich underpins allergic disease and parasitic worm infections, than macrophages from lung tissue or th

174 ymmetry between the AWC neurons can make the worm irrational.

175 larization of a sleep-active neuron when the worm is sleepy.

176 nization suggests that heterogeneity between worms is driven by the low rate at which bacteria succes

177 that overexpression of dcap-1 in neurons of worms is sufficient to increase lifespan through the fun

178 Inspired by the polychaete worm jaw, we report a novel approach to generate stiffne

179 and eosinophilia, correlating with enhanced worm killing but at the expense of increased tissue dama

180 In this study, we subjected worms lacking basic helix-loop-helix transcription facto

181 l-2 mutants have herniated intestines, while worms lacking its sole paralog (affl-1) appear wild type

182 Strikingly, worms lacking zip-3 were impervious to Pseudomonas aerug

183 ging caused by a null mutation in the single worm lamin homolog.

184 me parasites in chemical detail at the whole-worm level by MSI.

185 Here, worm-like "filomicelles" that self-assemble in water fro

186 ed that the N21F variant self-assembles into worm-like aggregates, causing loss of lipid membrane str

187 At pH 3.5, the amyloid aggregates were worm-like and consisted of intact protein.

188 Facivermis yunnanicus [1, 2] is an enigmatic worm-like animal from the early Cambrian Chengjiang Biot

189 iest stem-group arthropods were lobopodians, worm-like animals with annulated appendages.

190 nal ensembles: an extended regime exhibiting worm-like chain behavior, and a compact ensemble, which

191 Here, we use a discrete worm-like chain model and Brownian dynamics to simulate

192 ori, including approximating topology with a worm-like chain model applicable to a variety of structu

193 n together, the simulations suggest that the worm-like chain model can account semiquantitatively for

194 e applied molecular dynamics (MD), hybrid MD/worm-like chain polymer modeling, and live cell imaging

195 On a global scale, the CWPE appear in a worm-like conformation independently on the synthesis co

196 cles that undergo a morphology transition to worm-like micelles upon enzyme-triggered cleavage of cor

197 th "precursor" particles that transform into worm-like micelles, which extend and coalesce to form th

198 he first evidence that a transition state to worm-like topologies is actually experimentally accessib

199 ctural assignment of these intermediates via worm-like-chain analysis is hindered by brief dwell time

200 on caused by Thelazia gulosa (the cattle eye worm), likely acquired in California.

201 These worms live in aquatic environments, where they are likel

202 Worms live within a specialised tunnel of host intestina

203 f bioturbation by the freshwater oligochaete worm Lumbriculus variegatus, and find good quantitative

204 monstrate that the escape circuit of the mud worm, Lumbriculus variegatus, is a segmentally arranged

205 using arachidonic acid as the substrate and worm lysate as source of enzyme(s).

206 associated toxicity in vivo in a C. elegans worm model expressing Abeta42.

207 This novel worm model is ideal for screening molecules and genes to

208 Worm morphologies are encoded with mathematical graphs b

209 easing need to replace manual assessments of worm motility with automated measurements to increase th

210 the recently discovered non-luminescent cave worm Neoditomiya sp as the main source of luciferin and

211 t 6, 12 and 24 months, inactivation of adult worm nests, and safety.

212 6, 12, and 24 months; inactivation of adult worm nests; and safety.

213 e live infection with gastrointestinal-based worms nor is protection restricted to mucosal diseases.

214 of nonfermentable fiber (cellulose) expelled worms normally.

215 IVM alone for sterilizing, killing of adult worms or achieving sustained MF clearance.

216 the activity of Pol III in the gut of adult worms or flies is sufficient to extend lifespan; in flie

217 block copolymer nano-objects (e.g., spheres, worms or vesicles) in various media.

218 f sterically-stabilized PGMA-PMOEMA spheres, worms or vesicles, depending on the precise reaction con

219 ltiple morphologies (spherical, cylindrical, worm, or vesicular) in equilibrium with each other.

220 han IVM alone for sterilizing, killing adult worms, or achieving sustained MF clearance.

221 In wild-type worms, overexpression of spr-4 suppresses excitation and

222 th larval schistosomes (viability) and adult worms (pairing, egg laying) in culture without general t

223 Sarcoplasmic calcium dysregulation in dys-1 worms precedes overt structural phenotypes (e.g., mitoch

224 aenorhabditis elegans, defining 612 putative worm protein complexes linked to diverse biological proc

225 owever, most methods of measuring feeding in worms quantify either foraging behavior or food intake,

226 ed the behavioral deficits of tau transgenic worms, reduced phosphorylated and detergent-insoluble ta

227 asis, infection with Schistosoma haematobium worms, remains poorly understood due to a historical lac

228 tion factors FOXO1 and DAF-16 in mammals and worms, respectively.

229 aversive mechanical or blue light stimulus, worms respond first by briefly moving, and then become m

230 We also show that Tubifex worms retain microplastics for longer than they retain o

231 ering major cell lineages and tissues in the worm, reveal the complex and dynamic changes in gene exp

232 nction proteins in the nervous system of the worm reveals a great complexity of their distribution am

233 A map of a neuronal circuit in a marine worm reveals how simple networks of neurons can control

234 model captures mechanical properties of the worm's body and accurately reproduces neural responses t

235 me, and it is predominantly localized in the worm's intestinal tissue.

236 red neural dynamics by mapping them onto the worm's low-dimensional postures, i.e. eigenworm modes.

237 metabolic and developmental demands with the worm's monthly cycle.

238 Through the contraction of the worm's pharynx, a bacterial suspension is sucked into th

239 H69 cleavage leads to the activation of the worm's zip-2-mediated defense response pathway, consiste

240 ect on the structure and organization of the worm sarcomeres, indicating a crucial role of R805 in UC

241 NeuroPAL worms share a stereotypical multicolor fluorescence map

242 C complex I (NDUFS2-/-) disease invertebrate worms significantly improved mitochondrial membrane pote

243 Infection with filarial worms significantly reduced flight distance but increase

244 ation that is distributed in accordance with worm size and modulates fission behaviour.

245 ted SMADs, which are homologous to the small worms (SMA) and Drosophilia mothers against decapentaple

246 Both 'silencing' siRNAs bound by Worm-specific Argonautes (WAGO) and 'activating' siRNAs

247 coactivate the oestrogen receptor/ER and the worm steroid receptor DAF-12.

248 of XBP-1s in the neurons or intestine of the worm strikingly improves proteostasis in multiple tissue

249 We also find that behavioral trajectories of worms subject to oxidative stress resemble trajectories

250 Worms subjected to RNAi against M01F1.3 and ZC410.7 mani

251 w that it binds to life-extending ligands in worms such as oleic acid and oleoylethanolamide with hig

252 Infections with intestinal worms, such as Ascaris lumbricoides, affect hundreds of

253 f adult worms and rapid vacuolization of the worm surface.

254 Image acquisition for 80 worms takes 3-4 d, while the entire data analysis requir

255 e role of chemosensory signaling in filarial worm taxis, we employ comparative genomics, transcriptom

256 diversity as tadpoles have three times more worms than adults without their microbiota manipulated a

257 efits of WF-NTP relate to the high number of worms that can be assessed at the same time on a whole-p

258 tion is the last step in RQ biosynthesis, in worms the pathway begins with the arylamine precursor AA

259 In our conditions, for isogenic wild-type worms, the health decline of the individuals was scaled

260 developmental aberrations, and in flies and worms, their loss-of-function is fatal.

261 In worms, this reporter enables whole-brain imaging with fa

262 The invasion and migration of filarial worms through host tissues are complex and critical to s

263 and brain) but were also scattered in other worm tissues as well.

264 holipids occurred differentially abundant in worm tissues of the female, such as the gut, which is es

265 show how metabolic pathway usage allows the worm to adapt to different environments, and predict a s

266 tosomes rely on continuous pairing with male worms to fuel the maturation of their reproductive organ

267 action among E3s is a conserved feature from worms to humans.

268 significant effect by SAW on the ability of worms to learn post-exposure through associative learnin

269 Although this Cys is conserved from worms to mammals, a two amino acid deletion in the verte

270 h reduced lifespan in organisms ranging from worms to mammals.

271 ravel a neural circuit mechanism that allows worms to select and switch between these search modes de

272 ange in fluids from a standard media for the worms to the exceedingly viscous polyvinyl alcohol.

273 he importance of homogeneous exposure of the worms to the SAW-driven ultrasound, an aspect poorly con

274 diblock copolymer morphology from spheres to worms to vesicles are observed.

275 sing this dnc-1 KD model together with Multi-Worm Tracker (MWT), and tested whether 38 candidate neur

276 We compare the WF-NTP with other existing worm trackers, including those having high spatial resol

277 Using fluorescence multi-worm tracking, we quantify aggregation in terms of indiv

278 informatic tools for the analysis of complex worm transcriptomes to extract maximum the molecular inf

279 d to survey the microbial environment of the worm, use this information to make appropriate behaviour

280 prediction, protein aggregation in yeast and worms was observed to increase when translation was glob

281 ter-based health-education tool 'The Vicious Worm' was developed to create awareness and provide evid

282 ue triggers an import stress response in the worm, which indicates a conserved role in metazoa.

283 y levels against a highly prevalent nematode worm, which was associated with reduced adult survival p

284 tered by interactions with Branchiobdellidan worms, which are obligate ectosymbionts.

285 ghly variable morphologies such as planarian worms, which due to their extraordinary regenerative cap

286 h problem caused by blood-dwelling parasitic worms, which is currently tackled primarily by mass admi

287 ance of small RNAs and for heritable RNAi in worms, which typically persist for a finite number of ge

288 ey of its genome-wide diversity using single-worm whole genome sequencing of 223 individuals sampled

289 tends lifespan, promotes fat accumulation in worms with a specific enrichment of mono-unsaturated fat

290 Worms with increased levels of the epigenetic mark H3K9m

291 TRPV1 worms with low levels of phosphoinositide lipids display

292 les the simultaneous analysis of hundreds of worms with respect to multiple behavioral parameters.

293 enigmatic chaetognaths, also known as 'arrow worms', within a subgroup of lophotrochozoans, the gnath

294 coustic wave (SAW) irradiation of C. elegans worms-without cavitation-as a potential, ethically reaso

295 ility to perform structural studies in these worms would provide insight into the role of structure i

296 Xenoturbella and the acoelomorph worms (Xenacoelomorpha) are simple marine animals with c

297 in vivo studies of desiccation tolerance in worms, yeast, and tardigrades.

298 ve modifier of SMA across species, including worm, zebrafish, and mice.

299 thological defects across species, including worm, zebrafish, and mouse.

300 rved regulator of genome stability in flies, worms, zebrafish, and human germ cell tumors.