ライフサイエンスコーパス: worsen

1 more likely to stay the same or improve than worsen.

2 on and spread, and its impacts are likely to worsen.

3 trengthen as the severity of angle narrowing worsens.

4 antibiotics, her clinical symptoms and signs worsened.

5 er expert clinical management, some glaucoma worsened.

6 th day of admission, the patient's condition worsened.

7 , 8132 (64%) as no change, and 1387 (11%) as worsened.

8 ars and 10 months of age, and they gradually worsened.

9 mic index did not improve and trended toward worsening.

10 vents and neither cognitive nor neurological worsening.

11 Ktide in adipocytes completely prevented the worsening.

12 r greater pVO(2) increase without NYHA class worsening.

13 ssifier to depict morphologic and functional worsening.

14 persisted until old age (23 months), without worsening.

15 who are at risk for and/or develop clinical worsening.

16 he new onset (de novo heart failure (HF)) or worsening (acutely decompensated heart failure (ADHF)) o

17 nversion, all P<0.05) and predicted clinical worsening after 1 year (Fabry stabilization index >20%,

18 ting xerostomia after (177)Lu-PSMA showed no worsening after TAT.

19 (SDs) and seizures, known agents of clinical worsening after TBI.

20 d bilirubin interfered with creatinine, with worsening agreement in creatinine at high bilirubin leve

21 lymphocytes were more common as the disease worsened (All P < 0.05).

22 t of fibrosis, with colchicine significantly worsening an ischemic phenotype.

23 tly occurring outside clinics-where symptoms worsen and plasma C-reactive protein (CRP) becomes eleva

24 -type littermates at birth, but they rapidly worsened and died by postnatal day 9.

25 Caffeine worsened and L-theanine had a trend of worsening inhibit

26 alizumab administration, the asthma symptoms worsened and peripheral blood eosinophil count increased

27 he secondary efficacy outcomes were clinical worsening and discontinuation of supplemental oxygen amo

28 -year cumulative probabilities of disability worsening and improvement were 27.8% and 33.1%, respecti

29 escribed; however, her symptoms continued to worsen, and she began to have dyspnea when she was at re

30 The patient worsened, and diagnosis of a diffuse crystal storing his

31 Treatments can address one symptom but worsen another, which makes disease management difficult

32 This dysphoria may worsen as puberty progresses.

33 of the type of ventilatory defect, survival worsened as the best FVC (% predicted) got lower (>80: 8

34 sulted in hyperopic refractive outcomes that worsened as the corneal power increased.

35 The degradative SMC phenotype also worsens atherosclerotic disease and could thus be consid

36 Whilst high salt diets have been shown to worsen autoimmune disease, the immunological consequence

37 icity for outcomes of asthma improvement and worsening but poor sensitivity.

38 ic traces its roots back many decades and is worsened by a number of ill-conceived strategies and pol

39 a public health threat of global dimension, worsened by increasing drug resistance.

40 ings provide one explanation for how obesity worsens cancer outcomes and may point to a new metabolic

41 s, small molecule CGRP receptor antagonists, worsen cerebral ischemia.

42 Possible side effects include worsening cerebrospinal fluid leaks.

43 ed on prior HF history (i.e., de novo HF vs. worsening chronic HF) and treatment with an ACE inhibito

44 with de novo HF and 576 (66%) patients with worsening chronic HF.

45 (-/-) and S100a9(-/-) psoriatic mice exhibit worsened clinical symptoms relative to wild-type mice an

46 ral nervous system disease and progressively worsening clinical course.

47 e-negative endophthalmitis eyes was based on worsening clinical examination results (2 eyes) and decl

48 eyes was based on declining vision (3 eyes), worsening clinical examination results (2 eyes), and ret

49 ads to vascular damage, immunopathology, and worsening clinical outcomes.

50 at enhance Th17 cells act synergistically to worsen CNS autoimmunity.

51 ether concussion in sport is associated with worsening cognitive function in later life will likely h

52 ts and is neither significantly improved nor worsened compared with isogenic L. monocytogenes-primed

53 h the lens was found in 2 of 6 patients with worsening compared to 1 of 40 (3%) without worsening (P

54 In both cases, neurological worsening continued post-HSCT; however, the progression

55 nza season to identify illnesses with new or worsened cough, runny nose, sore throat, difficulty brea

56 ciated with a decreased risk of new onset or worsening diabetes (OR 0.59; 95% CI 0.39, 0.90; p = 0.01

57 ted factor 2 (Nrf2) may either ameliorate or worsen diabetic cardiomyopathy.

58 ent admission, she developed abdominal pain, worsening diarrhea and was diagnosed with CD exacerbatio

59 en these maps and individual trajectories of worsening disability in patients with multiple sclerosis

60 ents with MS (n = 37), whose trajectories of worsening disability over the 2 y preceding study entry

61 d the rate of change in brain-PAD related to worsening disability.

62 se reports have indicated that pregnancy can worsen disease activity and might contribute to disease

63 n of IFN-alpha/beta signaling in neurons can worsen disease course and disrupt complex interactions b

64 contrast to control antibodies, resulted in worsened disease and increased neurodegeneration.

65 Studies were used to assign probabilities of worsening disease among treated patients.

66 an cause tubule-interstitial damage, further worsening disease progression.

67 In CSF, worsening disease was associated with nominally signific

68 as defined as new or reappearing symptoms or worsening disease, with a Birmingham Vasculitis Activity

69 f retinal arteriolar diameter increased with worsening DR severity (mild NPDR: 10% vs PDR: 31%, P = 0

70 is associated with increasing nonperfusion, worsening DR severity and presence of PPL.

71 New onset or worsening drug-induced liver injury challenges coinfecte

72 ession of the atrioventricular groove, which worsened during stress and were related to malformation

73 rts depress intranodal SAN conduction, which worsens during autonomic stimulation and overdrive suppr

74 low biomass and viability and significantly worsened dysbiosis in the periodontitis-derived microbio

75 All 10 patients presented with worsening dyspnea and pleural effusions.

76 Participants whose glaucoma worsened each year accumulate -0.8 dB loss compared with

77 Indeed, we find debris removal sometimes worsens economic damages from congestion by increasing l

78 atients (51%) developed LEE (new onset, 120; worsened edema, 50).

79 sented with a 2-day history of progressively worsening edema of her face and lower extremities.

80 With worsening epidemiological trends for both the incidence

81 d their key regulator Ppargc1a Overnutrition worsened excitotoxicity-induced mitochondrial dysfunctio

82 oxygen delivery to the femoral circulation, worsening fetal acidosis.

83 g growth factor-beta 1 (TGFbeta1) expression worsens fibroproliferation following bleomycin-induced l

84 erves to sustain inflammasome activation and worsen fibrotic reactions.

85 enotypes in other tissues that significantly worsen following combined deletion of Gas1 and Boc Toget

86 Climate change is expected to worsen food insecurity and increase potential threats to

87 outcomes were negative, with non-significant worsening for both active groups vs. placebo in the P50

88 with lower odds of recovery, and persistent worsening frailty is an important adverse outcome of acu

89 minal pain and diarrhea for 2 years that had worsened from 2 months prior to admission.

90 We compared the rates of improved and worsened GERD symptoms after SG and RYGB.

91 The precise prevalence of new-onset or worsening GERD after SG is controversial.

92 Development of new-onset or worsening GERD symptoms following bariatric surgery vari

93 lthough SG patients reported higher rates of worsening GERD symptoms when compared to RYGB, the major

94 teral brain displacement was associated with worsening global cerebral autoregulation (p = 0.01 septu

95 ateral brain displacement is associated with worsening global cerebral autoregulation and cerebral au

96 Soil degradation is a worsening global phenomenon driven by socio-economic pre

97 Gpr27 knockout mice exhibited slightly worsened glucose tolerance with lower plasma insulin lev

98 intestinal microbiome-dependent metabolite, worsens graft-versus-host disease (GVHD).

99 Preoperative apical scarring led to worsening haze (P = .0001), more astigmatism (P = .002),

100 nfection but also signals increased risk for worsening health, for mortality, and for increased use o

101 rom audiometric and clinical evaluation by a worsened hearing threshold compared with baseline during

102 0.18), 8 versus 2 patients were admitted for worsening heart failure (10.4% versus 2.3%; P=0.062), an

103 y outcome was the composite of an episode of worsening heart failure (heart failure hospitalization o

104 inhibitor dapagliflozin reduced the risk of worsening heart failure and death in patients with heart

105 Dapagliflozin reduced the risk of death and worsening heart failure and improved symptoms across the

106 rtality or hospitalization for arrhythmia or worsening heart failure during 1 year of follow-up compa

107 and total number of inpatient and outpatient worsening heart failure events, with benefits seen early

108 mellitus who were recently hospitalized for worsening heart failure were randomly assigned to receiv

109 In patients with diabetes and recent worsening heart failure, sotagliflozin therapy, initiate

110 inpatient and outpatient events that reflect worsening heart failure.

111 00 person-years) and of hospitalizations for worsening HF (0.63 versus 0.99 per 1000 person-years) we

112 y outcome was the composite of an episode of worsening HF (HF hospitalization or an urgent HF visit r

113 confirmed most of cardiovascular deaths and worsening HF hospitalizations assessed by cardiologists

114 The number of patients hospitalized with worsening HF or diagnosed with new-onset HF was markedly

115 oratory outcome was the primary outcome plus worsening HF symptoms/signs leading to the initiation of

116 n-years; P=0.19), while hospitalizations for worsening HF were slightly higher in 2020 versus 2019 (1

117 and 0.78 versus 0.74 for hospitalization for worsening HF).

118 lizations, and 84.4% of hospitalizations for worsening HF.

119 ms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce.

120 t achieve an SVR after treatment experienced worsening HRQL scores in long-term follow-ups.

121 associated with long-lasting impairments and worsening HRQOL, whereas the negative effects of surgica

122 tter GABA is essential, and reuptake failure worsens human seizures.

123 Malignancy was accompanied by worsened hypoxia inside the tumor mass, creating a posit

124 The effects will continue to grow and worsen if economies begin to open without the proper pre

125 sterior lung bases in patients found to have worsened ILD at visual assessment.

126 h was not the case in wild-type animals, and worsens impairment in spatial learning following chronic

127 After critical illness, new or worsening impairments in physical, cognitive, and/or men

128 estrictions on movement were associated with worsen in psychomotor symptoms, indicating that future p

129 te change, and the situation is predicted to worsen in the future.

130 dministration of purified NS1 also failed to worsen in vivo vascular leakage in sublethally infected

131 Fibrosis improved in 34% of the children but worsened in 23%.

132 improved in the 0.7 g/kg/d ethanol group but worsened in the 2.8 g/kg/d ethanol group.

133 high levels of hospital admissions which are worsening in deprived areas.

134 There was greater worsening in mean logMAR VA from the visit before LTFU t

135 sion: A more severe trajectory of disability worsening in MS is associated with innate immune cell ac

136 ain, function, and inflammation] without any worsening in the remaining one domain) at weeks 16 and 5

137 Longitudinal increases (worsening) in OSDI scores were associated with increasin

138 months (improved=decreased RC, no change, or worsened=increased RC), and the association between chan

139 y, and ensuring real-world evidence does not worsen inequities.

140 xin-induced depletion of Tregs significantly worsened infection-induced fibrosis exacerbation as dete

141 sed lymphocyte number/function contribute to worsened infection/cancer.

142 We examined if rTM might worsen infectious diseases.

143 lammatory bowel disease, and yet its deficit worsens infectious and chemical colitis.

144 Eleven of 15 patients had worsening inflammation with miltefosine, with 10 of them

145 e was frequency of flares, defined as new or worsening inflammatory activity on examination or imagin

146 feine worsened and L-theanine had a trend of worsening inhibitory control (i.e. increased Stop-signal

147 Intestinal IR in C5aR2(-/-) mice led to worsened intestinal damage and increased neutrophil infi

148 In vivo, chemerin overexpression worsened IRR.

149 onse and to the timing of interventions that worsen, limit or reverse a potentially accelerating vent

150 C-type lectin-like receptor) perpetuates and worsens liver damage after toxic liver injury.

151 However, mice lacking D5R exhibited slightly worsened locomotor performance in response to L-DOPA and

152 he use of systemic steroids does not seem to worsen long-term outcomes of endophthalmitis compared to

153 e susceptible to bacterial infections, which worsen lung inflammation and contribute to lung function

154 ion, and nearly half of subjects experienced worsening lung inflammation and lung function at Week 4

155 ORC1 in NK cells to produce IFN-gamma, which worsened macrophage phagocytosis, clearance of secondary

156 e hypothesized that chronic ketogenesis will worsen metabolic dysfunction and oxidative stress during

157 Silencing Lcn2 expression worsens metabolic dysfunction in genetic and diet-induce

158 trate here that low maternal n-3 PUFA intake worsens MIA-induced early gut dysfunction, including mod

159 e syndrome is a term used to describe new or worsening multidimensional impairments in physical, psyc

160 post-intensive care syndrome as: (1) new or worsening multidimensional impairments; (2) physical dys

161 pathologies; however, complete loss of Dock3 worsened muscle function.

162 and doubled infarct volumes (p < 0.001) and worsened neurological deficits (median score = 9 vs 5 wi

163 of CysC-deficient (CysC knockout [KO]) mice worsened obesity-associated adipose tissue inflammation

164 l infiltration, blunted vascular repair, and worsened occlusive vasculopathy in mice.

165 e exposure is associated with development or worsening of allergic diseases such as asthma.

166 thma control/symptoms in predicting either a worsening of asthma or exacerbation after LAIV using a r

167 hort-term increase in the ICS dose alone for worsening of asthma symptoms is not recommended.

168 Because of rapid disease progression or worsening of clinical condition, radiologic response ass

169 ses in p-tau217 correlated with longitudinal worsening of cognition and brain atrophy.

170 %); 5-year cumulative incidence of sustained worsening of cup-to-disc ratio by >=0.2 was 26% (95% CI

171 Worsening of depressive symptoms was associated with lef

172 h left prefrontal areas were associated with worsening of depressive symptoms.

173 3 to 4 years would decrease mortality or the worsening of disease such that patients meet current spe

174 of the patients in the placebo group had had worsening of disease.

175 .3) were both significant predictors for the worsening of DME and visual acuity when the treatment in

176 es a significant risk for the development or worsening of dry eye symptoms.

177 endpoint was the resolution of NASH without worsening of fibrosis at 5 years.

178 NASH resolution with no worsening of fibrosis was observed in 24% of patients gi

179 se (NAFLD) Activity Score >=2 points without worsening of fibrosis, occurred in 43 participants (30%)

180 c fatty liver disease activity score without worsening of fibrosis.

181 of IOP elevation was effective in preventing worsening of glaucoma for the large majority of cases, b

182 re effective only for a short period, with a worsening of glycemia associated with continued decline

183 r (3) loss of response, defined as objective worsening of GVHD determined by increase in stage, grade

184 ular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome; t

185 roportion of patients with 1 or more flares (worsening of HES-related symptoms necessitating therapy

186 -negative HES, experienced 2 or more flares (worsening of HES-related symptoms or blood eosinophil co

187 orized as showing improvement, stability, or worsening of ILD.

188 iscriminative fibers for stimulation-induced worsening of intelligibility in a structural connectome.

189 ria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor patient

190 the diagnosis of morphologic and functional worsening of interstitial lung disease in patients with

191 Worsening of IRMA was seen in 5 eyes with no further inj

192 of sustained (2 or more consecutive visits) worsening of mean deviation by >=6 dB was 20% (95% CI 12

193 xacerbations, but did attenuate URTI-induced worsening of mPEF.

194 ts were osteoarthrosis of non-spinal joints, worsening of myelopathy, and wound complications.

195 ulder pain, arm paraesthesia, dysphagia, and worsening of myelopathy.

196 Fibrosis improvement (>=1 stage) with no worsening of NASH was achieved in 38% of patients receiv

197 mL/kg/min in peak oxygen consumption with no worsening of New York Heart Association class.

198 nd were 20% to 40% less likely to experience worsening of New York Heart Association functional class

199 e did not find any statistically significant worsening of outcomes for cPRA-100% recipients under KAS

200 investigator, overall survival (OS), time to worsening of pain (TWP), and objective response rate (OR

201 al dopamine synthesis capacity predicted the worsening of psychotic symptoms at follow-up (r = 0.35;

202 Those with high affinity haemoglobin had no worsening of pulmonary gas exchange during hypoxic exerc

203 e 3 conjunctival scarring on presentation or worsening of scarring during follow-up, even in the sett

204 liver fibrosis by one stage or more without worsening of steatohepatitis.

205 city at presentation predicts the subsequent worsening of sub-clinical total and psychotic symptoms,

206 e the composite risk factors for paradoxical worsening of TB SLC (OR 7.555, 95% CI: 1.78-32.02; P = 0

207 n the number of non-flowing capillaries or a worsening of the CBF deficit in APP/PS1 mice fed a Hfd a

208 etween ongoing injury and restitution led to worsening of the Mdr2 KO phenotype, suggesting caution i

209 ysis of male and female S63del mice showed a worsening of the neuropathy in the absence of eIF2alpha

210 xperience life-threatening episodes of acute worsening of their disease, termed acute exacerbation of

211 rienced no change, whereas 2 eyes (4.4%) had worsening of visual acuity.

212 r his first appointment due to an asymmetric worsening of visual acuity.

213 On worsening of visual field defect and optic disc damage,

214 al loss was defined as the development of or worsening of visual loss of one or more categories.

215 C virus (HCV) incidence has increased in the worsening opioid epidemic.

216 defined as the occurrence within 6 months of worsening or development of tractional retinal detachmen

217 ly of adipocyte-autonomous ATGL, and thereby worsen organ failure.

218 h comorbidities are increasing worldwide and worsen outcomes for people with diabetes, especially whe

219 rovement in hypoxic tumors and significantly worsened outcomes in normoxic tumors.

220 with ECG and mechanical changes and clinical worsening over 1 year.

221 hy components showed evidence of age-related worsening over 6.7 decades, at a rate indistinguishable

222 eration and to predict the risk of cognitive worsening over time in iPD.

223 tive potential of the background signal that worsens over days to weeks, diminishing sensitivity and

224 ures a marked ataxic gait that progressively worsens over time.

225 eurologic and motor dysfunction, but further worsens overall liver function, exacerbating hepatic fai

226 increase in NIT scores had their PRO scores worsen (P < .05).

227 e after intervention, whereas 2 participants worsened (P = 0.157).

228 h worsening compared to 1 of 40 (3%) without worsening (P = .04).

229 lood volume away from well-ventilated areas, worsening PaO2/FIO2.

230 ratio [OR] 10.21, P < .0053) and cases with worsening papilledema (3.5, P < .043) were associated wi

231 us, increase aggressive phenotypes, and thus worsen patient outcomes.

232 rip strength but exacerbated weight loss and worsened performance on the pole test.

233 gery changes, less post-surgery weight loss, worsening physical and mental health status, less social

234 ital for progressive shortness of breath and worsening productive cough of 2 weeks duration.

235 omoter mutations have been associated with a worsened prognosis in melanoma, the relationship between

236 Pulmonary hypertension worsens prognosis in patients with heart failure (HF) an

237 One-year survival decreased with worsening PS in non-HCC recipients where 1-year survival

238 ng impaired heart performance, symptoms, and worsening quality of life or life expectancy.

239 stable, with the exception of significantly worsened recall consistency of autobiographical informat

240 thin the same hospitalisation) significantly worsened renal function in the late follow-up and should

241 MIOX-TG mice had worsening renal functions with kidneys having increased

242 estern pattern score, there was increased KL-worsening risk (compared with quartile 1, HR for quartil

243 In contrast, Prph2R172W/Rom1+/- animals had worsened rod and cone function and exacerbated retinal d

244 63del Schwann cells ameliorated, rather than worsened, S63del neuropathy despite reduced levels of ph

245 od in which an antibiotic was prescribed for worsening sinus symptoms, and infrequent AECRS was defin

246 Despite worsening some motor characteristics, YAC84Q mice showed

247 ncreased DASS-stress score was associated to worsened SRP outcomes in terms of bleeding on probing (B

248 iting negative coping strategies demonstrate worsened SRP outcomes.

249 coping strategies were also associated with worsened SRP outcomes.

250 hest CT, RT-PCR or both, due to the risk for worsened surgical outcomes and nosocomial spread.

251 wer PD-1/PD-L1 interaction had significantly worsened survival.

252 months of the trial were more likely to have worsened symptom classification at 12 months.

253 This cross-reactivity may worsen symptoms of a subsequent infection through Ab-dep

254 r, SG patients also reported higher rates of worsening symptoms (17.8% vs 7.5%, p < 0.0001) even thou

255 Participants with worsening symptoms also showed atypical baseline cogniti

256 ividuals experiencing complications, such as worsening symptoms and functional impairment when a medi

257 ally relevant to help understand changing or worsening symptoms in an individual.

258 ndividuals with medication-resistant tremor, worsening symptoms when the medication wears off, and dy

259 individuals show improving, others stable or worsening symptoms.

260 ncompass a broader range-including sometimes worsening targets' affect or contravening their wishes i

261 ss observed in these clinical conditions may worsen the course of both periodontal disease and CKD.

262 Type II diabetes (T2D) may worsen the course of hepatitis C virus infection with a

263 Consumption of a western diet significantly worsened the adipocyte oxidant stress, but expression of

264 In one case, OCT worsened the agreement of the reader compared with the F

265 year with the first-line antibiotics without worsening the burden of gonorrhea.

266 oward ferroptosis in cardiomyocytes, thereby worsening the progression of diabetic cardiomyopathy.

267 ective buildup of toxic lipid species, which worsens the pro-inflammatory and pro-fibrotic shift obse

268 (especially B-cell lymphomas), which greatly worsens the prognosis.

269 emonstrate that whereas Gpbar1 gene deletion worsens the severity of liver injury, its pharmacologica

270 tastasis contributing as a major factor that worsens the survival of patients.

271 n pro-opiomelanocortin neurons of ob/ob mice worsens their glucose homeostasis, adiposity, hyperphagi

272 Activated neutrophils can cause or worsen tissue injury, underscoring the need for calibrat

273 Worsening traction after treatment was defined as the oc

274 Laser treatment resulted in worsening traction in a substantial proportion of eyes w

275 gging, breaks, rhegmatogenous detachment, or worsening tractional membranes.

276 the tumor microenvironment that can limit or worsen tumor progression.

277 a may limit imaging for PE because of either worsened ventilation defects on ventilation-perfusion sc

278 segments with MPRI < 2) was associated with worsened ventilatory efficiency (VE/VCO2) (P < 0.001) bu

279 ndicated by high intraocular pressure (IOP), worsening visual field, or optic nerve head changes in w

280 P = 0.64), and the hazard ratio for disease worsening was 1.11 (95% CI, 0.59 to 2.10; P = 0.73).

281 isual acuity in the cohorts with and without worsening was 1.7 (Snellen 20/1002; n = 5) and 0.24 (Sne

282 experiencing an episode of fatal or nonfatal worsening was 16.

283 omparison with no event) after an outpatient worsening was hazard ratio, 2.67 (95% CI, 2.03-3.52); af

284 Mild worsening was identified in post-ATI basal ganglia total

285 omly assigned patients, the first episode of worsening was outpatient augmentation of treatment in 40

286 as become an essential toolset to combat the worsening water stress resulting from population and ind

287 Given that coastal flooding will only worsen, we must reframe this problem as one that will di

288 Worsening Week 4 lung inflammation and pulmonary functio

289 In DAPA-HF, outpatient episodes of HF worsening were common, were of prognostic importance, an

290 ine features between groups with and without worsening were performed to determine features associate

291 ucing torsinB levels causes a dose-dependent worsening whereas torsinB overexpression rescues torsinA

292 5q models, these flies develop seizures that worsen with age.

293 ity; and further, these parameters appear to worsen with increasing EDS.

294 These effects will worsen with ongoing dependence on this energy source, sp

295 ship between LOXL1 expression and IOP, which worsened with age.

296 ield EZ at baseline, mean BCVA progressively worsened with each of 4 EZ grades in 185 eyes with grada

297 This sensation worsened with each subsequent intake.

298 In 5 of 6 cases, visual acuity worsened with onset of bullous epithelial edema, and in

299 nd data, mostly because financial protection worsened with stagnant or declining service coverage.

300 Proteostasis failure worsens with aging and is considered a cause of and a th