ライフサイエンスコーパス: worsening of

1 mately 24% improvement from baseline) with a worsening of 0.3% in the placebo group (P < 0.001).

2 owing: (1) worsening from no PDR to PDR, (2) worsening of 2 or more severity levels on reading center

3 Incidence or worsening of 8 pathologic features (foveal GA, foveal sc

4 s with de novo PD is associated with reduced worsening of a range of NMSs in preliminary analyses.

5 mprovement in accrual to adjuvant trials but worsening of accrual for neoadjuvant/metastatic trials.

6 The most common cause of death was worsening of acute respiratory distress syndrome (two [2

7 posure to grass pollen induced a significant worsening of AD.

8 variables associated with an improvement or worsening of adherence of >/=25%.

9 tissues, but this was not associated with a worsening of age-associated insulin resistance and, conv

10 culating IgE, Th2 cytokine production, and a worsening of AHR.

11 er ischemia-reperfusion injury mitigated the worsening of AKI.

12 on and weather changes may contribute to the worsening of allergic conjunctivitis.

13 e exposure is associated with development or worsening of allergic diseases such as asthma.

14 ips of ox-LDL to the incidence of any AMD or worsening of AMD remained after adjustment for history o

15 etween ox-LDL and AMD disease development or worsening of AMD.

16 Persistence or worsening of AMR in a subsequent biopsy occurred in 38.2

17 GF-beta target gene output, which paralleled worsening of aneurysm pathology and coincided with upreg

18 2 or more of the 4 CABP symptoms, having no worsening of any CABP symptoms, and not receiving any no

19 thma control/symptoms in predicting either a worsening of asthma or exacerbation after LAIV using a r

20 Acute worsening of asthma symptoms (exacerbation) is predomina

21 hort-term increase in the ICS dose alone for worsening of asthma symptoms is not recommended.

22 ticipants who exhibited no evidence of acute worsening of asthma symptoms, reversible airflow obstruc

23 ically significant exacerbations (defined as worsening of asthma that required the use of systemic co

24 agia progression-free survival (defined as a worsening of at least 1 point on the Mellow scale from b

25 The 60mg/kg/day dose was discontinued due to worsening of ataxia in 2 patients.

26 significant increase in brain Hcy levels and worsening of behavioral deficits.

27 They experienced slightly worsening of beta cell function and insulin sensitivity

28 Regression analysis revealed a significant worsening of BiS with strabismus for 2.5% (P = .009) and

29 ardial metabolism, often contributing to the worsening of cardiac function and health outcomes.

30 ed chemotherapy does not result in long-term worsening of cardiac function, cardiac symptoms, or heal

31 ty to diabetes mellitus is likely related to worsening of cardiac mitochondrial function because impa

32 -79% decrease, P < 0.05) during progressive worsening of cerebrovascular autoregulation in one patie

33 llow-up is needed to ascertain resolution or worsening of chronic kidney disease and hypertension.

34 Because of the rapid disease progression or worsening of clinic conditions, radiologic response asse

35 Because of rapid disease progression or worsening of clinical condition, radiologic response ass

36 infection or antigen that causes paradoxical worsening of clinical disease.

37 inical trials resulted in neutral effects or worsening of clinical outcomes.

38 ival inflammation and may play a role in the worsening of clinical parameters of periodontitis, such

39 induces asthma exacerbations, which leads to worsening of clinical symptoms and may result in a susta

40 muL; rates of new-onset CMV retinitis and of worsening of CMV retinitis (either increasing border act

41 Worsening of cognition (-1.05 points; 95% CI, -1.97 to -

42 ses in p-tau217 correlated with longitudinal worsening of cognition and brain atrophy.

43 0, whereas spread to neocortical regions and worsening of cognition is associated with beta-amyloid (

44 Furthermore, it implies that gradual worsening of conditions across a species' habitat may le

45 Respiratory disorders, particularly worsening of COPD, were the most common adverse events (

46 The respiratory disorders, in particular worsening of COPD, were the most common serious adverse

47 Mild adverse events, such as worsening of cough, occurred more frequently among child

48 tensive volume removal resulted in a further worsening of creatinine approximately half of the time,

49 %); 5-year cumulative incidence of sustained worsening of cup-to-disc ratio by >=0.2 was 26% (95% CI

50 extrinsic IgE-mediated form of AD induced a worsening of cutaneous symptoms.

51 creasing fat attenuation are associated with worsening of CVD risk factors beyond the associations wi

52 een associated with no improvement or even a worsening of CVD risk, at least in part through effects

53 uate which factors influence the progression/worsening of dental and periodontal tissue conditions of

54 suicidal ideation or behavior and no overall worsening of depression or anxiety in either group.

55 ; or discontinuation for lack of efficacy or worsening of depression or suicidality.

56 Worsening of depressive symptoms was associated with lef

57 h left prefrontal areas were associated with worsening of depressive symptoms.

58 The phenomenon of temporary paradoxical worsening of diabetic macular edema after insulin treatm

59 , 1.08 [95% CI, 0.44-2.61], P = .87), or the worsening of diabetic retinopathy (HR, 0.94 [95% CI, 0.8

60 in and the incidence of macular edema or the worsening of diabetic retinopathy in persons with type 1

61 Worsening of diabetic retinopathy, incidence of prolifer

62 th intrathecal variables are associated with worsening of disease in patients with relapsing-remittin

63 3 to 4 years would decrease mortality or the worsening of disease such that patients meet current spe

64 iral uptake, leading to enhanced viremia and worsening of disease.

65 of the patients in the placebo group had had worsening of disease.

66 xposure to a causative agent and progressive worsening of disease; conversely, diagnosing OA when it

67 d pressure reduction was not associated with worsening of diuresis or decongestion.

68 .3) were both significant predictors for the worsening of DME and visual acuity when the treatment in

69 mprovement of hypokinesia contrasting with a worsening of DOPA-unresponsive gait and balance disorder

70 es a significant risk for the development or worsening of dry eye symptoms.

71 n), involuntary movements (ie, dyskinesia or worsening of dystonia; five vs one), and depression (one

72 A transient worsening of erythroderma and pruritus occurred in 53% o

73 ncreased rate of new-onset CMV retinitis nor worsening of existing CMV retinitis in the first 6 month

74 ed pre-eclampsia was defined as new-onset or worsening of existing hypertension, dipstick proteinuria

75 ere were no notable safety issues, including worsening of extraintestinal manifestations.

76 However, despite weight gain, KCl prevented worsening of fasting glucose.

77 Statistically worsening of FAZ OCTA metrics was only seen between tert

78 approval include resolution of NASH without worsening of fibrosis and/or improvement in fibrosis wit

79 endpoint was the resolution of NASH without worsening of fibrosis at 5 years.

80 activity score by at least 2 points without worsening of fibrosis from baseline to the end of treatm

81 NASH resolution with no worsening of fibrosis was observed in 24% of patients gi

82 disease activity score [NAS] by >=2, with no worsening of fibrosis); 45% of patients had a histologic

83 with contribution from >1 parameter, without worsening of fibrosis, 1 year after the last dose of EPA

84 se (NAFLD) Activity Score >=2 points without worsening of fibrosis, occurred in 43 participants (30%)

85 orsening of NASH, or NASH resolution with no worsening of fibrosis, with the study considered success

86 ity score in 2 histologic categories without worsening of fibrosis.

87 c fatty liver disease activity score without worsening of fibrosis.

88 oint was NAFLD activity score </= 3, without worsening of fibrosis; or a decrease in NAFLD activity s

89 those with injury alone, inactivation caused worsening of forelimb function; the initial deficit was

90 d, SHRM and retinal thinning, development or worsening of foveal GA, and increased lesion size are im

91 ts receiving the higher dose had significant worsening of functional ability.

92 iation of MCID estimates for improvement and worsening of FVC% with patient reported outcomes (PROs)

93 s for disease progression defined by 48-week worsening of FVC, dyspnea (University of California, San

94 Rates of improvement or worsening of GERD symptoms, development of new-onset GER

95 of IOP elevation was effective in preventing worsening of glaucoma for the large majority of cases, b

96 ographic, morphological cardiac changes, and worsening of global disease severity but are not associa

97 at 6 weeks of age resulted in time-dependent worsening of glucose tolerance, impairment of insulin se

98 re effective only for a short period, with a worsening of glycemia associated with continued decline

99 ever, CTs cured 53% of animals and prevented worsening of glycemic control in nonprotected individual

100 Dose-related worsening of glycemic control was noted in 14.5% of pati

101 r (3) loss of response, defined as objective worsening of GVHD determined by increase in stage, grade

102 Recurrence or worsening of HAE symptoms (22 of 97) was the most common

103 sis of RCTs did not show significant risk in worsening of hard exudates and severity of DME in the li

104 al assays in these mice showed a significant worsening of HD pathological phenotypes.

105 Many episodes of worsening of heart failure (HF) are treated by increasin

106 ome was a composite of death from any cause, worsening of heart failure during the initial hospitaliz

107 ular causes, stroke, or hospitalization with worsening of heart failure or acute coronary syndrome; t

108 l increase in post-infarction scar size with worsening of heart function.

109 induced hepatotoxic effects, and monitor for worsening of hepatic fibrosis scores during MTX therapy.

110 roportion of patients with 1 or more flares (worsening of HES-related symptoms necessitating therapy

111 -negative HES, experienced 2 or more flares (worsening of HES-related symptoms or blood eosinophil co

112 ovascular mortality and hospitalization from worsening of HF (n=465), was investigated in 1245 patien

113 aturase activity significantly predicted the worsening of hyperglycemia (glucose area under the curve

114 These abnormalities contributed to worsening of hyperglycemia and glucose-intolerance in th

115 We investigated EMFAs as predictors of the worsening of hyperglycemia and incident type 2 diabetes

116 ion, high levels of KBs predicted subsequent worsening of hyperglycemia, and a common variant of GCKR

117 side increased adiposity and the progressive worsening of hyperphagia-associated hyperinsulinaemia.

118 Worsening of hypoxemia is frequent during low-flow extra

119 velop a deep learning-based method to depict worsening of ILD based on lung shrinkage detection from

120 orized as showing improvement, stability, or worsening of ILD.

121 ls; increase in VAT, IHL, and lipolysis; 45% worsening of IMGU; and decreased expression of lipid met

122 ic for malaria and other infections to avoid worsening of infection by iron treatment.

123 insulin suppression of lipolysis and only 8% worsening of insulin-mediated glucose uptake (IMGU).

124 iscriminative fibers for stimulation-induced worsening of intelligibility in a structural connectome.

125 ria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor patient

126 ed as discriminative for stimulation-induced worsening of intelligibility were mainly connected to th

127 The most common serious adverse events were worsening of interstitial lung disease (main study: six

128 the diagnosis of morphologic and functional worsening of interstitial lung disease in patients with

129 nt system implementation was associated with worsening of intraoperative nursing documentation time e

130 Worsening of intrinsic myocardial contraction in the tra

131 most common grade 3 or 4 adverse events were worsening of IPF, dyspnoea, and pneumonia.

132 ough, upper respiratory tract infection, and worsening of IPF; and the most common grade 3 or 4 adver

133 Worsening of IRMA was seen in 5 eyes with no further inj

134 n contributes to progression of RNP and thus worsening of ischemia.

135 New onset or worsening of isolated cerebellar ataxia in patients bein

136 parameter was indicative for the subsequent worsening of left ventricular ejection fraction in perma

137 of COPD, and this decline is paralleled by a worsening of lung function and health status.

138 systolic blood pressure over time predicted worsening of LVDF (P</=0.014).

139 sociated with a 184% increase in the odds of worsening of LVDF (P<0.0001).

140 Baseline age was a strong predictor of worsening of LVDF from normal/mild grade to more advance

141 The incidence of development or worsening of macular edema (ME) is variable in eyes with

142 plant was shown to prevent the recurrence or worsening of macular edema in uveitic patients with a hi

143 taract surgery may prevent the postoperative worsening of macular edema.

144 line BRCA mutations is safe without apparent worsening of maternal prognosis and is associated with f

145 of sustained (2 or more consecutive visits) worsening of mean deviation by >=6 dB was 20% (95% CI 12

146 he study, mice in the control group showed a worsening of memory and learning abilities, whereas mice

147 efit from high-folate status and could see a worsening of memory.

148 o CD8-deficient mice (CD8(null)) resulted in worsening of metabolic parameters compared with wild-typ

149 Conversely, transient worsening of mismatch by episodic hypoxemia or hypotensi

150 During treatment, no subjects displayed worsening of modified Melasma Area and Severity Index sc

151 e approximately 10% of the subjects showed a worsening of modified Melasma Area and Severity Index sc

152 ed with the degrees of cognitive decline and worsening of mood though the associations were relativel

153 BSR group showed greater improvement or less worsening of most CV risk factors, with an attenuation o

154 rated with no significant safety concerns or worsening of motor function.

155 nt mice had no shortening of lifespan and no worsening of motor or memory deficits.

156 administration in PD patients may result in worsening of motor symptoms, at least in part, by exacer

157 xacerbations, but did attenuate URTI-induced worsening of mPEF.

158 ts were osteoarthrosis of non-spinal joints, worsening of myelopathy, and wound complications.

159 ulder pain, arm paraesthesia, dysphagia, and worsening of myelopathy.

160 onance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration >/=

161 most common adverse events (nasopharyngitis, worsening of nasal polyps and asthma, headache, epistaxi

162 rosis and/or improvement in fibrosis without worsening of NASH by standardized evaluation of paired l

163 Fibrosis improvement (>=1 stage) with no worsening of NASH was achieved in 38% of patients receiv

164 ere fibrosis improvement (>=1 stage) with no worsening of NASH, or NASH resolution with no worsening

165 clopidogrel to aspirin correlates with less worsening of native coronary artery disease 1 year after

166 ular RNFL thickness loss was associated with worsening of NEI VFQ-25 scores over time.

167 aternal adverse outcomes without substantial worsening of neonatal or infant outcomes, compared with

168 a-CNS disease progression, no tumour-related worsening of neurological signs or symptoms, and no incr

169 mL/kg/min in peak oxygen consumption with no worsening of New York Heart Association class.

170 nd were 20% to 40% less likely to experience worsening of New York Heart Association functional class

171 t failure are closely intertwined, such that worsening of one condition is frequently accompanied by

172 smoke (SHS) exposure has been linked to the worsening of ongoing lung diseases.

173 trial had led to new episodes of violence or worsening of ongoing violence and abuse.

174 atins may protect against the development or worsening of open-angle glaucoma (OAG).

175 A total 79.4% of patients reported worsening of orthostatic tremor symptoms.

176 significant untoward consequences including worsening of outcomes and diminished quality of life as

177 e did not find any statistically significant worsening of outcomes for cPRA-100% recipients under KAS

178 matory cytokine production and autophagy and worsening of oxidative stress.

179 investigator, overall survival (OS), time to worsening of pain (TWP), and objective response rate (OR

180 Denosumab may delay worsening of pain compared with bisphosphonates.

181 fth had an increase, and the improvement and worsening of pain varied by baseline pain score.

182 He denied neurologic symptoms or worsening of pain while lying down.

183 ubset of cases can show delayed onset and/or worsening of papilledema with time.

184 She experienced worsening of parkinsonism with severe dyskinesias, and u

185 n of disease control, but is associated with worsening of patient-reported HRQoL and no detectable OS

186 reactivation can occur resulting in further worsening of patients.

187 Outcomes were mortality and worsening of pediatric cerebral performance category fro

188 r metabolic syndrome predicts tooth loss and worsening of periodontal disease in a cohort of 760 men

189 factors for development of periodontitis or worsening of periodontal measures.

190 ndrome may play a role in the development or worsening of periodontitis.

191 Some studies showed no improvement or worsening of PIH after laser treatment.

192 , whereas 40% experience new-onset or severe worsening of preexisting abnormalities of liver tests, i

193 tive agents appears useful in preventing the worsening of preexisting retinal neurodysfunction.

194 up; P = 0.017) and development of de novo or worsening of previous ascites without increasing rates o

195 predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in

196 with statistically significant or numerical worsening of PROs, QILD, and QLF.

197 was independently associated with subsequent worsening of proteinuria.

198 hs), and progressive disease (progression or worsening of proven or suspected lesion due to ECD).

199 al dopamine synthesis capacity predicted the worsening of psychotic symptoms at follow-up (r = 0.35;

200 is maintained at follow-up, with a possible worsening of PTSD caseness at follow-up from one study.

201 Worsening of pulmonary arterial hypertension was the mos

202 intravenous or subcutaneous prostanoids, or worsening of pulmonary arterial hypertension.

203 Those with high affinity haemoglobin had no worsening of pulmonary gas exchange during hypoxic exerc

204 tients with PXE worldwide may be at risk for worsening of PXE as a result of warfarin therapy.

205 g given exemestane with clinically important worsening of QOL at one time or another; specifically, 8

206 taking capecitabine had clinically relevant worsening of quality of life at end of treatment (255 [5

207 Progressive worsening of RA reservoir and conduit functions is relat

208 ia (MSIMI) was defined as the development or worsening of regional wall motion abnormality, reduction

209 diography, was defined as: 1) development or worsening of regional wall motion abnormality; 2) left v

210 currence of MSIMI, defined as development or worsening of regional wall motion abnormality; left vent

211 elated adverse events (myasthenia gravis and worsening of renal failure), and one patient who receive

212 s with systolic heart failure but may induce worsening of renal function (WRF) and hyperkalemia (HK).

213 le disease course, but dose reduction led to worsening of renal function and symptoms.

214 Worsening of renal function was defined as an annual dec

215 in-hospital loop diuretic administered, and worsening of renal function.

216 inary diagnostic criteria for PSR: transient worsening of residual poststroke focal neurologic defici

217 was not clinically effective and resulted in worsening of respiratory allergic symptoms.

218 Patients recorded daily worsening of respiratory symptoms and peak expiratory fl

219 ng the GHRH antagonist, MIA-602, resulted in worsening of retinal morphology and a significant altera

220 ce that regular IAI dosing not only can slow worsening of retinal perfusion associated with diabetic

221 ver, our data also suggest that VEGF-induced worsening of retinal perfusion in DME is superimposed on

222 IRR) and 20 experienced paradoxical clinical worsening of retinitis (paradoxical CMV-IRR).

223 reatment of Diabetic Retinopathy Study scale worsening of retinopathy (P </= 0.002), independent of e

224 Exploratory analysis was performed on worsening of retinopathy, defined as 1 or more of the fo

225 e of these treatments to reduce the rates of worsening of retinopathy, with or without PDR, does not

226 After 5 years of follow-up, a worsening of rhinitis was detected in 26.2%, with an inc

227 analyses showed significant estimated annual worsening of SARA (regression coefficient 0.86 points [S

228 e 3 conjunctival scarring on presentation or worsening of scarring during follow-up, even in the sett

229 ent adverse events (eg, insomnia, akathisia, worsening of schizophrenia, headache, anxiety) were repo

230 nia, agitation, and increased triglycerides; worsening of schizophrenia/drug ineffective was less fre

231 Worsening of serous RD was associated with appearance of

232 25% corresponded to a clinically meaningful worsening of SF-36 PCS scores.

233 r 2 years, but only by 5.4% in those without worsening of SF-36 PCS scores.

234 Within 3 days of acute worsening of sinonasal symptoms, subjects underwent a st

235 sed frequency of Ccr4(+) splenic T cells and worsening of skin inflammation, as indicated by epiderma

236 t may also participate to the development or worsening of some traits of the disease.

237 liver fibrosis by one stage or more without worsening of steatohepatitis.

238 city at presentation predicts the subsequent worsening of sub-clinical total and psychotic symptoms,

239 gnancy are consistent with gestation-induced worsening of subclinical pre-existing chronic cardiovasc

240 Worsening of symptom scores in surviving patients was co

241 QoL, but patients receiving placebo reported worsening of symptoms and other PROs.

242 n, pleuritic chest pain, and dyspnea) and no worsening of symptoms at 72 to 120 hours, without receip

243 attributed to ECD), and progressive disease (worsening of symptoms attributed to ECD).

244 Worsening of symptoms in concussive blast TBI was also o

245 nt depressive symptoms and with shorter-term worsening of symptoms in women.

246 For some patients there was a worsening of symptoms on changing from pyridoxine to pyr

247 failure, baseline symptoms of depression and worsening of symptoms over time are associated with incr

248 of anesthesia, skin injury, nonresolution or worsening of symptoms, and possible need for further or

249 uded needle-related discomfort and temporary worsening of symptoms, pressure to continue treatment an

250 erbations occur, which result in a permanent worsening of symptoms.

251 Acute-phase reactants were elevated with worsening of symptoms.

252 Worsening of systemic RV dysfunction or tricuspid regurg

253 e the composite risk factors for paradoxical worsening of TB SLC (OR 7.555, 95% CI: 1.78-32.02; P = 0

254 ic aberrant Type-I neural activity and [3] a worsening of the activity-dependent central auditory neu

255 e ALOX5 is responsible for the Hcy-dependent worsening of the AD phenotype in a relevant mouse model

256 tion of axonal lysosomes was revealed by the worsening of the amyloid plaque pathology arising from J

257 n the number of non-flowing capillaries or a worsening of the CBF deficit in APP/PS1 mice fed a Hfd a

258 mia and hypoxia play a major role in further worsening of the damage, a process referred to as 'secon

259 uce inflammatory pathways thereby leading to worsening of the disease.

260 ghout the observation period, with a general worsening of the drought conditions in recent years.

261 ients [29.4%]; P = .03) were associated with worsening of the EDSS score at 60 months.

262 A progressive worsening of the epilepsy with emergence of multiple sei

263 lobal increase of inflammation, leading to a worsening of the gastritis, measured by an increased epi

264 However, without further worsening of the insulin secretion defect, glucose homeo

265 etween ongoing injury and restitution led to worsening of the Mdr2 KO phenotype, suggesting caution i

266 ew onset IBS-like symptoms had a significant worsening of the mental component score.

267 late-born neurons are likely yielding to the worsening of the microcephaly phenotype postnatally.

268 , contrary to expectation, this results in a worsening of the muscle pathology implying that any futu

269 ysis of male and female S63del mice showed a worsening of the neuropathy in the absence of eIF2alpha

270 t in one might be achieved at the expense of worsening of the other.

271 f one condition is frequently accompanied by worsening of the other; the degree of clinical accelerat

272 ienced a significant and clinically relevant worsening of the rhinitis, with increase in emergency as

273 ng systemic corticosteroids and there was no worsening of the systemic condition, it is reasonable to

274 rrected transposition of the great arteries, worsening of the systemic right ventricle is accompanied

275 s associated with infection and a subsequent worsening of the ulcer.

276 6 month observation period that related to a worsening of the underlying infectious disease, measured

277 t symptom associated with the beginning or a worsening of the visual disturbance (36%), whereas migra

278 xperience life-threatening episodes of acute worsening of their disease, termed acute exacerbation of

279 who received only short-term treatment had a worsening of their pattern standard deviation with time

280 y allergic reactions, leading to significant worsening of their quality of life.

281 ther accumulation of IHTG is associated with worsening of these parameters has not been properly asse

282 s not required for subsequent development or worsening of thrombocytopenia).

283 also been associated with the development or worsening of thyroid eye disease in approximately 15% to

284 Conceptualizing worsening of TMJ intra-articular disorders as 4 stages a

285 prosthetic gradient of >/= 10 mm Hg and/or a worsening of transprosthetic regurgitation >/= 1/3 class

286 Worsening of ulcer was seen in 18.2% cases in group A an

287 ea and most common serious adverse event was worsening of underlying Crohn's disease.

288 erious adverse events in period 1 (excluding worsening of underlying disease) occurred in 1.3% of pat

289 statectomy (33.6 [95% CI, 27.8-39.2]); acute worsening of urinary obstruction and irritation with ext

290 The most common ocular adverse events were worsening of uveitis (0 [placebo] and 3 [sarilumab] pati

291 g prednisone treatment and 2 patients showed worsening of uveitis despite the systemic corticosteroid

292 ogenesis and is thought to contribute to the worsening of various inflammatory and disease processes.

293 y or as a result of medications, may lead to worsening of VF defects.

294 comes included intraocular pressure control, worsening of visual acuity, cystoid macular edema, retro

295 rienced no change, whereas 2 eyes (4.4%) had worsening of visual acuity.

296 r his first appointment due to an asymmetric worsening of visual acuity.

297 On worsening of visual field defect and optic disc damage,

298 lines compared with best BCVA in COMPASS and worsening of visual field mean defect (VFMD) >=2.5 dB co

299 al loss was defined as the development of or worsening of visual loss of one or more categories.

300 ovement and does not appear to contribute to worsening of wet AMD.