ライフサイエンスコーパス: wound repair

1 roxide (H2O2), impaired adenosine stimulated wound repair.

2 that epidermal SIRT1 plays a crucial role in wound repair.

3 -GRN-1, induces angiogenesis and accelerates wound repair.

4 tween macrophages and endogenous MSCs toward wound repair.

5 and resolution of the inflammatory phase of wound repair.

6 hat nerves provide cues essential for timely wound repair.

7 fluences macrophage-mediated inflammation in wound repair.

8 not produce WAE cells and exhibited impaired wound repair.

9 d to inhibition of proliferation and delayed wound repair.

10 eutics for immunological functions including wound repair.

11 epidermal morphogenesis, innate immunity and wound repair.

12 mplicated in angiogenesis, inflammation, and wound repair.

13 ws epithelial remodelling, thus facilitating wound repair.

14 ophages to complex tissue damage signals and wound repair.

15 keratinocytes (KCs) in psoriasis and during wound repair.

16 l cohesion during dynamic processes, such as wound repair.

17 in dissociation of leader cells and impaired wound repair.

18 inflammation and is required for successful wound repair.

19 we propose a role for EDA signaling in adult wound repair.

20 ophages and moderating scar formation during wound repair.

21 onR1 cross-linking and directly promoted ASM wound repair.

22 element required for cell proliferation and wound repair.

23 y elevated levels of cell stress and reduced wound repair.

24 to promote increased epithelial turnover and wound repair.

25 s in peripheral tissue and negatively impact wound repair.

26 further destruction and subsequent delay in wound repair.

27 are important in intercellular signaling and wound repair.

28 ntial role in collagen reorganization during wound repair.

29 tail transection, implicating Mmp9 in acute wound repair.

30 rmacological or genetic approaches disrupted wound repair.

31 fibrosis and promote regenerative cutaneous wound repair.

32 to mobilization of normal stem cells during wound repair.

33 y for actomyosin remodeling during embryonic wound repair.

34 egulated corneal epithelial cell fate during wound repair.

35 ered gene expression, but had no effect upon wound repair.

36 ht temporal regulation crucial for efficient wound repair.

37 catenin at the wound margin during embryonic wound repair.

38 dult organisms need efficient strategies for wound repair.

39 gral to tissue development, homeostasis, and wound repair.

40 ll functions, as a key effector of epidermal wound repair.

41 eutic targets for the treatment of defective wound repair.

42 -binding protein Shroom and during embryonic wound repair.

43 lial cells is a central signal driving small wound repair.

44 barrier function, inflammation and efficient wound repair.

45 ch as migration, that play critical roles in wound repair.

46 Active MMP-9 increased alveolar epithelial wound repair.

47 so function as the driving force during cell wound repair.

48 ediated mechanism, and this in turn impaired wound repair.

49 an important regulator of corneal epithelial wound repair.

50 eased epithelial cell migration, and mucosal wound repair.

51 tex of the wounded cells contribute to rapid wound repair.

52 ation and proliferation and improved mucosal wound repair.

53 obilize fibrocytes, such as inflammation and wound repair.

54 ol and MC2562 were effective in accelerating wound repair.

55 edox signaling pathway that promotes mucosal wound repair.

56 In vivo, lack of NONO resulted in defective wound repair.

57 lls are essential for tissue homeostasis and wound repair.

58 ted in physiological tissue regeneration and wound repair.

59 atory potential of skin keratinocytes during wound repair.

60 were resistant to diabetes-induced delay in wound repair.

61 ntified that modify fibrogenesis during skin wound repair.

62 impacts early stages of DETC activation and wound repair.

63 tin, suggesting potential benefit in corneal wound repair.

64 eby facilitating cytoskeletal remodeling and wound repair.

65 , so full induction of Ptgs2 is required for wound repair.

66 terns and events associated with periodontal wound repair.

67 n was further enhanced in tissues undergoing wound repair.

68 tant protection in terms of host defense and wound repair.

69 cadherin in in vitro restitution and in vivo wound repair.

70 wall to prevent blood loss and to facilitate wound repair.

71 rmal T cell (DETC) function during cutaneous wound repair.

72 interfollicular epidermis, as is seen during wound repair.

73 del to dissect the mechanisms of single-cell wound repair.

74 madelta T cells that play important roles in wound repair.

75 ll as in epithelial barrier organization and wound repair.

76 ont of SCs/progeny streaming from HFs during wound repair.

77 6 leads to reduced laminin production during wound repair.

78 r the autograft group at the early stages of wound repair.

79 , regulates Rho and Cdc42 during single-cell wound repair.

80 Depletion of Abr attenuates Rho activity and wound repair.

81 he miR-17~92 cluster, are upregulated during wound repair.

82 its therapeutic potential for improving skin wound repair.

83 ng macrophage behavior to promote subsequent wound repair.

84 ediating cellular senescence in pathological wound repair.

85 ginine (L-Arg), which has been implicated in wound repair.

86 essential for regulation of organ growth and wound repair.

87 Nrf2 activation in keratinocytes accelerates wound repair.

88 gulate cell adhesion to facilitate efficient wound repair.

89 )alpha and eicosanoids play in orchestrating wound repair.

90 n and open therapeutic avenues for promoting wound repair.

91 roliferation during early development and/or wound repair.

92 rely on stem cells (SCs) for homeostasis and wound repair.

93 d TGF-beta-signaling pathways during corneal wound repair.

94 ment to sites of mucosal injury to influence wound repair.

95 ecognition of commensals, tissue damage, and wound repair.

96 nd closure and inflammation during cutaneous wound repair.

97 te recruitment to promote intestinal mucosal wound repair.

98 as the processes of tissue regeneration and wound repair.

99 how they function in normal homeostasis and wound repair.

100 option of a morphogen-responsive function in wound repair.

101 were found to exhibit a significant delay in wound repair.

102 linking innate immune activation to mucosal wound repair.

103 cellular responses are often required during wound repair.

104 s normally associated with tissue injury and wound repair.

105 ion in human acute wounds, thus accelerating wound repair.

106 n, can induce decorin expression and enhance wound repair.

107 iched for genes involved in inflammation and wound repair.

108 skeletal remodeling processes in single cell wound repair.

109 namic process of tissue restructuring during wound repair.

110 s, epithelial-to-mesenchymal transition, and wound repair.

111 lation of extracellular matrix formation and wound repair.

112 contribute to age-associated alterations in wound repair.

113 lpha activation, inhibiting A2AAR-stimulated wound repair.

114 ranaceus has been reported to promote tissue wound repair.

115 he pattern recognition receptor NOD2 in skin wound repair.

116 ical mediators in the age-related decline in wound-repair.

117 abilizes HIF-1alpha during initial stages of wound repair (1-2 wk); whereas inflammation secondary to

118 de or loss of beta2AR gene deletion promoted wound repair, a finding that is, to our knowledge, previ

119 ration in plants and distinguish between the wound-repair ability of the tissue and its formation dur

120 Defective wound repair after CD47 loss is linked to decreased epit

121 strong proliferative response that promotes wound repair after colitis.

122 cellular matrix turnover plays a key role in wound repair after myocardial infarction (MI).

123 Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact a

124 we show that Pavarotti also functions during wound repair and confirm that while Pavarotti, Tumblewee

125 he reactivated embryonic gene program during wound repair and demonstrates that SOX11 and SOX4 play a

126 controls inflammation and fibroplasia during wound repair and diseases (eg, cancer).

127 tions further distinguish the mechanism from wound repair and dorsal closure.

128 rly relevant in biological processes such as wound repair and embryonic development where cell spread

129 icate Wnt/beta-catenin signaling in abnormal wound repair and fibrogenesis.

130 It is also evident at sites of wound repair and fibrosis, playing a key role in tissue

131 findings support a role for PKCbetaII in IEC wound repair and further demonstrate the ability of epit

132 gulating macrophage-mediated inflammation in wound repair and identify a potential target for the tre

133 ently, TLR3 activation was also shown to aid wound repair and increase the expression of genes associ

134 m M1 (inflammatory and antimicrobial) to M2 (wound repair and inflammation resolution) phenotype.

135 in embryogenesis, cell growth and survival, wound repair and inflammation, researchers now aim to de

136 hage plasticity during normal and pathologic wound repair and is a target for therapeutic manipulatio

137 iltration, and tissue injury while improving wound repair and mucosal healing.

138 These results extend the role of Fn14 in wound repair and muscle development to involvement in th

139 ay provide new therapeutic opportunities for wound repair and muscular dystrophies.

140 Bone marrow macrophages stimulate skeletal wound repair and osteoblastic bone formation by poorly d

141 al a potential role for thrombin and PAR1 in wound repair and pathophysiology of the adult heart.

142 activation to promote endothelial monolayer wound repair and reduce immune cell adhesion.

143 and mechanomodulatory approaches to augment wound repair and regeneration.

144 ung injury and that vimentin is required for wound repair and remodeling of the alveolar epithelium.

145 homeostasis by activating genes that promote wound repair and resolve inflammation while repressing g

146 nflammatory response; however, their role in wound repair and scarring is unknown.

147 and lung pathology associated with impaired wound repair and subsequent pulmonary edema.

148 ic regulation of TLR4 in pathologic diabetic wound repair and suggest a target for therapeutic manipu

149 a novel role for Tregs in facilitating skin wound repair and suggest that they use the EGFR pathway

150 results unravel a novel function of Nrf2 in wound repair and suggest the use of NRF2-activating comp

151 dinate the cytoskeletal changes required for wound repair and the concomitant activation of innate im

152 o cell adhesion regulation during intestinal wound repair and the development of IBD.

153 of Rho and Cdc42 zones during Xenopus oocyte wound repair and the role played by Abr, a dual guanine

154 ellate cells (HSCs) are critical for hepatic wound repair and tissue remodeling.

155 n, make it a promising substrate for corneal wound repair and tissue-engineering purposes.

156 Villin accumulates in the nucleus during wound repair, and altering the cellular microenvironment

157 keratinocyte growth factors, participate in wound repair, and are necessary for keratinocyte homeost

158 Angiogenesis is critical during development, wound repair, and cancer progression.

159 tein expression associated with endocytosis, wound repair, and cancer.

160 al cofactor ANKRD1 is sharply induced during wound repair, and its overexpression enhances healing.

161 drives tissue remodeling during development, wound repair, and metastatic invasion.

162 -1 may compensate for estrogen deficiency in wound repair, and potentially other contexts, is an impo

163 many aspects of metabolism, immune function, wound repair, and protection of multiple organ systems.

164 helial cells is essential for morphogenesis, wound repair, and the spread of many cancers, yet how in

165 ellular matrix during embryonic development, wound repair, and tumor invasion.

166 Resolution of intestinal inflammation and wound repair are active processes that mediate epithelia

167 The roles of other ROS in wound repair are little explored.

168 w this interaction influences the process of wound repair are not well understood.

169 in response to injury, but its functions in wound repair are unknown.

170 g cells to undergo mitosis is detrimental to wound repair as the adult fly epithelium accumulates DNA

171 mportant factors that can accelerate gastric wound repair as well as contribute to epithelial homeost

172 ms of corneal epithelial lesions and delayed wound repair, as well as their association with diabetes

173 re susceptible to DSS, and exhibited delayed wound repair at both the clinical and histologic levels.

174 Macrophages are important components of wound repair, both in fending off infection and in coord

175 rectly promotes mast cell activation and ASM wound repair but indirectly promotes ASM contraction via

176 ion by Pavarotti is not specific to cellular wound repair but is also used in normal development.

177 They are essential for wound repair, but also interfere with axonal regrowth.

178 In fact, they stimulate airway epithelial wound repair, but no mechanistic insights are available.

179 ay important roles in tissue homeostasis and wound repair, but their role in UV radiation (UVR)-media

180 s a key factor that integrates the timing of wound repair by controlling cell migration.

181 intestinal epithelial cells to RvE1 promoted wound repair by increasing cellular proliferation and mi

182 In response to damage, epithelial wounds repair by a series of events that integrate epith

183 nate cells necessary for pathogen control or wound repair can occur without recruitment of potentiall

184 Collective cell migration is a hallmark of wound repair, cancer invasion and metastasis, immune res

185 Myofibroblasts are a key cell type in wound repair, cardiovascular disease, and fibrosis and i

186 vestment in one aspect of personal immunity (wound repair) causes a temporary decrease in one aspect

187 lls, and these ANXA1-containing EVs activate wound repair circuits.

188 16 patients needed primary wound repair due to the leakage in insertion sites befor

189 During wound repair, epidermal cells at the edge of an injury e

190 ns (e.g., drug delivery, tissue engineering, wound repair, etc.) through judicious selection of the m

191 in normal intestinal homeostasis and during wound repair following mucosal injury.

192 ptional program is critical during cutaneous wound repair for the regulation of scar size; however, t

193 appaB pathway in the localized activation of wound repair genes around epidermal breaks.

194 identify microRNAs negatively impacting the wound repair, global miRNA profiling of wounds collected

195 n outside their niche, either in vitro or in wound-repair, hair follicle stem cells dynamically remod

196 l migration and proliferation during mucosal wound repair has not been explored.

197 and cancer metastasis; therefore, embryonic wound repair has received considerable attention as a mo

198 airway epithelium plays an important role in wound repair, host defense and is involved in the immuno

199 r of innate physiologic processes, including wound repair, immune response, coagulation and complemen

200 provides a unique ex vivo model for studying wound repair in a clinically relevant setting.

201 tial stem cell niche component that promotes wound repair in adipose, muscle, and lung tissues.

202 how that locally administered IGF-1 promotes wound repair in an estrogen-deprived animal model, the o

203 tin is required and sufficient for increased wound repair in an in vitro model of lung injury.

204 it to probe the dynamics of inflammation and wound repair in complex tissue damage.

205 or the regulation of excess inflammation and wound repair in diabetes.

206 ction of medial actomyosin structures during wound repair in early embryos involves disassembly of th

207 vel therapeutic target to enhance intestinal wound repair in inflammatory bowel diseases.

208 either intracellular Ca(2+) mobilization or wound repair in living tissues.

209 gator tails identifies a distinct pattern of wound repair in mammals while exhibiting features in com

210 the complex, multireceptor-driven process of wound repair in mice in a GEF-dependent manner.

211 ronment on primary keratinocyte function and wound repair in mice.

212 ronment on primary keratinocyte function and wound repair in mice.

213 , apocrine glands, and sebaceous glands) for wound repair in model animals, the present study was des

214 actin and myosin dynamics during single-cell wound repair in the Drosophila embryo.

215 --contributes to the increased efficiency of wound repair in the early embryo.

216 pha1 in Ca(2+) influx-mediated signaling and wound repair in the endothelium.

217 te the mechanisms of force generation during wound repair in the epidermis of early and late Drosophi

218 he cytoskeleton machinery during single cell wound repair in the genetically amenable Drosophila embr

219 nment, yet the signaling pathways initiating wound repair in vivo remain little understood.

220 interactions using DETC TCR tetramers delays wound repair in vivo, highlighting DETC as rapid respond

221 ithelialized faster in the first few days of wound repair in vivo.

222 t to recombinant CD44 or TLR2,4, and altered wound repair in wild-type but not RHAMM(-/-) mice.

223 istic of Type 2 immunity (e.g., fibrosis and wound repair) in Chlamydia-infected tissue.

224 TPase activity were analyzed during cellular wound repair, in which arrays close in association with

225 ilencing of Doux-1 improved the rate of cell wound repair induced by CSE treatment.

226 ole of adult skin stem cells in homeostasis, wound repair, inflammation, and cancer.

227 itical step of normal embryonic development, wound repair, inflammatory response, and tumor cell meta

228 Epithelial cell migration during wound repair involves a complex interplay of intracellul

229 Wound repair is a fundamental, conserved mechanism for m

230 Wound repair is a key feature distinguishing living from

231 Wound repair is controlled temporally and spatially to r

232 Mucosal wound repair is coordinated by dynamic crosstalk between

233 Efficient wound repair is critical to reestablish the mucosal barr

234 Thus, in zebrafish larvae, wound repair is driven by an autoregulatory circuit that

235 Embryonic wound repair is driven by the evolutionary conserved red

236 Skin wound repair is essential to restore barrier function an

237 versus pathogenic microbial interactions in wound repair is important.

238 We show that WDR26-mediated inhibition of wound repair is mediated through the inhibition of Rac f

239 k between epithelial and immune cells during wound repair is necessary for development of better pro-

240 tworks in generating mechanical force during wound repair is not well understood.

241 Wound repair is often associated with an accumulation of

242 Gastrointestinal mucosal wound repair is orchestrated by a series of spatial and

243 y due to enhanced viral spread and decreased wound repair, is likely involved.

244 etermining the variable outcome of mammalian wound repair, little is known about the modulation of im

245 ERK, or JNK pathways alone fail to activate wound repair loci.

246 rties desirable for a corneal stromal defect wound repair matrix that could be applied without the ne

247 As such, cells have a robust wound repair mechanism comprised of dynamic membrane res

248 cytoskeletal networks are reorganized during wound repair: microtubules extend into protrusions and a

249 ine stimulation was evaluated in an in vitro wound repair model and T cell-mediated cytotoxicity expe

250 how that in the Drosophila melanogaster cell wound repair model Rho GTPase arrays form in response to

251 In a model of excisional skin wound repair, Nbeal2-deficient mice exhibited impaired d

252 microvesicles and exosomes; plasma membrane wound repair; neuron pruning; extraction of defective nu

253 oV pathogenesis, we have identified that the wound repair pathway, controlled by the epidermal growth

254 ge-activated signaling pathways to promote a wound repair phenotype.

255 upregulated during the inflammatory phase of wound repair, predominantly expressed in epidermal kerat

256 ood that endogenous IGF-1 is involved in the wound repair process, the effects of exogenous IGF-1 adm

257 le containing byproducts associated with the wound repair process.

258 bleweed and Pebble are required for the cell wound repair process.

259 re involved in virtually every aspect of the wound repair process; however, the impact of commensal m

260 demonstrate that STING signaling facilitates wound repair processes and that analogous to MyD88-defic

261 beta2AR antagonism promoted wound repair processes in the early stages of wound repa

262 says were used to assess calcium signalling, wound repair, proliferation, apoptosis and contraction.

263 effects of exogenous IGF-1 administration on wound repair remain largely unclear.

264 n implicated in both conditions, its role in wound repair remains unclear.

265 chanism by which Amphiregulin contributes to wound repair remains unknown.

266 Thrombin plays a key role in wound repair, remodeling, and fibrosis after injury and

267 Skin wound repair requires a coordinated program of epithelia

268 Skin wound repair requires complex and highly coordinated int

269 Our results show that single-cell wound repair requires specific spatial and temporal cyto

270 The process of wound repair requires the coordinated participation of m

271 The cell wound repair response is an example of how specific path

272 and human skin and is an important part of a wound repair response.

273 ound repair processes in the early stages of wound repair, revealing a possible new avenue for therap

274 ut wounding methods has hindered single-cell wound repair studies.

275 ctors inducing greater bone regeneration and wound repair than wild-type growth factors, as well as r

276 One key component of wound repair that is often overlooked is mechanical forc

277 idelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled grow

278 nd Lpar1(-/-) mice display defective mucosal wound repair that requires cell proliferation and migrat

279 F), a cytokine, is known to be important for wound repair, the cellular and molecular mechanisms of S

280 the role of each cell type in the process of wound repair, the nature of the dynamic interplay betwee

281 efficient fibrin clearance can impede normal wound repair, the precise contribution of fibrin to bone

282 is known about the complex nature of gastric wound repair, the stepwise process that characterizes ep

283 cells contribute to tissue regeneration and wound repair through cellular programs that can be hijac

284 conditions including embryonic development, wound repair, tumor growth and metastasis.

285 Unfortunately for mammals, wound repair typically results in scarring and nonfuncti

286 rly stages of skin development and modulates wound repair upon injury.

287 ked whether TLR9 is important for intestinal wound repair using a dextran sulfate sodium (DSS)-induce

288 udy, we evaluate the dynamics of periodontal wound repair using micro-computed tomography (microCT) a

289 Ptgs2(-/-) mice had defects in wound repair, validating the biopsy technique as a syste

290 reveal that dermal adipocytes regulate skin wound repair via release of fatty acids that promote mac

291 ent lipid signaling that facilitates mucosal wound repair via spatial targeting of distinct PLC-betas

292 was found that MSCs promote lung epithelial wound repair via the transfer of functional mitochondria

293 f HC on AC activity and plasma membrane (PM) wound repair was measured in AEC type 1 exposed to normo

294 tification, keratinocyte differentiation and wound repair, was increased, whereas the Hh pathway was

295 show that lineage plasticity is critical in wound repair, where it operates transiently to redirect

296 cal treatment of mice with TIP39 accelerated wound repair, whereas TIP39-deficient mice had delayed r

297 fundamental mechanisms of fetal regenerative wound repair, which has the potential to provide insight

298 e demonstrated defects in intestinal mucosal wound repair, while systemic administration of ANXA1 pro

299 Acute and focal injuries trigger wound repair with tissue replacement.

300 ution of macrophages to helminth killing and wound repair, with specific attention paid to distinct c