ライフサイエンスコーパス: wounded

1 y or when an intact epithelial cell sheet is wounded.

2 ls increase when the local recipient skin is wounded.

3 thelial monolayers undergo self-healing when wounded.

4 romal thickness was 23% lower in the chronic wounded (277+/-15 microm) compared with the unwounded (3

5 lts in reduced proliferation in neonatal and wounded adult epidermis.

6 In wounded adult skin, the initial wave of dermal repair is

7 ssue relative to unwounded fetal controls or wounded adult skin.

8 These studies also demonstrated that the wounded alfalfa seedling infection model is a useful too

9 es from amniotic fluid were recruited to the wounded amnion where macrophage adhesion molecules were

10 When skin is wounded, an unknown Ag is expressed on damaged keratinoc

11 violence against health care: 677 (72%) were wounded and 261 (28%) were killed.

12 SV40-immortalized HCEC (THCE) monolayer was wounded and allowed to heal in the presence or absence o

13 Monolayers of transfected cells were scrape-wounded and assayed for their ability to migrate.

14 Cultured keratinocytes were scratch wounded and expression levels of the B2AR and catecholam

15 induced by wounding, further experiments on wounded and non-wounded leaf samples were carried out to

16 mpetitive RT-PCR, the mRNA for both genes in wounded and untreated tissue was quantified.

17 d substance P-positive nerve density in both wounded and unwounded eyes compared with vehicle-treated

18 stemic and maximizes at about 4-6 hr in both wounded and unwounded leaves, and then declines.

19 ncrease in PG activity in extracts from both wounded and unwounded leaves.

20 RNA sequencing analysis of 6,154 cells from wounded and unwounded mouse skin revealed that MCS-01 pr

21 evaluate neutral endopeptidase expression in wounded and unwounded skin as well as in cells derived f

22 al IFN-beta by LL37 required MAVS, and human wounded and/or psoriatic skin showed activation of MAVS-

23 erience, percentage of company killed, being wounded, and early age at enlistment), signs of lifetime

24 nd embryonic (day 17) chickens were excised, wounded, and placed on organ-culture rafts.

25 may have to deal with large numbers of ill, wounded, and probably contaminated people.

26 rimary cultures were established, monolayers wounded, and repair assessed (+/-) azithromycin (1 ug/mL

27 f care, is a humanitarian imperative for war wounded, and this paper reports the care in an Israeli d

28 acre (AOR, 10.63; 95% CI, 4.31-26.22), being wounded (AOR, 3.22; 95% CI, 0.95-10.89), and experiencin

29 12OH-JA-Ile and 12COOH-JA-Ile, accumulate in wounded Arabidopsis leaves in a COI1- and JAR1-dependent

30 PLDalpha, PLDbeta, and PLDgamma differed in wounded Arabidopsis leaves.

31 ent increases in levels of endogenous MDA in wounded Arabidopsis thaliana leaves, raising the possibi

32 iated stimulation of cell migration over the wounded area by altering the subcellular distribution of

33 cco transgene was rapid and localized in the wounded area following mechanical wounding.

34 vely to basal cells of the epithelium at the wounded area from 6 hours to 3 days after wounding.

35 ERF had impaired ability to migrate into the wounded area in a scratch assay, similar to cells treate

36 more MCM2-positive cells were present in the wounded area of the peripheral than of the central corne

37 cut edges of the epidermis migrate over the wounded area to re-epithelialize the wound.

38 The process of cell migration over the wounded area was associated with a significant increase

39 Twenty-four hours after injury, 50% of the wounded area was covered by new epithelium, whereas only

40 thelialization and stromal remodeling of the wounded area without the need for cadeveric donor cornea

41 gulating the fibrinolytic environment of the wounded area, as well as influencing events associated w

42 oliferation and migration of MPCs toward the wounded area.

43 s, and maintenance of the taste bud organ-in wounded areas of the tongue among animals treated with G

44 sclerotic complications favor the healing of wounded arteries, whereas the immobilization of CD31 ago

45 sues when seeds were exposed to MeJA or were wounded at the chalazal end of the seed.

46 mained unknown, but recent investigations in wounded balance epithelia have shown that proliferation

47 Conditioned medium from wounded but not intact IEC-6 monolayers resulted in incr

48 that heparin-binding proteins isolated from wounded, but not control, THCE-conditioned medium stimul

49 ce reconstituted with sex-mismatched BM were wounded by punch biopsy and incision.

50 rby canine kidney) confluent monolayers were wounded by scraping and examined by immunofluorescence f

51 ced skin barrier recovery in human epidermis wounded by tape stripping.

52 Control never wounded (C), chronic wounded with scrape the last week (

53 Wounded carrots can be promoted as an inexpensive rich s

54 ium, as well as in the tumor, but within the wounded cell layer little is known about the link betwee

55 NIMS images of phospholipids from a scratch-wounded cell monolayer were obtained.

56 ing a cell layer was determined by comparing wounded cells as described above with a cell layer margi

57 omyosin networks at the medial cortex of the wounded cells contribute to rapid wound repair.

58 Immunofluorescence analysis of scratch-wounded cells reveals that P2X7 inhibition results in an

59 Wounded cells such as Xenopus oocytes respond to damage

60 red to repair lesions formed in mechanically wounded cells.

61 erine residues in an ERK-dependent manner in wounded cells.

62 Explant cultures were wounded centrally with a trephine and maintained for up

63 1 was reduced in lysates of constitutive and wounded CLIC4(NULL) skin.

64 ly, localized microinjection of PMN-MPs into wounded colonic mucosa was sufficient to impair epitheli

65 cing pathogenic bacteria under the intact or wounded conditions.

66 stry was performed on nonconfluent or scrape-wounded confluent HCFs.

67 erentiated features in regenerating cells of wounded, confluent cultures.

68 the F-actin belt seen at the leading edge in wounded control cells.

69 chitosan scaffolds containing control DNA or wounded controls.

70 ular thin collagen fibers are present in the wounded cornea during the early phases of wound healing.

71 Isolated spleen NK cells migrated to the wounded cornea, and this migration was reduced by greate

72 In immunofluorescence studies of wounded cornea, p-p38, unlike p-ERK1/2, was immediately

73 understanding leukocyte migration within the wounded cornea.

74 feres with the normal reepithelialization of wounded cornea.

75 ve rise to fibroblasts and myofibroblasts in wounded cornea.

76 ype levels and increased CXCL1 production by wounded corneal explants >2-fold.

77 Furthermore in scrape-wounded corneal fibroblasts, ZO-1 was localized to nucle

78 Cells from the wounded corneal groups had significantly increased capac

79 PAO1 or 19660, deficient in ETA, adhered to wounded corneal tissue and initiated ocular disease simi

80 Chronic wounded corneas developed marked epithelial hyperplasia

81 Wounded corneas maintained in organ culture were examine

82 s CNTF accelerated nerve regeneration in the wounded corneas of diabetic mice and healthy animals, in

83 nical disruption of the basement membrane in wounded corneas prompted an increase in the abundance of

84 Lum-/- -wounded corneas showed delayed healing, reduced recruitm

85 EGFR activation slows epithelial migration, wounded corneas were allowed to heal in organ culture in

86 Gene expression patterns in normal and wounded corneas were surveyed with array-based quantitat

87 -13 mRNA was detected in epithelial cells of wounded corneas, but not in normal controls; MMP-14 was

88 In wounded corneas, diabetes markedly delayed sensory nerve

89 In cells from scrape- and freeze-wounded corneas, however, the fenamate-activated current

90 at diabetes reduces DC populations in UW and wounded corneas, resulting in decreased CNTF and impaire

91 In epithelial cells from heptanol-wounded corneas, these conductances were generally uncha

92 model of light-scattering haze formation in wounded corneas, which will improve the design of studie

93 ted with TGF-beta, normal ocular tissues and wounded corneas.

94 in the basal epithelial cells in normal and wounded corneas.

95 ) and collagenase III (MMP-13) in normal and wounded corneas.

96 ontrols; MMP-14 was found in both normal and wounded corneas.

97 revented neutrophil infiltration in diabetic wounded corneas.

98 proximal and distal cell zones in minimally wounded cotyledons and further enhanced in wounded tissu

99 imulated the migration of primary cells in a wounded-culture model as well as in a transwell migratio

100 Media transfer experiments (from wounded cultures to unwounded cultures) confirmed the ex

101 Wounded cultures were then incubated for time periods up

102 actor-A (VEGF-A) is strongly up-regulated in wounded cutaneous tissue and promotes repair-associated

103 blasts) and collagen deposition in skin from wounded CX3CR1 KO mice, as well as reduced neovasculariz

104 Increased accumulation of JA-Ile in wounded cyp94b3 leaves was associated with enhanced expr

105 cts of FBG on migration and proliferation of wounded dermal fibroblasts were investigated.

106 ded skin and the signal was localized to the wounded dermis, the site of scarless repair.

107 te to the upregulation of CD26 expression in wounded dermis.

108 ell subsets including RORgamma(+) ILC3s into wounded dermis; RORgamma(+) ILC3s are potent sources of

109 However, when stressed or wounded, diatoms can produce oxylipin molecules known to

110 acellular stromal layers between chronically wounded dogs and dogs with SCCED may be of relevance to

111 l changes are similar between experimentally wounded dogs and dogs with SCCED.

112 Experimentally wounded dogs did not form the superficial hyaline acellu

113 acellular zone that forms in experimentally wounded dogs is distinct from the hyaline lamina observe

114 We used wounded Drosophila embryos to define an evolutionarily c

115 es the resealing of primary skin fibroblasts wounded during the contraction of collagen matrices.

116 increased and prolonged TGF-beta 3 levels in wounded E16 animals correlated with organized collagen d

117 creased and delayed TGF-beta 3 expression in wounded E19 animals correlated with disorganized collage

118 dicate that the collagen organization of the wounded embryonic cornea recapitulate the native macrost

119 e three-dimensional collagen architecture of wounded embryonic corneas, whilst identifying temporal a

120 These wounded epidermal models can now be applied in therapeut

121 al cells and Jun kinase is phosphorylated in wounded epidermal tissues, suggesting that the JUN N-ter

122 vates inflammatory cytokines, was reduced in wounded epidermis from Smad7 tg mice compared to that in

123 adult mice, persistent Cx26 expression kept wounded epidermis in a hyperproliferative state, blocked

124 nd restoration of cell-cell junctions of the wounded epidermis.

125 The repair of wounded epithelia is primarily driven by the cells borde

126 stic pathogen Pseudomonas aeruginosa targets wounded epithelial barriers, but the cellular alteration

127 xperiments monitoring the healing process of wounded epithelial monolayers have demonstrated the nece

128 act as leader cells to direct movement of a wounded epithelium through a three-dimensional (3D) extr

129 gradients have recently been reported in the wounded epithelium, as well as in the tumor, but within

130 Accordingly, in a scratch-wounded epithelium, TGFbeta provokes cilium loss exclusi

131 and rapidly increased during regeneration of wounded epithelium.

132 Although wounded fbln5(-/-) skin showed enhanced neovascularizati

133 GF-beta regulation, we narrowed our study to wounded fetal animals.

134 HOXB13 expression was decreased in wounded fetal tissue relative to unwounded fetal control

135 this observation, TG2 activity in a freshly wounded fibroblast culture depends upon the redox potent

136 g edge of lamellipodia, especially in motile wounded fibroblasts and in freshly plated fibroblasts, b

137 lial cell sheets, they fail to capture how a wounded fibrous tissue rebuilds its 3D architecture.

138 lies downstream of hydrogen peroxide in the wounded fish and triggers depletion of inflammatory macr

139 ome-wide expression profiles in infected and wounded flies at each age for 12 of these lines.

140 ation in hyphal tips and lesion expansion on wounded hosts, but significantly promoted germ tube elon

141 ased in migrating airway epithelial cells in wounded human and mouse trachea.

142 alization was apparent by 12 h, however, the wounded human bilayered skin substitute was healed by da

143 sitive, human dermal fibroblasts, and scrape-wounded human dermal fibroblasts demonstrated the presen

144 aclitaxel-treated zebrafish skin and scratch-wounded human keratinocytes (HEK001) display reduced hea

145 ase in hBD-3 transcription in experimentally wounded human skin (P = .003).

146 ype was linked to the behavior of normal and wounded human skin equivalents (HSE) by comparing human

147 of neutral endopeptidase in normal skin and wounded human skin, however, has not been examined.

148 the role of eccrine glands in the repair of wounded human skin.

149 in 192 samples of healthy and experimentally wounded human skin.

150 Using experimentally wounded human T24 bladder epithelial cell monolayers as

151 When skin is wounded, human keratinocytes at the wound edge stop diff

152 We found that PMA treatment of wounded IEC monolayers resulted in 5.8+/-0.7-fold increa

153 , the tension did not decrease if cells were wounded in a low Ca(2+) Ringer's solution that inhibited

154 fghanistan, 52,087 service members have been wounded in combat.

155 of critically injured US military personnel wounded in Iraq or Afghanistan from February 1, 2002 to

156 hese measurements show that, for fibroblasts wounded in normal Ca(2+) Ringer's solution, the membrane

157 ) is released extracellularly when cells are wounded in the presence of Ca(2+).

158 After diabetic mice were wounded in the right eye and treated in both eyes with P

159 odel in which fibrin was added to the top of wounded keratinocyte monolayers grown on collagen.

160 In wounded keratinocytes, B2AR-binding affinity remained de

161 When skin is wounded, keratinocytes from the cut edges of the epiderm

162 When assimilate movement from a wounded leaf is blocked or the direction of assimilate m

163 ding, further experiments on wounded and non-wounded leaf samples were carried out to investigate the

164 in specific leaves that are remote from the wounded leaf.

165 als from plants that are synthesized both in wounded leaves and in distal, unwounded leaves in respon

166 can colonize and develop necrotic lesions on wounded leaves and stems.

167 of GOX or hydrogen peroxide to mechanically wounded leaves confirm these findings.

168 dulin-binding nuclear proteins isolated from wounded leaves exhibit specific CGCG box DNA binding act

169 cies containing OPDA-OPDA and OPDA-dnOPDA in wounded leaves is consistent with these lipids being the

170 Wounded leaves show faster, more extensive STB, suggesti

171 Metabolite analysis of wounded leaves showed that loss of CYP94B3 function in c

172 ous systemin, and reduced JA accumulation in wounded leaves to approximately 57% of wild-type (WT) le

173 e visualized patterns of mitotic activity in wounded leaves which suggest a role for cell division in

174 show that ACRE276 is transiently induced in wounded leaves within 15 min, but upon Avr9 elicitor tre

175 ) in undamaged responding leaves, but not in wounded leaves, and was largely dependent on the JA-conj

176 increased in pea chloroplasts isolated from wounded leaves, indicating that the induction in promote

177 itored as a function of time in mechanically wounded leaves.

178 ide synthase (AOS) or hydroperoxide lyase in wounded leaves.

179 d in roots and tuber periderm, as well as in wounded leaves.

180 ry fat pads of BALB/c mice, and animals were wounded locally by full thickness dermal incisions above

181 ed in untreated, healthy potato organs or in wounded mature leaves.

182 the speed and directionality of migration in wounded MCF10A breast epithelial monolayers, whereas ove

183 +) flux into the target cell that triggers a wounded membrane repair response in which lysosomes and

184 The Ca(2+) flux triggers a wounded membrane-repair response in which internal vesic

185 Twenty-four hours later, wounded mice received a single injection of BrdU.

186 Our results show that L(1p)T-FH applied to wounded mice significantly improved the expression of th

187 th recent prevalence and higher frequency in wounded military personnel.

188 ectacular distal leaf collapse phase seen in wounded Mimosa pudica We genetically link electrical sig

189 y origin of the large leaf movements seen in wounded Mimosa.

190 RUNX2-dependent vascular remodeling in an EC wounded monolayer assay, which is reversed by specific A

191 e capacity of cultured cells to repopulate a wounded monolayer is markedly accelerated by ShcD in an

192 ected cells were incapable of migration in a wounded monolayer model, and this effect was associated

193 PDL cell wounded monolayers also were treated in EMD coated tissu

194 Wounded monolayers and cells in subconfluent cultures se

195 found that EGF accelerated repair of scrape-wounded monolayers and that the EGFR-selective inhibitor

196 riggered MTOC reorientation in serum-starved wounded monolayers of 3T3 fibroblasts.

197 In wounded monolayers of the intestinal epithelial cell lin

198 Media from wounded monolayers stimulated cyclooxygenase-2 expressio

199 In wounded monolayers, phosphorylation was enhanced at the

200 OPG proteins were detected in unwounded and wounded mouse corneas by immunocytochemistry.

201 en CD11b, in unwounded and epithelial scrape-wounded mouse corneas.

202 Syndecan-1 extracted from wounded mouse skin also displayed an increase in dermata

203 chemically conjugated to FHs and applied to wounded mSMGs in vivo, formed new organized salivary tis

204 In contrast, wounded mSMGs treated with FHs alone or in the absence o

205 recruitment in regenerating and also needle wounded muscle in dysferlin-deficient mice.

206 xpression could be observed in both aged and wounded mutant tissues.

207 it a hyperproliferative phenotype similar to wounded native skin.

208 e microtubule cytoskeleton during healing of wounded NIH3T3 cell monolayers.

209 gistical challenges of providing care to the wounded of this impoverished nation.

210 Oxylipin signatures of wounded opr3 leaves revealed the absence of detectable 3

211 spond to elevated ethylene biosynthesis from wounded or auxin-treated leaves, and there are likely ad

212 proteins fibronectin and fibrinogen found in wounded or inflamed vessels support flow-induced PAK and

213 remained significant after control for being wounded or injured.

214 SV40-immortalized HCECs were wounded or stimulated with ATP and LPA.

215 0.2% FBS and subsequently were either scrape wounded or treated with 10% FBS, PDGF, or FGF-2 for 6 ho

216 The wounded PDL, GF, and MG-63 cell monolayers were treated

217 ilament bundles were visible in cells of the wounded periderm within 12 h after wounding.

218 Wounded pho1 leaves hyperaccumulated JA/JA-isoleucine in

219 eria isolated from larval oral secretions to wounded plants confirmed that three microbial symbionts

220 that AOS expression is limiting JA levels in wounded plants, but that the AOS hydroperoxide substrate

221 th co-localized and co-immunoprecipitated in wounded primary airway epithelial cultures.

222 tidylinositol-(PI)3 kinase is upregulated in wounded rabbit corneal epithelia.

223 For the in vitro experiments, wounded rabbit corneas were maintained in organ culture.

224 Furthermore, we found that wounded rat ATII cells exhibited decreased ASK1 phosphor

225 tures, normal animal eyes, and excimer laser wounded rat corneas were examined by Western blot.

226 h diffusion of mesenchymal stem cells to the wounded region and their subsequent differentiation.

227 and the maximum distance they migrated into wounded regions was significantly decreased by bacterial

228 When skin is wounded, resident cells encounter serum for the first ti

229 ium revealed an acute stress reaction of the wounded RHE (wRHE) in the first days after wounding.

230 When cells are ablated rather than wounded, Rho GTPase activation and F-actin accumulation

231 On wounded RMEC monolayers, EPCs showed clustering at the w

232 wounding or the application of glutamate to wounded roots was sufficient to trigger root-to-shoot Ca

233 linical need exists for 63% to 65% of combat-wounded service members and 11% to 20% of civilians who

234 rticipated in the early use of penicillin in wounded servicemen during World War II.

235 A precursors) could translocate axially from wounded shoots to unwounded roots in a LOX2-dependent ma

236 ith T. cruzi trypomastigotes are transiently wounded, show increased levels of endocytosis, and becom

237 they respond by developing tumors along the wounded site.

238 e insect-derived elicitor, at a mechanically wounded site.

239 ymes can inadvertently serve as reporters of wounded sites and constitute an "Achilles heel," allowin

240 ematodes by rapidly sending signals from the wounded sites to the whole plant.

241 nerve growth factor (NGF) also increased in wounded skin and increased CGRP in cultured adult dorsal

242 on pattern of type VI collagen in normal and wounded skin and investigated its specific function in n

243 integrated those findings with datasets from wounded skin and our transcriptomic data on cuSCC using

244 ally, expression of collagenase-1 in ex vivo wounded skin and re-epithelialization of partial thickne

245 Tregs in wounded skin attenuated IFN-gamma production and proinfl

246 We examined the localization of CLP in wounded skin by immunohistochemistry and found an upregu

247 Additionally, wounded skin from Smad7 tg mice exhibited accelerated re

248 orally induced Smad7 transgene expression in wounded skin in gene-switch-Smad7 transgenic (Smad7 tg)

249 However, in wounded skin in vivo, null keratinocytes rupture as they

250 crease in hBD-1 and hBD-3 mRNA expression in wounded skin increased the odds of persistent carriage b

251 Wounded skin models were inoculated with bacteria and le

252 kinetics of neutrophil infiltration into the wounded skin over extended durations.

253 Replacement of wounded skin requires the initially florid cellular resp

254 sted 3-dimensional reconstruction of in vivo wounded skin samples.

255 or TGF-beta1 were greatly reduced in GF mice wounded skin when compared with CV mice.

256 s in common between acutely UV-exposed skin, wounded skin, and cuSCC tumors, might enable us to ident

257 ls in the developing and hypoxic retina, the wounded skin, and tumor tissue, and is detected at conta

258 sed in sensory ganglia that projected to the wounded skin, but not in ganglia that projected to unwou

259 reduced Treg accumulation and activation in wounded skin, delayed wound closure, and increased proin

260 d that norepinephrine was present in freshly wounded skin, thus providing a potential mechanism for i

261 Hypoxia is a microenvironmental stress in wounded skin, where it supports wound healing by promoti

262 s to profile gene expression in infected and wounded skin.

263 ecreased tensile strength of both normal and wounded skin.

264 s or strain between wild-type and fbln5(-/-) wounded skin.

265 ting 1 day before vaccinia virus exposure to wounded skin.

266 at sites where epithelium is disrupted (e.g. wounded skin/bronchial epithelia) and where T cells freq

267 have one of the poorest visual outcomes for wounded soldiers, often resulting in blindness due to th

268 ving millions of doses of horse antitoxin to wounded soldiers.

269 n Management Task Force to optimize care for wounded soldiers; Musculoskeletal Action Plan for injury

270 rmediate filament protein rapidly induced in wounded stratified epithelia, regulates cell growth thro

271 Epithelium-derived cells were present in the wounded stroma 1 month after surgery.

272 Reduced Smad2 activation was observed in wounded stroma from Smad7 transgenic (Smad7 tg) mice, po

273 e tissue capsule that promote closure of the wounded stumps and prevent axon elongation.

274 ssessed by isolation of secreted HB-EGF from wounded THCE cells and by measuring the release of alkal

275 When a leaf of this mutant was wounded, the JA reporter gene was expressed in distal le

276 ncovers unknown effects of RT delivered on a wounded tissue and prompts to the use of anti-EGFR treat

277 structural and functional properties of the wounded tissue are restored to the levels before injury.

278 n organs so that locally reduced growth in a wounded tissue is balanced by appropriate growth elsewhe

279 messenger RNA expression was upregulated in wounded tissue of both Adm(AM+/+) and Adm(AM+/Delta) mic

280 ed by wound margin cells, rather than by the wounded tissue per se, and that it diffuses away from th

281 sis is essential for normal organ growth and wounded tissue repair but it may also be induced by tumo

282 infect plants; however, they could colonize wounded tissue.

283 sequent initiation of a successful repair of wounded tissue.

284 roblast migration and collagen deposition in wounded tissue.

285 the differences in the communication between wounded tissues and healthy, tumor-conditioned, and froz

286 Among the genes upregulated in wounded tissues are tumor necrosis factor-alpha (TNFalph

287 However, in wounded tissues overexpressing a flax AOS, levels of JA

288 bility to deliver angiogenesis regulators to wounded tissues.

289 y wounded cotyledons and further enhanced in wounded tissues.

290 When cells were wounded twice in normal Ca(2+) Ringer's solution, decrea

291 When cells are wounded twice, the subsequent resealing is generally fas

292 al care to manage polytrauma, critically ill-wounded warriors from the greater war on terrorism has b

293 ermis from Smad7 tg mice compared to that in wounded wild-type epidermis.

294 In comparison with wounded wild-type mouse skin, Smad4-deficient wounds had

295 n different concentrations of TGF-beta1 were wounded with a razor blade, and the wound area and time

296 Control never wounded (C), chronic wounded with scrape the last week (W), and chronic wound

297 d with scrape the last week (W), and chronic wounded without scrape the last week (WW) corneas were p

298 leaf on a young poplar tree is mechanically wounded, wound-induced (win) mRNAs are detected in the u

299 Here we study membrane dynamics in wounded Xenopus laevis oocytes at high spatiotemporal re

300 Here, we studied active RhoA and Cdc42 in wounded Xenopus oocytes, which assemble and close a dyna

301 We investigated this by live imaging in wounded zebrafish larvae, where damage of the fin tissue