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3 term metabolic function of microencapsulated xenogeneic adult porcine islets (API) was assessed in a
5 When rejection occurred on days 4 and 8 in xenogeneic and allogeneic recipients, 60% (57-68) and 55
11 possibility of imaging inflammation in both xenogeneic and syngeneic tumor models, which resulted in
12 find that cardiac fibroblasts that express a xenogeneic antigen can be effectively targeted and ablat
13 We estimated the decrease in expression of a xenogeneic antigen, Galalpha1-3Gal, which might be neede
15 ursor experiments have been carried out in a xenogeneic background in order to utilize species-specif
16 licited immune response of healthy dogs to a xenogeneic BAL was blocked and BAL performance significa
18 wo strategies to induce tolerance across the xenogeneic barrier, namely thymus transplantation and mi
21 ial, but also to understanding the nature of xenogeneic barriers and mechanisms of heterochronicity,
23 e transplant tolerance across allogeneic and xenogeneic barriers, and to support long-term thymopoies
28 nts of antigenicity in a clinically relevant xenogeneic biomaterial (i.e. BP) and further validates a
30 nction has important implications for use of xenogeneic biomaterials, particularly in vascular applic
31 onstrate that anti-CD40L in combination with xenogeneic BMT can tolerize preexisting peripheral and i
37 une response against the therapeutic and the xenogeneic carbohydrate galactose-alpha1-3-galactose, an
40 on of KO mice with pig kidney membranes (ie, xenogeneic cell membranes expressing an abundance of alp
41 s play an important role in the rejection of xenogeneic cells and therefore represent a major obstacl
43 contributes significantly to phagocytosis of xenogeneic cells by macrophages and suggest that genetic
45 recent years, hepatic support systems using xenogeneic cells have been developed to support patients
46 nsplantation of a bioartificial adrenal with xenogeneic cells may be a treatment option for patients
51 ly high precursor frequency was detected for xenogeneic cellular responses in the rat anti-mouse comb
54 y xenogeneic chimeras (rat --> mouse), mixed xenogeneic chimeras exhibit superior immunocompetence fo
56 We have previously demonstrated that mixed xenogeneic chimerism and donor-specific T-cell tolerance
57 e ability of anti-CD40L mAb to promote mixed xenogeneic chimerism and donor-specific tolerance in B6
60 lability of human adrenal glands, sources of xenogeneic chromaffin cells will need to be identified i
66 e purpose of this study is to determine if a xenogeneic collagen matrix (CM) might be as effective as
68 of inducing tolerance in a highly disparate xenogeneic combination and may have clinical potential t
69 lity has not been demonstrated in discordant xenogeneic combinations because of the difficulty in ach
70 ion in a pig-to-human model also reduces the xenogeneic consumption of human platelets by the porcine
71 the effect that these modifications have on xenogeneic consumption of human platelets in the absence
72 human CD19(+) B-lineage cells purified from xenogeneic cord blood stem cell/MS-5 murine stromal cell
73 We wished to determine the extent to which xenogeneic cornea fragments placed in the eyes of normal
78 man CD19(+) cells developing in human/murine xenogeneic cultures show differential expression of the
81 stems, ubiquitous defense mechanisms against xenogeneic DNA that hinder the use of genetic approaches
82 ght to improve on this strategy by combining xenogeneic DNA vaccination with an agonist anti-glucocor
83 In contrast to allogeneic donor ECDI-SPs, xenogeneic donor ECDI-SPs induced production of xenodono
86 porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated.
87 he bacterial ClpCP protease is the target of xenogeneic (dys)regulation by a SPO1 phage-derived facto
91 tolerance in allogeneic and closely related xenogeneic (eg, rat-to-mouse) combinations, the ability
93 c, nude rats injected intraperitoneally with xenogeneic endothelial cells (ECs) produce antibodies ag
94 redox systems may provide a means to protect xenogeneic endothelial cells from NK cell-mediated cytot
95 erated from monocytes under the influence of xenogeneic endothelial cells in the absence of exogenous
98 f specific T cell receptor-Vbeta occurs in a xenogeneic environment in a predictable fashion parallel
102 l biological scaffolds made of allogeneic or xenogeneic extracellular matrix derived from non-autolog
103 ival 3 weeks after injection of syngeneic or xenogeneic ferumoxides-labeled stem cells (cardiac-deriv
104 r tumorigenesis, we selectively targeted the xenogeneic form of survivin, a survival protein overexpr
106 an embryonic stem (hES) cells in defined and xenogeneic-free conditions will contribute substantially
110 om biomolecules induced smaller and necrotic xenogeneic GB; spider venom activated the innate immune
113 of PBMC engraftment is development of acute xenogeneic graft- versus-host disease (GVHD) due to huma
115 t, in a preclinical humanized mouse model of xenogeneic graft-versus-host disease (GVHD), sGARP preve
116 onstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe
117 a-treated Treg in a humanized mouse model of xenogeneic graft-versus-host disease confirmed IFN-alpha
118 e induction of IFNgamma-secreting Tregs in a xenogeneic graft-versus-host disease model and in adopti
119 T cells and complete rescue from hyperacute xenogeneic graft-versus-host disease modeling early and
120 ls mediated tumor rejection without inducing xenogeneic graft-versus-host disease, thus resulting in
121 generated Tregs that consistently suppressed xenogeneic graft-vs-host disease in immunodeficient mice
122 munosuppression by human Tregs in a model of xenogeneic graft-vs.-host disease induced by the transfe
125 d could influence the findings; for example, xenogeneic grafts may not recognize host inhibitory sign
126 nd residual host immune function against the xenogeneic grafts results in defective development and m
127 to enhance the recruitment of host huTreg to xenogeneic grafts to regulate cell-mediated xenograft re
131 R gene also conferred resistance to DEX in a xenogeneic GVHD model in sublethally irradiated NOD-scid
137 Murine complement is capable of resisting xenogeneic hematopoietic engraftment through an antibody
139 osuppression allows long-term functioning of xenogeneic hepatocyte retransplants and suggests that he
140 tocytes might address this problem; however, xenogeneic hepatocytes are thought to be functionally in
144 e-specific autoimmunity was seen only when a xenogeneic homolog of PAP was used as the immunogen.
149 hibiting allogeneic pig T cell responses and xenogeneic human anti-pig T cell responses in vitro.
152 ostimulatory pathways block the rejection of xenogeneic human embryonic-stem-cell-derived pancreatic
155 fficient zygote genome editing technologies, xenogeneic human pluripotent stem cells may also open ne
156 We conclude that porcine Kupffer cells bind xenogeneic human RBC by recognition of a carbohydrate ep
158 is a murine T cell clone that recognizes the xenogeneic (human) class I MHC HLA-A2.1 molecule (A2) an
159 f primary GalT-KO skin grafts led to an anti-xenogeneic humoral response with no evidence for sensiti
160 , we explore the transcriptome of individual xenogeneic hybrids of human mesenchymal stem cells and m
161 between cells of different organisms (i.e., xenogeneic hybrids) can occur, and for humans this may o
162 shows that conferred advantages are rare in xenogeneic hybrids, whereas risks of cellular dysregulat
166 not appear to differ in the nature of their xenogeneic immune response to the administered rabbit se
167 and exhibited similar levels of anti-rabbit xenogeneic immune response, the NZW mice had significant
170 tested this hypothesis in a human-into-mouse xenogeneic islet transplant model and validated the conc
172 nal requirements for tolerance induction for xenogeneic islet transplantation using donor ECDI-SPs.
175 nologic challenges facing transplantation of xenogeneic islets, and the concerns regarding transmissi
177 mechanisms of post-transplant proteinuria in xenogeneic kidney transplantation and a potential strate
180 is to investigate the effect of filling with xenogeneic material the postextractive sockets of two su
181 results suggest that indirect recognition of xenogeneic MHC antigen plays a predominant role in graft
184 survival of T cells positively selected by a xenogeneic MHC, as well as incomplete intrathymic deleti
185 ed decreased signal intensity not only for a xenogeneic mismatch in species but, surprisingly, also f
188 t efficiency have been explored in a primate xenogeneic model of in utero hematopoietic stem cell tra
189 the induction of tolerance in the discordant xenogeneic model of pig-to-rodent thymic transplantation
191 ive at impairing tumor development in murine xenogeneic model, activating the innate immune response
201 his study reports the establishment of fully xenogeneic mouse-->rat multilineage chimeras and evaluat
205 inocytes was developed four decades ago, the xenogeneic nature of that conventional CEA culture syste
206 further genetic modification of the pig, and xenogeneic NK cell recognition and activation may be inh
208 of JAM-C in homing of human B cells, using a xenogeneic nonobese diabetic/severe combined immunodefic
209 of T cells (and T cell subsets) after either xenogeneic or allogeneic activation in vitro or in vivo.
211 Immunization of mice with plasmids encoding xenogeneic orthologues of tumor differentiation antigens
213 uch as eptifibatide, interfere directly with xenogeneic PBPC-platelet interactions and may further am
217 prolong allogeneic islet graft survival and xenogeneic pig islet graft survival in diabetic NOD mice
218 prolongs allogeneic islet graft survival and xenogeneic pig islet graft survival in diabetic NOD mice
221 een with either allogeneic (rat-into-rat) or xenogeneic (pig-into-rat) transplants over 28 days, comp
223 d ASGR1 expression as well as ASGR1-mediated xenogeneic platelet phagocytosis in vitro and ex vivo on
225 tiated cell lines are capable of recognizing xenogeneic porcine aortic endothelial cells in a calcium
226 rge-animal model raises the possibility that xenogeneic porcine islet tissue will also survive in hum
228 CD4 T cells are specifically tolerant of the xenogeneic porcine thymus donor and the recipient, but a
231 he hypothesis that porcine sialoadhesin is a xenogeneic receptor that mediates porcine macrophage bin
233 ouse embryonic ovarian somatic cells to form xenogeneic reconstituted ovaries, which are cultured und
238 ever, the immunogenicity of cells expressing xenogeneic reporter constructs limits their survival and
242 uTreg) suppress CD4+ T cell-mediated antipig xenogeneic responses in vitro and might therefore be use
246 repared from monocytes ex vivo without using xenogeneic serum and may be used for immunotherapy.
249 standing of the mechanisms and importance of xenogeneic silencing and counter-silencing in the succes
252 ession of foreign DNA in a process known as 'xenogeneic silencing.' Counter-silencing by a variety of
254 opoietic engraftment across highly disparate xenogeneic species barriers poses a major obstacle to ex
256 ant in the rejection of solid organs in some xenogeneic species combinations, its role in the rejecti
258 This could present major limitations to xenogeneic stem cell transplantation as an approach to t
259 use of homologous stem cells, allogeneic or xenogeneic stem cells have been studied extensively in e
260 ated inflammatory reaction to allogeneic and xenogeneic stem cells may elicit a spectrum of effects,
270 Our results support the interpretation that xenogeneic thymic transplantation is a feasible strategy
271 normal mice usually remain healthy following xenogeneic thymic transplantation, thymus-grafted congen
276 t include alternative sources of islets (eg, xenogeneic tissue or human stem cells), extrahepatic sit
281 haracterize further the cellular response to xenogeneic tissues, we used the intracellular fluorescen
283 LIV in the mediastinum, suggesting that full xenogeneic tolerance was not achieved in euthymic mice.
284 t before syngeneic, suboptimal syngeneic, or xenogeneic transplant exhibited superior function compar
286 rent research efforts in both allogeneic and xenogeneic transplantation are presented and discussed.
287 ed from the islets of the pancreas can cross xenogeneic transplantation immune barriers, induce tissu
297 luenza virus type 1 (Sendai virus [SV]) as a xenogeneic vector to deliver the G glycoprotein of RSV.
299 linical efficacy of synthetic, allogeneic or xenogeneic vessels has been limited by thrombosis, rejec
300 llogeneic BALB/c or phylogenetically related xenogeneic WF rat stimulator cells while having undetect