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1 lf the chance that they are related to a non-yeast protein).
2 me (the subcellular distribution of all 6100 yeast proteins).
3 eric or tetrameric coiled-coil domain from a yeast protein.
4 rvation, essentiality, and connectivity of a yeast protein.
5 shows 48% identity and 64% similarity to the yeast protein.
6 that is 29% identical and 47% similar to the yeast protein.
7 ional as well as a structural homolog of the yeast protein.
8 residues, compared with 985 residues in the yeast protein.
9 ations at 35 positions of the 436-amino acid yeast protein.
10 ons (QR) in the in vivo concentration of any yeast protein.
11 ich collectively modify approximately 50% of yeast proteins.
12 inst autodegradation than both the human and yeast proteins.
13 functional compatibility between the fly and yeast proteins.
14 ,000 proteotypic peptides for 4,030 distinct yeast proteins.
15 physiologically phosphorylates mammalian and yeast proteins.
16 neration of specific antibodies to rFXIII or yeast proteins.
17 ted information about potential orthologs of yeast proteins.
18 s motif is found in 1,139 of 5,889 predicted yeast proteins.
19 First, we purified Rtf1 and its associated yeast proteins.
20 ermined the subcellular localization of 2744 yeast proteins.
21 unctions with confidence values to these new yeast proteins.
22 her Hsl1 or Swe1 in the absence of any other yeast proteins.
23 dentified as describing interactions between yeast proteins.
24 ression and/or function of 18 of the fission yeast proteins.
25 ese questions in a reconstituted system with yeast proteins.
26 what was previously described for homologous yeast proteins.
27 lphenols could be limited by the presence of yeast proteins.
28 counterparts, or the surfaces of structured yeast proteins.
29 tituted Mcm2-7 loading with purified budding yeast proteins.
30 s related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is
31 singly, the level of isoaspartyl residues in yeast proteins (50-300 pmol of isoaspartyl residues/mg o
32 , we demonstrate that 73% of the variance in yeast protein abundance (47% in E. coli) is explained by
33 validated the depletion mechanism with known yeast protein abundances, and we observed greater than t
34 athway are found, but the orthologs of three yeast proteins, accounting for the route from phosphomev
35 o the identification of an orthologue of the yeast protein Ada1 and the novel protein encoded by CG44
36 ed Drosophila melanogaster homologues of the yeast proteins Ada2, Ada3, Spt3, and Tra1 and showed tha
37 haracteristics are similar for the human and yeast proteins, although the details differ and the hTBP
38 loop containing the coordinating His in the yeast protein and the fourth Cys in the bovine protein a
39 e activation of Put3p requires no additional yeast proteins and can occur in the presence of certain
42 nificant overlaps between stress aggregating yeast proteins and proteins that aggregate during ageing
43 this prediction, we examined the full-length yeast proteins and truncated versions thereof consisting
47 nding by Yap8 does not require an additional yeast protein, and Yap8 is regulated neither at the leve
48 f ligand binding sites, interactions between yeast proteins, and functional consequences of human nsS
49 e modification of Rpl3 and potentially other yeast proteins, and now designate it Hpm1 (Histidine pro
50 codon adaptation index value for identified yeast proteins approximates to that predicted for the en
54 lectrophoresis showed no evidence that other yeast proteins are substrates of this acetyltransferase.
57 king the localization and abundance of 5,330 yeast proteins at single-cell resolution under three dif
58 ophagosomes by binding to the ubiquitin-like yeast protein Atg8 (LC3 in mammals), which is needed for
60 ein interaction network, we first classified yeast proteins by their evolutionary histories into isot
61 ection of a pHis containing peptide from the yeast protein, Cdc10, suggests an unexpected role for hi
65 ur results suggest that, at least in budding yeast, protein-coding and noncoding Pol II-transcribed g
68 s paper, we focus on a set of well-validated yeast protein complexes provided by Munich Information C
70 bears sequence homology to Cdc73p, a budding yeast protein component of the RNA polymerase II-associa
72 cture determination of Bud31p, a 157-residue yeast protein containing an unusual Zn3Cys9 cluster, dem
74 ctions between Ure2p and naturally occurring yeast proteins could similarly affect [URE3] formation,
78 antibodies to approximately 5,000 different yeast proteins deposited on a glass slide and found that
80 hobic core with the signal sequence from the yeast protein dipeptidyl aminopeptidase B, so that the r
81 iol oxidation status of almost 300 different yeast proteins distributed among various cellular compar
82 , a nuclear localization sequence, and small yeast protein domains that mediate either homodimerizati
83 Prompted by recent studies showing that the yeast protein Dot6 and its homolog Tod6 can bind to a PA
84 rt the identification of the remaining three yeast proteins (Dph1, -3, and -4) and show that all five
85 to the founding member of the subfamily, the yeast protein Drs2, which has been linked to ribosomal a
87 ding protein-related proteins, including the yeast proteins encoded by the OSH gene family (OSH1-OSH7
89 lomerase cofactor identified was the budding yeast protein Est1, which is conserved through humans.
90 the telomerase reverse transcriptase and the yeast proteins Est1p and Est3p as the only telomerase-sp
94 munoprecipitates with Duo1p and Dam1p out of yeast protein extracts, and shows interdependent localiz
95 , and Duo1p/Dam1p coimmunoprecipitation from yeast protein extracts, these analyses indicated that Du
97 be reclassified as mammalian isoforms of the yeast protein family Yip, Yip6b, and Yip6a, respectively
99 hat injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phle
102 y of the N-domain, while both domains of the yeast protein fold in isolation into stable structures a
103 e we demonstrate the rapid release of intact yeast proteins for LESA-MS by electroporation using a ho
104 e pathways discovered by interrogating 4,733 yeast proteins for their ability to diminish toxicity in
107 kov random field method to the prediction of yeast protein function based on multiple protein-protein
109 i mutant is WRB, a protein homologous to the yeast protein Get1, which is involved in the insertion o
112 the catalytic role of this histidine in the yeast protein (His432) using a combination of X-ray crys
114 Eaf3p (Esa1p-associated factor-3 protein), a yeast protein homologous to the Drosophila dosage compen
115 es interaction approaches with mammalian and yeast protein homologs suggest that this mechanism is ev
117 l functionality is illustrated with a 36-kDa yeast protein identified from a processed cell extract a
120 s paper, we tested additional TPR-containing yeast proteins in a cell-free TBSV replication assay and
123 Here, we analyze levels of 4084 GFP-tagged yeast proteins in the progeny of a cross between a labor
124 t a two-proteome model (mixture of human and yeast proteins) in a sixplex isobaric labeling system to
125 family of proteins with homology to several yeast proteins, including Vps5p and Mvp1p, that are requ
126 e-stranded RNA virus, we overexpressed 5,500 yeast proteins individually in Saccharomyces cerevisiae,
128 quately explains the genome-wide patterns of yeast protein interaction and human gene expression for
130 ccording to our measure in different baker's yeast protein interaction networks, outperforming existi
137 racted with LUC7L2, a mammalian homolog of a yeast protein involved in recognition of non-consensus s
138 ategy was used to (i) quantify low abundance yeast proteins involved in gene silencing, (ii) quantita
139 fied a strong signature of ERC between eight yeast proteins involved in meiotic crossing over, which
144 ngoid base production in cells inhibited for yeast protein kinase 1 (Ypk1) activity, that Ypk1 transm
146 ed ULK1 and ULK2, mammalian orthologs of the yeast protein kinase Atg1, which is required for autopha
147 n kinase N 1 (PKN1), which in part resembles yeast protein kinase C, has been shown to be under the c
149 posed previously that the FHA2 domain of the yeast protein kinase Rad53 has dual specificity toward p
150 ere, we demonstrate that the PrLD-containing yeast protein kinase Sky1 is a stress granule component.
152 -throughput method to identify substrates of yeast protein kinases that employs a collection of yeast
155 , the in vitro substrates recognized by most yeast protein kinases: we identified over 4,000 phosphor
168 s class II mMOB1, a mammalian homolog of the yeast protein MOB1, and show that its phosphorylation ap
171 te the importance of uncharacterized fission yeast proteins Mso1 and Sec1 in membrane trafficking dur
174 bed the nucleic acid binding properties of a yeast protein, Nab2, that contains this zinc finger moti
176 n, we demonstrate that human Dullard and the yeast protein Nem1p perform similar functions in mammali
177 The CAI value distribution for identified yeast proteins now more closely approximates that predic
179 adapt recent results on the localization of yeast proteins obtained by Snyder and colleagues using a
180 This work also revealed that additional yeast proteins participate in reducing beta-keto esters,
181 over, the LIM domain region from the fission yeast protein paxillin like 1 (Pxl1) also localizes to S
183 how that an isolated peptide ligand from the yeast protein Pbs2 recognizes its biological partner, th
185 in with similarity to Sds22p, a regulator of yeast protein phosphatase 1 (PP1) activity in the nucleu
186 ow that the catalytic subunit of the budding yeast protein phosphatase 1 (PP1) homolog, Glc7, regulat
187 d upon deletion of the catalytic subunits of yeast protein phosphatase 2A, suggesting that lower PKA
189 phosphatase drives this reversal in budding yeast, protein phosphatase 1 (PP1) and protein phosphata
190 gical networks of moderate size, such as the yeast protein physical interaction network, they either
191 ing homology to annotated yeast ORFs and non-yeast proteins plus a simple region extension procedure,
192 ates, were evaluated by considering over 450 yeast proteins previously examined in numerous studies,
193 A comprehensive analysis uncovered a set of yeast proteins promoting protein-based inheritance that
194 tioning algorithm we identify subnetworks in yeast protein-protein interaction (PPI), genetic interac
196 cs and microarray datasets and represent the yeast protein-protein interaction network as a weighted
199 singly, by integrating topologies of bakers' yeasts protein-protein interaction, genetic interaction
200 nd MOG-5 proteins are closely related to the yeast proteins PRP16, PRP2, and PRP22, respectively.
201 y, symplekin has significant similarity to a yeast protein, PTA1, that is a component of the yeast po
202 st structure of an FHA domain, FHA2 from the yeast protein Rad53, and demonstrated that FHA2 binds to
203 Recently, we reported that two homologous yeast proteins, Rai1 and Dxo1, function in a quality con
205 to the disaggregation process, providing the yeast protein-recovery system with substrate specificity
206 icient BMV RNA replication requires Lsm1p, a yeast protein related to core RNA splicing factors but s
209 re, we characterize mto2p as a novel fission yeast protein required for MT nucleation from noncentros
211 specific pre-mRNA cleavage with recombinant yeast proteins requires incorporation of the Ysh1 endonu
214 ybrid analysis of the 17 soluble class E Vps yeast proteins revealed that Vps46p/Did2p interacts with
216 Furthermore, the prion conformation of the yeast protein Rnq1 and the level of expression of a suit
219 the tetra-BRCT structures from the conserved yeast protein Rtt107 in free and ligand-bound forms.
220 identified and characterized two homologous yeast proteins, Sbe2p and Sbe22p, through their suppress
221 oteins pass the NPC by simple diffusion, two yeast proteins, ScSrc1/ScHeh1 and ScHeh2, are actively i
225 red some unexpected variances within several yeast protein sequences due to amino acid mutations and/
228 t RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell c
229 on of the Src homology 3 (SH3) domain of the yeast protein Sho1 with its cognate proline-rich (PR) se
231 ngle-molecule analysis with purified budding yeast proteins shows that Rad52 competes with Sgs1 for D
232 served coiled-coil protein homologous to the yeast protein Snf7, a key component in the ESCRT-III (en
237 The structural similarity of the E. coli and yeast proteins suggests that most fRMsrs use three cyste
240 a GPI-anchored version of the amyloidogenic yeast protein Sup35NM (Sup35GPI) was expressed in neuron
243 is demonstrated in an experiment to identify yeast protein targets of the immunosuppressive drug, cyc
245 pICln interacts directly with a homolog of a yeast protein that binds a PAK-like kinase and participa
247 Among these proteins is ecm29p, a 200-kDa yeast protein that contains numerous HEAT repeats as wel
248 and SNX2 are mammalian orthologs of Vps5p, a yeast protein that is a subunit of a large multimeric co
249 is an Src homology 3 (SH3) domain-containing yeast protein that is involved in a variety of cellular
252 are the first demonstration of an endogenous yeast protein that requires the exposure of the alpha-am
253 y with Nud1p and Cdc11p, budding and fission yeast proteins that anchor regulatory pathways involved
254 ffecting growth and viability, implying that yeast proteins that are essential under laboratory condi
255 of a strategy to identify human homologs of yeast proteins that are known to be involved in Golgi ho
256 whole-proteome mass spectrometry to identify yeast proteins that are regulated by lysine 11 (K11)-lin
257 -like antibodies, we searched for endogenous yeast proteins that could bind to 2G12 in a panel of Sac
258 revealed that it has homology to a group of yeast proteins that function in the biosynthesis of very
259 PIN(+)] or [URE3] or overexpression of other yeast proteins that have stretches of polar residues sim
260 his approach led to the identification of 58 yeast proteins that interacted with p33 replication prot
262 edictions, this update contains 63 human and yeast proteins that were manually curated from literatur
263 d silencing screen was performed to identify yeast proteins that, when tethered to a telomere, suppre
266 gh localizations have been measured for many yeast proteins through systematic GFP fusions, similar s
269 k established that mutational switching of a yeast protein to a mammalian-like cytokine was specific
270 ly, we used live-cell imaging of six budding-yeast proteins to define a pathway for association of re
271 d revealed approximately 16% of the detected yeast proteins to have multiple phosphorylation isoforms
273 The poly(ADP-ribosyl)ation of three of these yeast proteins, together with two human homologues, was
274 of vacuolar polyP metabolism to K-PPn of two yeast proteins, Top1 (DNA topoisomerase 1) and Nsr1 (nuc
276 equires in addition one of a pair of related yeast proteins, Tre1 and Tre2, that also contain PPxY mo
277 Currently, the DB hosts information on 5330 yeast proteins under three external perturbations (DTT,
279 rog (approximately 600 pmol) sample of total yeast protein, we identify 1,252 phosphorylation sites o
280 tuting these processes with purified budding yeast proteins, we show that ubiquitylation is tightly r
283 This is apparently the first example of a yeast protein where mutagenesis of AUG1 does not lead to
284 script 4)-associated protein (SAP) family of yeast proteins, which are involved in regulation of the
285 complex, Derlin-1, is a homologue of Der1, a yeast protein whose inactivation prevents the eliminatio
286 aining and testing set of approximately 1300 yeast proteins with an experimentally known localization
287 veloping our system, we apply it to the 4700 yeast proteins with currently unknown localization and e
288 larly affect [URE3] formation, we identified yeast proteins with domains that are compositionally sim
289 predictions for individual proteins (on the yeast proteins with known localization, 92% versus 74%).
290 ometry (LC-MS/MS) run, we have identified 22 yeast proteins with molecular weights from 14 to 35 kDa.
293 osphorylates two recently identified fission yeast proteins with RS repeats, Srp1 and Srp2, in vitro.
295 by a simple and automated procedure for 192 yeast proteins, with positive responses identified by th