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1 ; P = .61 for lutein/zeaxanthin vs no lutein/zeaxanthin).
2 ne, beta-carotene, lycopene, and lutein plus zeaxanthin.
3 es, including the unique macula pigment meso-zeaxanthin.
4 on of all-E-lutein and puffing also of all-E-zeaxanthin.
5 otene (20%), with minor levels of lutein and zeaxanthin.
6 ay can provide a high enough level (2 mg) of zeaxanthin.
7 e was rich in antheraxanthin, capsanthin and zeaxanthin.
8 est degradation rates followed by lutein and zeaxanthin.
9 well as the tightly regulated production of zeaxanthin.
10 to be partially phosphorylated and contained zeaxanthin.
11 r adjusting for dietary intake of lutein and zeaxanthin.
12 pha-carotene, beta-cryptoxanthin, and lutein/zeaxanthin.
13 ellow, blue-absorbing carotenoids lutein and zeaxanthin.
14 aggregate of the carotenoid all-trans 3R,3'R-zeaxanthin.
15 ls showing continuous exposure to lutein and zeaxanthin.
16 is affected by both DeltapH and the level of zeaxanthin.
17 e-epoxidation of LHCII-bound violaxanthin to zeaxanthin.
19 tene, 0.28; beta-cryptoxanthin, 0.35; lutein/zeaxanthin, 0.28; lycopene, 0.15; folate, 0.26; alpha-to
20 arotene, 0.53; beta-carotene, 0.39; lutein + zeaxanthin, 0.46; lycopene, 0.32; and alpha-tocopherol,
21 [98.7% CI, 0.76-1.07]; P = .12 for lutein + zeaxanthin; 0.97 [98.7% CI, 0.82-1.16]; P = .70 for DHA
23 1 of the following 4 groups: placebo; lutein/zeaxanthin, 10 mg/2 mg; omega-3 long-chain polyunsaturat
24 capsule containing 10 mg of lutein, 1 mg of zeaxanthin, 100 mg of docosahexaenoic acid, and 30 mg of
25 e randomly assigned to daily placebo; lutein/zeaxanthin, 10mg/2mg; omega-3 long-chain polyunsaturated
26 acids (LCPUFAs) (1 g) and/or lutein (10 mg)/zeaxanthin (2 mg) vs placebo were tested in a factorial
27 were randomized to receive lutein (10 mg) + zeaxanthin (2 mg), DHA (350 mg) + EPA (650 mg), lutein +
29 % (468 eyes [399 participants]) for lutein + zeaxanthin, 31% (507 eyes [416 participants]) for DHA +
30 id contents (beta carotene, 14.25 mug/100 g; zeaxanthin, 35.21 mug/100 g; lutein 174.59 mug/100 g) as
32 Studies in BCO2-knockout mice revealed that zeaxanthin accumulates in the inner mitochondrial membra
33 oducts and/or state 1-state 2 transitions or zeaxanthin accumulation, namely, npq4, stt7, stt7 npq4,
34 , which is necessary for the accumulation of zeaxanthin, affects the excited-state chlorophyll relaxa
35 idual carotenoid contents, including lutein, zeaxanthin , alpha-carotene, beta-carotene, and lycopene
37 oxide, together with (all-E)-lutein, (all-E)-zeaxanthin and (all-E)-beta-carotene were found at high
38 the relations between intakes of lutein and zeaxanthin and age-related macular degeneration (AMD) ha
39 as characterized by high levels of all-trans-zeaxanthin and all-trans-beta-carotene (755 and 332mug/g
41 immon powder for all-trans-lutein, all-trans-zeaxanthin and all-trans-beta-cryptoxanthin, respectivel
43 as the direct comparison between lutein plus zeaxanthin and beta-carotene, were assessed for genotype
44 plasma xanthophyll concentrations (lutein + zeaxanthin and beta-cryptoxanthin) and hydrocarbon carot
46 is-violaxanthin, lutein, beta-cryptoxanthin, zeaxanthin and cis-antheraxanthin) were investigated at
51 hin monomeric LHC proteins depending on both zeaxanthin and lutein and on the formation of a radical
52 mical quenching, despite the absence of both zeaxanthin and lutein and show that tobacco can regulate
54 arotene and the non-provitamin A carotenoids zeaxanthin and lutein, and is inactive with all-trans-ly
58 n mice and primates of a binding protein for zeaxanthin and meso-zeaxanthin, the pi isoform of glutat
59 e protective carotenoid pigments, especially zeaxanthin and myxoxanthophyll, were up-regulated in the
62 eration of a strain constitutively producing zeaxanthin and showing improved photosynthetic productiv
64 ends on the nutritional uptake of lutein and zeaxanthin and that it is inversely associated with the
67 ding protein of photosystem II) or pigments (zeaxanthin and/or lutein) required for photoprotective t
68 ndomized controlled clinical trial of lutein/zeaxanthin and/or omega-3 fatty acids, the Age-Related E
69 luate the efficacy and safety of lutein plus zeaxanthin and/or omega-3 long-chain polyunsaturated aci
70 and tocotrienols), xanthophylls (lutein and zeaxanthin) and flavonoids (3-deoxyanthocyanidins-3-DXAs
71 -based macular xanthophylls (MXs; lutein and zeaxanthin) and the lutein metabolite meso-zeaxanthin ar
73 content on a chlorophyll basis, particularly zeaxanthin, and a major down-regulation of light absorpt
75 enotypes was lutein, followed by its esters, zeaxanthin, and beta-carotene, while antheraxanthin and
77 nthin, alpha-carotene, beta-carotene, lutein/zeaxanthin, and lycopene) and the evolution of lung func
78 ng affinities between human BCO2 and lutein, zeaxanthin, and meso-zeaxanthin are 10- to 40-fold weake
80 nce on the putative role of the MXs (lutein, zeaxanthin, and meso-zeaxanthin) in AMD and report findi
81 ounts of the xanthophyll carotenoids lutein, zeaxanthin, and meso-zeaxanthin, but the underlying bioc
82 nt containing a fixed combination of lutein, zeaxanthin, and omega-3 LC-PUFAs during 12 months signif
84 containing 20 mg/day of lutein, 4 mg/day of zeaxanthin, and other antioxidants (vitamin C, vitamin E
85 LHCs), the de-epoxidation of violaxanthin to zeaxanthin, and the photosystem II subunit S (PsbS) work
88 lacks VDE and cannot convert violaxanthin to zeaxanthin; and npq1 npq4, which lacks both VDE and PsbS
89 total content of carotenoids (sum of lutein, zeaxanthin, antheraxanthin, alpha- and beta-carotene, an
91 human BCO2 and lutein, zeaxanthin, and meso-zeaxanthin are 10- to 40-fold weaker than those for mous
93 tional changes under the presence of DeltapH/zeaxanthin are related to the PsbS role in the current n
94 d zeaxanthin) and the lutein metabolite meso-zeaxanthin are the major constituents of macular pigment
97 Shortage of the dietary carotenoids lutein, zeaxanthin as well as fish consumption are reported AMD
99 Thiamine, riboflavin, pyridoxine, lutein, zeaxanthin, beta-carotene and alpha-/gamma-tocopherol we
101 surface responses were generated for lutein, zeaxanthin, beta-cryptoxanthin and beta-carotene in kaki
102 ds in humans (phytoene, phytofluene, lutein, zeaxanthin, beta-cryptoxanthin, alpha-carotene, beta-car
103 ng time on the bioactive components (lutein, zeaxanthin, beta-cryptoxanthin, phytate, tannin and vita
104 a-carotene, beta-carotene, lycopene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocophero
105 eshly harvested orange hybrid maize; lutein, zeaxanthin, beta-cryptoxanthin, tannin and vitamin C inc
106 ncludes variants in or near genes related to zeaxanthin binding in the macula (GSTP1), carotenoid cle
107 ric antenna complexes of Photosystem II upon zeaxanthin binding; however, the amplitude of carotenoid
108 gy were evaluated in all yogurt samples, and zeaxanthin bioaccessibility after in vitro digestion was
109 tip-end had highest zeaxanthin and TC in the zeaxanthin biofortified sweet-corn, and highest lutein a
110 C) and quality parameters was evaluated in a zeaxanthin-biofortified and a commercial yellow sweet-co
111 n resulted in significant inhibition of meso-zeaxanthin biosynthesis during chicken eye development.
112 se of the system, we assembled the five-gene zeaxanthin biosynthetic pathway in a single step and sho
113 vitamin C, beta-cryptoxanthin, and lutein + zeaxanthin but lower folate and vitamin D concentrations
114 yll carotenoids lutein, zeaxanthin, and meso-zeaxanthin, but the underlying biochemical mechanisms fo
115 itro oxidation of beta-carotene, lutein, and zeaxanthin by (1)O(2) generated various aldehydes and en
116 ble for the transformation of lutein to meso-zeaxanthin by a double-bond shift mechanism, but its ide
117 into consideration, the idea that lutein and zeaxanthin can influence cognitive function in older adu
118 ation of individual carotenoids such lutein, zeaxanthin, canthaxanthin, ss-carotene and beta-apocarot
119 st that increased dietary intake of lutein + zeaxanthin (carotenoids), omega-3 long-chain polyunsatur
122 as significantly related to serum lutein and zeaxanthin combined (r = 0.31, P = 0.002), GD (r = 0.24,
124 ation-based study in centenarians found that zeaxanthin concentrations in brain tissue were significa
125 a relation between cognition and lutein and zeaxanthin concentrations in the brain tissue of deceden
126 change in provitamin A carotenoid and lutein/zeaxanthin concentrations was associated with a slower d
128 Arabidopsis thaliana mutant that accumulates zeaxanthin constitutively, have reported that this xanth
129 nt with the high rate of habitual lutein and zeaxanthin consumption in Utah AREDS2 subjects prior to
131 This type of quenching, together with high zeaxanthin content, appears to underlie photoprotection
133 e of lung cancer in former smokers, lutein + zeaxanthin could be an appropriate carotenoid substitute
134 REDS2 and other studies suggests that lutein/zeaxanthin could be more appropriate than beta carotene
135 REDS2 and other studies suggests that lutein/zeaxanthin could be more appropriate than beta-carotene
136 cherichia coli strains engineered to produce zeaxanthin demonstrated that only mouse BCO2 is an activ
137 photomixotrophically at moderate light, the zeaxanthin-dependent component of NPQ emerged upon stron
138 ential spectroscopy in vivo, we identified a zeaxanthin-dependent optical signal characterized by a r
140 relative to D3, combined with an increase in zeaxanthin-dependent quenching (qZ) relative to D4.
141 component of quenching was less dependent on zeaxanthin, despite the near-complete violaxanthin to ze
143 e main fraction among berry varieties having zeaxanthin di-palmitate as major compound, while leaves
145 as not modified after 6 months of lutein and zeaxanthin dietary supplementation despite plasma levels
146 ) for those randomized to not receive lutein/zeaxanthin (difference in yearly change, 0.03 [99% CI, -
147 antioxidant activity and contents of rutin, zeaxanthin dipalmitate and 2-O-beta-d-glucopyranosyl-l-a
148 ied by an accumulation of up to 36mg/100g FW zeaxanthin dipalmitate and further minor xanthophyll est
151 1 (high pigment1 [hp1]), Deetiolated1 (hp2), Zeaxanthin Epoxidase (hp3), and Intense pigment (Ip; gen
153 ified at different physical positions in the zeaxanthin epoxidase gene (ABSCISIC ACID DEFICIENT 1/ZEA
154 r flesh colour beta-carotene hydroxylase and zeaxanthin epoxidase were ranked first and forty-fourth
155 suggest that loss of function of DDB1, DET1, Zeaxanthin Epoxidase, and Ip up-regulates CHRC levels.
156 in epoxidase gene (ABSCISIC ACID DEFICIENT 1/ZEAXANTHIN EPOXIDASE, or ABA1/ZEP) in TG01 and TG10.
158 tio comparing lutein/zeaxanthin vs no lutein/zeaxanthin for progression to cataract surgery was 0.68
159 hich may be due to the strong requirement of zeaxanthin for rapid thermal dissipation and unsaturated
160 es not require a transthylakoid pH gradient, zeaxanthin formation, or the phosphorylation of light-ha
163 enhanced liberation and bioaccessibility of zeaxanthin from these tubular aggregates in goji berries
165 s (vde lhcsr KO and vde psbs KO) showed that zeaxanthin had a major influence on LHCSR-dependent NPQ,
166 oral supplementation with LCPUFAs or lutein/zeaxanthin had no statistically significant effect on co
168 y acids, and macular xanthophylls lutein and zeaxanthin have been associated with a lower risk of pre
169 antioxidants such as vitamin C, lutein, and zeaxanthin have been associated with lower incidence and
170 otenoids, particularly lycopene, lutein, and zeaxanthin, have been found to have important biological
171 he signal implies an increased efficiency of zeaxanthin in controlling chlorophyll triplet formation.
173 the differential distributions of lutein and zeaxanthin in human donor retinas mapped with confocal r
176 ne, beta-cryptoxanthin, lutein, lycopene and zeaxanthin in minimally processed fresh food products, w
177 kale were stable (except alpha-carotene and zeaxanthin in peach) for 13, 9.7, 5.7, 2.5 and 7.5months
181 2) assessed the value of substituting lutein/zeaxanthin in the AREDS formulation because of the demon
184 f the macular pigment carotenoids lutein and zeaxanthin in the human retina occurs early in life.
185 lex: (1) the accumulation of photoprotective zeaxanthin in the LHCI antenna and the PSI reaction cent
188 ole of the MXs (lutein, zeaxanthin, and meso-zeaxanthin) in AMD and report findings on AMD-associated
193 associations were found between lutein plus zeaxanthin intake and presence at baseline or developmen
195 alpha-Carotene, beta-carotene, and lutein/zeaxanthin intakes were inversely associated with the ri
202 nt violaxanthin is reversibly converted into zeaxanthin, is ubiquitous among green algae and plants a
204 ons of alpha- and beta-carotene, lutein plus zeaxanthin (L + Z), and alpha-tocopherol were routinely
205 luate the efficacy and safety of lutein plus zeaxanthin (L+Z) and/or omega-3 long-chain polyunsaturat
206 9 eyes were analyzed (119 in the lutein plus zeaxanthin [L + Z] group and 120 in the placebo group).
207 ophylls, by characterizing the suppressor of zeaxanthin-less (szl) mutant of Arabidopsis (Arabidopsis
211 ed a 60% lutein content reduction and 40% in zeaxanthin loss, showing lutein more susceptibility to i
215 (alpha-carotene, beta-carotene, lutein plus zeaxanthin, lycopene, and beta-cryptoxanthin) and risk o
216 e, beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, lycopene, folate, and alpha-tocopherol in re
218 Dietary intakes of antioxidants (lutein/zeaxanthin [LZ], beta-carotene, and vitamin C), long-cha
220 min A, vitamin B6, beta-carotene, lutein and zeaxanthin, magnesium, copper, docosahexaenoic acid, ome
221 R, 1.18; 95% CI, 0.96-1.45; P = 0.12; lutein/zeaxanthin main effect HR, 1.04; 95% CI, 0.85-1.28; P =
222 ogic studies suggest that dietary lutein and zeaxanthin may be of benefit in maintaining cognitive he
226 n 1 eye were assigned randomly to lutein and zeaxanthin, omega-3 fatty acids, both, or placebo, and m
227 f dietary supplementation containing lutein, zeaxanthin, omega-3 polyunsaturated fatty acids, and vit
228 benefit of daily supplementation with lutein/zeaxanthin on AMD progression, secondary exploratory ana
229 AREDS2 was to evaluate the effects of lutein/zeaxanthin on the subsequent need for cataract surgery.
230 o mediate crocetin formation, did not cleave zeaxanthin or 3-OH-beta-apo-8'-carotenal in the test sys
231 for extracting xanthophylls such as lutein, zeaxanthin or beta-cryptoxanthin and carotenes such as b
235 On the basis of delta(34)S, Y, U, Cu, Rb, zeaxanthin palmitate and total carotenoid content, discr
236 ared with a previously reported constitutive zeaxanthin pathway, our inducible pathway was shown to h
237 lementation with 10 mg of lutein and 2 mg of zeaxanthin per day can slow the rate of progression of a
240 als are needed to determine whether maternal zeaxanthin prenatal supplementation can raise infant mac
241 is up-regulated 23-fold at the time of meso-zeaxanthin production during chicken eye development, an
242 (r = 0.36; P = 0.0142), with serum lutein + zeaxanthin (r = 0.44; P = 0.0049) and with skin caroteno
247 to-monomer transition, and in a violaxanthin/zeaxanthin-rich membrane, at an all-atom resolution.
248 extreme quintiles of predicted plasma lutein/zeaxanthin score, we found a risk reduction for advanced
252 ated the effectiveness of a high dose lutein/zeaxanthin supplement for MPOD volume and SC levels with
254 at is the long-term safety profile of lutein/zeaxanthin supplementation, should other carotenoids be
256 dase (VDE) is the key enzyme responsible for zeaxanthin synthesis from violaxanthin under excess ligh
257 ns, plants accumulate a specific carotenoid, zeaxanthin, that was shown to increase photoprotection.
258 lowest quintile of dietary intake of lutein/zeaxanthin, the hazard ratio comparing lutein/zeaxanthin
259 y analysis of lutein/zeaxanthin vs no lutein/zeaxanthin, the hazard ratio of the development of late
261 of a binding protein for zeaxanthin and meso-zeaxanthin, the pi isoform of glutathione S-transferase
262 es of a bona fide CCD, and is able to cleave zeaxanthin, the presumed precursor of saffron apocaroten
263 -beta-ionone ring and that the conversion of zeaxanthin to crocetin dialdehyde proceeds via the C30 i
264 dy of research has linked macular lutein and zeaxanthin to reduced risk of degenerative eye disease.
265 show that the high light-induced binding of zeaxanthin to specific proteins plays a major role in en
267 can esterify lutein, beta-cryptoxanthin, and zeaxanthin using multiple acyl donors, yet it has a pref
268 or participants randomized to receive lutein/zeaxanthin vs -0.19 (99% CI, -0.25 to -0.13) for those r
269 at baseline, the direct comparison of lutein/zeaxanthin vs beta carotene showed hazard ratios of 0.76
270 tory analyses of direct comparison of lutein/zeaxanthin vs beta carotene showed hazard ratios of 0.82
271 eaxanthin, the hazard ratio comparing lutein/zeaxanthin vs no lutein/zeaxanthin for progression to ca
277 and beta-carotenes, lutein, violaxanthin and zeaxanthin was found under blue 33% treatment in compari
278 ly significant increase in plasma lutein and zeaxanthin was shown in the L + Z group after 3 months a
281 e degradation of this component, and that of zeaxanthin, was low, suggesting E- to Z-isomerization.
282 ncluding beta-carotene, lycopene, lutein and zeaxanthin were determined in three isolates of heterocy
285 of alpha-carotene, beta-carotene, and lutein/zeaxanthin were inversely associated with risk of ER-, b
286 metric isomers of the carotenoids lutein and zeaxanthin were separated using TIMS (R > 110) for [M](+
289 e, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, a
290 e studied the dependence of NPQ reactions on zeaxanthin, which is synthesized under light stress by v
291 n known to contain strikingly high levels of zeaxanthin, while the physical deposition form and bioac
293 macular pigment xanthophylls lutein (L) and zeaxanthin (Z) and n-3 fatty acids may reduce this damag
295 An oral preparation containing lutein (L), zeaxanthin (Z), vitamin C, vitamin E, copper, and zinc o
299 complex of PSII (LHC-II) and the xanthophyll zeaxanthin (Zea) into proteoliposomes, we have tested th
300 tation with omega-3 fatty acids, lutein plus zeaxanthin, zinc, or beta-carotene had no statistically