ライフサイエンスコーパス: zebrafish

1 helial identity downstream of ETV2 (Etsrp in zebrafish).

2 tonin, leading to altered larval behavior in zebrafish.

3 l fates during aging of telomerase deficient zebrafish.

4 t body axis and spine morphogenesis in adult zebrafish.

5 y and an operant-conditioning task in larval zebrafish.

6 n, as a key regulator of spine patterning in zebrafish.

7 te decisions during cardiac trabeculation in zebrafish.

8 is, and in preclinical studies in cystinotic zebrafish.

9 IM during Mycobacterium marinum infection of zebrafish.

10 bolomics studies using mice, Drosophila, and zebrafish.

11 ith OCRL-targeting siRNA, and in orcl-mutant zebrafish.

12 assically used in primate studies, to larval zebrafish.

13 blotting assay and generated pomgnt1 mutant zebrafish.

14 finding induced by loss of NOVA2 ortholog in zebrafish.

15 iversity in BMP-dependent gene expression in zebrafish.

16 n the ontogeny of hunting behavior in larval zebrafish.

17 onal and anatomical census of RGCs in larval zebrafish.

18 role in granulopoiesis in humans, mice, and zebrafish.

19 ion in shaping social avoidance responses in zebrafish.

20 yses of intestinal tissues from patients and zebrafish.

21 active neuron populations in freely swimming zebrafish.

22 lates the development of the GnRH3 system in zebrafish.

23 od that was used to knockdown genes in adult zebrafish.

24 uld not predict the AFFF phenotype in larval zebrafish.

25 s in Xenopus tropicalis, Xenopus laevis, and zebrafish.

26 nd induced mispatterning of blood vessels in zebrafish.

27 size changes rapidly in both C. elegans and zebrafish [2, 3], where mitotic centrosome area scales m

28 yte recruitment following wounding in larval zebrafish,(6-9) where H(2)O(2) activates the SFK Lyn to

29 Here, we reveal, in adult zebrafish, a logic of the V2a interneuron rhythm-generat

30 In zebrafish, a mutation of bicra that mimics one of the lo

31 3P) imaging through the head of intact adult zebrafish allows structural and functional imaging at ce

32 hat prokr1b is not required for fertility in zebrafish, although its loss determine changes also at t

33 etabolism in photoreceptors using a mcu(-/-) zebrafish and a rod photoreceptor-specific Mcu(-/-) mous

34 In zebrafish and chick, the transition from quiescence to r

35 spontaneous reprogramming of Muller glia in zebrafish and compares this knowledge to research effort

36 regeneration following myocardial injury in zebrafish and described each step of the regeneration pr

37 al-time imaging of intestinal peristalsis in zebrafish and histologic analyses of intestinal tissues

38 BA-implicated HSP90 pathway genes sensitized zebrafish and human cholangiocytes to biliatresone-induc

39 in preventing biliatresone-induced injury in zebrafish and human cholangiocytes.

40 Using zebrafish and human endothelial cells in vitro, we show

41 cient to enhance tumor cell dissemination in zebrafish and mice.

42 ing Uberon anatomical entity annotations for zebrafish and mouse genes to construct gene networks by

43 s shows an upregulation of collagens in both zebrafish and mouse macrophages following heart injury.

44 th of patient-derived GBM xenografts in both zebrafish and mouse models.

45 factors involved in mutant mRNA decay, as in zebrafish and mouse.

46 ion-recall curves than PPI networks for both zebrafish and mouse.

47 the differentiated cardiomyocyte: studies in zebrafish and neonatal mammals have convincingly demonst

48 strate the conserved function of thrombin in zebrafish and provide insight into the role of kringle 1

49 cord tissue stiffness in regenerating adult zebrafish and provides the tissue mechanical basis for f

50 Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathwa

51 Non-mammalian vertebrates (zebrafish and salamanders) and invertebrates (Drosophila

52 pathways affecting responses to nicotine in zebrafish and smoking in humans.

53 Both ocrl mutant zebrafish and zebrafish injected with ocrl morpholino sh

54 With data from two model organisms (mice, zebrafish) and five laboratories, we show that ground tr

55 phila melanogaster (fruit fly), Danio rerio (zebrafish), and Oryza sativa (rice).

56 s, including yeast, nematode, fruit fly, and zebrafish, and discuss emerging methods for creating mur

57 gulator of genome stability in flies, worms, zebrafish, and human germ cell tumors.

58 t toxicity was detected on the growth of the zebrafish, and images of high quality were obtained.

59 veloped a discovery pipeline using nematode, zebrafish, and mammalian cell models.

60 ficantly reduced tumor cell extravasation in zebrafish, and niclosamide drastically impaired metastas

61 in vivo (rat chronic hypoxia-induced PH and zebrafish angiogenesis).

62 By contrast, adult zebrafish are able to repair spinal cord tissue and rest

63 Zebrafish are an ideal cell transplantation model.

64 The escape response and rhythmic swimming in zebrafish are distinct behaviors mediated by two functio

65 In contrast to mice, myog(-/-)zebrafish are viable, but have hypotrophic muscles.

66 Zebrafish are well suited for such investigations, but b

67 ng to successful spinal cord repair in adult zebrafish are, however, currently unknown.

68 ontrols pMN cell fate specification, we used zebrafish as a model system to investigate prdm8 functio

69 njured human heart and hence put forward the zebrafish as a model to study the poorly understood doub

70 It also further establishes the zebrafish as a powerful model to carry out longitudinal

71 These observations establish the zebrafish as a useful tool for the analysis of CPHD gene

72 timal growth and rearing of immunosuppressed zebrafish at 37 degrees C; optimized intraperitoneal and

73 Using a zebrafish behavior-based screening strategy, we discover

74 Within otherwise naive zebrafish blastoderm explants, however, Nodal induces C

75 Sea lamprey (jawless fish) and zebrafish (bony fish) support the unbranched axon concep

76 erize the molecular changes occurring in the zebrafish brain exposed to acrylamide at metabolite, tra

77 accomplishes long-range distribution in the zebrafish brain.

78 phagosomal NO produced in microglia of live zebrafish brains, we found that single-stranded RNA of b

79 pb is involved in the initial development of zebrafish by supporting the integrity of the EVL, likely

80 odel to study NMDARs in early development in zebrafish, by generating CRISPR-mediated lesions in the

81 In immune-deficient larval zebrafish, C4S and C6S increased the numbers of viable t

82 Zebrafish can faithfully regenerate injured fins through

83 We characterized zebrafish carrying a homozygous mutation that introduces

84 In contrast to other vertebrates, zebrafish carrying a homozygous, maternal zygotic snx14

85 re the bioavailable effect concentrations in zebrafish cell lines and embryos.

86 med genome-wide RNA tomography sequencing on zebrafish, chicken, mouse, and human embryos.

87 shh -GFP is still expressed along the adult zebrafish CNS neuraxis in most locations seen in larvae.

88 sensors to directly examine Ca(2+) uptake in zebrafish cone mitochondria, we found that loss of MCU r

89 nd Crb2b as well as mammalian Crb1 and Crb2, zebrafish Crb1 does not localize to the subapical region

90 We conclude that zebrafish Crb1 has diverged from other vertebrate Crb pr

91 Moreover, zebrafish Crb1 is not required for retinal morphogenesis

92 Here, we show that, unlike zebrafish Crb2a and Crb2b as well as mammalian Crb1 and

93 line" hypothesis by generating germline-free zebrafish Danio rerio and testing the effect of the pres

94 have generated IL-4/13A and IL-4/13B mutant zebrafish (Danio rerio) and, together with an existing I

95 Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically d

96 ge neuronal populations in behaving mice and zebrafish demonstrate real-time movement-corrected 3D tw

97 ating neuronal progenitors while mutant ugdh zebrafish do not phenocopy the human disease.

98 essential for proper zinc modulation during zebrafish egg activation and presents the first evidence

99 els in embryos developed from MTH1 knock-out zebrafish eggs microinjected with N6-methyl-dATP compare

100 mitotic spindle [1], is notably large in the zebrafish embryo (246.44 +/- 11.93 mum(2) in a 126.86 +/

101 In the current study, we showed that the zebrafish embryo is permissive to M. kansasii infection,

102 D1 mutant Mycobacterium marinum strains in a zebrafish embryo model of tuberculosis and (iv) in vivo

103 Assessment of cell proliferation across zebrafish embryo segmentation, using the FUCCI transgeni

104 hich controls body axis morphogenesis in the zebrafish embryo.

105 on channel and show reduced cytotoxicity and zebrafish-embryo toxicity.

106 We propose a model in which uniquely large zebrafish embryonic centrosomes direct spindle placement

107 -ACVR1 enhances pSmad1/5 activation, we used zebrafish embryonic dorsoventral (DV) patterning as an a

108 chick embryonic heart ultrasound images, and zebrafish embryonic microscope images, with the average

109 Here, we show that zebrafish embryonic tissue explants, prepared prior to g

110 splanted melanoma-derived cells into G2 tert zebrafish embryos and observed that tissue environment w

111 ordings of beating atria in 381 live, intact zebrafish embryos at 2 and 5 days post-fertilization hig

112 -tocopherol transfer protein (alpha-TTP)] in zebrafish embryos causes death within 24 h post-fertiliz

113 AFFF toxicity was assessed in zebrafish embryos in comparison with four major constitu

114 FRET nanoprobes can be imaged in developing zebrafish embryos over seven days with toxicity similar

115 Exposure of zebrafish embryos to 17beta-estradiol (E2) during liver

116 ifferent combinations of steroid mixtures in zebrafish embryos to assess their joint activities on ph

117 Using tegmental hindbrain nuclei neurons in zebrafish embryos together with subcellular imaging, opt

118 Zebrafish embryos were exposed to 0.1, 1.0, 10, 50, and

119 transcripts during embryogenesis, we treated zebrafish embryos with ethanol during pre-gastrulation p

120 tible to digestive enzymes and did not alter zebrafish embryos' morphology and development.

121 of Escherichia coli (E. coli) and transgenic zebrafish embryos, we are able to design optimized antib

122 olecular analysis of fully intact and living zebrafish embryos.

123 characterize candidate genes for HRV in live zebrafish embryos.

124 of a legacy AFFF sample and its toxicity in zebrafish embryos.

125 stem to deplete specific mRNA transcripts in zebrafish embryos.

126 tial for the development of the body axis in zebrafish embryos.

127 g phenotype in Delta-like 4 (Dll4) knockdown zebrafish embryos.

128 Lgp2 deficiency enhanced, HSPC emergence in zebrafish embryos.

129 l monitoring of the wound response in living zebrafish embryos.

130 te, development, and biological functions of zebrafish embryos.

131 lar development in wild-type and etv2 mutant zebrafish embryos.

132 lecular information extracted from unlabeled zebrafish embryos.

133 Zebrafish enables analysis of cellular processes in an o

134 we show that a relatively high proportion of zebrafish enteric glia proliferate under physiological c

135 Mutant zebrafish exhibit different behaviours depending on the

136 r demonstrated that juvenile csf1r-deficient zebrafish exhibit systemic macrophage depletion.

137 VDD zebrafish exhibited elevated hepatic triglycerides, atte

138 esr2b(-/-) mutant zebrafish exhibited significantly increased expression o

139 The present study used zebrafish exposure experiments with three model compound

140 tion enhancer elements (TREEs) important for zebrafish fin regeneration, we performed ATAC-seq from b

141 ablish an ethologically relevant paradigm in zebrafish for studying how the brain is shaped by experi

142 These findings highlight the feasibility of zebrafish for studying M. kansasii pathogenesis and for

143 le method based on spontaneous preference of zebrafish for using the larger available hole to pass an

144 prehensive guide for using immunocompromised zebrafish for xenograft cell transplantation and credent

145 nal gradient index profiles in eye lenses of zebrafish from late larval to adult stages.

146 Using a zebrafish genetic screen, we identified the ric1 gene as

147 a proinflammatory Vibrio symbiont native to zebrafish governs its own spatial organization using swi

148 Because zebrafish harbor a full complement of cobalamin metaboli

149 The zebrafish has recently emerged as a model system for inv

150 Zebrafish have become a valuable model for investigating

151 Zebrafish have emerged as a convenient model to study el

152 tical clarity and experimental advantages of zebrafish have made this an essential model organism for

153 lomerase reverse transcriptase (tert) mutant zebrafish have premature short telomeres and anticipate

154 Zebrafish have two Larp6 family genes: larp6a and larp6b

155 ut not the alpha10, subunits are enriched in zebrafish HCs.

156 ically upregulated at the injury site during zebrafish heart regeneration, and that absence of runx1

157 epicardial subpopulations in the developing zebrafish heart.

158 r activity to the inflow tract in developing zebrafish hearts, demonstrating deep conservation of its

159 Using a CRISPR/Cas9 Zebrafish her6::Venus reporter combined with mathematica

160 similarity to those previously described in zebrafish, highlighting the well-conserved nature of hab

161 arried out single cell RNA sequencing of the zebrafish hindbrain at three different stages of pattern

162 A comparison of zebrafish, human and mouse regulatory elements enabled t

163 tion of multiple neuronal populations in the zebrafish hypothalamus during defensive responses to a v

164 t proteins (FPs) currently the main tool for zebrafish imaging.

165 The development of the zebrafish immune system is well understood, thereby use

166 ce of producing more bone, we use transgenic zebrafish in which Hh levels could be experimentally man

167 Administration of leflunomide to ttc7a(-/-) zebrafish increased gut motility, reduced intestinal tra

168 Furthermore, ssbp1 suppression in zebrafish induced signs of nephropathy and reduced optic

169 es are widely used to study gene function in zebrafish: induction of genetic mutations, usually using

170 Both ocrl mutant zebrafish and zebrafish injected with ocrl morpholino showed truncated

171 In zebrafish, irf6 and esrp1/2 share expression in periderm

172 The zebrafish is ideal for studying embryogenesis and is inc

173 large scale application of this technique to zebrafish is the lack of a cost-effective method by whic

174 system for vertebrate skin patterning is the zebrafish; its alternating blue stripes and yellow inter

175 d complex behaviors.SIGNIFICANCE STATEMENT A zebrafish lacking cdnf grows normally and shows no overt

176 eta signaling in OFT formation, we generated zebrafish lacking the TGF-beta receptor Alk5 and found a

177 n to sensing osmolarity, basal skin cells in zebrafish larvae are also sensitive to changes in the pa

178 in situ hepatic glutathione redox mapping in zebrafish larvae carrying targeted mutations in glutathi

179 c3a.1(-/-) zebrafish larvae have impaired neutrophil directed migra

180 Moreover, c3a.1(-/-) zebrafish larvae have impaired recruitment to localized

181 We show that loss of tcf12 in zebrafish larvae perturbs GnRH neuronal patterning with

182 e absence of over-riding visual information, zebrafish larvae show intrinsic lateralized motor behavi

183 Zebrafish larvae swim in punctuated bouts separated by l

184 lect high spatial resolution video of single zebrafish larvae swimming in a naturalistic environment

185 ced significantly more vascular disease in a zebrafish larvae systemic infection model over 72 h comp

186 c tools to ablate tendon progenitor cells in zebrafish larvae, finding that larval tendons display hi

187 a transcripts were artificially increased in zebrafish larvae, T cell development was significantly i

188 tic potential, proven by a xenotransplant in zebrafish larvae, we have studied the role of the plasma

189 ere, we focus on light-seeking navigation in zebrafish larvae.

190 d reduced optokinetic behavioral response in zebrafish larvae.

191 In contrast, zebrafish lateral line hair cells, which detect water mo

192 The zebrafish lens shows evidence of a gradient of refractiv

193 epth functional analysis, the Tsc2-deficient zebrafish line cannot be used for studies of TANDs or ne

194 We developed a transgenic zebrafish line that allows for cell-type-specific labeli

195 sm, we generated a whole body gpr27 knockout zebrafish line.

196 generated foxc1a and foxc1b single knockout zebrafish lines and bred them to obtain various allelic

197 A new study in zebrafish (Liu et al., 2020) now demonstrates a critical

198 9-containing (alpha9*) nAChR operates at the zebrafish LL efferent synapse.

199 on (22-100%) for targeted knock-ins at eight zebrafish loci and efficient integration at safe harbor

200 ace is evident in the embryonic epidermis of zebrafish loss-of-function mutants in the cognate Matrip

201 g the stem cell properties of Muller glia in zebrafish may provide cues to unlock the regenerative po

202 st step in melanoma invasion, we developed a zebrafish melanoma model in which constitutive activatio

203 By replacing leucine with glycine in the zebrafish MetRS-binding pocket (MetRS-L270G), we enabled

204 Tspyl1 depletion in zebrafish mimicked the patients' phenotype with early le

205 role of NFATC1 in this process, we used the zebrafish model as it offers unique attributes for live

206 The results establish a zebrafish model for investigating the mechanisms of deve

207 ylation to disease progression, we develop a zebrafish model of the SCL deficiency and find that SIRT

208 As such, this zebrafish model provides a unique opportunity to study t

209 em, and thus exemplify the advantages of the zebrafish model to study the effects of upf1-deficiency

210 These effects were corroborated in a zebrafish model where fulvestrant inhibited neutrophil-

211 was performed for the first time on a living zebrafish model with [EuL(4a)].

212 Here, using a zebrafish model, we genetically ablate all embryonic ten

213 Using the zebrafish model, we show that impacting golgin-97/245-bi

214 recruitment in response to inflammation in a zebrafish model.

215 Zebrafish models are a powerful system for discovery, li

216 icantly suppressed migration in vitro and in zebrafish models.

217 a large amount of data from small groups of zebrafish moving between compartments of their tank and

218 In the retina of zebrafish, Muller glia have the ability to reprogram int

219 Analysis of a zebrafish mutant, spondo, whose spine is dysmorphic, pro

220 Using whole-genome sequencing of zebrafish mutants isolated in an unbiased genetic screen

221 CRISPR/Cas9-mediated REEP5 loss-of-function zebrafish mutants show sensitized cardiac dysfunction up

222 otagmin 2a (Syt2a) during development of the zebrafish nervous system.

223 ing molecules that play an important role in zebrafish neural patterning and brain development.

224 Using the zebrafish neural tube as a model, we uncover the in vivo

225 Each hair cell (HC) precursor of zebrafish neuromasts divides to form two daughter HCs of

226 erin-mediated adhesion in the development of zebrafish ocular motor (sub)nuclei.

227 Neurogenesis in the zebrafish olfactory epithelium requires the bHLH proneur

228 The larval zebrafish optic tectum has emerged as a prominent model

229 Her9, the zebrafish ortholog of human HES4, is a basic helix-loop-

230 ative atlas of cellular architecture for the zebrafish posterior lateral line primordium, an experime

231 ty of a large set of progestins on human and zebrafish PR and highlights major interspecies differenc

232 segment lineage assignment in the developing zebrafish pronephros by repressing Tfap2a activity.

233 genetic deletion in the kringle 1 domain of zebrafish prothrombin.

234 hypomorphic and EOfAD-like mutations in the zebrafish psen1 gene to explore the effects of age and g

235 n and its regulation can directly affect the zebrafish regenerative potential.

236 Using larval zebrafish, researchers are elucidating the function of m

237 Pomgnt1 mutation in zebrafish resulted in a loss of matriglycan, retention o

238 Genetic disruption of irf6 and esrp1/2 in zebrafish resulted in cleft of the anterior neurocranium

239 Llgl1 depletion in zebrafish resulted in larger and dysmorphic cardiomyocyt

240 targeted mutation or morpholino knockdown in zebrafish, results in Sox2 downregulation and causes the

241 Here we show that the larval zebrafish retina extracts a diversity of naturalistic mo

242 We here use the zebrafish retina to address this gap, exploiting its sui

243 F3B mutant mRNA expression in the developing zebrafish retina.

244 3D organisation of multiple cell classes in Zebrafish retinal organoids and cell distributions in mo

245 These results in zebrafish reveal a developmental window of susceptibilit

246 s of co-housed GFP-positive and GFP-negative zebrafish revealed a naturally occurring picornavirus th

247 Subsequent in vivo experiments in zebrafish revealed a role for the ETS factor FEV in endo

248 Analysis of sav1 mutant zebrafish revealed dysplastic morphology and expansion o

249 New biosensors and live imaging in zebrafish revealed that neutrophil chemoattractant synth

250 Zebrafish RNA-seq datasets show a preponderance of 3' al

251 and behaviour in several species, including zebrafish, rodents and humans.

252 It was suggested that the zebrafish's color pattern arises from a single type of i

253 aging, we examined mitochondrial motility in zebrafish sensory and motor axons.

254 In zebrafish, SerRSS101D/S241D, a phosphorylation-mimicry m

255 r reporters, we observed that while bcar1-/- zebrafish showed no arterial angiogenic or heart defects

256 Zebrafish significantly discriminated size ratios from 0

257 We found that microridges on zebrafish skin cells contained both actin and keratin fi

258 The channel is present in zebrafish sperm and carries a proton inward current that

259 study, Chen and colleagues demonstrated that zebrafish spinal cord radial glia differentiate into cel

260 In the zebrafish spinal cord, neural progenitors form stereotyp

261 arian physiology, we generated a ZIP9-mutant zebrafish strain using a CRISPR/Cas9 system.

262 We report a collection of 1200 transgenic zebrafish strains made with the gene-break transposon (G

263 A new zebrafish study identifies compounds that shield ears an

264 oxide by micropipette perfusion to unwounded zebrafish tail fins.

265 In both zebrafish tail injury and murine acute lung injury model

266 ophysiological recordings from ENs of larval zebrafish that directly illustrate how synaptic inhibiti

267 mpact on muscle growth in juvenile and adult zebrafish that escape the larval lethality.

268 We show that zebrafish that lack appropriate social stimuli in a sens

269 become a powerful tool for genome editing in zebrafish that permits the rapid generation of loss of f

270 al of this review is to highlight studies in zebrafish that utilized live-imaging techniques to analy

271 epithelial component of pharyngeal teeth in zebrafish (the enamel organ) is derived from medial endo

272 In zebrafish, this mechanism controls premature melanoblast

273 lity, DomA (0.09 - 0.18 ng) was delivered to zebrafish through caudal vein microinjection during dist

274 e morphology and physiology of RBs in larval zebrafish to better understand how mechanosensory stimul

275 dissected a cardiac regeneration enhancer in zebrafish to elucidate the mechanisms governing spatiote

276 RAP) and RNA sequencing, TRAP-seq, in larval zebrafish to identify genes differentially expressed in

277 output is required, for instance, for larval zebrafish to learn conditioned fictive swimming.

278 etic tools in mammalian cells and in vivo in zebrafish to specifically analyze ciliary signaling and

279 microglia also prune myelin sheaths, we used zebrafish to visualize and manipulate interactions betwe

280 ery with immunology, we genetically modified zebrafish to visually report on virus infections.

281 producibility, we built a more comprehensive zebrafish transcriptome annotation that addresses these

282 Here, we report the crystal structure of the zebrafish VDR ligand-binding domain in complex with the

283 Here, we measure sensory computations in zebrafish vestibular neurons across multiple axes in viv

284 Using zebrafish we have previously demonstrated that cells der

285 stnatal and adult mice, as well as embryonic zebrafish, we demonstrate that endothelial-specific gain

286 ugh a screen of known bioactive chemicals in zebrafish, we identified a new pathway regulating tendon

287 over 12-h periods in live prefeeding larval zebrafish, we show that muscle grows more during day tha

288 ceived in both external and internal organs, zebrafish were exposed to specific 50 nm light wavebands

289 CRISPR-Cas9-edited zebrafish were used as an in vivo model to assess gene f

290 responsiveness and serotonergic signaling in zebrafish, which is well recognizable through the modify

291 e tested the effects of identified agents in zebrafish with disruption of ttc7a, which develop intest

292 ition of the downstream AKT target, mTOR, in zebrafish with ganglioneuroma effectively reduced the tu

293 Zebrafish with mmachc deficiency recapitulate the severa

294 To address this issue, zebrafish with mutations in mitfa and tfec, two members

295 hese processes, we analyzed the phenotype of zebrafish with mutations in the three known TH nuclear r

296 sterol promoted this phenotype; treatment of zebrafish with statins, cholesterol synthesis inhibitors

297 field, largely focused on recent studies in zebrafish, with comparisons to amniotes where appropriat

298 derivative of 5-FU was shown in a colorectal zebrafish xenograft model that led to significant reduct

299 tumour-macrophage co-culture, migration and Zebrafish xenograft studies.

300 Targeted testing in zebrafish yielded positive results for two p38 inhibitor