ライフサイエンスコーパス: zinc deficiency

1 Zap1 controls their response to zinc deficiency.

2 ew all of the disease states associated with zinc deficiency.

3 lights a few of the diseases associated with zinc deficiency.

4 in 50% were consistent with the presence of zinc deficiency.

5 f zinc homeostasis and adaptive responses to zinc deficiency.

6 mpaired regeneration, as well as significant zinc deficiency.

7 ome Mexican American children are at risk of zinc deficiency.

8 ated that these genes respond differently to zinc deficiency.

9 oped and developing countries pose a risk of zinc deficiency.

10 than were their wild-type littermates during zinc deficiency.

11 is that are commonly associated with dietary zinc deficiency.

12 p target whose expression is increased under zinc deficiency.

13 a central player in the response of yeast to zinc deficiency.

14 s the basis for a field-deployable assay for zinc deficiency.

15 nduces target gene expression in response to zinc deficiency.

16 ith the increased oxidative stress caused by zinc deficiency.

17 ace of enterocytes and endoderm cells during zinc deficiency.

18 Ys1 mRNA expression patterns in response to zinc deficiency.

19 ell surfaces and internalized during dietary zinc deficiency.

20 purposes in the prevention and treatment of zinc deficiency.

21 r activation of transcription in response to zinc deficiency.

22 a result showing gene-modulating effects of zinc deficiency.

23 d promoter element (ZRE) under conditions of zinc deficiency.

24 l disease (SCD) may be due, in part, to mild zinc deficiency.

25 ion that occur in the early stages of rodent zinc deficiency.

26 berrant Th1/Th2 cytokine balance observed in zinc deficiency.

27 xpression of its target genes in response to zinc deficiency.

28 0 (products of Th2) were not affected during zinc deficiency.

29 Apoptosis is potentiated by zinc deficiency.

30 health effects of mild-to-moderate maternal zinc deficiency.

31 (NIDDM) may cause vulnerability to moderate zinc deficiency.

32 her they are primary or secondary effects of zinc deficiency.

33 ainst the accelerated cognitive decline with zinc deficiency.

34 r zinc release from LROs and survival during zinc deficiency.

35 d rice (BFR) in preschool-aged children with zinc deficiency.

36 nnii pneumonia are also at increased risk of zinc deficiency.

37 ality of antibody responses in children with zinc deficiency.

38 ption could contribute to the alleviation of zinc deficiency.

39 y level was more pronounced in children with zinc deficiency.

40 opogenic CO2 emissions on the global risk of zinc deficiency.

41 zinc importers are upregulated during severe zinc deficiency.

42 components required for GAS survival during zinc deficiency.

43 al regulation of target genes in response to zinc deficiency.

44 increase in the human population at risk of zinc deficiency.

45 hat ZnT mutations play in transient neonatal zinc deficiency.

46 ndernutrition, suboptimum breastfeeding, and zinc deficiency.

47 lows for the expression of genes required in zinc deficiency.

48 ecreases the oxidative stress that occurs in zinc deficiency.

49 the Tsa1 chaperone function in tolerance to zinc deficiency.

50 ting/refeeding, and increased with beta cell zinc deficiency.

51 ca burdened with high prevalence of iron and zinc deficiency.

52 echanism to ensure decreased Hnt1 protein in zinc deficiency.

53 ommunity-based sample of children at risk of zinc deficiency.

54 .24, 6.90) children had an increased risk of zinc deficiency.

55 sponse is induced under conditions of severe zinc deficiency.

56 regarding how cells respond to the stress of zinc deficiency.

57 c acids is promising in alleviating iron and zinc deficiencies.

58 es of Arabidopsis to micronutrient (iron and zinc) deficiencies.

59 To discover molecular signatures of human zinc deficiency, a combination of transcriptome, cytokin

60 t in zinc (3 mg/kg zinc), we determined that zinc deficiency accelerated Alzheimer's-like memory defi

61 l trait A46, also known as bovine hereditary zinc deficiency, Adema disease, and hereditary parakerat

62 rease in cells in the proliferative phase as zinc deficiency advanced.

63 ly both in proportion and absolute number as zinc deficiency advanced.

64 Neither did zinc deficiency affect the intracellular distribution of

65 Zinc deficiency affects close to half of all children in

66 Zinc deficiency affects many organ systems, including th

67 Zinc deficiency alone induced unrestrained cellular prol

68 Zinc deficiency also affects development of acquired imm

69 d the populations who are at highest risk of zinc deficiency also receive most of their dietary zinc

70 Zinc deficiency alters autonomic nervous system regulati

71 Whether zinc deficiency alters the rate of production of myeloid

72 n patients owing to the less recognized mild zinc deficiency among the 'at-risk population' as in the

73 of this review is to present the evidence of zinc deficiencies and toxicities as well as treatment in

74 Some genes are induced under mild zinc deficiency and act as a first line of defense again

75 Here we established a mouse model of dietary zinc deficiency and acute A. baumannii pneumonia to test

76 objective was to determine the prevalence of zinc deficiency and anemia and their interrelation among

77 The prevalence of zinc deficiency and anemia was high in this population o

78 genetically lacking Slc30a7 suffer from mild zinc deficiency and are prone to development of prostate

79 The examples of applications shown here, zinc deficiency and cadmium toxicity, demonstrate that t

80 nment and suggests that the relation between zinc deficiency and cognitive development may vary by ag

81 Zinc deficiency and contaminated water are major contrib

82 In many diseases, zinc deficiency and elevated level of Hh ligand co-exist

83 ncentrations among young children at risk of zinc deficiency and examined the relations between these

84 Because zinc deficiency and excess result in toxicity, animals h

85 sion, differential responsiveness to dietary zinc deficiency and excess, and differential responsiven

86 alcohol abuse is associated with significant zinc deficiency and immune dysfunction within the alveol

87 s suggest the need for prevention of chronic zinc deficiency and improvement of general nutritional s

88 This study was designed to determine if zinc deficiency and inappropriate urinary zinc losses ar

89 genes allow cells to adapt to conditions of zinc deficiency and include genes involved in maintainin

90 PC alpha-defensin dysfunction is mediated by zinc deficiency and involved in the pathogenesis of AH.

91 Prepubertal children with SCD-SS may have zinc deficiency and may benefit from zinc supplementatio

92 To identify targets of zinc deficiency and mechanisms of zinc acclimation, we u

93 hageal cell proliferation induced by dietary zinc deficiency and reduced the incidence of esophageal

94 protein, a transcription factor that senses zinc deficiency and responds by up-regulating genes invo

95 Zinc deficiency and retinitis pigmentosa are both import

96 ost resistance to infections observed during zinc deficiency and supplementation.

97 Further investigation of the incidence of zinc deficiency and the ability of anemia to screen for

98 r data suggest a causal relationship between zinc deficiency and the overproduction of Hh ligand.

99 he identification of populations at risk for zinc deficiency and to monitoring the effects of zinc in

100 nol A, ethanol, fluoxetine hydrochloride and zinc deficiency) and four human induced pluripotent stem

101 improved water and sanitation, vitamin A and zinc deficiencies, and ambient particulate matter pollut

102 Thirty were increased in zinc deficiency, and 17 were decreased.

103 nds to copper limitation and is turned on in zinc deficiency, and Crr1 is required for growth in zinc

104 -regulation of zinc transporter genes during zinc deficiency, and the WAKL4 T-DNA insertion resulted

105 Iron and zinc deficiency are prevalent during infancy in low-inco

106 isiae, homeostatic and adaptive responses to zinc deficiency are regulated by the Zap1 transcription

107 iciency anemia, night blindness, and risk of zinc deficiency are summarized.

108 ifying population groups at elevated risk of zinc deficiency, are sparse and difficult to interpret b

109 and proliferation, yet the mechanisms of how zinc deficiency arrests these processes remain enigmatic

110 ing the public health importance of maternal zinc deficiency as it relates to fetal growth and develo

111 , and infants are particularly vulnerable to zinc deficiency as they require large amounts of zinc fo

112 us DNA sequences was decreased markedly with zinc deficiency, as assayed by electrophoretic mobility-

113 hageal cell proliferation induced by dietary zinc deficiency, as measured by the labeling index, the

114 The accurate estimation of zinc deficiency at the population level is important, as

115 Specifically, we focus on a zinc deficiency B. distachyon basic leucine zipper trans

116 everity was associated with greater relative zinc deficiency (B = -1.503, t9 = -2.82, p = .026).

117 ed households may be predisposed to iron and zinc deficiency because of nondietary factors such as ch

118 using a periorificial and/or acrodermatitis: zinc deficiency, biotin deficiency, kwashiorkor, and ess

119 tion in foliar tissue under ozone stress and zinc deficiency, but did not affect the sensitivity to i

120 e (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due

121 people estimated to be placed at new risk of zinc deficiency by 2050 was 138 million (95% CI 120-156)

122 on of RC reduced the estimated prevalence of zinc deficiency by a median of 11 (range: 4-18) percenta

123 Mild to moderate zinc deficiency can be best detected through a positive

124 ty to NMBA-induced carcinogenesis induced by zinc deficiency can be inhibited by alpha-difluoromethyl

125 f zinc ions in rhodopsin and examine whether zinc deficiency can lead to rhodopsin dysfunction.

126 These data support the concept that zinc deficiency can result in alterations in iron transp

127 Zinc deficiency caused no change in the cell cycle statu

128 Dietary zinc deficiency causes a marked increase in the accumula

129 Zinc deficiency causes exaggerated inflammatory response

130 Zinc deficiency causes immune dysfunction.

131 t with this hypothesis, we demonstrated that zinc deficiency causes increased reactive oxygen species

132 It was recently shown that zinc deficiency causes sizable losses among the precurso

133 Zinc deficiency causes thymic atrophy and lymphopenia.

134 Zinc deficiency, cell-mediated immune dysfunction, susce

135 i pneumonia to test the hypothesis that host zinc deficiency contributes to A. baumannii pathogenesis

136 Zinc deficiency contributes to many clinical disorders,

137 Zinc deficiency correlates only with severe chronic panc

138 The mechanisms through which zinc deficiency could influence health outcomes are well

139 he mechanisms responsible for the effects of zinc deficiency, cultured human Ntera-2 (NT2) neuronal p

140 In HuT-78, a Th0 cell line, zinc deficiency decreased gene expression of thymidine k

141 Zinc deficiency decreased natural killer cell lytic acti

142 nd behavior in animals; the relation between zinc deficiency, depression, and ADHD in patient and com

143 subpopulation was expanded in psoriasis and zinc-deficiency dermatitis, attesting to disease relevan

144 Secondary outcomes were prevalence of zinc deficiency, diarrhea prevalence, and growth.

145 his nutritional requirement in humans is the zinc deficiency disease, acrodermatitis enteropathica.

146 time, mutations in the ECD can result in the zinc-deficiency disease Acrodermatitis enteropathica.

147 Zinc deficiency disrupts their folding, and the ubiquiti

148 Therefore, zinc deficiency due to loss-of-function ZnT8 mutations s

149 Dietary zinc deficiency during pregnancy down-regulated ZnT1 and

150 Maternal dietary zinc deficiency during pregnancy exacerbated these effec

151 Maternal zinc deficiency during pregnancy may be widespread among

152 ould be considered in populations at risk of zinc deficiency, especially where there are elevated rat

153 ins function at multiple levels, and dietary zinc deficiency exaggerated the deleterious effect of al

154 to down-regulate sulfate assimilation under zinc deficiency experience increased oxidative stress.

155 Before transplant, patients with zinc deficiency had higher urinary zinc to creatinine ra

156 Zinc deficiency has also been implicated in diarrheal di

157 x months of age; however, transient neonatal zinc deficiency has been documented in exclusively breas

158 Zinc deficiency has been shown to contribute to the prog

159 oblem reserved for underdeveloped countries, zinc deficiency has increasing pediatric prevalence in t

160 mutation, associated with transient neonatal zinc deficiency, has on ZnT1, ZnT3, and ZnT4 upon hetero

161 tation in SLC30A2 and can result in neonatal zinc deficiency if unrecognized.

162 meaning non-haem iron deficiency anaemia and zinc deficiency immune malfunction are a risk.

163 Zinc deficiency impairs overall immune function and resi

164 Zinc deficiency impairs the antibody-mediated immune res

165 lectrolytic iron in addressing both iron and zinc deficiencies in low socio-economic populations of s

166 Growth retardation has been associated with zinc deficiency in adolescent human populations, but ani

167 The role of zinc deficiency in alpha-defensin was evaluated in acute

168 Zinc deficiency in an experimental human model caused an

169 ed transcriptional activation in response to zinc deficiency in cells, suggesting a conserved pathway

170 During the last decade, the significance of zinc deficiency in childhood growth, morbidity, and mort

171 Zinc deficiency in children is an important public healt

172 inding of NF-kappaB to DNA were decreased by zinc deficiency in HuT-78.

173 ators of inflammation, and we show here that zinc deficiency in immune cells, including microglia, po

174 It is thought that there is a high risk of zinc deficiency in India, but there are no representativ

175 bution to progress toward the eradication of zinc deficiency in infants and young children in the dev

176 Although there is a greater risk of zinc deficiency in persons consuming lactoovovegetarian

177 Zinc deficiency in pregnant experimental animals limits

178 Zinc deficiency in rats enhances esophageal cell prolife

179 reased cell proliferation induced by dietary zinc deficiency in rats plays a critical role in esophag

180 an extensive discussion of the influence of zinc deficiency in selected diseases.

181 role in human immunity, and it is known that zinc deficiency in the host is linked to increased susce

182 ified the gene responsible for the inherited zinc deficiency in the lethal milk (lm) mouse.

183 ears focused attention on the possibility of zinc deficiency in the United States.

184 Zinc deficiency in this yeast induces the unfolded prote

185 Zinc deficiency increased mZIP4 protein levels at the pl

186 Zinc deficiency increased plasma membrane levels of mZip

187 Zinc deficiency increased the forestomach cell prolifera

188 12 PSC surveys, the estimated prevalence of zinc deficiency increased with increasing CRP deciles, a

189 nal TBARS in group 2 indicates that moderate zinc deficiency increases oxidative stress to the retina

190 umulation of IRP2 protein was independent of zinc deficiency-induced intracellular nitric oxide produ

191 ve element isoform mRNA was decreased during zinc deficiency-induced iron accumulation.

192 Finally, we demonstrate zinc deficiency-induced quiescence occurs independently

193 Zinc deficiency induces quiescence and resupply stimulat

194 We conclude that zinc deficiency induces the production of a low-molecula

195 Zinc deficiency is a cause of immune dysfunction and inf

196 Human zinc deficiency is a global public health problem.

197 Zinc deficiency is a major cause of childhood morbidity

198 Dietary zinc deficiency is a major risk factor for pneumonia.

199 Zinc deficiency is a potential risk factor for disease i

200 Zinc deficiency is a relatively common problem in childr

201 Zinc deficiency is also a global problem, especially in

202 Zinc deficiency is also associated with acute and chroni

203 One consequence of zinc deficiency is an elevation in cell and tissue iron

204 common nutritional deficiency in the world; zinc deficiency is associated with poor growth and devel

205 Experimental studies reported that zinc deficiency is associated with renal damage and coul

206 Zinc deficiency is closely associated with stunting, res

207 D2 may contribute more to Zap1 function when zinc deficiency is combined with other environmental str

208 Zinc deficiency is common among populations at high risk

209 nably improve zinc status in countries where zinc deficiency is common and rice is a staple, but its

210 Zinc deficiency is commonly attributed to inadequate abs

211 Zinc deficiency is currently responsible for large burde

212 Zinc deficiency is discussed in another, and the arsenic

213 elopment of intervention programs to control zinc deficiency is hampered by the lack of sensitive, sp

214 Zinc deficiency is implicated in the pathogenesis of hum

215 Zinc deficiency is increasingly recognized as an importa

216 deficiency, but whether they can also reduce zinc deficiency is less certain.

217 e public health importance of this degree of zinc deficiency is not well defined.

218 Zinc deficiency is one of the most consistently observed

219 Maternal zinc deficiency is relatively common in developing count

220 ansplant is rapidly improved and biochemical zinc deficiency is reversed after liver transplantation.

221 Zinc deficiency is spatially dependent over short distan

222 Zinc deficiency is the most prevalent malnutrition in th

223 morbidity and mortality in populations with zinc deficiency is unclear.

224 ells relative to zinc-replete cells, whereas zinc deficiency is visually asymptomatic but distinguish

225 inc by enterocytes, and the ensuing systemic zinc deficiency leads to dermatological lesions and immu

226 Secondary outcomes were zinc deficiency, linear growth, infection-related morbid

227 In children in developing countries, zinc deficiency may be common and associated with immune

228 Decreased production of IL-2 in zinc deficiency may be due to decreased activation of NF

229 Mild-to-moderate zinc deficiency may be relatively common worldwide, but

230 ive development are unclear, it appears that zinc deficiency may lead to deficits in children's neuro

231 both animal and human studies suggests that zinc deficiency may lead to delays in cognitive developm

232 Zinc deficiency may result in abnormal dark adaptation o

233 These responses to dietary zinc deficiency mimic those found in the adult intestine

234 to diverse physiological stresses, including zinc deficiency, nitrogen starvation, and inhibition of

235 study supports the contention that moderate zinc deficiency occurs frequently in subjects with NIDDM

236 American race-ethnicity was associated with zinc deficiency (odds ratio: 0.26; P = 0.02).

237 ying full datasets yield estimates of global zinc deficiency of 31%-37% for these demographic groups.

238 We investigate the effect of zinc deficiency on DNA damage, expression of DNA-repair

239 imed to determine the effects of alcohol and zinc deficiency on Paneth cell (PC) antimicrobial peptid

240 ntestine and the effects of maternal dietary zinc deficiency on these patterns of expression were exa

241 ion of undernutrition (stunting, anemia, and zinc deficiency), overweight, and obesity in Ecuador to

242 y-treatment effect on PZn (P = 0.026) and on zinc deficiency (P = 0.032) was found; PZn in the Zn+fil

243 In the early phases zinc deficiency, p53 targets responsible for cell cycle

244 ed, makes it difficult to isolate effects of zinc deficiency per se from those of generalized protein

245 Of the 200 children, 78.5% had zinc deficiency (plasma zinc concentration < 65 ug/dL) a

246 ignificant time-by-treatment effects on PZC, zinc deficiency prevalence, FADS activity, I-FABP, or fe

247 m1 and various CAH genes are up-regulated in zinc deficiency, probably due to reduced carbonic anhydr

248 the result of vesicular zinc trapping and ER zinc deficiency rather than overload.

249 decades, the estimated global prevalence of zinc deficiency remains high.

250 The biochemistry of human nutritional zinc deficiency remains poorly defined.

251 2-49 y have excess body weight and anemia or zinc deficiency, respectively.

252 Zinc deficiency results in dysfunction of both humoral a

253 Dietary zinc deficiency results in stunted growth, skin lesions,

254 In zinc deficiency, RNAPI is specifically degraded by prote

255 Subacute zinc deficiency significantly increases systemic inflamm

256 y exploring the transcriptional responses to zinc deficiency, studies of the yeast Saccharomyces cere

257 a good food source for groups suffering from zinc deficiency such as the elderly groups or vegetarian

258 layed some classic manifestations of dietary zinc deficiency, such as reduced food intake and poor bo

259 Thymocyte apoptosis is potentiated by zinc deficiency, suggesting that these iron chelators ma

260 d ZIP3 are expressed in roots in response to zinc deficiency, suggesting that they transport zinc fro

261 udies using cultured HepG2 cells showed that zinc deficiency suppressed cell proliferation and cell p

262 two exclusively breast-fed infants developed zinc deficiency that was associated with low milk zinc c

263 metabolic consequences (much more than with zinc deficiency) that included altered energy, polyamine

264 ded phosphatidate phosphatase was induced by zinc deficiency through a mechanism that involved intera

265 rs with infants harboring transient neonatal zinc deficiency (TNZD).

266 e needed from other populations with endemic zinc deficiency to confirm the potential age-specific ef

267 Finally, zinc deficiency up-regulates the mammalian ER stress res

268 oexistence of OW/OB and stunting, anemia, or zinc deficiency was found in 2.8%, 0.7%, and 8.4% of sch

269 rely deficient in both copper and zinc ions, zinc deficiency was not a consistent feature shared by t

270 Zinc deficiency was present in all affected individuals

271 Greater zinc deficiency was required to alter mZip3 distribution

272 oncentrations (ie, population at new risk of zinc deficiency) was our measure of impact.

273 Using an in vivo model of acute dietary zinc deficiency, we show that feeding a zinc deficient d

274 ey data, estimates of prevalence of iron and zinc deficiency were comparable but vitamin A deficiency

275 ties of specific serum microRNAs for dietary zinc deficiency were identified by acute responses to zi

276 fects on the fecal microbiota of protein and zinc deficiency were probed independently in a murine mo

277 In contrast, during periods of dietary zinc deficiency when secretion of zinc by the pancreas a

278 and conservation are derepressed during mild zinc deficiency, whereas the energy-dependent zinc impor

279 unologic functions, is adversely affected by zinc deficiency, which can dysregulate intracellular kil

280 is proteolytically removed during prolonged zinc deficiency while the remaining eight-transmembrane

281 Although the mechanisms linking zinc deficiency with cognitive development are unclear,

282 ism by which L. monocytogenes can respond to zinc deficiency within a variety of environments and dur

283 ine the public health importance of maternal zinc deficiency worldwide.

284 In an animal model of Alzheimer's disease, zinc deficiency worsened cognitive decline because of an

285 We hypothesized that subacute zinc deficiency would amplify immune responses and oxida

286 In response to zinc deficiency, Zap1 activates transcription of many ge

287 Thus, during zinc deficiency, Zap1 mediates the repression of two of

288 duration are the immunological hallmarks of zinc deficiency (ZD) in humans and higher animals.

289 Dietary zinc deficiency (ZD) in mice enhances cellular prolifera

290 Zinc deficiency (ZD) in rats increases esophageal cell p

291 IP4 gene, which is induced during periods of zinc deficiency, ZIP5 gene expression is unaltered by di