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1 ng to GC bases as reported for the wild-type zinc finger.
2 a DNA-binding residue in the first of three zinc fingers.
3 cation, confirming a functional role for the zinc-fingers.
4 ted that the transcription factor GLI family zinc finger 1 (GLI1) mediates Sulf2 expression during HC
5 of the stem cell-expressed genes GLI family zinc finger 1 (Gli1) or achaete-scute homolog 1 (Ascl1).
6 ce transcription factors, VASCULAR PLANT ONE-ZINC FINGER 1 (OsVOZ1) and OsVOZ2, and promotes their de
7 ulation, which expresses the Teashirt family zinc finger 1 (Tshz1) and belongs to the direct pathway,
8 al transcription factor vascular endothelial zinc finger 1 (VEZF1) as a direct target of miR-483-3p.
11 The transcription factor GLI1 (GLI family zinc finger 1) plays a key role in the development and p
12 stochemistry staining for Glis1 (GLIS family zinc finger 1) was conducted in developing heart of mice
15 show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bili
19 ese results suggest an active role for GATA3 zinc finger 2 mutants in ER-alpha positive breast tumors
20 memory retrieval-associated increases in BLA zinc finger 268 (zif268) and activity regulated cytoskel
21 that PCFU self-renewal requires GLIS family zinc finger 3 (GLIS3), a zinc-finger transcription facto
22 iginal alpha-helical segment in the Cys2His2 zinc finger 3 of transcription factor Egr1 (also known a
23 g three distinct targeted mutations of A20's zinc finger 7 (ZF7) ubiquitin-binding motif uniformly de
24 odule within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heteroc
25 te that, in addition to binding DNA, PRDM9's zinc fingers also mediate its multimerization, and we sh
26 but coincided in upregulation of a DHHC-type zinc finger and an aspartyl protease gene, possible cand
29 n thermogenic gene activation and identified zinc finger and BTB domain-containing 7b (Zbtb7b) as a p
32 In this study, we investigate the role of Zinc finger and SCAN domain containing 4 (ZSCAN4) in hum
33 ly contacts U1 snRNA at the Sm site with its zinc finger and traps snRNP biogenesis intermediates in
34 e., KLF4, KLF6, PLZF (promyelocytic leukemia zinc finger), and KLF15, are induced in TG neurons early
40 en using small inhibitory RNAs revealed that zinc-finger antiviral protein (ZAP) inhibited virion pro
43 this geometry are enriched in genomes where zinc fingers are prevalent and specificity transitions w
44 DNA binding activity of the rapidly evolving zinc finger array of PRDM9 (PR domain zinc finger protei
46 gnal amplifier in BCCs with implications for zinc finger-based signal transduction and therapeutics.
49 TAGGGAA-3') and encompasses a Myc-associated zinc finger-binding site that regulates KRAS transcripti
50 plex, Tramtrack, and Bric-abrac/poxvirus and zinc finger (BTB/POZ) transcription factor family and ma
51 ted uniquely at 48 hpi and genes involved in zinc finger CCCH protein, glycosyltransferase, 1-aminocy
52 ovel RNA-binding protein interactors ZC3H14 (zinc finger CCCH-type containing 14) and THOC1 (THO comp
53 is coselected with the U12 splicing factor, zinc finger CCCH-type, RNA binding motif, and Ser/Arg ri
54 onal change process, revealing that a unique zinc finger (CCCH) in VP2 acts as the major low pH senso
57 m-resolution crystal structure of human CCHC zinc finger-containing protein ZCCHC4, a 28S rRNA-specif
61 d polyadenosine RNA-binding protein, ZC3H14 (Zinc finger CysCysCysHis domain-containing protein 14),
62 etase Long Chain Family Member 5 (ACSL5) and Zinc Finger DHHC-Type Containing 6 (ZDHHC6), was charact
64 of 25 kDa) is mediated by a subset of Golgi zinc finger DHHC-type palmitoyltransferase (zDHHC) enzym
65 on SbMATE expression arise from a WRKY and a zinc finger-DHHC transcription factor (TF) that bind to
66 rm upregulates BTV mRNA translation, whereas zinc-finger disruption decreases viral mRNA translation,
67 transcription regulators with a well-defined zinc finger DNA-binding domain and there is evidence tha
69 and both its physical interaction to GR and zinc finger domain appear to be required for ZNF764 to r
71 DD8 trimer, specifically bound to the second zinc finger domain of PARP-1 and attenuated its activati
75 catalytic SET domain and an intervening MYND zinc finger domain, as well as an extended C-terminal do
77 a forms a two-site interaction with the GLI1 zinc-finger domain and acetylation site, stabilizing an
80 packed against N-terminal GRF-type and C2H2 zinc finger domains and a C-terminal CCHC domain, creati
81 transcription factors that contain conserved zinc finger domains involved in binding to target DNA se
86 s with CRISPR/Cas9-mediated depletion of the zinc finger E-box binding homeobox 1 (ZEB1) in claudin-l
87 to hypoxia because carbonic anhydrase IX and zinc finger E-box binding homeobox 1 (Zeb1) protein leve
93 Previous studies have suggested that the zinc-finger epithelial-mesenchymal transition transcript
94 tanding of how a single mutation in the KLF1 zinc finger exerts effects on erythroid physiology in CD
95 n synthesis were detected at lower rates and zinc finger family transcripts were of poorer quality.
96 ctor 6 (KLF6), a transcription factor of the zinc finger family, regulates lipid homeostasis in clear
99 mbryo polarity rests on a previously unnamed zinc finger gene (cucoid), or pangolin (dTcf), respectiv
101 in Kruppel-associated box domain-containing zinc finger genes on chromosome 19, both of which are as
102 n Sonic hedgehog (SHH) signaling, GLI family zinc finger (GLI)-mediated diverse gene transcription ou
106 of the TSHZ3 gene, encoding for the teashirt zinc-finger homeobox family member 3 (TSHZ3) transcripti
107 ein-RNA complex containing the N-terminal, 4-zinc finger human (h) ZAP RNA-binding domain (RBD) and a
108 lving the sixth PHD domain and its preceding zinc finger in MLL3 and MLL4 specifically recognizes an
109 )S double mutation, which disrupts both CCHC zinc fingers in the NC domain, does not abrogate Alix-me
111 dimerization of CESA6 through its N-terminal zinc finger is critical in defining its functional prope
115 alysis provides evidence that the engineered zinc finger motif adopts a folded structure in which the
116 phosphates but involves interactions with a zinc finger motif in the Sin3-associated protein 30 (SAP
117 s stimulate HDAC activity and that the SAP30 zinc finger motif performs roles similar to that of the
120 is NEIL3 C terminus has two highly conserved zinc finger motifs containing GRXF residues (designated
122 an cells revealed that intact PIN domain and Zinc finger motifs in human hUTP23 are essential for 18S
123 arsenic interacts with the N- and C-terminal zinc finger motifs of GATA-1, causing zinc loss and inhi
125 shift assays showed that wild-type, but not zinc-finger mutant ZFP36L1, bound to HIF1A 3'UTR and med
127 rat expressing the G551D variant obtained by zinc finger nuclease editing of a human complementary DN
130 developed a novel Bace1(-/-) rat line using zinc-finger nuclease technology and compared Bace1(-/-)
132 an approach for improving the specificity of zinc finger nucleases (ZFNs) that engineers the FokI cat
133 iew, we introduce the three central methods, zinc finger nucleases (ZFNs), transcription activator-li
134 ccurring nucleases, including meganucleases, zinc finger nucleases, and transcription activator-like
135 ry and development of DNA-editing nucleases (Zinc Finger Nucleases, TALENs, CRISPR/Cas systems) has g
136 go, first with meganucleases and followed by zinc finger nucleases, transcriptional activator-like ef
137 to enable such high-precision targeting with zinc-finger nucleases (ZFNs), we have developed an expan
138 genome editing proteins, Cre recombinase and zinc-finger nucleases, under conditions in which (-30)GF
140 strate how a missense mutation in the second zinc finger of Kruppel-like factor-1 (KLF1) leads to deg
142 rol genes that include homologs of mammalian Zinc finger of the cerebellum and Purkinje cell protein
143 sis likely through replacing zinc within the zinc fingers of the critical transcription factor GATA-1
144 5 causal missense variants in or near IKZF5 zinc fingers, of which 2 occurred de novo and 3 co-segre
145 estored by C-terminal fusion with ETO's NHR4 zinc-finger or the repressor domain 3 of N-CoR, while ot
146 tors, and express the promyelocytic leukemia zinc finger (PLZF) transcription factor that distinguish
148 ve confirmed that speckle-type pox virus and zinc finger (POZ) protein (SPOP) functions as a substrat
150 the rapidly evolving Kruppel-associated box-zinc finger protein (KRAB-ZFP) family linked primarily t
151 these effects and identify a cluster of KRAB zinc finger protein (KZFP) genes that modifies VM-IAPs i
152 the Kruppel-associated box (KRAB)-containing zinc finger protein (KZFP) ZFP57 protects select ICRs fr
153 ked to recruitment of the monocytic leukemia zinc finger protein (MOZ) histone acetyltransferase to t
156 The nuclear matrix protein Cip1-interacting zinc finger protein 1 (CIZ1) promotes DNA replication in
157 In this study, we identify the conserved zinc finger protein 277 (ZNF277) as a new uS5-associated
159 r, reduced expression 1 (REX1; also known as zinc finger protein 42), to be selectively down-regulate
163 ion of parkin interacting substrate protein (zinc finger protein 746) and aminoacyl tRNA synthetase c
165 tor for male-specific lethal [MSL] proteins) zinc finger protein binds these GA repeat motifs, increa
166 ut ZNF274, a Kruppel-associated box-A-domain zinc finger protein capable of recruiting epigenetic mac
167 mage sites, allowing identification of ZPET (zinc finger protein proximal to RAD eighteen)/ZNF280C as
169 that ARS2 (arsenite-resistance protein 2), a zinc finger protein that is essential for early mammalia
170 important for brain function, we engineered zinc finger protein transcription factors (ZFP-TFs) to t
171 for awn inhibition in wheat, encodes a C2H2 zinc finger protein with EAR motifs which putatively fun
175 Here, we report the specific binding of zinc finger protein ZNF768 to the sequence motif GCTGTGT
179 Zfp189, which encodes a previously unstudied zinc finger protein, is the highest-ranked key driver ge
183 pproaches on two large, independent Cys2His2 zinc finger protein-DNA interaction datasets. We demonst
189 rolin (TTP), encoded by the Zfp36 gene, is a zinc-finger protein that regulates RNA stability primari
192 ing RNA AC099552.4 (p = 1.2 x 10(-7)), and a zinc-finger protein ZNF655 (gene-based p = 5.0 x 10(-6))
193 osophila Doublefault (Dbf) protein as a C2H2 zinc-finger protein, primarily expressed in testes, that
196 tetrapods, the Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs), binds to specific EREs
197 hat Kruppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) control the timely and plei
198 -genome activation, implying that other KRAB-zinc finger proteins (KZNFs) recruit KAP1 prior to blast
200 our known CRBN neo-substrates [Ikaros family zinc finger proteins 1 (IKZF1) and 3 (IKZF3), casein kin
202 family of ubiquitously expressed human C2H2 zinc finger proteins comprised of ZFX, ZFY and ZNF711.
204 well as genes coding for aminotransferases, zinc finger proteins, and several uncharacterized protei
208 EERV (Snerv) 1 and 2, Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) that repressed NEERV by
209 For brain development, primate-specific KRAB zinc-finger proteins (KZNFs) are specifically up-regulat
210 domain to the amino terminus of one or both zinc-finger proteins (ZFPs) in the ZFN dimer, as well as
211 ology approach, we identify a new network of zinc-finger proteins that are expressed in one class of
212 myelodysplastic syndrome 1 (MDS)/EVI encode zinc-finger proteins that have been recognized as import
213 ese include DNA-targeting techniques such as zinc-finger proteins, transcription activator-like effec
214 introduce three epigenome-editing platforms: zinc-finger proteins, transcriptional activator-like eff
216 orted genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831
217 e different tuning mechanisms of a synthetic zinc-finger repressor library, whose affinity and cooper
218 LZF(lo)RORgammat(lo) (promyelocytic leukemia zinc finger, retinoic acid-related orphan receptor gT) i
220 We also found that promyelocytic leukemia zinc finger seemed to play a role in regulating NKT cell
221 PR-domain-containing proteins (PRDMs) are zinc-finger sequence-specific chromatin factors that hav
222 While it is known that shared and unique zinc finger sequences in CTCF and CTCFL enable CTCFL to
226 ly comprises 44 activating and 12 inhibitory zinc-finger TFs and 83 cognate promoters, combined in a
227 TZF domain of MEX-5 contains an unstructured zinc finger that folds upon binding of its RNA target.
228 EIL3 contains two tandem C-terminal GRF-type zinc fingers that are absent in the other NEIL paralogs.
229 nteractions through mutations of 2 of its 11 zinc fingers that are not required for CTCF binding to i
230 al DNA-binding domain (DBD) containing three zinc fingers, the automodification domain (A), and the C
231 slocates to the nucleus and interacts with a zinc finger transcription factor (FgZC1), also required
232 and identified the constitutively expressed zinc finger transcription factor (TF) Zfp281 as a bidire
234 er unmask a mutual requirement for Hivep3, a zinc finger transcription factor and adapter protein.
239 tion between Drosophila FOXO (dFOXO) and the zinc finger transcription factor Kruppel homolog 1 (Kr-h
240 gene 3 (Peg3), an imprinted gene encoding a zinc finger transcription factor postulated to function
241 Here, we have identified the C. elegans zinc finger transcription factor PQM-1 as a regulator of
247 mechanism through which STAT3 and the Ikaros zinc finger transcription factors Aiolos and Ikaros coop
250 and negatively regulates Snai1 and ZEB1, two zinc finger transcription factors that lead to increased
251 r 1-3 (GLIS1-3), a subfamily of Kruppel-like zinc finger transcription factors, function as key regul
253 otrophin signalling system; a high number of zinc finger transcription factors; and novel factors tha
255 (NuRD) complex binding are required for the zinc-finger transcription factor CASZ1 to function as a
258 equires GLIS family zinc finger 3 (GLIS3), a zinc-finger transcription factor important in pancreas d
259 utoregulatory, cis-acting motif in the che-1 zinc-finger transcription factor locus, a terminal selec
260 udy, we identified the pepper homolog of the zinc-finger transcription factor LOL1 (LSD ONE LIKE1; Cc
261 s sex-specifically spliced and encodes a BTB zinc-finger transcription factor proposed to be a master
263 homeodomain transcription factor Cut and the zinc-finger transcription factor Tramtrack-69 (Ttk69).
264 Accumulating evidence indicates that the zinc-finger transcription factor ZEB1 is predominantly e
265 otein interaction with the sequence-specific zinc-finger transcription factor ZNF143 and activates th
266 , we demonstrate that SlBBX20, a B-box (BBX) zinc-finger transcription factor, is a positive regulato
270 he PR/SET domain-containing (PRDM) family of zinc finger transcriptional regulators play diverse deve
271 eviously demonstrated that expression of the zinc finger transcriptional repressor Blimp1/PRDM1 is es
272 y, transcriptional targets recognized by the zinc finger transcriptional repressor Prdm1/Blimp1, an e
273 ing only two predicted genes, including C2H2 zinc finger transcriptional repressor TraesCS5A02G542800
274 des and RNA interference targeting mRNA, and zinc finger transcriptional repressors and CRISPR-Cas9 m
277 of target mRNAs, mediated through its tandem zinc finger (TZF) domain, TTP promotes the deadenylation
280 h substitutions that reduced the affinity of zinc fingers, we developed ZFNs specific for the TRAC lo
281 a chimeric CESA5 by replacing its N-terminal zinc finger with its CESA6 counterpart to investigate th
282 capsid proteins, a pH-sensing histidine of a zinc finger within the receptor-binding VP2 protein, and
283 vious studies suggested that the RanBP2-type Zinc Finger (ZF) domain is a suitable scaffold to invest
284 ps for the best characterized members of the zinc finger (ZF) family of MBPs in propagating DNA methy
286 ne family of proteins modified by H(2) S are zinc finger (ZF) proteins, which contain multiple zinc-c
287 e N-tier ring is structurally divided into a zinc finger (ZF) sub-ring followed by the oligosaccharid
288 finger protein-1 (Miz-1) is a poly-Cys2His2 zinc finger (ZF) transcriptional regulator of many cell
289 rotein oligomerization, such as a C(2) H(2) -zinc finger (ZF), and a leucine zipper (LZ), whose roles
292 h heterozygous variants affecting the fourth zinc finger (ZF4) of Wilms' tumor 1 (WT1) (p.Ser478Thrfs
293 ata revealed that the last four of the eight zinc fingers (ZFs) (i.e. ZF5-8) in ZBTB24 confer specifi
294 Gag or Gag mutants carrying deletions in NC zinc fingers (ZFs) or a nonmyristoylated version of Gag.
295 ctor (CTCF), containing a tandem array of 11 zinc fingers (ZFs), modulates the three-dimensional orga
298 trate and further show that ZFP91 harbours a zinc finger (ZnF) motif, related to the IKZF1/3 ZnF, cri