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1 contains five Cys3His domains (annotated as "zinc-finger" domains).
2 ect role in regulating EKLF turnover via its zinc finger domain.
3 ith two deacetylase domains and a C-terminal zinc finger domain.
4 on, dependent upon the integrity of the CCCH zinc finger domain.
5 ical role of residues within the second EKLF zinc finger domain.
6 members of this family in possessing a CCHC zinc finger domain.
7 ransferase domain, Eco1p harbors a conserved zinc finger domain.
8 only four amino acid nucleotide contacts per zinc finger domain.
9 residue within a novel viral integrase-like zinc finger domain.
10 lization sequences located within the tandem zinc finger domain.
11 the critical features of the tristetraprolin zinc finger domain.
12 located in exon 10 and affect the C-terminal zinc finger domain.
13 o identify the functional activities of each zinc finger domain.
14 short sequence containing a central putative zinc finger domain.
15 ant role in DNA binding by SNAPC through its zinc finger domain.
16 an N-terminal deletion mutant containing the zinc finger domain.
17 form is a protein with two OB folds and one zinc finger domain.
18 rization regions, one of which is the distal zinc finger domain.
19 TA-3-like transcription factor with a single zinc finger domain.
20 e deacetylase 1 (HDAC1) corepressors via its zinc finger domain.
21 bind GC-rich target sequences through their zinc finger domain.
22 g as an E3 ubiquitin ligase through the RING zinc finger domain.
23 a marked enrichment of mutations within the zinc finger domain.
24 ein with a cysteine 2-histidine 2 (Cys2His2) zinc finger domain.
25 of Haloferax volcanii (RhoII) is fused to a zinc finger domain.
26 nd predicted to encode a protein lacking the zinc finger domain.
27 acid substitution within a C-terminal double zinc finger domain.
28 mouse strains differing only in their PRDM9 zinc finger domain.
29 kDa protein that contains a double C2H2-type zinc finger domain.
30 ced by mutation of cysteines in the putative zinc finger domain.
31 interaction domain within TTP was the tandem zinc finger domain.
32 hat Gfi-1 recognizes through its DNA binding zinc-finger domain.
33 g domain that includes the carboxyl-terminal zinc-finger domain.
34 Munc13 binding is mediated by the alpha-RIM zinc-finger domain.
35 cked the N-terminal region, but retained the zinc-finger domain.
36 arly permutated GTPase domain and an unusual zinc-finger domain.
37 n, a central GTPase domain, and a C-terminal zinc-finger domain.
38 fferent protein isoforms that contain a C2H2 zinc-finger domain.
39 ct Fru isoforms, each containing a different zinc-finger domain.
40 hich contains a RAD18-like ubiquitin-binding zinc-finger domain.
41 vivo and in vitro through their conserved C-zinc finger domains.
42 e domain 5), a 23-kDa protein containing two zinc finger domains.
43 nd Homothorax (Hth) do not occur through the zinc finger domains.
44 ein with a zinc finger-associated domain and zinc finger domains.
45 ity of MBNL3 requires the CX(7)CX(4-6)CX(3)H zinc finger domains.
46 ty of Psh1 is dependent on both its RING and zinc finger domains.
47 affinity and binding specificity of designed zinc finger domains.
48 s contain a stretch of distinct, Ran-binding zinc finger domains.
49 within a region encompassing MDM2 acidic and zinc finger domains.
50 t a cardiac alpha-actin promoter through its zinc finger domains.
51 the highly conserved C-terminal DNA-binding zinc finger domains.
52 the DNA through their highly conserved three zinc finger domains.
53 ter activity, in a manner dependent upon the zinc finger domains.
54 sites were mapped to MLL1 C-terminal and MOF zinc finger domains.
55 es in the linker regions connecting adjacent zinc finger domains.
56 owever, little homology exists outside their zinc finger domains.
57 g over 100 human candidate RBPs that contain zinc finger domains.
58 tors that share homology in three C-terminal zinc finger domains.
59 insight into the normal function of U2AF1's zinc finger domains.
60 hat lead to the disruption of the C-terminal zinc finger domains.
61 y is negatively regulated by their conserved zinc finger domains.
62 amtrack, and Bric-a-brac)/POZ (POX virus and zinc finger) domain.
63 n the BORIS molecule lacking the DNA-binding zinc fingers domain.
64 target DNA reminiscent of canonical C(2)H(2) zinc-finger domains.
65 transcriptome, and this binding requires its zinc-finger domains.
66 binding to transcription factors containing zinc-finger domains.
67 virus and zinc-finger, POZ) and DNA-binding (zinc-finger) domains.
68 o acid substitution of conserved residues in zinc finger domain 1 (His299Tyr) or domain 2 (Arg328Leu;
70 main structure, including an N-terminal C2H2 zinc finger domain, a central putative core transposase
71 erogeneous-backbone foldamers that mimic the zinc finger domain, a ubiquitous and biologically import
72 onarily conserved nuclear protein with a PHD zinc-finger domain, a motif commonly found in chromatin-
74 ate that the N-terminal, but not C-terminal, zinc finger domain adopts a stably folded conformation i
75 d is involved in zinc atom coordination in a zinc-finger domain, although aspartic acid has been show
76 signal that is composed of three parts: the zinc finger domain, an adjacent linker sequence, and a d
77 tion foci targeting sequence) domain, a CXXC zinc finger domain and a pair of BAH (bromo adjacent hom
78 gether, our studies indicate that the double zinc finger domain and adjacent accessory domain precedi
79 his 96-amino acid region contains the double zinc finger domain and an accessory domain that enhances
81 self between Phe16 and Asn17 of the proximal zinc finger domain and between Cys49 and Thr50 in the C-
85 strategies, namely, targeted deletion of the zinc finger domain and generation of a EUCOMM LacZ repor
86 uced EVI1 DNA binding through its C-terminal zinc finger domain and induced cancer cell proliferation
88 ty TTP-ARE binding occurs between the tandem zinc finger domain and the preferred nonamer UUAUUUAUU.
89 1 inactivates MDM2 via direct action on this zinc finger domain and what is the chemical nature of th
90 packed against N-terminal GRF-type and C2H2 zinc finger domains and a C-terminal CCHC domain, creati
91 activity decreased upon removal of the CCHC zinc finger domains and a short segment of basic amino a
92 t recognizes 9-bp target DNA sites via three zinc finger domains and activates genes in response to c
93 1-LIKE (REIL1) and REIL2 have four conserved zinc finger domains and are Arabidopsis thaliana homolog
94 s predicted to encode a protein with several zinc finger domains and glutathione S-transferase activi
95 amily whose members contain both DNA-binding zinc finger domains and protein-protein-interacting SCAN
96 ses can be reprogrammed: New combinations of zinc finger domains and serine recombinase catalytic dom
99 a forms a two-site interaction with the GLI1 zinc-finger domain and acetylation site, stabilizing an
102 ) that share characteristic tandem CCCH-type zinc-finger domains and can be rapidly induced by multip
104 ARP13 binds viral RNA via its four CCCH-type zinc-finger domains and targets it for degradation by re
105 ivation of HCMV early promoters, a predicted zinc finger domain, and a putative helix-loop-helix moti
106 roteins, Ros87, which contains a prokaryotic zinc finger domain, and Ml452-151, lacking the zinc ion.
107 binding is exclusively mediated by the Prdm4 zinc finger domain, and we characterize its tripartite c
108 and both its physical interaction to GR and zinc finger domain appear to be required for ZNF764 to r
109 nctioning of the protein while the remaining zinc finger domains appear to contribute but are not abs
110 -negative effect is dependent on the UBX and Zinc finger domains, appended to the N and C terminus of
112 DNA binding platform consisting of multiple zinc finger domains are currently being developed for cl
113 plementation rescue approach showed that the zinc finger domains are required for both primitive and
116 o-immunoprecipitation experiments, and their zinc finger domains as well as the Crx homedomain are ne
117 catalytic SET domain and an intervening MYND zinc finger domain, as well as an extended C-terminal do
119 operativity between Vpr and Sp1 requires the zinc finger domain at the C terminus and the glutamine-r
122 , its close paralog sertoli cell gene with a zinc finger domain-beta (SERZ-beta) are the main members
123 C3) and its paralog Sertoli cell gene with a zinc finger domain-beta (SERZ-beta; DHHC7) based on over
125 single- and double-stranded DNA, whilst the zinc finger domain binds only to single-stranded DNA.
126 ation of Cth2 is contained within its tandem zinc finger domain, but it is independent of mRNA-bindin
128 cleaved form of Glis2 loses one of its five zinc finger domains, but it is still able to bind DNA.
129 yses indicated that both the homeodomain and zinc finger domains, but not the middle region, of MST12
130 quence specificity of the mutant recombinant zinc finger domain by performing biophysical measurement
132 subunit ZIF-1, proteins tagged with the ZF1 zinc-finger domain can be quickly degraded in all somati
133 sidue fragment of ZFa, which consists of two zinc finger domains connected by a linker that remains u
134 oiled-coil interaction between MBD2 and GATA zinc finger domain containing 2A (GATAD2A/p66alpha) prot
135 class of over 100 previously uncharacterised zinc finger domain containing genes, located on the long
136 on factor, PHF20/TZP (referring to Tudor and zinc finger domain containing protein), binds to Akt and
139 identified a transcriptional repressor, GATA zinc finger domain-containing 2B (GATAD2B), that interac
140 patients with two mutated ankyrin repeat and zinc-finger domain-containing 1 (ANKZF1) alleles (homozy
141 ular E3 ubiquitin ligase ring-finger and CHY zinc-finger domain-containing 1 (RCHY1) as an interactin
142 ich domains, suggesting that GhCHR encodes a zinc-finger domain-containing transcription factor.
145 rly viral activities, whereas the C-terminal zinc finger domain contributed primarily to very late ev
146 that interaction of arsenite with the PARP-1 zinc finger domain contributes to the inhibition of PARP
147 hat a 73-amino acid peptide spanning the TTP zinc finger domain, denoted TTP73, forms a dynamic, equi
149 vitro studies show that PRDM16, through its zinc finger domains, directly interacts with the MED1 su
150 A/H2B, with an arginine cluster on the Sgf11 zinc finger domain docking on the conserved H2A/H2B acid
151 that the evolutionarily conserved EGL-9 MYND zinc finger domain does not have a major role in HIF-1 r
155 complex formed between the second and third zinc finger domain (F2F3) of CPSF30 and the C-terminal d
156 we identify a novel factor containing a FYVE zinc finger domain for interaction with endosomal lipids
157 ults shed light on asymmetrical roles of the zinc finger domains for Egr-1 to scan DNA efficiently in
158 ions confirmed the importance of a conserved zinc finger domain found in all herpesvirus ORF30 termin
159 the early endosome antigen 1 (EEA1) FYVE (a zinc finger domain found in the proteins Fab1, YOTB/ZK63
160 hat the Nup358 zinc finger domain, but not a zinc finger domain from an unrelated protein, binds to C
161 lele lacking exons 2 and 3 that encodes both zinc finger domains (Gata5(tm)(2)(Eem)), and we show tha
162 s) peptide linkage between the catalytic and zinc-finger domains has high activity in vitro, whereas
163 ies of a protein fragment comprising the six zinc finger domains have been examined to reveal apparen
164 endonucleases based on designed Cys(2)His(2) zinc finger domains have proven to be effective tools fo
167 nd DNA- bound M2-1 establish the role of the zinc finger domain in base-specific recognition of RNA.
169 e solve the solution structure of the RNF126 zinc finger domain in complex with the BAG6 UBL domain.
172 interacts with the coactivator p300 via its zinc finger domain in vivo to mediate Pdx-1 activation.
174 RARalpha physically interacts with Sp1 via zinc finger domains in Sp1 as determined by co-immunopre
175 ing zinc finger protein 1) POZ (POxvirus and Zinc finger) domain in Schwann cells causes a neuropathy
178 proteins composed of multiple OB folds and a zinc finger domain, in a single polypeptide, have been d
179 hat encodes a protein with a single C(2)H(2) zinc-finger domain, in controlling the morphogenesis of
180 rate transcription factor that contains nine zinc-finger domains, including a GATA-type zinc finger t
181 BEC3G (APO3G), a cytidine deaminase with two zinc finger domains, inhibits human immunodeficiency vir
182 structure shows the second, third and fourth zinc finger domains inserted deep into the major groove
184 transcription factors that contain conserved zinc finger domains involved in binding to target DNA se
185 ain remains active regardless of whether the zinc finger domain is bound at its cognate site and can
186 We show that the conserved N-terminal C2H2 zinc finger domain is essential for direct DNA binding a
188 ws that the specific native structure of the zinc finger domain is strictly required for the optimal
189 al region of MBNL1, containing its four CCCH zinc-finger domains, is sufficient to mediate repression
190 TTP binds to mRNA through its central tandem zinc finger domain; it then promotes mRNA deadenylation,
192 , Vpr was able to associate with Sp1 via the zinc finger domain located in the C-terminal region of S
193 RAF)2 mutant lacking the N-terminal RING and zinc finger domains located at the N terminus of the mol
194 a isoforms, each having unique C-termini and zinc finger domains, may control different aspects of pr
196 he addition of this collection of predefined zinc finger domains, most 5'-CNN-3'-, 5'-GNN-3'-, and 5'
197 l deubiquitinating domain and the C-terminal zinc finger domain of A20 were involved in the inhibitio
199 nstead, it interacts preferentially with the zinc finger domain of another, nonubiquitinated Rad18 an
201 ssense mutation that alters a residue in the zinc finger domain of END-3 results in misspecification
203 rtantly, the key residue cysteine 417 at the zinc finger domain of IKKgamma has been found to be muta
204 report that a mutation, E339D, in the second zinc finger domain of KLF1 is responsible for HS in the
208 Although a mutation at Cys-305 within the zinc finger domain of MDM2 has been shown to drastically
210 ndicate that the widely conserved C-terminal zinc finger domain of measles virus V protein is both ne
212 show for the first time how mutations in the zinc finger domain of NEMO can lead to pathway specific
214 DD8 trimer, specifically bound to the second zinc finger domain of PARP-1 and attenuated its activati
215 first zinc finger unit of YY1, mimicking the zinc finger domain of pho (a drosophila homologue of YY1
217 t arginine 488 located within the C-terminal zinc finger domain of the GR DNA-binding domain plays a
223 varian carcinoma cells, we show that the two zinc finger domains of EVI1 bind to DNA independently an
225 results reveal that none of the Cys(2)His(2) zinc finger domains of MTF1 have dramatically low metal
227 interacts with the evolutionarily conserved zinc finger domains of the E3 RING ubiquitin ligase Siah
232 d that the deletion of the POZ (POxvirus and Zinc finger) domain of the transcription factor Miz1 (My
235 re, we present the solution structure of the zinc-finger domain of human DNA ligase IIIalpha, the fir
237 nstrate that both the RNA polymerase and the zinc-finger domains of DNA primase are involved in the s
239 -arginine mutation (C417R) found in the NEMO zinc finger domain on dendritic cell (DC) function.
240 ne), PHD (plant homeodomain) and ZZ (ZZ-type zinc finger) domains, participate in protein-protein int
241 To examine the role that the UvrA C-terminal zinc finger domain plays in DNA binding, an eleven amino
243 its coding sequence predicts tandem C(2)H(2) zinc finger domains present in a class of proteins gaini
244 ity of each domain in the context of the six zinc finger domain protein by individually mutating one
246 ike1 (DCL1) and other proteins including the zinc-finger-domain protein Serrate (SE) and a double-str
248 mode of DNA recognition by the Cys(2)His(2) zinc finger domain provides an ideal scaffold for design
249 esides within the HIT domain, the C-terminal zinc finger domain provides stabilizing contacts that lo
250 odes a nuclear protein that has two FCS-type zinc finger domains (PS51024) and bears nuclear localiza
251 ognizes a 9-bp target DNA sequence via three zinc-finger domains, rapidly activates particular genes
253 We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-li
254 BCL11B mutations disrupted the structure of zinc finger domains required for this transcription fact
256 OPI association, yet inspection of these two zinc finger domains reveals features that also clearly d
257 ginine to glycine substitution in the second zinc finger domain, suggesting that the double zinc fing
258 oforms that contain the conserved C-terminal zinc finger domain, suggesting that they could all bind
259 7, which contains a RING finger domain and a zinc finger domain that are mostly conserved with those
260 Human DNA ligase III contains an N-terminal zinc finger domain that binds to nicks and gaps in DNA.
261 ity of TTP is mediated by an internal tandem zinc finger domain that preferentially recognizes U-rich
262 letion and chimeric proteins to identify the zinc finger domains that are selectively used for either
263 port the development and characterization of zinc finger domains that bind to 15 of the 16 5'-CNN-3'
264 d an approach based on linkage of predefined zinc finger domains that each recognize a three-base pai
265 RPIN contains ubiquitin-like domain and Npl4-zinc finger domains that mediate the interaction with th
266 protein containing three Cys(2)-His(2)-type zinc-finger domains that bind the target DNA sequence GC
267 ly associates with Ikaros through C-terminal zinc-finger domains that mediate heterodimerization betw
268 om DNA-binding proteins by genetic fusion to zinc-finger domains that specifically bind unique DNA se
269 n archaeo-eukaryotic primase and a UL52-like zinc finger domain, the role of these domains has not be
270 g a database of experimentally characterized zinc finger domains, the amino acid sequence for a ZFP e
271 and 3 (TAB2 and TAB3) by modifying the Npl4 zinc finger domain through S-adenosyl methionine-depende
273 work shows that Zap1 uses four of its seven zinc finger domains to contact the ZRE and that two of t
274 By shuffling our repertoire of modified zinc finger domains to create randomly generated polydac
275 of all human transcription factors use C2H2 zinc finger domains to specify site-specific DNA binding
276 lacking the really interesting new gene and zinc finger domains (TRAF2DN) develop small lymphocytic
278 e identified Kruppel-like factor 6 (KLF6), a zinc finger domain transcription factor, as an essential
280 AAP20 contains a conserved ubiquitin-binding zinc-finger domain (UBZ), and binds K-63-linked ubiquiti
281 tutions at the cleavage site of the proximal zinc finger domain were also tested as substrates of the
282 onserved region located outside of the C2-C2 zinc finger domain where yeast SUI3 mutations are locali
284 d all other family members contain a ZZ-type zinc finger domain, which in other organisms is implicat
286 n, PHD2 contains an evolutionarily conserved zinc finger domain, which we have previously proposed re
288 hat combines two functionally essential C2H2 zinc-finger domains, which are probably involved in tran
289 This 1045 amino acid protein possesses a zinc finger domain with a tandem array of four FLYWCH zi
291 s process by the specific association of its zinc finger domain with the histone H3 amino terminus.
292 gans HIL proteins have functionally distinct zinc finger domains, with specificity residing in the N-
294 is highly conserved and is dependent on its zinc-finger domains (ZF1-3) and the corresponding HMG DN
297 s a RNA recognition motif (RRM), a CCHC type zinc finger domain (Zinc Knuckle, ZnK) and a C-terminal
298 se) polymerase-1 (PARP-1) has two homologous zinc finger domains, Zn1 and Zn2, that bind to a variety
299 IsoT has four ubiquitin binding domains: a zinc finger domain (ZnF UBP), which binds the proximal u
300 Specifically, both Sgf11 and Sgf73 contain zinc finger domains (ZnF) that appear essential for the