ライフサイエンスコーパス: zinc ion

1 n fold and the incorporation of a structural zinc ion.

2 nc finger domain, and Ml452-151, lacking the zinc ion.

3 utamate side chain chelating the active site zinc ion.

4 ) spanning two cysteines that coordinate the zinc ion.

5 different electronic environments around the zinc ion.

6 (alpha)His2 coordination with the catalytic zinc ion.

7 enzyme active site just above the catalytic zinc ion.

8 is suggested that ADAL1 contains a catalytic zinc ion.

9 tion of Asp44 to the catalytically essential zinc ion.

10 L3 and form a tetragonal binding site for a zinc ion.

11 e delta-sulfur of methionine coordinated the zinc ion.

12 ions 108, 114, 133, and 139 coordinating one zinc ion.

13 second coordination sphere of the catalytic zinc ion.

14 coordination of the catalytically essential zinc ion.

15 odimeric and that its active site contains a zinc ion.

16 n the departing amide nitrogen by the second zinc ion.

17 not be participating in coordination of the zinc ion.

18 c substituents displace the Pf-M17 catalytic zinc ion.

19 cies and is regulated by coordination with a zinc ion.

20 ee conserved histidine residues coordinate a zinc ion.

21 ther health disorders involving an excess of zinc ions.

22 ) in solution in the absence and presence of zinc ions.

23 ot cation selective and cannot be stopped by zinc ions.

24 box family, the members of which do not bind zinc ions.

25 UNV ZBD displays a novel fold containing two zinc ions.

26 , with the interaction enhanced by nickel or zinc ions.

27 e-3 in vitro through chelation of inhibitory zinc ions.

28 substrate allantoate closer to co-catalytic zinc ions.

29 nucleophilic hydroxide that bridges the two zinc ions.

30 o assume a direct interaction of TDP-43 with zinc ions.

31 induced by Sap6; and that Sap6 itself bound zinc ions.

32 egation in either the presence or absence of zinc ions.

33 e in fluorescence intensity in comparison to zinc ions.

34 er folding of the peptide in the presence of zinc ions.

35 rter ZnT8 mediates granular sequestration of zinc ions.

36 active cleaved forms by chelation of labile zinc ions.

37 XC, HXE) and has recently been shown to bind zinc ions.

38 mate the K(d) value of the more weakly bound zinc ion (2 muM).

39 LG is directly stabilized by an active site zinc ion, a good LG is mainly stabilized by active site

40 irect consequence of linked movements of the zinc ion, a zinc-bound bound water molecule, and the sub

41 rporate nearly normal amounts of stabilizing zinc ions (A4V, L38V, G41S, D90A, and G93A) exhibited ma

42 affold is designed to accommodate one or two zinc ions able to activate a nucleophilic hydroxide for

43 It was recently shown that zinc ions accelerated heparin-induced oligomerization of

44 underlying catalytic mechanism, in which two zinc ions activate a water molecule for nucleophilic att

45 ys12/Lys128 leaving group stabilization with zinc ion activation of the Thr64 nucleophile and the sub

46 Chelation of cellular zinc ions after rapid stretch injury, however, increases

47 The zinc ions also serve to activate a water molecule that h

48 The M2-1 protein was found to incorporate zinc ions, although the specific role(s) of the zinc bin

49 the RING finger-like domain coordinates two zinc ions, analysis of the primary sequence suggests an

50 We demonstrated that zinc ion and a Michael acceptor-based peptidomimetic inh

51 PV M(pro) in complex with dual inhibitors, a zinc ion and a Michael acceptor.

52 The bottom of the cylinder includes the zinc ion and a number of polar side chains that make mul

53 up of anacardic acid chelating the catalytic zinc ion and forming a hydrogen bond to a key catalytic

54 Herein, a previously unidentified zinc ion and its coordination by three Cys residues of t

55 Each SOD1 monomer binds to 1 copper and 1 zinc ion and maintains its disulfide bond (Cys-57-Cys-14

56 4 forms a bidentate chelate complex with the zinc ion and makes hydrogen bond interactions with conse

57 f the coordination geometry of the catalytic zinc ion and other enzyme-inhibitor interactions in the

58 the two domains and has binding sites for a zinc ion and substrates L-homocysteine and 5-methyl-tetr

59 The zinc ion and the protein residues that are bound directl

60 heir backbone atoms close to the active-site zinc ion and their side chain occupying the S1 subsite.

61 CPSF-73 at 2.1 A resolution, complexed with zinc ions and a sulphate that might mimic the phosphate

62 ide-binding ability of PCBP1 was impaired by zinc ions and alterations of intracellular zinc affect s

63 and derived reactive nitrogen species target zinc ions and cysteine thiols, we assessed the ability o

64 ed zinc finger domain of human PrimPol binds zinc ions and is essential for maintaining primase activ

65 stal structure contains both classical axial zinc ions and novel zinc ions at hexamer-hexamer interfa

66 omain has a metallophosphatase fold, and two zinc ions and one reaction product phosphocholine are id

67 carboxylate groups with the two active site zinc ions and the two conserved residues, Lys167 and Asn

68 t histidine known to coordinate a structural zinc ion, and a previously described nonsense transition

69 of His143, strengthen the catalytic role of zinc ion, and improve the transition state stabilization

70 res: it has an N-terminal motif that binds a zinc ion, and its transcription is under the control of

71 n CQ formed stable coordinate bonds with the zinc ion, and the hydroxyl group from CQ formed an effec

72 ar localization and its dominant response to zinc ions, APLP1 is mainly affected by extracellular zin

73 plasma was enhanced approximately 2-fold by zinc ions, approximately 3-fold by calcium ions, and app

74 e folds as a (beta/alpha)(8) barrel, and two zinc ions are bound in the active site.

75 The zinc ions are coordinated to a number of ligands, includ

76 he CXXC domain has a novel fold in which two zinc ions are each coordinated tetrahedrally by four con

77 The two zinc ions are found to participate intimately in the cat

78 led to the identification of a contaminating zinc ion as solely responsible for the observed effects.

79 imilar electronic change in the level of the zinc ion as well as the configuration of the ZBD.

80 phyla that have three cysteines ligated to a zinc ion (as opposed to the more common Cys-Cys-His liga

81 Staining for VMAT2 and zinc ion, as a surrogate for insulin, reveals a wide ran

82 by a conserved catalytic domain containing a zinc ion, as well as a prodomain that regulates enzyme a

83 novel fold and that the protein also binds a zinc ion at a four-cysteine site.

84 he interaction of the thiolate of CSA with a zinc ion at the base of the active site suggests that th

85 This enzyme contains a zinc ion at the heart of its active site: this ion stabi

86 ins both classical axial zinc ions and novel zinc ions at hexamer-hexamer interfaces.

87 nt of the substrate and the two co-catalytic zinc ions at the active site governs catalytic specifici

88 Aqueous zinc ion batteries (ZIBs) are truly promising contenders

89 Rechargeable zinc-ion batteries (ZIBs) are emerging as a promising al

90 volution on the zinc negative electrode of a zinc-ion battery based on copper hexacyanoferrate.

91 tate rapid restoration of Pho8 activity when zinc ions become available.

92 f HDAC7, we show that HDAC7, via its surface zinc ion binding site, binds to a 28 residue stretch in

93 derate CP ("regulation of gene expression," "zinc ion binding," "BMP signaling pathway," and "ruffle"

94 amics, membrane dynamics, RNA processing and zinc ion binding.

95 s and for the interaction of ETPs with other zinc ion-binding protein targets involved in gene expres

96 C37, C44, C53) form a classical tetrahedral zinc ion-binding site, which preserves the structure of

97 enes involved in DNA-binding, RNA-binding or zinc-ion-binding.

98 from Haemophilus influenzae with one and two zinc ions bound in the active site, respectively.

99 the single anomalous diffraction (SAD) from zinc ions bound intrinsically in Pol II.

100 We found here that zinc ions bound to APP and APLP1 E2 domains and mediated

101 ith EDTA results in complete removal of both zinc ions, but the relatively weaker chelator PAR chelat

102 the first one canonically coordinated to the zinc ion by means of the sulfonamide group and the secon

103 pothesized that oxidation and release of the zinc ion by peroxynitrite (ONOO(-)), a potent oxidant ge

104 lases involving recruitment of the catalytic zinc ion by the substrate upon active site binding.

105 We have examined the ligation state of the zinc ion by X-ray absorption spectroscopy and biochemica

106 r, our data demonstrate that coordination of zinc ions by cysteine residues within the CRD is require

107 Our results revealed that zinc ion can efficiently induce the dimerization of the

108 Labile zinc ions can be difficult to detect with probes that re

109 Recently it was shown that zinc ions can provoke the aggregation of endogenous TDP-

110 They show that zinc ions can transactivate TrkB independent of neurotro

111 ic effects of the substitutions and bridging zinc ions cause isoelectric precipitation at neutral pH.

112 rrier concentration, pH, and the presence of zinc ions changes, DNA:HK complexes showed dynamically r

113 This activity depends upon the zinc ion chelating properties of the compound as well as

114 , the previously proposed binding of a third zinc ion close to the active site of IMP-6 mutant S121G

115 Since zinc ions colocalize with glutamate in small clear vesic

116 asmic ballast, which unexpectedly contains a zinc ion complex and a guanosine nucleotide binding site

117 ce of fluorescence intensity on logarithm of zinc ions concentration in extraordinary wide range, fro

118 used as an indicator of changes in cellular zinc ion concentrations.

119 ature sizes of 250 nm, by first patterning a zinc-ion-containing aqueous photoresin using two-photon

120 e, a class III amidohydrolase, with a single zinc ion coordinated by His-6, His-8, His-179, and Glu-2

121 The ZBD contains a zinc ion coordinated with four cysteine residues.

122 An unexpected zinc ion, coordinated by three cysteine and one histidin

123 changes that account for differences in the zinc ion coordination geometry.

124 We demonstrate here that divalent zinc ions coreleased with insulin from beta-cells in res

125 Zinc ions could be replaced by cadmium ions without sign

126 tudy motifs required for the MVV Vif to bind zinc ion, Cul5, and the cofactor CypA.

127 and can be purified with 1.8 or 1.0 equiv of zinc ion, depending on the experimental conditions.

128 fluorescent probe (Mito-MPVQ) for biological zinc ions detection was developed based on quinolone pla

129 component of the binding site for the second zinc ion, differ significantly from previous mbetal stru

130 lity, and membrane integrity, resulting from zinc ion dissolution as well as possible mechanical cell

131 Finally, we applied ZTRS to detect zinc ions during the development of living zebrafish emb

132 es reveal that ETPs react with p300, causing zinc ion ejection.

133 rol of coordination between ellagic acid and zinc ions enables the macroscopic self-assembly behavior

134 in contrast to earlier reports of <<1 labile zinc ion/Escherichia coli cell, the zf1-zf2 zinc affinit

135 are consistent with Zn(II) levels >>1 labile zinc ion/eukaryotic cell.

136 species that generate potentially cytotoxic zinc ion fluctuations as a major executor of neuronal, a

137 investigations caution against interpreting zinc ion fluctuations in the early phase (24h) after inj

138 eochromocytoma (PC12) cells express cellular zinc ion fluctuations that depend on the production of n

139 inc ion from folded protein but 1.9 equiv of zinc ion from denatured protein, indicating different af

140 weaker chelator PAR chelates only 1 equiv of zinc ion from folded protein but 1.9 equiv of zinc ion f

141 es zinc transporter-8 (ZnT8), which delivers zinc ion from the cytoplasm into insulin granules.

142 reflect the release of chelated calcium and zinc ions from complexes with citrate.

143 sors responded effectively to the release of zinc ions from pancreatic cells at the nanomolar level w

144 P: a group that interacts with the catalytic zinc ion, functionality that enhances affinity to the su

145 In situ metal-templating by zinc ions gives quantitative yields of the Mn(2) product

146 e outer-shell scattering indicating that the zinc ion has inner-shell interactions with one or more R

147 the ZBD and resulted in partial loss of the zinc ion, impairing binding to the ssDNA template.

148 The binding between AVMB ligands and zinc ion in acetonitrile was studied using isothermal ti

149 Similar to the zinc ion in Cu/Zn-SODs, SOD5 Glu-110 helps orient a key

150 mined the role of the structurally important zinc ion in defining the folding free energy surface of

151 d cells, the enzyme acquired a nonactivating zinc ion in its active site, an apparent consequence of

152 ination, indicating an essential role of the zinc ion in maintaining the catalytic activity and stabi

153 istidine residues in this motif coordinate a zinc ion in mZIP4 homodimers at the plasma membrane.

154 The structure reveals a zinc ion in the active site and suggests how the substra

155 amate group essential for chelation with the zinc ion in the active site of HDAC and the key structur

156 f the inhibitor tetrazole ring to the second zinc ion in the active site, the hydrogen bonding of Lys

157 (beta/alpha)(8) barrel and contains a single zinc ion in the active site.

158 The involvement of a second zinc ion in the catalytic mechanism lowers the energetic

159 on and specific implications for the role of zinc ion in the fatal neuropathology associated with SOD

160 ished that Hcy is ligated to a tightly bound zinc ion in the MetE active site.

161 Evidence of a catalytic zinc ion in the native zinc enzyme coordinated by H79, H

162 tivation, mammalian eggs release billions of zinc ions in an exocytotic event termed the "zinc spark.

163 in is stabilized upon binding of one and two zinc ions in analytical ultracentrifugation experiments.

164 of fluorescent sensors for studies of mobile zinc ions in biology.

165 ned data highlight the importance of the two zinc ions in maintaining structure as well as a relative

166 escence based biosensor for the detection of zinc ions in milk samples.

167 nc fingers, the protein contains three bound zinc ions in novel coordination sites, including an unus

168 ing to hypothesize the direct implication of zinc ions in pathological aggregation of TDP-43.

169 ablishing the binding topology of structural zinc ions in proteins is an essential part of their stru

170 e simultaneous accumulation of magnesium and zinc ions in the biomass.

171 ale energy storage, but the intercalation of zinc ions in the cathode materials is challenging and co

172 In the absence of zinc ions in the sample emission of pyrene embedded in t

173 o-beta-lactamase superfamily and contain two zinc ions in their active sites.

174 In this work, exchange of zinc ions in Zn5Cl4(BTDD)3, H2BTDD = bis(1H-1,2,3-triazo

175 The recently synthesized ZnAF-2 zinc ion indicator provided high zinc ion selectivity in

176 To fabricate the sensors, the zinc ion indicator ZnAF-2 {6-[N-[N',N'-bis(2-pyridinylme

177 stain electron microscopy demonstrated that zinc ions induce auto-association process of this TDP-43

178 OD1 and that the presence of copper, but not zinc, ions inhibits fibrillation.

179 as of increased concentration of calcium and zinc ions inside Saccharomyces cerevisiae cells with the

180 ed recently; however, both proteins have two zinc ions instead of two iron ions in the catalytic cent

181 a structural explanation for pentacoordinate zinc ion intermediates, a unifying view for the observed

182 e iron ions out of cells, rather than moving zinc ions into cells, as is the case in human cells.

183 (ZIPs) represent a major route for entry of zinc ions into cells, but how ZIPs promote zinc uptake h

184 in vivo zinc concentration gradients to move zinc ions into the cytoplasm.

185 One zinc ion is coordinated by His-447, His-449, Cys-455, an

186 The second zinc ion is coordinated by His-459, Cys-467, and Cys-469

187 The bound zinc ion is coordinated by three histidine residues (His

188 suggests that uptake of a second equivalent zinc ion is evolutionary favored.

189 e peptide/oligourea hybrid to coordinate the zinc ion is not affected by the foldamer replacement.

190 t to the textbook MDR mechanism in which the zinc ion is proposed to remain stationary and attached t

191 inhibitors reveals that the chelation of the zinc ion is slightly different, leading the inhibitor ba

192 nuclear zinc-active site in which one of the zinc ions is readily exchangeable with other divalent ca

193 The active site of CPSF-73, with two zinc ions, is located at the interface of the two domain

194 as activated up to approximately 200-fold by zinc ions (K(D) (app) approximately 0.5 microM), calcium

195 3 by reducing its affinity for the essential zinc ion, leaving the mutant protein unable to bind the

196 The zinc ion level is raised to 4-5 muM after LPS treatment,

197 peptidases that contain a single, catalytic zinc ion ligated by the histidines and aspartic acid wit

198 r is a self-contained domain stabilized by a zinc ion ligated to a pair of cysteines and a pair of hi

199 culations on cluster models suggest a single zinc ion may be sufficient to support phosphoethanolamin

200 hese results suggest that AREDS vitamins and zinc ions may slow the progression of AMD, in part throu

201 yrophosphatase/diesterase, a promiscuous two-zinc ion metalloenzyme of the alkaline phosphatase enzym

202 hat phosphonoacetate hydrolase is also a two-zinc ion metalloenzyme.

203 s within bonding distance to the active-site zinc ion, mimicking the presumed tetrahedral transition

204 Here, we demonstrate that zinc ions, not free cysteine residues, bind sulfide in v

205 The two zinc ions occupy a compact conformation with an average

206 ibitors, which interact with the active-site zinc ion of CSN5 through an unprecedented binding mode.

207 ic zinc ion partially oxidizes the catalytic zinc ion of the enzyme.

208 t and channel of ATX but no interaction with zinc ions of the catalytic site.

209 turbidimetry, we investigated the impact of zinc ions on Tau in the absence of heparin and found tha

210 in MeCN by using either the proper ratio of zinc ions or acid.

211 state, a water molecule is coordinated to a zinc ion pair in the active site but is imperfectly orie

212 ism was explained by surface accumulation of zinc ion-PAN complex on the microsphere/sample solution

213 er, the binding of TACE Pro to the catalytic zinc ion partially oxidizes the catalytic zinc ion of th

214 tidine ((His)6) tagged fusion containing one zinc ion per DapE monomer.

215 onomers of SOD1 such that the binding of one zinc ion per homodimer has a more profound effect on the

216 UreG(Str) binds one nickel or zinc ion per monomer (K(d) approximately 5 microM for ea

217 calcium-binding protein S100B also binds one zinc ion per subunit with a relatively high affinity (K(

218 MS analysis indicated a stoichiometry of two zinc ions per highly active PPR65 monomer.

219 de zinc efflux regulator SczA, and binds two zinc ions per protomer.

220 ties and/or reduces the labile intracellular zinc ion pool.

221 iber and hydrogel doped with the fluorescent zinc ion probe molecule meso-2,6-Dichlorophenyltripyrrin

222 The sensors were used to monitor zinc ion release events from glucose-stimulated pancreat

223 s slides and their application in monitoring zinc ion release from beta pancreatic cells in cell cult

224 ppositely charged metal ions and suppressing zinc ion release from the NPs through exudation, as evid

225 Whether zinc ions released during traumatic brain injury are tox

226 In the unfolded state, the zinc ion remains bound to the unfolded polypeptide via t

227 tein residues that are bound directly to the zinc ion represent a functional charge/dipole complex, a

228 Removal of both zinc ions results in loss of activity, and reconstitutio

229 idues 40-108) stabilized by three structural zinc ions (root mean square deviation 0.30 +/- 0.04 A) a

230 d zinc binding group to coordinate catalytic zinc ion/s, and a variety of hydrophobic groups to probe

231 ich in chemistry mediated by the active site zinc ion selectively and covalently inhibits MMP-2, -3,

232 ized ZnAF-2 zinc ion indicator provided high zinc ion selectivity in physiological solutions containi

233 analytical properties of fluorescence-based zinc ion-sensing glass slides and their application in m

234 An optical diffuser is incorporated into the zinc ion sensor based on optical fiber and hydrogel dope

235 Solid-state zinc ion sensor is developed with high enough resolution

236 The study showed that the zinc ion sensors responded effectively to the release of

237 urface of glass slides, which then served as zinc ion sensors.

238 meric microspheres is explored on example of zinc ions sensors.

239 he coordination environment of the catalytic zinc ions show that the active site gorge comprising maj

240 btain a maximum accumulation of selenium and zinc ions (simultaneously) in the biomass.

241 his response was related to sequestration of zinc ions since addition of zinc sulfate blocked aspirin

242 Zinc ions specifically induced APP and APLP1 oligomeriza

243 e substrate aminocarbonyl group by the first zinc ion; stabilization of the negative charge developed

244 Coordination to zinc ion stabilizes the charge-transfer excited state of

245 structures, electrochemical performance, and zinc ion storage mechanisms.

246 another active site residue located near the zinc ion, such as His265.

247 rminal domain harbors the binding site for a zinc ion that is ligated by four cysteines.

248 , modifying the local environment of a bound zinc ion that would otherwise inhibit NFS1 activity in c

249 aled that SMYD2 contains three tightly bound zinc ions that are important for maintaining the structu

250 endogenous inhibition after SCI by means of zinc ions that have been shown to boost KCC2 function in

251 heterocycle directly bound to an active site zinc ion, the product-bound TgPBGS active site contains

252 In the presence of calcium and zinc ions, the ch5E1 binding affinity increases 10-20-fo

253 We show here that despite binding two zinc ions, the domain adopts a homodimeric structure hig

254 In the presence of zinc ions, the protein forms macroscopic clusters, exhib

255 vestigating the exact concentrations of free zinc ions, the thresholds of compromised zinc buffering

256 despite the known cytotoxicity of cobalt and zinc ions, these results suggest that iron oxide nanopar

257 nhibitors; they do not bind to the catalytic zinc ion, they are noncompetitive with respect to substr

258 it contains PGH, which is coordinated to the zinc ion through the hydroxamic acid hydroxyl and carbon

259 aspase-3 in vitro by sequestering inhibitory zinc ions, thus allowing procaspase-3 to autoactivate it

260 the active site of the apoenzyme contains a zinc ion tightly bound to His32 and Asp215 from one mono

261 ontain hydroxamate moiety that chelates with zinc ion to become the cofactor of HDAC enzymes.

262 phenylalanine (F) molecules coordinate with zinc ions to form a robust, layered, supramolecular amyl

263 Supplementation of excess zinc ions to monozinc NDM-1 has differential effects on

264 The high binding affinity of zinc ions to OTOS trimers suggests that the six-membered

265 All living cells need zinc ions to support cell growth.

266 activating cell-cell adhesion: adsorption of zinc ions to the bacterial cell surface increases cell w

267 ing and reveals how Y306 and the active site zinc ion together bind and activate the scissile amide l

268 isk and the activity of a beta-cell specific zinc ion transporter, ZnT8.

269 a4 strands, and is bridged and stabilized by zinc ion via coordinating residues from different chains

270 As in SNM1A, only one zinc ion was located in the Artemis active site.

271 other members of this enzyme class, a second zinc ion was present in the beta-CASP domain that leads

272 c stability as well as their affinity toward zinc ions, we developed a novel nucleotide scaffold, nuc

273 mbined with our previous results on divalent zinc ions, we propose a model that links the microscopic

274 rescent heteroditopic ligands (9 and 10) for zinc ion were prepared and studied.

275 ne in vitro via alkyl transfer provided that zinc ions were present.

276 Zinc ions were shown to enhance activation of the intrin

277 ively high drug content (6% w/w) if divalent zinc ions were used as an ionic "bridge" between the PLG

278 tallohydrolase may contain a pentacoordinate zinc ion, which contrasts with the native states of arch

279 reproducible and repeatable and specific for zinc ion, which has been applied to various milk samples

280 on and also show that the thiol binds to the zinc ion, which in turn perturbs the metal-bound histidi

281 te acts as a counterion for the Lewis acidic zinc ion, which provides the activation of the aldehyde.

282 Zinc ions, which are cosecreted with insulin from beta-c

283 between oxygen on the hydroxyl group and the zinc ions, which expands the stable electrolyte temperat

284 hat over this pH range water is bound to the zinc ion while Glu78 is protonated.

285 te is found to form the fourth ligand of the zinc ion with its 3-carboxylate oxygen and to hydrogen b

286 uncomplexed LasA contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two meta

287 Interactions of zinc ions with Abeta are mediated by the N-terminal Abet

288 a coli and is capable of binding up to three zinc ions with high affinity.

289 erved between 0.001microg/l to 10microg/l of Zinc ions, with a lowest detection limit of 0.001microg/

290 hibitory terminals, are richly supplied with zinc ions, yet the functional role of this pool of zinc

291 ve and selective sensing systems of divalent zinc ion (Zn(2+)) in organisms has been a growing intere

292 In human body, 30-40% of the total zinc ion (Zn(2+)) is localized in the nucleus.

293 In cardiovascular stent applications, zinc ion (Zn(2+)) will be gradually released into the su

294 Zinc ions (Zn(2+)) are imported into the early secretory

295 Zinc ions (Zn(2+)) are localized in presynaptic vesicles

296 formed larger aggregations and released less zinc ions (Zn(2+)) at greater temperature and salinity,

297 ne is TLR4, which causes an increase of free zinc ions (Zn(2+)) that is required for the MyD88-depend

298 ed sensor platforms for quantifying cellular zinc ions (Zn(2+)).

299 the complex crystallized in the presence of zinc ion, Zn(2+) is evidently not directly involved in t

300 bstrate is loosely bound to the more exposed zinc ion (Znbeta2+) at an average distance of 3.8 A +/-