ライフサイエンスコーパス: zinc transporter

1 with the proposed role of Zrc1 as a vacuolar zinc transporter.

2 take process indicative of a plasma membrane zinc transporter.

3 that maps to SLC39A10, a gene that encodes a zinc transporter.

4 manganese transport capability to a related zinc transporter.

5 ostate cells upon downregulation of the ZIP1 zinc transporter.

6 he Drosophila ortholog of the mammalian ZIP7 zinc transporter.

7 eviously, SLC30A10 had been presumed to be a zinc transporter.

8 asis, including the functional properties of zinc transporters.

9 (Ke4, Slc39a7) belongs to the ZIP family of zinc transporters.

10 ose homologs in plant and yeast are putative zinc transporters.

11 h the identification and characterization of zinc transporters.

12 hypothesize that many of these proteins are zinc transporters.

13 e members of a growing family of prokaryotic zinc transporters.

14 lar requirements is regulated by an array of zinc transporters.

15 ration of Zn(2+) and increased expression of zinc transporters.

16 distribution to intracellular organelles by zinc transporters.

17 83-96-182 cluster suppressed five additional zinc transporters.

18 uced expression of another MTF1 target gene, zinc transporter 1 (ZnT-1), was also down-regulated by C

19 Zinc transporter 1 (ZnT1) and Zrt/Irt-like proteins ZIP8

20 evated levels of metallothionein isoform and zinc transporter 1 (ZnT1) transcripts.

21 between zinc binding by MT and its efflux by zinc transporter 1 (ZnT1) was examined genetically.

22 transcription without altering induction of zinc transporter 1 (ZnT1).

23 the ubiquitous zinc efflux transporter ZnT1 (zinc transporter 1).

24 Zinc transporter-1 and zinc transporter-7 expression inc

25 , and its target gene Zn-T1 that encodes the zinc transporter-1 was not significantly altered in HCCs

26 se (Mn(2+)) is extruded from the cell by the zinc transporter 10 (ZnT10).

27 f altered mRNA levels for metallothionein 1, zinc transporter 2, and uroguanylin, all of which have b

28 Here we show that zinc transporter 3 (ZnT-3), which maintains a high conce

29 At these synapses, zinc transporter 3 (ZnT3) moves zinc into vesicles where

30 d deposition is dependent on the activity of zinc transporter 3 (ZnT3), a neocortical synaptic vesicl

31 severe reduction of vesicular levels of the zinc transporter 3 (ZnT3).

32 esynaptic vesicular zinc transporter protein zinc transporter 3 (ZnT3).

33 containing the adaptor protein (AP) -3 cargo zinc transporter 3 was generated from PC12 cells and was

34 Zinc transporter-3 (ZnT-3), a member of a growing family

35 Here we use zinc transporter-3 (ZnT3) knockout mice, which are deple

36 esponse to interneuron loss was indicated by zinc transporter-3 (ZnT3)-- and beta-synuclein--LI, as w

37 A genome-wide mapping study using male F(2) zinc transporter 7-knockout mice (znt7-KO) and their wil

38 Zinc transporter-1 and zinc transporter-7 expression increased when cellular zi

39 autoantibodies to islet antigen-2 (IA-2) and zinc transporter 8 (ZnT8) in patients with established t

40 Zinc transporter 8 (ZnT8) is a major autoantigen abundan

41 Recently we demonstrated that zinc transporter 8 (ZnT8) is a major target of autoantib

42 diatric patients and 2) to determine whether zinc transporter 8 (ZnT8), a recently described target o

43 ion allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western

44 -specific CD4(+) T cells in three adults and zinc transporter 8 (ZnT8)-specific CD4(+) T cells in fiv

45 insulinoma-associated protein 2 (IA-2), and zinc transporter 8 (ZnT8).

46 A), GAD (GADA), islet antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A) were measured by radioimmunoa

47 HLA-DR3-negative, HLA-DR4-positive, or anti-zinc transporter 8 antibody-negative, fewer participants

48 We examined whether zinc transporter 8 autoantibodies (ZnT8A; arginine ZnT8-

49 a-associated protein-2 autoantibody (IA-2A), zinc transporter 8 autoantibody (ZnT8A), and GAD autoant

50 autoantibodies (GADAs), IA2 antigen (IA-2A), zinc transporter 8, thyroid peroxidase, gastric parietal

51 mature beta cells, including urocortin-3 and zinc transporter 8, upon transplantation into mice.

52 Zinc transporter-8 (ZnT8) primarily functions as a zinc-

53 SLC30A8 encodes zinc transporter-8 (ZnT8), which delivers zinc ion from

54 Abs) against insulin, GAD, IA-2 (IA-2A), and zinc transporter-8 (ZnT8A) for prediction of rapid progr

55 (insulin, glutamate decarboxylase, IA2, and zinc transporter-8), but the molecular identity of a fif

56 These findings indicate that zinc transporter activity regulates liver tissue growth

57 Collectively, these data implicate zinc transporter alterations as a dominant driver of ald

58 verexpression of the miR-183 cluster reduced zinc transporter and intracellular zinc levels in benign

59 that modulate HDAC activity: ZRT1 encodes a zinc transporter and is repressed by RPD3 (Rpd3p is zinc

60 ence that FET4 is a physiologically relevant zinc transporter and this provides a rationale for its r

61 luated the response of metallothionein (MT), zinc transporter, and cytokine genes to a modest (15 mg

62 These results indicate that hZip2 is a zinc transporter, and its identification provides one of

63 zipt-7.1 encodes a zinc transporter, and zipt-7.1(lf) mutants display sperm

64 Mammalian zinc transporters are classified in two major families:

65 Transcripts for 20 of 23 zinc transporters are expressed in fetal human RPE, 16 o

66 Multiple zinc transporters are expressed in neurons, yet little i

67 show that the plasma membrane ZIP1 and ZIP3 zinc transporters are expressed on distinct neuronal pop

68 Zinc transporters are genetically associated with cardio

69 sculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernou

70 We also assessed which zinc transporters are responsible for supplying zinc to

71 The objective was to evaluate erythrocyte zinc transporters as candidate molecules with the potent

72 Similar loops are found in other types of zinc transporters but not manganese transporters.

73 SLC30A9 encodes a putative zinc transporter (by similarity) previously associated w

74 ers play the major role while the Msc2/Zrg17 zinc transporter complex active in the endoplasmic retic

75 Zinc transporter eight (SLC30A8) is a major target of au

76 Mutation of a zinc transporter encoded by sur-7, which suppresses the

77 nding sites in the BMC of human ZIP4 (hZIP4) zinc transporter exert different functions: one conserve

78 The array of zinc transporters expressed by the RPE may play a key ro

79 The effect of various growth factors on zinc transporter expression also was examined.

80 rocyte and leukocyte zinc concentrations and zinc transporter expressions were not altered.

81 The ZIP zinc transporter family is responsible for zinc uptake f

82 narily conserved Zrt, Irt-like protein (ZIP) zinc transporter family members.

83 Zip14 is a member of the SLC39A zinc transporter family, which is involved in zinc uptak

84 human and murine models to characterize the zinc transporter family, Zip, during T cell activation a

85 YiiP is a proton-coupled zinc transporter found in the cytoplasmic membrane of Es

86 ructure of ZnuA, the periplasmic domain of a zinc transporter from Synechocystis 6803, has been deter

87 s used to measure transcript abundance for a zinc transporter from the ZIP family of transporters in

88 n can be modulated by regulation of specific zinc transporters function.

89 plasma zinc and cytokine concentrations and zinc transporter gene expression in peripheral blood mon

90 P), plasma and cellular zinc concentrations, zinc transporter gene expression, and other metabolic in

91 Transcripts of the two zinc transporter gene families (ZnT and Zip) were screen

92 factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to seque

93 Messenger RNA for the zinc transporter gene ZNT1 was abundant in photosyntheti

94 ression of either ZAP1 or the Zap1-dependent zinc transporter gene ZRT2 restores pathogenicity to a s

95 the result of the regulation of the ZIP-type zinc transporter gene.

96 ted genes encode the Zrt1p, Zrt2p, and Zrt3p zinc transporter genes and Zap1p itself.

97 WAKL4 was required for the up-regulation of zinc transporter genes during zinc deficiency, and the W

98 We report here the cloning of the first zinc transporter genes from plants, the ZIP1, ZIP2, and

99 Transcript levels for the zinc transporter genes ZnT1 and Zip3 were increased and

100 The mouse mZip1 and mZip3 zinc transporters have been implicated in zinc acquisiti

101 The Zrt/IRT-like protein (ZIP) family of zinc transporters have recently been identified as the m

102 ed on the crystal structure of YiiP, a close zinc transporter homologue from Escherichia coli, reveal

103 ed directly with decreased expression of the zinc transporter hZIP1.

104 cribe the characterization of hZip2, a human zinc transporter identified by its similarity to zinc tr

105 Inhibition of a zinc transporter improves the maturation and survival of

106 The observation that hZIP1 is the major zinc transporter in K562 cells, coupled with its express

107 ected insight into the fundamental role of a zinc transporter in mammalian pulmonary vascular homeost

108 p14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response

109 nvestigated cdf-2, which encodes a predicted zinc transporter in the cation diffusion facilitator fam

110 PDAC led to dysregulation of zinc transporters in both human and mouse pancreas.

111 er risk; however, the exact role of zinc and zinc transporters in cancer progression is unknown.

112 Regulation of absorption by zinc transporters in the enterocyte, together with satur

113 The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to

114 f a microRNA cluster that regulates multiple zinc transporters, including hZIP1.

115 es with the increased expression of specific zinc transporters, including two that are essential in o

116 Transcription of the ZRT1 and ZRT2 zinc transporters increases in zinc-limited cells, and t

117 t1p and Zrt2p) and vacuolar membrane (Zrt3p) zinc transporters indicated that enzyme expression was s

118 ZIP14 (slc39A14) is a zinc transporter induced in response to pro-inflammatory

119 This granular zinc transporter is also a major self-antigen found in t

120 he identification of a variety of copper and zinc transporters is consistent with the importance of c

121 ), a member of a growing family of mammalian zinc transporters, is expressed in regions of the brain

122 Four putative zinc transporters, known as ZnT-1 through ZnT-4, have no

123 -1 subfamily of ZIP (Zrt-, Irt-like Protein) zinc transporters (LZTs) with the cellular prion protein

124 Altered expression and function of zinc transporters may contribute to the pathogenesis of

125 Measures of metallothionein or cellular zinc transporters may fulfill that role.

126 olymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with

127 is up-regulated through IL-6, and that this zinc transporter most likely plays a major role in the m

128 ganese transporter mutant but not a vacuolar zinc transporter mutant.

129 encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder a

130 luate the current paradigm that SLC30 family zinc transporters operate exclusively to decrease cytoso

131 We found that the Zrc1 and Cot1 vacuolar zinc transporters play the major role while the Msc2/Zrg

132 c acquisition in the ZAP1 regulon, including zinc transporters (Pra1 and Zrt1) and other zinc-regulat

133 These results demonstrate that the vacuolar zinc transporters, previously implicated in metal detoxi

134 rom the actions of the presynaptic vesicular zinc transporter protein zinc transporter 3 (ZnT3).

135 Here, we identify the astrocytic zinc transporter protein ZIP12 as a candidate mechanism

136 The expression of zinc transporter proteins was determined by RT-PCR.

137 transporter identified by its similarity to zinc transporters recently characterized in fungi and pl

138 We found that ZnT3, the vesicular zinc transporter responsible for loading zinc into vesic

139 xpression for cytokines, DNA repair enzymes, zinc transporters, signaling molecules, etc., suggest th

140 Ectopic expression of the zinc transporter SLC30A1 or treatment with exogenous zin

141 The zinc transporter SLC30A2/ZnT2 plays a critical role in m

142 We further linked the putative zinc transporter SLC30A9 to mitochondrial ribosomes and

143 for example, a nonsynonymous variant in the zinc transporter SLC39A8 influences seven of the traits,

144 tudy, we identified deficiency of a specific zinc transporter, SLC39A8 (ZIP8), in AEC2s from both IPF

145 alanine or threonine at position 391 in the zinc transporter solute carrier family 39, member 8 prot

146 accumulate zinc, and its homology with known zinc transporters, suggest that ZnT-3 is responsible for

147 te-binding protein (SBP) genes of the AztABC zinc transporter system.

148 ctively, our studies indicate that these two zinc transporter systems play vital roles in maintaining

149 study demonstrates that ZIP7 is a functional zinc transporter that acts by transporting zinc from the

150 er ZIP14 (SLC39A14) is viewed primarily as a zinc transporter that is inducible via proinflammatory s

151 e Znt7 gene encodes a ubiquitously expressed zinc transporter that is involved in transporting cytopl

152 roliferation by activating ZIP9 (SLC39A9), a zinc transporter that is widely expressed in human melan

153 s provide compelling evidence that ZIP4 is a zinc transporter that plays an important role in zinc ho

154 ates rapid transitions in the composition of zinc transporters to mediate homeostasis, likely minimiz

155 We use zinc chelators and mice deficient in zinc transporters to show that synaptically released zin

156 dy, insulinoma-associated protein 2 antigen, zinc transporter type 8 antigen) and donor-specific allo

157 se-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant.

158 To test whether hZip2 is a zinc transporter, we examined (65)Zn uptake activity in

159 Zinc transporters were identified in a human RPE cell li

160 l ion transporters, such as copper, iron and zinc transporters were upregulated and transferase-encod

161 that the ycdH operon encodes a high-affinity zinc transporter whereas YciC may function as part of a

162 between deleterious mutations in the SLC30A8 zinc transporter, which transports zinc into the secreto

163 A10, based on the structure of the bacterial zinc transporter YiiP, and performed functional studies.

164 ue-profiling microarray data showed that the zinc transporter ZIP12 (slc39a12) is highly expressed in

165 Coding ZIP12 polymorphisms in zinc transporter ZIP12 (SLC39A12) were associated with a

166 Slc39a12 encodes the zinc transporter ZIP12.

167 ng glucose uptake, cell surface abundance of zinc transporter ZIP14 and mediated zinc transport incre

168 Zinc transporter Zip14 KO mice display a phenotype that

169 The zinc transporter ZIP4 (SLC39A4) is mutated in humans wit

170 Zinc transporter ZIP4 (ZIP4) is a zinc importer required

171 bsorbed in the small intestine mainly by the zinc transporter ZIP4, a representative member of the Zr

172 We have observed that a zinc transporter, ZIP4 (SLC39A4), was substantially over

173 oncentrations and was inhibited by silencing zinc transporter Zip6.

174 codes the endoplasmic reticulum-to-cytoplasm zinc transporter ZIP7.

175 The zinc transporter ZIP9 (SLC39A9) was recently characteriz

176 irst loss-of-function mutation (H54R) in the zinc transporter ZnT-2 (SLC30A2) in mothers with infants

177 ZnT7, a novel member of the zinc transporter (ZnT) family, was identified by searchi

178 Metal regulation of the mouse zinc transporter (ZnT)-1 gene was examined in cultured c

179 A cDNA encoding a second zinc transporter (ZnT-2) was isolated from a rat kidney

180 The present experiments show that the zinc transporter ZnT2 (Slc30a2) is localized to the zymo

181 The zinc transporter ZnT2 imports zinc into secretory vesicl

182 more, upon heterodimerization with ZnT1, the zinc transporters ZnT2 and ZnT4 surprisingly localized a

183 mice lacking the synapse-specific vesicular zinc transporter ZnT3 (ZnT3KO mice) have reduced activat

184 of animals deficient in the synaptic vesicle zinc transporter ZnT3, indicating that vesicular zinc re

185 fied by the lack of zinc signal in vesicular zinc transporter Znt3-deficient mice.

186 synaptic zinc is dependent on the vesicular zinc transporter, ZnT3.

187 l regulatory element (ZTRE), in the SLC30A5 (zinc transporter ZnT5) promoter and showed that substitu

188 A high-ranking candidate, the zinc transporter ZnT8 (Slc30A8), was targeted by autoant

189 The islet-specific zinc transporter ZnT8 is a major self-antigen found in i

190 SLC30A8 encodes a zinc transporter ZnT8 largely restricted to pancreatic i

191 The islet-specific zinc transporter ZnT8 mediates granular sequestration of

192 The islet-specific zinc transporter ZnT8 mediates zinc enrichment in the in

193 identified variants in SLC30A8, encoding the zinc transporter ZnT8, associated with diabetes risk.

194 rs13266634 in the SLC30A8 gene encoding the zinc transporter ZnT8, is associated with an increased r

195 E cells that stably expressed a tagged human zinc transporter ZnT8.

196 variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.

197 C-terminus of the secretory granule-enriched zinc transporter, ZnT8.

198 Zinc transporters (ZnTs) facilitate zinc efflux and zinc

199 Zinc transporters (ZnTs) mediate zinc efflux and compart

200 the structure of the periplasmic domain of a zinc transporter, ZnuA, from Synechocystis 6803 and foun

201 Unique to these ABC zinc transporters, ZnuA has a highly charged and mobile

202 The A. baumannii inner membrane zinc transporter ZnuABC is required for growth under low

203 n to bind to zinc, and in the absence of the zinc transporter ZnuABC, Ybt improves Y. pestis growth i

204 ism, and many Enterobacteriaceae express the zinc transporters ZnuABC and ZupT to acquire this metal

205 zinc chelation by expressing a high affinity zinc transporter (ZnuABC).

206 identified a mutation (N44I) in the vacuolar zinc transporter ZRC1 that changed the substrate specifi

207 n have mutations in either the high-affinity zinc transporter ZRT1 or its zinc-dependent transcriptio

208 lta mutant (defective in the plasma membrane zinc transporters Zrt1p and Zrt2p) grown in the presence

209 Our results indicate that another zinc transporter, Zrt3p, mobilizes this stored zinc in z