ライフサイエンスコーパス: zona pellucida

1 osis event that occurs upon contact with the zona pellucida.

2 ppearing sperm are not able to penetrate the zona pellucida.

3 l binding, penetration, and signaling by the zona pellucida.

4 ciated, sperm-binding ligand on the ovulated zona pellucida.

5 red for secretion and incorporation into the zona pellucida.

6 required for mouse sperm binding to the egg zona pellucida.

7 nd an inner, thick extracellular matrix, the zona pellucida.

8 and secreted prior to incorporation into the zona pellucida.

9 binding sulfated carbohydrates of the oocyte zona pellucida.

10 blocked hatching of the blastocysts from the zona pellucida.

11 exocytosis, enabling sperm to penetrate the zona pellucida.

12 nding sites were distributed over the entire zona pellucida.

13 zonadhesin with differing avidities for the zona pellucida.

14 edominant form capable of binding to the pig zona pellucida.

15 induced acrosome reaction, and penetrate the zona pellucida.

16 cles in ovaries isolated from mice lacking a zona pellucida.

17 e involved in the sperm's passage across the zona pellucida.

18 e distinct native B cell determinants of the zona pellucida.

19 rior to secretion and incorporation into the zona pellucida.

20 fic and human sperm do not bind to the mouse zona pellucida.

21 rus into the oviduct, and binding to the egg zona pellucida.

22 ible existence of a P-selectin ligand in the zona pellucida.

23 -selectin ligand is expressed in the porcine zona pellucida.

24 triggered by adhesion to the mammalian egg's zona pellucida.

25 rovulated, adult mZP3-/- females also lack a zona pellucida.

26 grown oocytes, the oocytes completely lack a zona pellucida.

27 affects sperm binding and penetration of the zona pellucida.

28 mete recognition and penetration through the zona pellucida.

29 ion along the oviduct and penetration of the zona pellucida.

30 l contact between the sperm and the oocyte's zona pellucida.

31 are incapable of fusing with eggs that lack zona pellucida.

32 protein in the egg's extracellular coat, the zona pellucida.

33 ole in mediating the binding of sperm to the zona pellucida.

34 sperm binding and/or penetration through the zona pellucida.

35 ted the interaction of this protein with the zona pellucida.

36 ADAM2 with ADAM3 in sperm binding to the egg zona pellucida.

37 pigs and named for its binding to the oocyte zona pellucida.

38 rom these mutant mice cannot bind to the egg zona pellucida.

39 phic sperm with reduced ability to penetrate zona pellucida.

40 ire more thrust to penetrate the cumulus and zona pellucida.

41 acellular matrix of mouse eggs, known as the zona pellucida.

42 hrough the oocyte prior to assembly into the zona pellucida.

43 drastically deficient in adhesion to the egg zona pellucida (0.3% of wild type) and to the egg plasma

44 -parathyroid hormone (Pth)-calcitonin (Calc)-zona pellucida 2 (2p2) was established.

45 Autoantibody to a zona pellucida 3 (ZP3) epitope was found to induce autoi

46 olled by regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed

47 unction of CPEB after pachytene, we used the zona pellucida 3 (Zp3) promoter to generate transgenic m

48 t an analysis of the pattern of evolution of Zona Pellucida 3 (ZP3), a protein present on the avian e

49 ld-type mice, we have generated human ORMDL3 zona pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that overex

50 n with the ZP3330-342 peptide of the ovarian zona pellucida 3 glycoprotein, ZP3.

51 h an epitope-specific autoantibody to murine zona pellucida 3 induces severe ovarian disease in neona

52 lgus macaques immunized with monkey or human zona pellucida 3 peptide (pZP3) in adjuvant, developed T

53 o found in an interaction domain of the ZP3 (zona pellucida 3) protein.

54 forms immune complex with endogenous ovarian zona pellucida 3, and a pathogenic CD4(+) T cell respons

55 Dot1l knockout in growing oocytes using the Zona pellucida 3-Cre (Zp3-Cre) transgenic mice.

56 ility and, given the conserved nature of the zona pellucida, a similar phenotype is expected in other

57 To prevent polyspermy, the zona pellucida, a structure that surrounds mammalian egg

58 as a template the structure of CUB domain in zona pellucida adhesion protein PSP-I/PSP-II from porcin

59 of sperm to produce a secretory response to zona pellucida agonists.

60 t resulted in human sperm penetration of the zona pellucida and accumulation in the perivitelline spa

61 mice lacking ZP3 (Zp3(tm/tm)) do not form a zona pellucida and are infertile.

62 in Zp3-null mice, which never form a visible zona pellucida and are sterile.

63 ted normal motility, and could penetrate the zona pellucida and bind to the oolemma.

64 oviducts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos t

65 epare for the prospective penetration of the zona pellucida and fusion with the egg.

66 Acrosome reaction, binding to zona pellucida and fusion with the oolemma were lower in

67 that they demonstrate maximal binding to the zona pellucida and greatly increased sensitivity to iono

68 tein specifically reacted with ZP3 of oocyte zona pellucida and its affinity-purified antibodies comp

69 vealed significant reductions in a subset of zona pellucida and lectin-type proteins between wild-typ

70 MII) oocytes exhibited irregularities of the zona pellucida and meiotic spindle.

71 ly embryo transduction protocols (removal of zona pellucida and subzonal microinjection).

72 ole of ZP2 in mediating sperm binding to the zona pellucida and support a model in which human sperm-

73 Sperm also bind transiently to the egg zona pellucida and the egg plasma membrane and then fuse

74 ctions between the cumulus cells outside the zona pellucida and the oocyte within.

75 is incorporated throughout the width of the zona pellucida and the transgenic mice are fertile.

76 st undergo capacitation in order to bind the zona pellucida and undergo a Ca(2+) ionophore-induced ac

77 P3, human sperm did not bind to the chimeric zona pellucida, and notwithstanding the absence of mouse

78 tion, sperm motility, metabolism, binding to zona pellucida, and proteasome-mediated catabolism.

79 he sperm is induced by sperm adhesion to the zona pellucida, and signaling in the egg by gamete fusio

80 nteracts with the female reproductive tract, zona pellucida, and the oolemma.

81 es is known to have binding activity for the zona pellucida, and this action may serve to anchor sper

82 The multimeric forms did not bind the zona pellucida as avidly as did the p105/45 monomer.

83 ting that the changes that take place in the zona pellucida at fertilization affected the interaction

84 In addition, heterologous zona pellucida binding assays revealed that sperm from s

85 These include a zona pellucida binding domain, which is present in a num

86 Zona pellucida binding protein 1 (ZPBP1), a spermatid an

87 , regulatory inhibitor subunit 1B (PPP1R1B), zona pellucida binding protein 2 (ZPBP2), and gasdermin

88 family of zinc finger 3 (AIOLOS; IKZF3) and zona pellucida binding protein 2 (ZPBP2).

89 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GS

90 s that rabbit proacrosin contains a specific zona pellucida binding site and that the loop containing

91 ike the latter, does not inhibit human sperm-zona pellucida binding under hemizona assay conditions.

92 ed, there was no significant effect on sperm-zona pellucida binding; however, fertilization was reduc

93 uding motility, capacitation, binding to the zona pellucida, binding to the oocyte membrane, and pene

94 Many candidates have been proposed as zona pellucida-binding proteins.

95 les in mouse eggs is required to produce the zona pellucida block to polyspermy.

96 ontact with the egg extracellular matrix, or zona pellucida, by the matrix glycoprotein ZP3.

97 Ability to penetrate the zona pellucida, cleavage rate, cleavage kinetics, and bl

98 Although a zona pellucida composed of ZP2 and ZP3 was formed around

99 The mouse zona pellucida consists of three glycoproteins that are

100 The mouse egg extracellular coat, or zona pellucida, consists of three glycoproteins, called

101 g shortly after blastocyst hatching from the zona pellucida constitute a major cause of pregnancy los

102 Results show that the ovulated zona pellucida contains at least two distinct ligands fo

103 The mouse zona pellucida contains three glycoproteins, ZP1, ZP2, a

104 Rgs2(-/-) eggs also underwent premature zona pellucida conversion in vivo.

105 ases that were sufficient to cause premature zona pellucida conversion.

106 nucleus, cytoplasm, perivitelline space, and zona pellucida-could be visually differentiated in both

107 channels during gamete interaction inhibits zona pellucida-dependent Ca2+ elevations, as demonstrate

108 ZP3, the glycoprotein agonist of the zona pellucida, depolarizes sperm membranes by activatin

109 lass, DPY, and terminating in a crosslinking zona pellucida domain and membrane anchor sequence.

110 des a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-depend

111 e also controls the arrangement of two other zona pellucida domain proteins, Dumpy and Piopio, extern

112 eins possess an N-terminal signal peptide, a zona pellucida domain, a consensus furin-like cleavage s

113 ct structure and contained peptides from the zona pellucida domain, which is involved in cell differe

114 We show here that the zona pellucida domain-containing protein Dusky-like is e

115 DYF-7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-associates into m

116 In the absence of the zona pellucida, embryos lacking CTNNB1 undergo fission a

117 ibit the in vitro binding of murine sperm to zona pellucida-enclosed eggs.

118 es of capacitation, the ability to undergo a zona pellucida-evoked acrosome reaction, develops more s

119 e shotgun cell adhesion protein gene and the zona pellucida family transmembrane protein gene, CG1319

120 w comparisons to be made with the process of zona pellucida formation in mammals.

121 Oocyte growth and zona pellucida formation proceed normally, but other asp

122 Treatment of zona pellucida-free eggs with chymotrypsin reduces the a

123 e normal when null spermatozoa were added to zona pellucida-free eggs, but in the presence of the ext

124 the oocyte membrane, and penetration of the zona pellucida-free oocyte.

125 he ability of Tenr mutant sperm to fertilize zona pellucida-free oocytes and to bind to, but not fert

126 sults demonstrate that a genetic defect in a zona pellucida gene causes infertility and, given the co

127 in coordinating the expression of the three zona pellucida genes during oogenesis.

128 coproteins in this regard because only human zona pellucida glycoprotein 3 (ZP3) and bovine proopiome

129 eta1,3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida glycoprotein 3 Cre (ZP3Cre)] and Control

130 erm to specific O-linked oligosaccharides on zona pellucida glycoprotein 3.

131 public RNA and proteomic data, we identified zona pellucida glycoprotein 4 (ZP4) as a novel target fo

132 Each zona pellucida glycoprotein is synthesized in growing oo

133 rides located at the sperm combining site of zona pellucida glycoprotein mZP3.

134 to be a cell-surface receptor for the murine zona pellucida glycoprotein ZP3, standard immunoelectron

135 ZP3, an egg zona pellucida glycoprotein, produces a sustained increa

136 protein that functions as a receptor for the zona pellucida glycoprotein, ZP3, and as an inducer of t

137 specific oligosaccharide ligands within the zona pellucida glycoprotein, ZP3, via beta1,4-galactosyl

138 Zona pellucida glycoproteins are responsible for species

139 ctin glycoprotein ligand-1 (PSGL-1) and from zona pellucida glycoproteins of porcine oocytes indicate

140 of these female fertilization proteins, the zona pellucida glycoproteins ZP2 and ZP3, are part of th

141 mZP3 (approximately 83 000 Mr), one of three zona pellucida glycoproteins, and once bound undergo the

142 hange, such as the physiological stimulus of zona pellucida glycoproteins, results in a loss of chira

143 ess GalTase bound ZP3 but did not bind other zona pellucida glycoproteins.

144 ndings and reveal novel functions for murine zona pellucida glycoproteins.

145 This extracellular matrix is known as the zona pellucida in eutherian mammals and consists of thre

146 This matrix is known as the zona pellucida in mammals and is critically important fo

147 tively induced Ab to ZP3335-342 bound to the zona pellucida in the functional and degenerative ovaria

148 These embryos do not hatch from the zona pellucida in vitro, fail to grow in culture, and ex

149 e and produced antibody that bound to native zona pellucida in vivo.

150 ere to the extracellular coat of the egg, or zona pellucida, in a species-specific manner.

151 tein tyrosine phosphorylation as well as the zona pellucida-induced acrosome reaction.

152 cous media and in their ability to fertilize zona pellucida-intact eggs.

153 e oocytes and to bind to, but not fertilize, zona pellucida-intact oocytes suggests that the normal-a

154 purified antibodies completely blocked sperm-zona pellucida interaction in mice.

155 s that sp56 may function in acrosomal matrix-zona pellucida interactions during and immediately follo

156 l adhesion event between mouse sperm and the zona pellucida is a high affinity event which is suffici

157 SignificanceHatching from the zona pellucida is a prerequisite for embryo implantation

158 The mammalian zona pellucida is an egg extracellular matrix to which s

159 The zona pellucida is an extracellular matrix consisting of

160 The zona pellucida is an extracellular matrix that mediates

161 The mouse zona pellucida is composed of three glycoproteins (ZP1,

162 The mouse zona pellucida is composed of three glycoproteins (ZP1,

163 The mouse zona pellucida is composed of three glycoproteins (ZP1,

164 In mice, the zona pellucida is composed of three glycoproteins, but t

165 The mouse zona pellucida is composed of three glycoproteins, ZP1,

166 The mouse egg zona pellucida is constructed of three glycoproteins, ca

167 After fertilization, the zona pellucida is modified ad minimus by cleavage of ZP2

168 crosomes indicates that sperm binding to the zona pellucida is not sufficient to induce acrosome exoc

169 iates species-specific adhesion to the egg's zona pellucida, is a speciation gene in placental mammal

170 Recently the zona pellucida like domain containing 1 protein (ZPLD1,

171 embryos, these data are consistent with the zona pellucida maintaining interactions between granulos

172 nal-vesicle-intact oocytes but that lacked a zona pellucida matrix and had a disorganized corona radi

173 present in MVA and is incorporated into the zona pellucida matrix of transgenic mice.

174 en mutated to prevent incorporation into the zona pellucida matrix, complementing earlier studies ind

175 rane domain and assembled into the insoluble zona pellucida matrix.

176 Via its bipartite zona pellucida module (ZP-N/ZP-C), UMOD forms extracellu

177 erm initiate fertilization by binding to the zona pellucida (mZP), the specialized extracellular matr

178 uter covering of the egg known as the murine zona pellucida (mZP).

179 protein with a signal peptide followed by 3 zona pellucida N domains, consistent with extracellular

180 in which the supramolecular structure of the zona pellucida necessary for sperm binding is modulated

181 ized the physical interaction of EVs and the zona pellucida of 4- to 8-cell stage embryos using trans

182 The antiserum also failed to label the zona pellucida of oocytes examined by laser scanning con

183 that mediate recognition and binding to the zona pellucida of the egg are still not understood.

184 steps: sperm bind and penetrate through the zona pellucida of the egg, adhere to the egg plasma memb

185 ctivity interferes with sperm binding to the zona pellucida of the ovum.

186 Recombinant ZP3R/sp56 bound to the zona pellucida of unfertilized eggs but not to 2-cell em

187 SED1 binds specifically to the zona pellucida of unfertilized oocytes, but not to the z

188 specific manner to the extracellular matrix (zona pellucida) of the oocyte.

189 The extracellular coat, or zona pellucida, of the mouse egg consists of three glyco

190 , that constitute the extracellular coat, or zona pellucida, of the oocyte.

191 ered steps, including the acrosome reaction, zona pellucida penetration, sperm-egg attachment, and me

192 Adhesion to the egg's zona pellucida promotes Ca2+ influx through voltage-sens

193 rm to the recombinant N-terminal part of the zona pellucida protein 2 randomizes chirality in capacit

194 The cuticle collagen ROL-6 and zona pellucida protein NOAH-1 display aberrant annular l

195 ptor is closely related to that of the mouse zona pellucida protein ZP2.

196 hey do not acrosome-react in response to egg zona pellucida proteins and have reduced fertilizing abi

197 luorophore conjugated to solubilized porcine zona pellucida proteins to observe zona receptors on liv

198 g genes encoding antifreeze glycoprotein and zona pellucida proteins, are highly expanded in the icef

199 ass spectrometric analysis of the native rat zona pellucida proteome (defined as the fraction of the

200 of the transient immunocontraceptive porcine zona pellucida (PZP), and found that repeated vaccinatio

201 However, the sperm proteins that recognise zona pellucida receptors remain contentious despite long

202 Sperm at the surface of the zona pellucida remained acrosome-intact for more than 2

203 e folliculogenesis and those that encode the zona pellucida required for fertilization and early embr

204 present in a number of proteins such as the zona pellucida sperm binding proteins, and uromodulin, I

205 t occur until the morula stage, and that the zona pellucida suffices to maintain blastomere proximity

206 The extracellular zona pellucida surrounding mammalian eggs is formed by i

207 metalloendopeptidase that cleaves ZP2 in the zona pellucida surrounding mouse eggs to prevent additio

208 required for formation of the extracellular zona pellucida surrounding mouse eggs.

209 The mammalian zona pellucida surrounding ovulated eggs mediates sperm

210 tion in mammals is mediated primarily by the zona pellucida surrounding ovulated eggs.

211 The zona pellucida surrounding ovulated mouse eggs contains

212 fertilization occurs when sperm contact the zona pellucida surrounding the egg.

213 rcome barriers and penetrate the cumulus and zona pellucida surrounding the egg.

214 The zona pellucida surrounding the pig oocyte contains two M

215 The extracellular zona pellucida surrounds mammalian eggs and mediates tax

216 The extracellular zona pellucida surrounds ovulated eggs and mediates game

217 with high K(+) or by addition of solubilized zona pellucida (sZP).

218 ocytes and secreted to form an extracellular zona pellucida that mediates sperm binding and fertiliza

219 Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key st

220 Mammalian oocytes synthesize and secrete a zona pellucida that surrounds the growing oocytes, ovula

221 ZP3 is a protein in the mammalian egg coat (zona pellucida) that binds sperm and stimulates acrosoma

222 urrounded by a thick extracellular coat, the zona pellucida, that plays important roles during early

223 y a relatively thick extracellular coat, the zona pellucida, that plays vital roles during oogenesis,

224 ce of BSA, as measured by the ability of the zona pellucida to induce the acrosome reaction and by su

225 required for the structural integrity of the zona pellucida to minimize precocious hatching and reduc

226 n to the mammalian egg extracellular matrix (zona pellucida) to allow penetration of the egg coat.

227 Uromodulin is a zona pellucida-type protein essentially produced in the

228 at about 75-80% of the murine sperm bound to zona pellucida under well defined in vitro conditions is

229 rabbit sperm and shown to bind to homologous zona pellucida using an in vitro assay.

230 Although porcine sperm first contact the zona pellucida via their plasma membrane, the regions of

231 e sperm were able to fertilize eggs once the zona pellucida was removed but displayed persistent abno

232 At fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2

233 P-ZP3 associate with the inner aspect of the zona pellucida, which is distinct from the plasma membra

234 o establish a tenacious association with the zona pellucida, yet they are capable of fertilization.

235 nd humans, is dependent on the presence of a zona pellucida (ZP) around growing oocytes and unfertili

236 odular extracellular segment that includes a zona pellucida (ZP) domain and several plasminogen N-ter

237 Proteins harboring a zona pellucida (ZP) domain are prominent components of v

238 The zona pellucida (ZP) domain is a bipartite protein struct

239 ations; the Tecta(L1820F,G1824D/+) mouse for zona pellucida (ZP) domain mutations causing stable mid-

240 We show in Drosophila that the zona pellucida (ZP) domain protein Piopio interacts and

241 x, which contains chondroitin proteoglycans, Zona Pellucida (ZP) domain proteins, and other glycoprot

242 Additionally, we identify two zona pellucida (ZP) domain proteins, Piopio (Pio), and D

243 f protein, bone morphogenetic protein-1) and zona pellucida (ZP) domain-containing protein we find pr

244 proteins share a sequence designated as the zona pellucida (ZP) domain.

245 h includes a domain of eight cysteines and a zona pellucida (ZP) domain.

246 filaments and extracellular matrices through zona pellucida (ZP) domains.

247 f these proteins is related to mammalian egg zona pellucida (ZP) glycoproteins ZP1-3 and possesses an

248 ics (OMD), cortical granule (CG) status, and zona pellucida (ZP) hardening as well as the integrity o

249 ics (OMD), cortical granule (CG) exocytosis, zona pellucida (ZP) hardening, and spindle/chromatin int

250 of an egg by a single sperm, the egg coat or zona pellucida (ZP) hardens and polyspermy is irreversib

251 e involved directly in binding to the female zona pellucida (ZP) in a species-specific manner.

252 regulation of fertilization, including sperm-zona pellucida (ZP) interactions as well as the early ev

253 The zona pellucida (ZP) is a highly organized extracellular

254 The zona pellucida (ZP) is an extracellular matrix that surr

255 ) is essential to fertilization, and the egg zona pellucida (ZP) is generally believed to be an in vi

256 The zona pellucida (ZP) is vital for species-specific fertil

257 strom resolution, comprised of the bipartite zona pellucida (ZP) module in a helical arrangement with

258 ge leading to conformational activation of a Zona Pellucida (ZP) polymerisation domain.

259 All mutant oocytes had an altered zona pellucida (ZP) that was thinner than the control ZP

260 tilization the spermatozoon binds to the egg zona pellucida (ZP) via sperm receptor(s) and undergoes

261 tion, mammalian sperm must first bind to the zona pellucida (ZP), a glycoprotein matrix surrounding t

262 expression of an antibody that binds to the zona pellucida (ZP), a glycoprotein matrix that surround

263 The zona pellucida (ZP), an ovarian extracellular structure,

264 spermatozoa bound tightly or penetrated the zona pellucida (ZP), and fewer underwent acrosome reacti

265 Zona pellucida (ZP), the extracellular matrix sheltering

266 of the morphological characteristics of the zona pellucida (ZP), trophectoderm (TE), blastocoel (BC)

267 alpha-EC) binds to the microvillar region of zona pellucida (ZP)-free eggs, the region of the membran

268 on defects also show impaired binding to the zona pellucida (ZP).

269 P2, a major component of the oocyte-specific zona pellucida (ZP).

270 r matrix coating of the oocyte, known as the zona pellucida (ZP).

271 pecies-specific binding activity for the egg zona pellucida (ZP).

272 rounding eggs in fish (chorion) and mammals (zona pellucida [ZP]) regulate gamete recognition before

273 At fertilization, spermatozoa bind to the zona pellucida (ZP1, ZP2, ZP3) surrounding ovulated mous