ライフサイエンスコーパス: oma

1 sis (DE; potentially associated with SUP and OMA).

2 or cell lines using the Affymetrix HG-U95Av2 OMA.

3 ing patients diagnosed with CSU and starting OMA.

4 d axis alone is not sufficient to induce TSH-omas.

5 ta(PV/PV) mouse) spontaneously developed TSH-omas.

6 Olerud-Molander Ankle Score (OMAS) 1 year after randomization (range, 0-100 points, w

7 sponses to acute VPI alone with omapatrilat (OMA) (1 micromol/kg IV bolus) (n=6), acute low-dose SQ B

8 re, we define the RNA binding specificity of OMA-1 and demonstrate that OMA-1/2 are required to repre

9 Both OMA-1 and OMA-2 are expressed only in oocytes and 1-cell

10 OMA-1 and OMA-2 are redundant proteins required for oocy

11 tion of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive r

12 Depletion of both oma-1 and oma-2 in embryos leads to embryonic lethality.

13 eport here a distinct redundant function for OMA-1 and OMA-2 in the 1-cell embryo.

14 llowing restricted and distinct functions of OMA-1 and OMA-2 in the maturing oocyte and 1-cell embryo

15 We have shown previously that OMA-1 and OMA-2 repress global transcription in P0 and P

16 t two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocyte

17 at two C. elegans CCCH zinc finger proteins, OMA-1 and OMA-2, have an essential and redundant functio

18 We show here that OMA-1 and OMA-2, previously shown to regulate oocyte mat

19 oogenesis and suggest that interplay between OMA-1 and other factors for overlapping binding sites he

20 OMA-1 binds with high affinity to a conserved region of

21 39 facilitates subsequent phosphorylation of OMA-1 by another kinase, GSK-3, at T339 in vitro.

22 9 and T339 are essential for correctly-timed OMA-1 degradation in vivo.

23 phosphorylation at T239 is required both for OMA-1 function in the 1-cell embryo and its degradation

24 that MBK-2 directly phosphorylates MEI-1 and OMA-1 in vitro and that this activity is essential for d

25 Heritable silencing of oma-1 is a dose-dependent process where the inheritance

26 Our results reveal that OMA-1 is a sequence-specific RNA-binding protein require

27 mitosis, but ectopic expression of wild-type OMA-1 is sufficient to repress transcription in both som

28 OMA-1 phosphorylated at T239 is only detected within a s

29 ation results in improper degradation of the OMA-1 protein in embryos.

30 We also show that OMA-1 protein is directly phosphorylated at T239 by the

31 In wild type animals, OMA-1 protein is expressed at a high level exclusively i

32 Degradation of MEI-1 and OMA-1 requires the dual-specificity YAK-1-related (DYRK)

33 yed degradation of maternal SKN-1 protein in oma-1(zu405) embryos and resultant elevated levels in C

34 In oma-1(zu405) embryos, the C blastomere is transformed to

35 KN-1, PIE-1, MEX-3, and MEX-5, is delayed in oma-1(zu405) mutant embryos.

36 These observations suggest that oma-1, in addition to its role in oocyte maturation, con

37 unit MEI-1 and the oocyte maturation protein OMA-1, must be degraded during this transition .

38 SPN-2 binds to the RNA-binding protein OMA-1, which in turn binds to the mei-1 3' untranslated

39 ensable for silencing of the endogenous gene oma-1.

40 d at the C. elegans oocyte maturation factor oma-1.

41 ene that is essential for oocyte maturation, oma-1.

42 OMA-1/2 are normally degraded after the first mitosis, b

43 ng specificity of OMA-1 and demonstrate that OMA-1/2 are required to repress the expression of a glp-

44 OMA-1/2 binding to TAF-4 is developmentally regulated, r

45 serves as a developmental switch, converting OMA-1/2 from oocyte to embryo regulators.

46 Oocytes in oma-1;oma-2 mutants initiate but do not complete maturat

47 ometriosis group (48 had SUP [10.2%], 83 had OMA [17.7%], and 339 had DE [72.1%]) and 881 were assign

48 This new OMA 2.0 algorithm is used in the OMA database from the M

49 Both OMA-1 and OMA-2 are expressed only in oocytes and 1-cell embryos,

50 OMA-1 and OMA-2 are redundant proteins required for oocyte maturat

51 MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators

52 Depletion of both oma-1 and oma-2 in embryos leads to embryonic lethality.

53 a distinct redundant function for OMA-1 and OMA-2 in the 1-cell embryo.

54 stricted and distinct functions of OMA-1 and OMA-2 in the maturing oocyte and 1-cell embryo, ensuring

55 Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation an

56 We have shown previously that OMA-1 and OMA-2 repress global transcription in P0 and P1 by seque

57 and lowered abundance of four target mRNAs (oma-2, egg-1, pup-2, and tra-2); GLD-2 depletion also lo

58 1 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and func

59 elegans CCCH zinc finger proteins, OMA-1 and OMA-2, have an essential and redundant function in oocyt

60 We show here that OMA-1 and OMA-2, previously shown to regulate oocyte maturation, r

61 (12 wk), 36 +/- 4%; ENA (20 wk), 22 +/- 6%; OMA (20 wk), 14 +/- 2%].

62 at 12 wk [GS scores: ENA (32 wk), 34 +/- 5%; OMA (50 wk), 38 +/- 8%].

63 ent disease phenotypes (SUP: 6.2% [3 of 48]; OMA: 7.2% [6 of 83]; and DE: 7.4% [25 of 339]; P = .84).

64 Omapatrilat (OMA), a vasopeptidase inhibitor, simultaneously inhibits

65 AIP also contributes to invariant coding of OMAs across different visual formats.

66 ENA and OMA administered beginning on day 2 after surgery were e

67 It is concluded that, in this model, OMA affords greater long-term renoprotection than ENA wh

68 We present improvements in the OMA algorithm: (i) refining the pairwise orthology infer

69 We compared the actions of OMA alone and with diuretic (OMA+D) to ACEI+D in a model

70 OMA alone did not increase plasma renin activity and ald

71 lary wedge pressures to a greater level than OMA alone or ACEI+D.

72 ute activation of renin and aldosterone with OMA alone such as occurs with ACEI+D and OMA+D.

73 chelator dipyridyl (DP), or oxalomalic acid (OMA), an aconitase inhibitor.

74 hema for combining the data derived from the OMA analysis of a few lung cancer cell lines with immuno

75 ake, and GSH concentration were inhibited by OMA and DP, indicating a central role for iron-regulated

76 In comparison to OrthoMCL, OMA and OrthoFinder, JustOrthologs decreases ortholog id

77 ds [bi-directional best hit (BBH), outgroup, OMA and QuartetS-C (QuartetS followed by clustering)], i

78 log data downloaded from Orthologous MAtrix (OMA) and Ensembl Compara as the base for the conversion.

79 mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultane

80 ding to the 3 endometriosis phenotypes (SUP, OMA, and DE).

81 At week 20, OMA- and ENA-treated rats exhibited less GS than did unt

82 mulating hormone (TSH)-secreting tumors (TSH-omas) are pituitary tumors that constitutively secrete T

83 statistically significant difference in mean OMAS at 3 and 6 months in favor of nail fixation.

84 d using the Olerud and Molander Ankle Score (OMAS) at 4 months after randomisation, in the per-protoc

85 h only an increase in seroma formation after OMA, but without an increased risk of surgical site infe

86 The results obtained with OMA-BV showed overall agreements compared with the resul

87 conducting polymer gas-sensing technology of OMA-BV to measure the concentration of acetic acid in th

88 ech Microbial Analyzer--Bacterial Vaginosis (OMA-BV), which determines a patient's BV status on the b

89 ressure (BP), arterial stiffness and whether OMA can predict arterial stiffness in hypertensive (HTN)

90 OMA+D decreased pulmonary arterial and pulmonary capilla

91 e immediately increased with ACEI+D, whereas OMA+D resulted in higher plasma renin activity and a del

92 the actions of OMA alone and with diuretic (OMA+D) to ACEI+D in a model of pacing-induced congestive

93 ith OMA alone such as occurs with ACEI+D and OMA+D.

94 This new OMA 2.0 algorithm is used in the OMA database from the March 2017 release onwards, and ca

95 genomes and precomputed alignments from the OMA database, which currently contains over 2100 complet

96 The Orthologous MAtrix (OMA) database is a leading resource for identifying orth

97 osed patients' profile, and an assessment of OMA efficacy and safety.

98 ited States (OMA-US) and the European Union (OMA-EU) prescribing information, including subgroups acc

99 36%) and 359 (34%) patients were OMA-US- and OMA-EU-eligible, respectively.

100 rate was lower with ACEI+D than with either OMA group.

101 High density oligonucleotide microarrays (OMAs) have been used recently to profile gene expression

102 le, we present six major new developments in OMA: (i) a new web interface; (ii) Gene Ontology functio

103 on a multiplicative mixing of signals about OMA identity and visual format, particularly evidenced b

104 f dilbit to zebrafish early life stages, and OMAs in exposures exacerbate toxicity.

105 nto the understanding of pathogenesis of TSH-omas in patients.

106 al index (ABI) were significantly higher but OMA (in control, with cold- and warm-stimulation, NT, CS

107 The presence of oil-mineral aggregates (OMAs) in the WAFs greatly increased toxicity, despite al

108 ed T3 and TSH levels, but no discernible TSH-omas, indicating that the dysregulation of the pituitary

109 These results suggest that OMA is a sensitive index to predict arterial stiffness i

110 OMA is an established resource to elucidate evolutionary

111 The pre-specified non-inferiority OMAS margin was -6 points and superiority testing was in

112 analyze whether opisthenar microvessel area (OMA, measured with Optical Coherence Tomography (OCT) an

113 nsistently, outperformed the highly specific OMA method and that, while consuming only 0.5% additiona

114 (P = 0.002) more seromas were detected after OMA (n = 34, 18.1%) compared with primary suture (n = 5,

115 nce of activated MAP kinase, do not occur in Oma oocytes.

116 ive primary suture, onlay mesh augmentation (OMA), or sublay mesh augmentation.

117 The OMA ortholog IDs and Ensembl gene IDs were converted to

118 Many methods have been proposed, including OMA (Orthologous MAtrix).

119 Here, we describe the OMA pipeline available as a standalone program for Linux

120 Ontology function predictions as part of the OMA pipeline; (iii) better support for plant genomes and

121 l endometriosis (SUP), ovarian endometrioma (OMA; potentially associated with SUP), and deep endometr

122 The Orthologous Matrix (OMA) project is a method and associated database inferri

123 The Oma prophase arrest is released by inactivation of a MYT

124 The two OMA protein functions are strictly regulated in both spa

125 Here, we show that OMA proteins also repress transcription in P2-P4 indirec

126 OMA proteins bind to both the 3' UTR of the zif-1 transc

127 Phosphorylation of OMA proteins displaces SPN-2 from the zif-1 3' UTR, rele

128 serves as a developmental switch, converting OMA proteins from specific translational repressors in o

129 rylation by MBK-2 facilitates the binding of OMA proteins to TAF-4 and simultaneously inactivates the

130 Soon after the first mitotic cycle, OMA proteins undergo developmentally regulated degradati

131 e activity and the timing of degradation for OMA proteins, thereby allowing restricted and distinct f

132 OMA provides pairwise and groupwise orthologs, functiona

133 tcomes were the Olerud-Molander Ankle Score (OMAS), quality of life, and complications (such as infec

134 the Olerud-Molander Ankle Score at 6 months (OMAS; range, 0-100; higher scores indicate better outcom

135 Both treatments normalized SBP, but OMA resulted in more sustained reduction of proteinuria

136 At 4 months after randomisation, the mean OMAS score was 65.9 in the early weight-bearing and 61.2

137 and study center, a 1-point increase in peak OMAS score was associated with (1) 1.0 additional day wi

138 le function equivalent to that with surgery (OMAS score, 66.0 [95% CI, 63.6-68.5] for surgery vs 64.5

139 ined the relationship between patients' peak OMAS scores and days with fever (body temperature > 38.0

140 Patients' peak OMAS scores spanned the full range of possible values (0

141 Out of 297 recorded units, 38% were OMA-selective in at least one format.

142 Although we found no fully invariant OMA-selective neuron, we discovered a population code th

143 set of units maintaining a relatively stable OMA selectivity across formats despite considerable resc

144 tly after stimulus presentation, followed by OMA selectivity.

145 OMA standalone is available under the permissive open so

146 Another key feature of OMA standalone is that users can combine their own data

147 We compare OMA standalone to other methods in the context of phylog

148 ards, and can be run on custom genomes using OMA standalone version 2.0 and above.

149 also discuss other potential applications of OMA standalone, including identifying gene families havi

150 glomerular capillary hydraulic pressure with OMA than with ENA, at similar mean arterial pressures.

151 zed by the presence of multiple myelomatous "omas" throughout the skeleton, indicating that there is

152 rmation about observed manipulative actions (OMAs) to the other nodes of the network.

153 ncreasing proteinuria, whereas the remaining OMA-treated rats demonstrated a substantially slower inc

154 At this extremely late time point, OMA-treated rats exhibited GS scores similar to those of

155 ectives were to characterize the patterns of OMA updosing (defined as changes in dose and/or injectio

156 The primary endpoint was the frequency of OMA updosing at 3 months.

157 OMA updosing is frequent in particular in cases of sever

158 ation is available on the use of omalizumab (OMA) updosing since its introduction as a second-line th

159 ab treatment according to the United States (OMA-US) and the European Union (OMA-EU) prescribing info

160 lergy; 379 (36%) and 359 (34%) patients were OMA-US- and OMA-EU-eligible, respectively.

161 2, but only the difference in control versus OMA values was statistically significant [GS scores: con

162 At 1 year, the median OMAS was 80.0 (IQR, 60.0-90.0) in the fixation group com

163 of the vasopeptidase inhibitor omapatrilat (OMA) was compared with that of enalapril (ENA) in male M

164 The side effects of OMA were not more frequent after updosing.

165 om the 2021 Ohio Medicaid Assessment Survey (OMAS), which is conducted via web, telephone, and mail.

166 ng via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, includi

167 vealed an increase in seroma formation after OMA with an odds ratio of 4.3 (P = 0.004) compared with

168 Thus, OMA with or without a diuretic possesses beneficial card

169 Acute administration of OMA with or without diuretic results in more favorable c