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1 ician takes action that a nonphysician would be incapable of performing.
2 helial venules (HEVs), whereas naive T cells were incapable of sticking.
4 A poliovirus (PV) mutant (termed GG), which is incapable of producing 3AB, VPg, and 3CD proteins due
6 with anti-CD20 during Pneumocystis infection are incapable of mounting a protective immune response w
7 ted in GPR54 KOs and that such animals would be incapable of showing a compensatory rise in LH secret
9 that, although the modified RS-O(-) fragment is incapable of forming a pi bond with the Fe(III) cente
10 ry of 1:1, resulting in DNP-ATP-proCsp9 that is incapable of forming a productive Apoptosome with Apa
12 hereas others suggest that estrogen not only is incapable of providing a benefit, but actually can be
14 xes destabilized the WT NRS-Ad3' complex; it was incapable of forming a B complex on a native gel.
15 g in a spontaneously unfolded structure that was incapable of forming a homodimer with itself or a he
18 on- or binding-incompetent beta(2a) subunits were incapable of entering a CaMKII-dependent high-activ
19 inment at photopic intensities at which they were incapable of supporting a visually guided behavior.
20 s, which express SVCT2 at the mRNA level and were incapable of transporting AA, showed a predominance
21 First, we found that beta-catenin null cells were incapable of undergoing acinar to ductal metaplasia
22 spectrin-actin binding domain peptides that were incapable of binding actin had no deleterious effec
26 production in the mouse fibroblasts, but it is incapable of stimulating adiponectin expression in th
29 igens and shared self-antigens but generally are incapable of provoking an effective immune response,
30 nts, even if sequestered within the nucleus, are incapable of transactivating an IgH reporter gene.
31 (E)-induced GnRH/LH surge and thus E should be incapable of inducing an LH surge in the absence of G
32 of the identified mutants, denoted hydEF-1, is incapable of assembling an active [Fe] hydrogenase.
33 trast to A416P, either A420P or A425P mutant was incapable of interacting and regulating cellular Src
36 ing the Wnt signaling pathway in SW480 cells is incapable of inducing apoptosis in these cells, confi
37 Similarly, AG879, a selective ErbB2 TKI, was incapable of inducing apoptosis in FET6alphaS26X cel
38 Furthermore, CII (256-276, N(263), D(266)) was incapable of preventing arthritis in DR1 IL-4(-/-) m
39 uracil-DNA glycosylase activity and, hence, was incapable of acting as a uracil-processing DNA repai
41 -catalytic interface, the B subunit seems to be incapable of binding ATP, which is a marked differenc
43 strated basal ATPase activity, but PC lipids were incapable of stimulating ATPase activity highlighti
44 in four out of 10 patients CD4+CD25+ T cells were incapable of suppressing autologous CD4+CD25- T-cel
47 lung and spleen, while susceptible C3H mice were incapable of limiting bacteria growth, especially i
48 -independent defense mechanisms, macrophages are incapable of restricting BCG growth and of confining
50 s based on sodium bisulfite treatment of DNA are incapable of distinguishing between the two modified
53 methods to measure formaldehyde-induced DPCs were incapable of discriminating between endogenous and
55 genes, results in a null mutant strain that is incapable of establishing bloodstream infection in vi
58 M, we have determined that a CaM mutant that is incapable of binding calcium binds to RyR1 at the apo
60 s, in multiple cancer types in which ABT-737 is incapable of causing cell death, ABT-737 may have add
61 e cholesterol crystal phase, and cholesterol is incapable of displacing ceramide from the bilayer pha
64 d cdc37-S14A or cdc37-S14,17A overexpression was incapable of protecting cka2-13 mutants on media con
66 erestingly, an inactive form of CORM-A1 that is incapable of releasing CO failed to promote both vaso
69 pth and slow relaxation time and, therefore, are incapable of ensuring complex inter-pulse dynamics a
70 l-DNA-oligonucleotides of opposite chirality are incapable of forming contiguous Watson-Crick base pa
71 tivates barbed end capping by CP and why V-1 is incapable of uncapping CP-capped actin filaments, the
73 ects of 5-aza was dissociated, CHOP ablation was incapable of modulating cytotoxicity; however, neutr
74 waves incident to a highly scattering medium are incapable of penetrating deep into the medium due to
75 trate, and so following fertilization, sperm were incapable of stimulating Delta 90 cyclin B1 degrada
76 aled that bare doped silicon microelectrodes are incapable of resolving different grades of attached
78 ver, many culture-expanded therapeutic cells are incapable of targeting diseased tissues following sy
81 207A/G208A; AA), in which the mutant ERalpha is incapable of binding DNA and can signal only through
82 previously that encephalitogenic CD4 T cells are incapable of inducing EAE when B cells are the sole
84 M5eta or TRIM5theta show that these isoforms are incapable of restricting either HIV type 1 (HIV-1) o
87 gen invasion assays, Bmp2 mutant endothelium is incapable of undergoing EMT, and addition of BMP2 pro
90 tant of B. bronchiseptica defective for hurP was incapable of regulating expression of BhuR in a heme
92 etal-oxide-semiconductor (CMOS) counterparts are incapable of capturing fast dynamical processes with
93 nal requirement for early flagellar assembly is incapable of repressing FlbD in a class II flagellar
95 ctural similarity, however, BchL is found to be incapable of substituting for the Fe protein in a nit
96 averaged boundary shear stress and therefore is incapable of accounting for the fluctuating forces en
99 ytes isolated from mouse preantral follicles are incapable of recovering from an experimentally induc
100 e and its mammalian homolog were reported to be incapable of deglycosylating full-length glycoprotein
101 otassium channel alpha-subunit, Kv8.2, which is incapable of forming functional channels on its own.
102 d Asp-AT-PLP-AFPA complex revealed that GabR is incapable of facilitating further steps of the transa
103 take action for future needs: other animals are incapable of anticipating future needs, and any futu
104 iotensin II peptide (SII-angiotensin), which are incapable of activating G proteins, to isolate the t
105 ning its ability to interact with E-protein, is incapable of inducing GABAergic (Pax2)- and suppressi
107 ly uses thioredoxin as an electron donor and is incapable of using glutathione for this function.
110 ast, NOS2(-/-) mice, but not Phox(-/-) mice, were incapable of controlling H37Rv infection and died e
112 thin the short gH cytoplasmic tail, 824L gH, is incapable of executing hemifusion despite normal cell
116 firming earlier studies, the E6 and E7 genes were incapable of immortalizing human fibroblasts but di
117 markedly attenuated in IgE(-/-) animals that are incapable of producing IgE in response to A. fumigat
118 xpression and that Ei in homozygous DKO mice is incapable of triggering Igkappa gene transcription.
119 s taken at day 3, when they lack FcgammaRII, were incapable of preventing immunoreceptor tyrosine-bas
121 ners (approximately 200 residues) appears to be incapable of existing in a context other than immedia
126 ulate fractions enriched for Axl1p or Ste23p are incapable of cleaving insulin, suggesting that the f
128 nced shedding of noninfectious particles and are incapable of antagonizing interferon (IFN) effective
129 inally differentiated effector phenotype and were incapable of transitioning into a memory state.
130 R1-deficient hematopoietic stem cells (HSCs) were incapable of reconstituting irradiated recipients a
131 Given this new evidence, we assert that BAT is incapable of operating its depository in the spirit o
133 ctated by the polar orientation of KOPS, and is incapable of recognizing KOPS while translocating alo
135 ld-type FPR or a mutant form, DeltaST, which is incapable of undergoing ligand-stimulated phosphoryla
137 technique for all traumatic brain injury, it is incapable of providing long-term prognostic informati
138 H. pylori mutants lacking either GGT or VacA are incapable of preventing LPS-induced DC maturation an
140 ansdifferentiation, the myofibroblastic HSCs are incapable of expressing many MMPs; however, the majo
141 severely altered in gametocyte development, are incapable of producing mature-stage gametocytes, and
143 ium binding-deficient form of the C2C domain is incapable of stimulating membrane fusion, further und
145 tained with free virus, infected MDMs or DCs were incapable of transferring MeV to HAE when applied t
146 t in the synthesis of the bba64 gene product was incapable of infecting mice via tick bite even thoug
147 the phosphorylation-mimicking mutant, S381E, was incapable of bundling microfilaments, it retains the
148 owever, even the most effective combinations were incapable of generating more than 65% of any partic
151 ting in formation of fewer sporozoites which were incapable of infecting naive mice or hepatocytes in
154 Accordingly, neutrophils from this patient were incapable of producing neutrophil extracellular tra
156 previously characterized ABINs, mouse ABIN-3 was incapable of inhibiting NF-kappaB activation by proi
157 urface and presents no lipid or a lipid that is incapable of mediating NKT cell selection and/or is r
158 C(2) receptor for VIP and PACAP (Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of
159 tween attP and attB, the S. aurantiaca cells were incapable of building normal fruiting bodies but fo
161 th in-frame deletions of either arrA or arrB are incapable of growing on As(V), yet both are able to
162 at, unlike the isogenic wild-type parent, it is incapable of propagating on certain groEL mutant host
163 22) monomers, bending them into a shape that is incapable of forming ordered beta-sheets or fibrils.
167 olase-dead RelMtb mutant, RelMtb(H80A), that is incapable of hydrolyzing (p)ppGpp but still able to s
168 tained at normal levels, neurofascin 155 low is incapable of preserving paranodal structure, thus ind
172 y was selective for free ADMA and L-NMMA and was incapable of hydrolyzing peptide incorporated methyl
173 lacking both permeases, DeltafpuBDeltafatCD, was incapable of using petrobactin as an iron source and
175 an be blocked by a Src mutant (SrcS17A) that is incapable of being phosphorylated and activated by PK
178 recruited to the BID promoter and hence p53 is incapable of upregulating pro-apoptotic BID in hypoxi
179 , deficient-in-replication flaviviruses that are incapable of developing productive, spreading infect
182 s finding marks the first time a CcP variant is incapable of forming protein cross-links and confirms
183 lt of translation inhibition, as lamotrigine was incapable of perturbing protein synthesis in vivo or
184 ly long chain lengths of csaB bacilli, which are incapable of binding proteins with SLH-domains to SC
186 h lacks the first 40 amino residues of muNS, is incapable of restoring reovirus growth in the complem
187 espiratory fate in otherwise wild-type mice, is incapable of promoting respiratory fate in the absenc
189 bypass Rhb1p's requirement for growth, they are incapable of suppressing Rhb1p's requirement for res
190 ded an alphaT* subunit (alphaT*(R238E)) that was incapable of undergoing rhodopsin-dependent nucleoti
191 ells are no longer pluripotent, because they are incapable of giving rise to primitive endoderm and h
192 IA protein that assembles constitutively and is incapable of binding RLC still displays strong locali
195 al quantum number n = 3, they have proven to be incapable of handling Rydberg states having quantum n
196 en recognized in a rare gastrinoma, where it was incapable of binding secretin or signaling, and poss
197 e mutant version was completely inactive and was incapable of undergoing self-cleavage to generate th
198 AP-1 sites similar to wild-type Zta, but it was incapable of binding several degenerate Zta sites, i
201 made equivalent levels of IL-12, yet PP pDCs were incapable of producing significant levels of type I
202 rg(-/-) mice lacking both DAP12 and FcRgamma were incapable of sustaining slow neutrophil rolling on
203 Smads using a mutant type I receptor, which is incapable of activating Smads but still retains the k
204 r, current liquid-metal-based strain sensors are incapable of resolving small pressure changes in the
205 L2 oncoprotein lacks the splicing domain and is incapable of altering splice-site selection despite r
207 e to bind substrate similar to wild type but was incapable of releasing substrate during its transfer
208 hat chlorobiphenyl vancomycin analogues that are incapable of binding substrates nevertheless inhibit
212 hiroptical response of a molecular monolayer is incapable of inducing such a large chiroptical effect
214 the nitrite-reducing activities of the cell are incapable of reducing sulfite at a rate sufficient t
219 required HIF-1alpha, but its presence alone was incapable of inducing target gene expression under n
222 rtantly, DCs generated from Ifnar1(-/-) mice were incapable of initiating Th2 responses in vivo These
223 Consistent with this, centrally injected SCF was incapable of increasing thalamic mast cell populatio
226 judicious use of ventilatory modalities that are incapable of meeting the ventilatory demands of the
229 at the helicase-dead mutant recq4 transgenes are incapable of rescuing the null mutation, demonstrati
230 osed surfaces of cross-linked viruses should be incapable of accessing the target cell surface and me
232 ion in the absence of cAMP, the F435W mutant is incapable of adopting the fully extended and active c
233 ) Escherichia coli K12 MG1655 DeltamotA that is incapable of encoding the motor torque generator for
236 nkyrin-B, a closely related ankyrin isoform, is incapable of preserving the lateral membrane followin
237 of the S4 segment within the voltage sensor is incapable of producing the observed gating charge val
239 ion-defective mutant of SpRheb (SpRheb-SVIA) is incapable of restoring the normal cell cycle profile
240 deletion mutant of V. cholerae strain N16961 is incapable of surviving the passage through the infant
242 p2d/d as in control mice, the uterine stroma is incapable of undergoing the decidual reaction to supp
245 g the polyamines spermidine and spermine and was incapable of recovering the acetylated polyamine N(1
246 xpression of 5 HOXA13-upregulated genes; but was incapable of repressing the expression of Ngef and C
247 retrieved the grape from an experimenter who was incapable of seeing the grape rather than an experim
249 rd Nanopore reads, because existing packages were incapable of assembling the long read lengths (5-50
252 s that the exercise countermeasures employed were incapable of providing the high intensity needed to
253 ient in components of the Nalp3 inflammasome were incapable of secreting the proinflammatory cytokine
254 ere we report that geriatric satellite cells are incapable of maintaining their normal quiescent stat
256 t) and exogenous (community) viruses, and to be incapable of controlling them as quickly and effectiv
257 legs are too slow to generate waves, should be incapable of propelling themselves along the surface.
262 redox center, C489S, C490S, and C489S/C490S, are incapable of reducing thioredoxin and can only be re
264 with deletions of the gene for NADPH oxidase were incapable of expressing this early oxygen-dependent
266 st prominently the D129G CaM mutation, which was incapable of stimulating Thr(286) autophosphorylatio
267 once formed during transcription, appear to be incapable of interconverting through unfolding and re
270 3 did not have comparable effects, and tmRNA was incapable of attacking TnaC-tRNA(2)(Pro) in stalled
273 eta receptor 1 (IFNAR-deficient mice), which are incapable of responding to type I IFNs, were substan
275 e or mutated CD28 in its cytosolic tail that is incapable of binding to Lck, phosphoinositide 3-kinas
276 2-R86K, an SH2-deficient mutant of Grb2 that is incapable of binding to PLD2, failed to induce an enh
277 is locked into an extended conformation that is incapable of transitioning to a compressed filament.
278 D71A mutant receptor, which binds ligand but is incapable of transitioning to an active state, failed
279 ILK-binding competent LIM5-deletion mutant, was incapable of localizing to cell-ECM contact sites, s
280 fference in the motif and lacks the C target are incapable of editing tobacco psbE C214 substrates, i
281 binding that are unable to localize to PC-HC are incapable of stimulating transcription from reporter
282 Additionally, exogenously introduced p53 was incapable of activating transcription from p53 respo
285 ne (A795P) enhances NF-kappaB activation but is incapable of mediating TRIF-dependent IFN response fa
286 mice, CD8+ T cells lack NKG2D expression and are incapable of mounting tumor-specific responses.
288 c cells (BMDC) isolated from MyD88(-/-) mice were incapable of producing two important Th1 instructiv
290 led that RAGE-binding AGEs free of endotoxin were incapable of inducing vascular cell adhesion molecu
292 null mice cannot fertilize eggs in vitro and are incapable of fusing with eggs that lack zona pelluci
293 Significantly, RhoA-T37A mutant, known to be incapable of interacting with many well-known Rho eff
297 sion of a dominant-negative form of Cas that is incapable of interacting with Crk inhibits Bmx-induce
298 ode a noncytopathic VEEV capsid protein that is incapable of interfering with the innate immune respo
299 gative p53 or in heterozygous p53 knockouts, is incapable of synergizing with Ha-ras to induce bladde
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