ライフサイエンスコーパス: (broadly|widely) applicable

1 ell for datasets without DNA-seq and thus is widely applicable.

2 pears to be especially simple, sensitive and widely applicable.

3 and predictable trends; thus, the system is widely applicable.

4 d by CFSE dilution is less sophisticated and widely applicable.

5 s more closely, ensuring any conclusions are widely applicable.

6 ing patients in specialized stroke wards-are widely applicable.

7 ging and therapy, which may prove to be more broadly applicable.

8 Our algorithm should thus be broadly applicable.

9 easible transition interventions that can be broadly applicable.

10 cific charged interactions and have not been broadly applicable.

11 inexpensive building blocks and is mild and broadly applicable.

12 onate-containing N-heterocyclic carbene, are broadly applicable.

13 etic manipulation we describe here should be broadly applicable.

14 techniques need to be sensitive (</=10(-4)), broadly applicable, accurate, reliable, fast, and afford

15 super-resolution imaging protocols, and are broadly applicable across biology.

16 Our workflow is broadly applicable across imaging platforms and analysis

17 , suggesting that the microcosm findings are broadly applicable across marine habitats.

18 rotein complex mapping studies and should be broadly applicable across organisms as more CF-MS datase

19 This analog-sensitive approach should be broadly applicable across the PARP family and has the po

20 rivers that emerge as the most important and broadly applicable across these key vegetation and distu

21 ession signature is disease-specific or more widely applicable across diseases.

22 ng drug response between patients to develop broadly applicable adherence criteria.

23 ultiple individuals is necessary to identify broadly applicable 'allelic elements'.

24 tperforms existing methods and constitutes a widely applicable alternative to available tools.

25 STAMP provides a robust, widely applicable analytical framework for high-confiden

26 is work discloses a powerful and potentially widely applicable analytical method for the investigatio

27 ne or more nitrogen-containing moieties, and broadly applicable and efficient catalytic transformatio

28 MARQUIS is a versatile method, broadly applicable and extendable to multiple mass spect

29 In this work, we present a broadly applicable and flexible tool: T-lex2.

30 Here, we present a broadly applicable and inexpensive biosensing technology

31 -2 in cancer cells could potentially lead to broadly applicable and innovative therapeutic avenues.

32 on, the proteomic strategy described here is broadly applicable and is a promising route for large-sc

33 particular imaging targets, the approach is broadly applicable and is expected to improve resolution

34 The surface functionalization procedure is widely applicable and can be precisely controlled, allow

35 The concept of Epi-ID is widely applicable and can be readily applied to other ch

36 to native antibody cysteine residues, it is widely applicable and enables high drug loading for impr

37 Our procedure is widely applicable and is especially suited for applicati

38 This technique is widely applicable and is not limited to crystal growth p

39 Thus, we propose InFlo to be a scalable and widely applicable and robust integrative network modelli

40 lopment of more effective, safe, convenient, broadly applicable, and easy to manufacture vaccines for

41 al autonomy of coordinated neural systems is broadly applicable, and our findings provide evidence of

42 These approaches are becoming modular and broadly applicable, and show a strong potential for diss

43 he ergodic principle are a well-established, widely applicable, and powerful alternative analysis app

44 Therefore, our findings provide a broadly applicable approach for classifying functionally

45 ing of patients it may prove a versatile and broadly applicable approach for localizing neurological

46 A new study in this issue describes a broadly applicable approach for this task that explicitl

47 Our results illustrate a broadly applicable approach to design physiological prot

48 rogenic nanoparticles represents a novel and broadly applicable approach to prevent the formation of

49 These results describe a potentially broadly applicable approach to understanding the interac

50 ing in propelling tumorigenesis, providing a widely applicable approach for targeting lung cancer.

51 for peptide conjugation, we describe a new, widely applicable approach to peptide conjugation based

52 Collectively, this report demonstrates a widely applicable approach toward understanding infectio

53 These findings validate I-SELEX as a broadly applicable aptamer discovery platform that enabl

54 hermore, our experimental approach should be broadly applicable as a complement to mutagenesis for st

55 action, microRNA-based therapeutics might be broadly applicable as a therapy for this type of deafnes

56 f solutions is fast, easily implemented, and widely applicable, as is shown by applications ranging f

57 A broadly applicable automated process could greatly incre

58 st-improved photoelectrodes, which should be widely applicable because our measurements can be perfor

59 PET imaging is a widely applicable but a very expensive technology.

60 This approach is powerful and broadly applicable, but has limitations when symptoms do

61 sting inhibition of autophagy as a potential broadly applicable cancer therapy.

62 Our highly customizable pipeline is widely applicable, capable of detecting filopodia in fou

63 A broadly applicable catalyst system consisting of water-s

64 fforts toward the creation of new useful and broadly applicable catalyst systems are ongoing.

65 ir immutable +2 oxidation state, a broad and widely applicable catalytic chemistry has also emerged,

66 Yet there are no reports of broadly applicable, catalytic methods for the synthesis

67 Discovery of this broadly applicable, chemoselective, and solvent-versatil

68 We present an algorithm that implements a widely applicable class of blocking-threshold blocking-t

69 sion-weighted or diffusion-weighted MRI is a widely applicable clinical tool, and the "mismatch" betw

70 tic objectives are defined, based on which a broadly applicable combination therapy is proposed to co

71 dy SCA10 RNA toxicity and potentially define broadly applicable compounds targeting RNA AU base pairs

72 We believe that our synthesis provides a broadly applicable conceptual framework to understand an

73 eople worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive.

74 The proposed widely-applicable deformation mechanism is useful for de

75 ove SDM predictions by explicitly modeling a widely applicable direct physiological effect: climate-i

76 l development of an extremely simple and yet broadly applicable directing group for Pd(II) , Rh(III)

77 The development of a broadly applicable dispersion quantification method will

78 These characteristics make aptamers broadly applicable (e.g., as an analytical, diagnostic,

79 This broadly applicable E2 delivery platform shows promise as

80 hrough the development and validation of new widely applicable electrical and optical sensing mechani

81 Broadly applicable enantioselective C-B and C-Si bond-fo

82 However, widely applicable enantioselective Suzuki-Miyaura variat

83 dative quenching pathway is operable in this broadly applicable fluorination protocol.

84 This approach may be broadly applicable for designing effective and enduring

85 mental and computational approaches that are broadly applicable for efficient elucidation of disease-

86 ational removal of ssDNA exonucleases may be broadly applicable for enhancing the efficacy and ease o

87 Our methodology should be broadly applicable for epigenomic comparisons and provid

88 These methods are broadly applicable for high throughput single cell chemi

89 karyotic cells, we expect this assay will be broadly applicable for investigating mechanisms of MMR i

90 n contact for free-ranging hosts, and may be broadly applicable for investigations in wildlife diseas

91 Water activity measurements were broadly applicable for measuring deliquescence points wh

92 m all three germ layers and therefore may be broadly applicable for modeling of epithelia.

93 the Cre-switchable PET reporter mice will be broadly applicable for non-invasive long-term tracking o

94 This concept might be broadly applicable for protective antibody responses to

95 This assay should be broadly applicable for studying the mechanisms of AAA+ p

96 isperse polyvalent molecules may not only be broadly applicable for the inhibition of toxins and path

97 covery and validation that is accessible and broadly applicable for the progression of efforts toward

98 for a range of insects renders this strategy broadly applicable for the species-specific control of a

99 bust, and easy-to-use tool is expected to be broadly applicable for the synthesis of challenging pept

100 nds were tested in vitro, making this method broadly applicable for tool compound development.

101 This framework is broadly applicable for understanding the mechanisms of s

102 ork details a new technical resource that is widely applicable for correlative analyses of single cel

103 The split intein approach should be widely applicable for engineering artificial gene circui

104 Our method should be widely applicable for investigations of tRNA charging as

105 ation technique with Monte Carlo sampling is widely applicable for quantifying the effects of inhomog

106 FKF1/GI- and CRY2/CIB1-based systems will be widely applicable for the light-dependent control of tra

107 nteractions) approach described here will be widely applicable for the study of combinatorial phenoty

108 This innovative methodology is widely applicable for the study of phonotaxis and spatia

109 utic recombinant fusion proteins become more widely applicable for the treatment of various types of

110 Taxon-BRI provides a broadly applicable framework for standardization and err

111 enhanced ascorbate peroxidase 2 (APEX2) as a broadly applicable genetic tag that generates EM contras

112 These methods advance our ability to develop broadly applicable genetic tools and to elucidate the un

113 e cell gene expression data, which should be widely applicable given the rapid expansion of single ce

114 for such materials and paving the way for a broadly applicable high-throughput-discovery and materia

115 Together, these data establish a widely applicable high-throughput and high-resolution me

116 These studies established a broadly applicable HIV-1 trimer production system as wel

117 that our process represents an important and broadly applicable improvement to the state of the art f

118 ly straightforward and can be expected to be broadly applicable in fragment-based drug design.

119 ination of HDX stability fingerprints may be broadly applicable in many applications for understandin

120 In conclusion, this versatile method is broadly applicable in screening and characterisation of

121 We expect the method to be broadly applicable in the chemical sciences, and to comp

122 ordination mechanism suggests that it may be widely applicable in a variety of gene regulatory and st

123 o the investigated process, and will thus be widely applicable in cell biology.

124 cellular stress and signaling, which may be widely applicable in mammalian cells, and in ECs, it pro

125 The methodology is widely applicable in unconventional gas development regi

126 hway inaccessible to biology and report on a widely applicable in vitro platform for the controlled c

127 h ratios (UVVR) suggesting these metrics are broadly applicable indicators of microtidal marsh vulner

128 nvestigated whether these molecules are more broadly applicable inhibitors of beta2m amyloid formatio

129 A broadly applicable IR spectroscopic technique is present

130 m a transition metal using donor ligands--is broadly applicable, leading to a number of unprecedented

131 develop a simple, externally validated, and widely applicable long-term risk score model for CKD in

132 Increasing physical activity is a simple, widely applicable, low cost global strategy that could r

133 s and nanostructured minerals provide a new, broadly applicable mechanism to stabilize proteins in th

134 nonequilibrium thermodynamics, we present a widely applicable mechanism for a similar effect, the Ma

135 s through electrosteric complementarity in a widely applicable mechanism.

136 This study demonstrates a broadly applicable mechanistic principle for how cells a

137 In this protocol, we describe a broadly applicable method based on fluorescence recovery

138 Temporal variance is a simple and broadly applicable method for analyzing bacterial swarmi

139 ration sequencing has generated a need for a broadly applicable method to remove unwanted high-abunda

140 Here we describe a broadly applicable method using bioluminescence resonanc

141 n gene expression and introduces hiCLIP as a widely applicable method for discovering new, especially

142 We experimentally demonstrate a widely applicable method for entanglement-enhanced measu

143 Here, we present a simple, versatile and widely applicable method that allows exquisite N-termina

144 b(hi) DCs has been hindered by the lack of a widely applicable method to distinguish between them.

145 Here we present a new and widely applicable method, based on cross-sectional data

146 ential routes towards ultimately achieving a widely applicable methodology for the asymmetric alkylat

147 ng requires the development of efficient and broadly applicable methods for delivering programmable n

148 A set of broadly applicable methods for efficient catalytic addit

149 in looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromat

150 tebrates on sedimentary habitats and develop widely applicable methods to estimate depletion and reco

151 The MRF-MGL represents an effective, broadly applicable model for the storage, analysis, and

152 guide and wall plasticizer into a simple but widely applicable model of tip growth.

153 warrants further studies that may lead to a broadly applicable molecular imaging tool to examine abn

154 ever, we still have some very innovative and widely applicable nanomaterials, which have tremendous p

155 brain functional network strength provides a broadly applicable neuromarker of sustained attention.

156 continuous electroencephalography (EEG) as a broadly applicable, noninvasive method for neuromonitori

157 Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenol

158 Thus, MuGENT is a broadly applicable platform for accelerated evolution an

159 ty within a single disease and establishes a widely applicable platform for genotype-phenotype correl

160 We have thus established a widely applicable platform to wire redox enzymes in an a

161 A broadly applicable, practical, scalable, efficient and h

162 that Dynamic BH3 Profiling can be used as a broadly applicable predictive biomarker to predict cytot

163 Our findings provide widely applicable prescriptive guidelines for utilizing

164 tion process that should serve as useful and broadly applicable principles for future design of more

165 In this article, we describe a broadly applicable process for identifying degrader hits

166 omparisons with a potential for establishing broadly applicable quantitative BKV DNA load cutoffs for

167 A novel, more affordable, and widely applicable quantitative polymerase chain reaction

168 To address this, we have developed a widely applicable recruitment assay system through which

169 d for sampler calibration, making o-DGT more widely applicable, reliable, and cost-effective compared

170 We demonstrate sPREs as a practical, widely applicable, robust, and very sensitive technique

171 The method provides a broadly applicable route for (18)F labelling of biologic

172 necessary to show whether this technique is widely applicable, safe in the long-term, and effective

173 we introduce a computationally scalable and widely applicable statistical method (SEER) for the iden

174 Here we introduce a broadly applicable strategy for robustly controlling pro

175 This broadly applicable strategy may lead to decreased pestic

176 ene capping is introduced as a practical and broadly applicable strategy that can expand the scope of

177 er models or datasets, making it unclear how widely applicable such models are.

178 surface processes, sulfidation represents a broadly applicable surface modification approach to modu

179 We have realized a reliable and broadly applicable surface modification strategy that re

180 These experiments point the way to more broadly applicable tandem catalytic transformations.

181 Here we describe a broadly applicable technique called 'Ligation in situ Hy

182 We present here a straightforward, broadly applicable technique for real-time detection and

183 which aim towards rendering it a general and widely applicable technique that combines the highest po

184 CANE is a broadly applicable technology for dissecting causality a

185 tes that IDLV-mediated HDR is a powerful and broadly applicable technology to carry out site-specific

186 RM or their binding motifs, and is thus more widely applicable than motif-based methods for predictin

187 Although widely applicable, the search for novel spectral editing

188 atments targeting ALT may hold promise for a broadly applicable therapeutic modality specific to mese

189 thaliana seedlings in vivo, structure-seq is widely applicable, thereby opening new avenues to explor

190 of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for the management of BKV

191 cation-based band gap tuning we describe are broadly applicable to 3D metal halide perovskites and wi

192 s (lower capital and operating costs) and is broadly applicable to a host of electronically conductiv

193 tform for solid-state protein studies and is broadly applicable to a variety of systems and experimen

194 aining in communication skills that would be broadly applicable to a wide clinical audience.

195 ods validated here are general and should be broadly applicable to allow the direct and rapid detecti

196 Beyond chemokines our approach is broadly applicable to alternative systems of chemo- and

197 We expect this technique to be broadly applicable to any assembly where very short scal

198 the study of mammalian cells, but it can be broadly applicable to any cell or tissue of interest, gi

199 This exclusion list strategy should be broadly applicable to any class of RNA and improves the

200 The strategies described herein are broadly applicable to any full-length IgG or Fc-based AD

201 EM data sets from the same specimen area, is broadly applicable to biological and environmental sampl

202 The system may be broadly applicable to controlling invasive fishes and re

203 This method for TI into AAVS1 may be broadly applicable to correction of other monogenic dise

204 ransferable, the method should be robust and broadly applicable to counting colocalized molecules in

205 lization and communication in science and is broadly applicable to courses of any size and sub-discip

206 This report describes chemistry that is broadly applicable to cysteine-rich peptides and the inf

207 tection of protein S-acylation levels and is broadly applicable to different classes of S-palmitoylat

208 tigation of essential gene functions in vivo broadly applicable to diverse microorganisms and amenabl

209 Our approach is broadly applicable to elucidating pathogen-host interact

210 roteins regulate NK cell function and may be broadly applicable to Fcgamma-receptor-bearing cells.

211 This approach can be broadly applicable to functional imaging of other brain

212 Our approach can be broadly applicable to functional imaging of other core b

213 he computational approaches applied here are broadly applicable to global optimization problems.

214 of omics-driven predictive modelling that is broadly applicable to guide biological discovery.

215 T cell, suggesting that this approach may be broadly applicable to heterogeneous and resistant tumor

216 D-PSR method is broadly applicable to holographic microscopy application

217 microbe-phenotype triangulation may be more broadly applicable to human microbiome studies.

218 Rapid conductance measurements will be broadly applicable to IC-based sensors that undergo anal

219 This method should be broadly applicable to identify compounds or proteins mod

220 tinase inhibitors and may be a strategy more broadly applicable to inhibiting proteins that require u

221 genetic variants in native context, which is broadly applicable to investigate and improve protein fu

222 targeting was not required, the approach is broadly applicable to LABC with different phenotypes.

223 The method should be broadly applicable to many bosonic and fermionic species

224 s suggest that this targeted approach may be broadly applicable to many diseases in which cells suffe

225 Furthermore, the new approach is broadly applicable to many other phagocytes and will ena

226 tanding of tombusvirus-host interactions are broadly applicable to many other viruses, which also usu

227 This new insight is broadly applicable to many types of molecular threading

228 It is broadly applicable to mechanistic studies of chromatin i

229 We expect that the method will be broadly applicable to modeling and predicting paired mac

230 veal design principles that are likely to be broadly applicable to morphogen-patterned tissues.

231 lts suggest that the underlying chemistry is broadly applicable to nucleic acid sensing.

232 als, this mRNA delivery technology should be broadly applicable to numerous research and therapeutic

233 ing information when changing scales, and is broadly applicable to other areas.

234 t trajectory, this approach may well be more broadly applicable to other battery chemistries.

235 This methodology can be broadly applicable to other bioconjugated systems, biose

236 te structure and catalytic activity could be broadly applicable to other CCD members and provide insi

237 ent loading in the Mississippi Basin and are broadly applicable to other coupled human-natural system

238 ticles or semiconductors, are believed to be broadly applicable to other heterostructures with novel

239 Our findings are broadly applicable to other instances of signaling in ex

240 e cryptic inhibitor envelope approach may be broadly applicable to other lead optimization campaigns

241 the SSZ-13 growth mechanism may prove to be broadly applicable to other materials.

242 We expect that the methods developed are broadly applicable to other obligates, particularly to r

243 s for N- and O-glycosylation that are likely broadly applicable to other plant cell-wall-degrading en

244 hibit improved voltage sensitivity should be broadly applicable to other types of PeT-based voltage-s

245 t this five-dimensional imaging method to be broadly applicable to problems in energy, materials, env

246 icacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to Staphylococcus aureus.

247 analytical approaches demonstrated here are broadly applicable to studies of dynamic biological syst

248 Our approach is broadly applicable to study human immunity and can help

249 This analytical method is broadly applicable to study membrane protein interaction

250 The SunTag should be broadly applicable to study translational regulation in

251 dynamics and the approach presented here is broadly applicable to studying order in macromolecular s

252 -molecule fluorescence imaging and should be broadly applicable to studying protein-DNA interactions.

253 iple binding of the Et4N(+) guest, but it is broadly applicable to the deconvolution of other intrica

254 The IsoTaG platform is broadly applicable to the discovery of PTM sites that ar

255 s employed in this study are likely to prove broadly applicable to the fine analysis of folding mecha

256 Our chemoproteomic platform should be broadly applicable to the investigation of other bio-ort

257 oreover, the approach we have taken would be broadly applicable to the study of disease-prone human c

258 ChIP-nexus will be broadly applicable to the study of in vivo transcription

259 ng and solving such structures which will be widely applicable to a range of functional materials.

260 RS3D is widely applicable to a variety of RNA folding architectu

261 y of production and isolation should make it widely applicable to basic research of the eye.

262 This pipeline is widely applicable to different experimental paradigms, i

263 These results are widely applicable to diverse microbial infections includ

264 RPAf is widely applicable to investigate its mechanism of action

265 This hierarchical surface chemistry is widely applicable to many analytes and provides a genera

266 ermination of oligomeric structures would be widely applicable to membrane proteins where paramagneti

267 We show that this method is widely applicable to nanostructures of different sizes,

268 xperimental and modeling strategies could be widely applicable to other biological systems.

269 pproach to vaccination against HPAIVs may be widely applicable to other emerging strains of influenza

270 ut regulation of HSC differentiation, and is widely applicable to other hierarchical biological syste

271 long with the low material demand, PrA-MS is widely applicable to protein characterization and is uni

272 These methods should be widely applicable to research involving green algae.

273 These guidelines are widely applicable to similar families of polymers and sm

274 The method is widely applicable to studies of other metal ion transpor

275 Our experimental strategy should be widely applicable to study conformational dynamics in GP

276 sHRP should be widely applicable to studying mechanisms of communicatio

277 challenges to address for the methods to be widely applicable to supplement high-throughput experime

278 This approach is widely applicable to the analysis of spontaneous or stim

279 The method is widely applicable to the biophysical investigation of co

280 esis strategies and have the potential to be widely applicable to the doping of colloidal chalcogenid

281 tations, we suggest the approach proposed is widely applicable to the evaluation of effects of planne

282 These findings could be widely applicable to the many homogeneous transfer hydro

283 ample of self-organization and could be more widely applicable to the modelling of other complex syst

284 generation 2-photon fluorescence imaging is widely applicable to the study of Ca(2+)-contraction cou

285 ate parameters using FRAP recovery data is a broadly applicable tool for systems where intracellular

286 Shotgun metagenomic DNA sequencing is a widely applicable tool for characterizing the functions

287 Cellular volume perturbation is a widely applicable tool to detect transient protein inter

288 We then apply a new and widely applicable tool to generate conditionally phospho

289 ibration constructs, provide a practical and broadly applicable toolbox for the investigation of mole

290 ed using dynamic pathway regulation, but few broadly applicable tools are available to achieve this.

291 Broadly applicable tools for the efficient delivery of m

292 mpounds are central to modern chemistry, and broadly applicable transformations that generate them ef

293 ionary origins may thus present powerful and broadly applicable treatment strategies for cancer.

294 echnology may therefore provide a practical, broadly applicable treatment that can generate anti-tumo

295 immunotherapy is a short-term available and broadly applicable treatment.

296 thod represents the first, to our knowledge, broadly applicable use of unactivated alcohols as latent

297 ropose a chemotactic precision index that is broadly applicable, valid, and allows for a straightforw

298 These components comprise manageable and widely applicable ways to reduce health-care-associated

299 To determine if our observations are more widely applicable, we investigated if isozyme competitio

300 tal-organic frameworks, but not for the more widely applicable zeolites, where new materials are usua