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1 Here, we constructed five vaccine candidates, designated 2012-RBD, 2013-RBD, 2014-RBD, 2015-RBD, and
2 pression of a TDP-43 CTF (amino acids 208-414, designated 208 TDP-43 CTF), previously identified in F
3 broadly reactive monoclonal antibodies (mAbs), designated 3/11 and AP33, recognizing a distinct, but
4 cid (12) was obtained in tritium-labeled form, designated [(3)H]PSB-13253, with a specific activity o
5 hain antibody (single-chain fragment variable, designated 4D5), we generated bivalent chemical Hercep
7 additional, sympatric cytoforms of S. suzukii, designated 'A' and 'B,' each with species status, in K
8 sus clones of L10 (designated SFV6) and A7(74) (designated A774wt) were used to construct a panel of
9 dicated that the protein encoded by this gene, designated AAEL001915, belongs to a clade of RTKs rela
10 ct aromatic amino acid aminotransferase (ArAT), designated Ab-ArAT4, that is coexpressed with known t
11 H) binding domains against both TcdA and TcdB (designated "ABA") that reverses fulminant CDI in mice
12 with equal numbers of a prototype ABSA strain, designated ABSA 1014, and any one of several UPSA stra
14 ncoding a 30-kDa Ae. aegypti salivary protein, designated Aed a 3, was isolated from an expression li
16 we identified a novel D604N missense mutation, designated anisotropy1 (any1), in the essential primar
17 SP, preparative separation into two fractions, designated anthocyanins (AF) and copigments (CF), was
18 We demonstrate in this article that this CAR, designated anti-PSCA-DAP12, consisting of DAP12 fused
19 calcium-dependent membrane-targeting protein (designated Arabidopsis [Arabidopsis thaliana] Soybean
20 oteins, two peptides with an unknown function (designated ARACIN1 and ARACIN2) have been identified.
23 , and Ser(227) were replaced by aspartic acid (designated as D-Tg) or alanines (designated as A-Tg).
24 tutive double knockout mutants were generated (designated as dpe2-1xphs1a and mex1xphs1b) both lackin
25 (Fuc)-enriched Reishi polysaccharide fraction (designated as FMS) induce antibodies against murine Le
26 ium cobalt oxide synthesized at 800 degrees C (designated as HT-LiCoO2) for the oxygen evolution reac
27 creatic resection databases of 3 institutions (designated as institutions A, B, or C) were queried on
28 um cobalt oxide, synthesized at 400 degrees C (designated as LT-LiCoO2) that adopts a lithiated spine
29 were previously Sanger sequenced, with 55 (61%) designated as carrying the wild-type pncA gene and 33
35 cterize another such factor encoded by PD0956, designated as an antivirulence secreted protease "PrtA
37 -engineered the extracellular regions of beta, designated as beta-c1, for prokaryotic production to b
39 riod of constant activity in nongrowing cells, designated as constant activity stationary phase, make
40 ization of this mesoporous thin film material, designated as CoPIZA/FTO, which is equipped with large
41 pation of a distantly related partner protein, designated as CPT-binding protein (SlCPTBP), which is
43 s active site FeMo-cofactor, yielding a state, designated as E4, which contains two iron-bridging hyd
45 l and molecular features from mice and humans, designated as extended pluripotent stem (EPS) cells, w
46 show the presence of a mononuclear iron site, designated as Fe16, which was previously identified as
48 ferent splicing variants have been identified, designated as HD3alpha, -beta, -gamma, and -delta, res
49 stinct CD11b(hi)F4/80(hi)Ly6C(lo) TAM subsets, designated as MHC-II(lo) and MHC-II(hi) TAM, both of w
50 The dissociation constant of the best aptamer, designated as P4G13, was estimated to be 17 nM by elec
52 there are two D14 homologs in P. trichocarpa, designated as PtD14a and PtD14b that are over 95% simi
53 nd distinct molecular and functional features, designated as region-selective pluripotent stem cells
54 air that resembles and is linked to RRS1/RPS4, designated as RRS1B/RPS4B, which confers recognition o
56 ural antisense transcript at the MALAT1 locus, designated as TALAM1, that positively regulates MALAT1
59 collection of these estimated transcriptomes, designated as the expressome, has provided unique oppo
61 rization of an extracellular elicitor protein, designated AsES, produced by an avirulent isolate of t
65 We show that, for the first of these mutants, designated awake1, the maternal allele is required for
67 e but rather a beta-1,4-glucuronyltransferase, designated B4GAT1, towards both alpha- and beta-anomer
68 ve carbohydrate-responsive regulatory protein, designated BadR (Borrelia host adaptation Regulator),
69 f bezafibrate and medroxyprogesterone acetate (designated BaP) has potent in vivo anticancer activity
74 eus (MRSA) that was susceptible to vancomycin (designated BR-VSSA) but that acquired the vanA gene cl
75 ralizing diverse HIV-1 primary virus isolates (designated broadly neutralizing antibodies [bNAbs]) re
81 study, an R2R3-MYB transcription factor gene, designated CaMYB31, was isolated and characterized in
82 hospitals and National Cancer Institute (NCI) -designated cancer centers within federal exchange net
83 ived care at a National Cancer Institute (NCI)-designated cancer center (8.6% [95% CI, 8.1%-9.2%] amo
87 ver CD34+ cells were comprised of two subsets, designated CD34+CD146+ and CD34+CD146-, and hematopoie
89 xenograft study with an optimized compound 50 (designated CFI-400437) support the potential of these
90 nclude with the identification of compound 48 (designated CFI-400945) as a novel clinical candidate f
91 K223 include a predicted alpha-helical region (designated CH) immediately preceding the conserved C-t
92 describe here a human antibody clonal lineage, designated CL6649, members of which bind a third conse
93 ies encoded by one particular IGHV1-69 subset, designated CLL69C, with the HCDR3 encoded by the IGHD3
94 The genomic sequence of the resistant virus, designated clone 7, contained mutations in 16 open rea
95 nase in Magnaporthe oryzae, and urate oxidase (designated ClUrase) were functionally characterized.
96 two separable regions of the C-terminal tail, designated cluster 1 (Thr(347), Thr(349), and Ser(350)
100 atment alone or in combination with anti-CD20 (designated combo therapy) inhibited T1D development.
101 The demethylation of a specific CpG site (designated CpG 2), which is juxtaposed to a key cAMP-r
102 ntification of a cDNA for a DGAT1-type enzyme, designated CpuDGAT1, from the transcriptome of C. avig
103 as9 and a modified guide RNA scaffold gRNA2.0 (designated CRISPR-Act2.0) yielded stronger transcripti
104 developed a sequence-based subtyping approach, designated CRISPR-multi-virulence-locus sequence typin
105 ence indicates that this transposon insertion, designated CRISPR3*, is a gain-of-function (GOF) mutat
106 tebrate-like cryptochrome gene of the monarch (designated cry2), which encodes a putative transcripti
110 tivate T cells via chimeric CD28 and CD3-zeta (designated "D-CAR") upon binding with carbohydrate in
112 inant GPCMV with a targeted deletion of gp145 (designated Delta145), a viral protein kinase R (PKR) i
114 er of avian retrovirus, encodes a novel miRNA, designated E (XSR) miRNA, using the canonical miRNA bi
115 singly, the EDM of TTF-1(+) lung cancer cells (designated EDM-TTF-1(+)) displayed an anti-angiogenic
118 fy an Arabidopsis thaliana long-noncoding RNA, designated ELF18-INDUCED LONG-NONCODING RNA1 (ELENA1),
119 tive and efficient inhibitors of both enzymes, designated enkephalinases, have been designed that mar
120 gh four different G-protein-coupled receptors; designated EP1-4, which couple to separate intracellul
121 s homolog of another type of E3 ligase, UBE3C, designated ETC-1, as a regulator of the cytoplasmic IF
123 ere a novel fibrinogen-binding protein of GBS, designated FbsC (Gbs0791), which is encoded by the pro
124 of a synthetic model complex ([Fe6S9(SEt)2](4-); designated Fe6(RHH)) into the catalytic component of
126 ry and characterization of a second polymorph, designated Form II, which can be isolated as single cr
127 asurements estimated by 2 mathematical models (designated Formula 1 and Formula 2) were compared to t
132 MR solution structure of this trimeric domain, designated gp41-M-MAT, shows that the three MPER pepti
133 at the F. fujikuroi polyketide synthase PKS13, designated Gpy1, is responsible for gibepyrone A biosy
137 by the orthologous human ICR (hIC1) sequence, designated H19(hIC1) We show that hIC1 can functionall
138 as the cause of severe respiratory infections, designated hantavirus pulmonary syndrome, with case fa
141 contains a knob-like alpha-helical protrusion, designated "hDicer-specific helix," that separates the
142 broadly neutralizing combinations of two NAbs, designated HEPC74/HEPC98, also displayed enhanced pote
144 tigenic site on the globular head domain of F, designated here antigenic site VIII, which occupies an
145 anscriptomic data, we identified a gene locus, designated here as hps, that appears to encode for a n
146 biopsy specimen-derived EBV (NPC-EBV) genomes, designated HKNPC2 to HKNPC9, were then determined.
150 With appropriate precautions and resources, designated hospitals in the United States can safely p
153 into a highly specific aggregation inhibitor (designated HTB1M) of two familial amyotrophic lateral
155 frameshift variant that creates a novel gene, designated IFNL4, encoding the interferon-lambda4 prot
158 that protects neurons and limits inflammation, designated "immune privilege." However, there is not a
160 e expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenoty
161 kinase (CDK) inhibitors have been identified, designated interactors of CDKs or Kip-related proteins
162 Here we describe an insecticidal protein, designated IPD072Aa, that is isolated from Pseudomonas
163 315 and B. multivorans ATCC 17616 in parallel (designated iPY1537 and iJB1411, respectively) to compa
164 T3 substrate and identified JAK3 inhibitor VI (designated JI6 hereafter) as a novel FLT3 inhibitor, w
165 re, we report a novel A577V missense mutation, designated jiaoyao1 (jia1), in the second of the glyco
166 we report a novel C-terminal Hsp90 inhibitor, designated KU675, that exhibits potent antiproliferati
167 ibe a mutant murine methionyl-tRNA synthetase (designated L274GMmMetRS) that charges the noncanonical
169 sponse regulator encoding gene (LMOf2365_0414), designated lbrA, was found to be highly expressed in
170 e near-complete cranium of a large individual, designated LES1, with an endocranial volume of approxi
172 ms have been described during fly development, designated "long" and "short," differing by a 177-nt t
174 lethanolamine (LPE) with acyl-coenzyme A (CoA), designated LYSOPHOSPHATIDYLETHANOLAMINE ACYLTRANSFERA
177 alis secretes nanosized exosome-like vesicles, designated MalaEx, that carry allergens and can induce
179 nthetic threshold-dependent gene drive system, designated maternal-effect lethal underdominance (UD(M
182 loped a neutralizing monoclonal antibody (MAb), designated Mersmab1, which potently blocks MERS-CoV e
183 the emergence of antibiotic-resistant strains, designated methicillin-resistant S. aureus (MRSA), sta
184 s in DNA methylation and expression of Isyna1 (designated mIno1), which encodes the rate-limiting enz
185 e retina, we generated a knockout mouse model, designated "miR-183C(GT/GT)," using a gene-trap embryo
186 rial haplotypes from different mouse strain(s)-designated Mitochondrial Nuclear Exchange (MNX)-we sho
188 of mutagenized seeds identified a mutant line, designated MO12, which produced brown seeds as opposed
190 ydrophobic base of the capsid (core) proteins, designated motifs I, II, and III, are highly conserved
191 Here we report a novel bioluminescence assay, designated MPO activity on a polymer surface (MAPS), f
192 encodes 11 homologues of plant PR-1 proteins, designated MpPR-1 proteins, but their precise mode of
193 sive disease caused by drug-resistant strains, designated MRSA (methicillin-resistant S. aureus), is
194 the C-terminal FeS-containing globular domain (designated N-Rip1), results in a marked stabilization
195 independent nsp15 mutant mouse coronaviruses, designated N15m1 and N15m3, and found that these virus
196 overy of a diversified family of fish viruses, designated nackednaviruses, which lack the envelope pr
200 ing the conformation of the resultant protein (designated NifDK(Fe)) similar to the one upon insertio
201 firmly establishing the M-cluster-bound NifEN (designated NifEN(M)) as the only protein other than Ni
202 We isolated a 1000th generation descendant, designated NT that exhibited increased biofilm and agg
204 nce plasmid-encoded open reading frames (ORFs) (designated ORF3 and ORF4) exhibit significant identit
205 o recombinant hypoallergenic mosaic molecules, designated P and Q, which were constructed out of elem
207 signed hepatocyte-specific regulatory element, designated P3, which is a cluster of evolutionary cons
209 , we evaluated synthetic, poly-basic peptides, designated p5 and p5+14, as alternative radiotracers f
210 ide libraries, we identified a tetramer (FSSE, designated P5779) as a specific MD-2 antagonist preven
211 study characterized an E. coli O157:H7 strain, designated PA2, that belongs to the hypervirulent clad
213 e, we describe the isolation of a pen3 allele, designated pen3-5, that encodes a dysfunctional protei
214 e of a putative GPI lipid remodelling protein, designated PerA, in the human pathogenic fungus Asperg
216 identify a family of nuclear protein kinases, designated Photoregulatory Protein Kinases (PPK1-4; fo
218 d a unique mouse Pneumocystis surface protein, designated Pneumocystis cross-reactive antigen 1 (Pca1
219 lasma-encoded purine nucleoside phosphorylase (designated PNPHyor) has been cloned and characterized
220 tinct families of replicative DNA polymerases, designated polymerase B (Pol B), Pol C, and Pol D, hav
222 have been identified in Arabidopsis thaliana--designated PORA, PORB, and PORC--that are differential
224 This putative photoperiod insensitive allele (designated Ppd-A1a.4) includes a 684 bp deletion which
225 ugh the use of an alternate upstream promoter, designated Pro1, that is active only in immature NK ce
226 ets by extending long cytoplasmic protrusions, designated proplatelets, into sinusoidal blood vessels
227 process, they extend long branching processes, designated proplatelets, into sinusoidal blood vessels
228 r formation with a catalytically dead paralog, designated prozyme, which binds with high affinity to
229 equences of type 2 PRRSVs, a consensus genome (designated PRRSV-CON) was generated by aligning these
230 dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with I
232 ous purification steps, homogeneous fractions (designated PTW, STK-1000R and PF) were analyzed by sug
234 lidated data set, we trained a neural network, designated Q1VarPred, specifically for predicting the
236 ynthetic bacterium Rhodopseudomonas palustris, designated regulatory proteins RpBphP2 and RpBphP3, ar
238 mutations yielding constitutive Rgg2 activity, designated Rgg2Sp*, were identified, and five of them
241 prion strain isolated from IND24-treated mice, designated RML[IND24], emerged during a single passage
242 pose that these previously unidentified cells, designated "rogue GC B cells," are a major driver of a
243 >95%) short-chain galactooligosaccharide (GOS), designated "RP-G28," significantly improved clinical
244 domas secreting mAbs with anti-LukAB activity (designated SA-13, -15, and -17) were generated from B
247 ogenetically distinct clades of S Senftenberg, designated SC1 and SC2, harboring variations in Salmon
248 here the discovery of two novel DNA sequences, designated SEGS-1 and SEGS-2 (forsequencesenhancinggem
253 9266 forms the core of an extended pseudoknot, designated SL9266/PK, involving long distance RNA-RNA
256 isolate that carries a novel prophage element, designated Spn1, which was detected in both integrated
257 culine poppy mutants revealed a genetic locus, designated STORR [(S)- to (R)-reticuline] that encodes
259 chemoautotrophic As(III)-oxidizing bacterium, designated strain SY, was isolated from an As-contamin
263 esized a novel class of glucoside amphiphiles, designated tandem malonate-based glucosides (TMGs).
264 the set of messenger RNAs targeted by miR-218, designated TARGET(218), defines a neuronal gene networ
266 ls express a high-affinity uracil transporter (designated TbU3) that is clearly distinct from the pro
269 y a short element upstream of the restart AUG, designated "termination upstream ribosomal binding sit
270 Atg13, and mutation of these residues to AAAA (designated the FIP200-4A mutant) abolished its canonic
271 SAM cluster) and a [Fe4S4]-like cluster pair (designated the K cluster) that can be processed into a
273 that, upon maturation of a cofactor precursor (designated the L-cluster) on NifEN, the cluster specie
275 eins containing a SAM-binding [Fe4S4] cluster (designated the SAM cluster) and a [Fe4S4]-like cluster
276 ymal markers share a unique 44 gene signature, designated the "mesenchymal metabolic signature" (MMS)
277 n FH and a group of closely related molecules, designated the FH-related (FHR) proteins, are currentl
280 structurally independent RNA binding domains, designated the N-terminal domain (NTD) and the dimeric
281 developed a fluorescent-based reporter system, designated the Traffic Light Reporter, which provides
286 composed of a number of distinct phylogroups, designated types IA1, IA2, IB, IC, II, and III, which
287 e derived ten human embryonic stem cell lines (designated UCSFB1-10) from single blastomeres of four
290 of a regulator of cell size and proliferation, designated upp-L (upregulated by p12), which encodes a
291 them were associated with an apparent operon, designated vfrAB, that had not been characterized prev
295 tance is conferred by a single dominant locus, designated Xo1, that maps to a 1.09 Mbp fragment on ch
296 undancy, CD103(-/-) mice were crossed to mice (designated Y3) whose T cells expressed a mutant IL-2Rb
298 from the stem region of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and
299 glycyl-glycyl-cysteine peptide-based chelator (designated ZHER2:V2) has the best biodistribution prof
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