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1 ant formed puncta but failed to recruit Orai1, thereby preventing.
2 isrupt the generation of a chemokine gradient, thereby preventing a chemokine from properly performin
3 icipate in this resetting process in the worm, thereby preventing a decline in germ cell epigenetic s
4 forming growth factor-beta-activated kinase 1, thereby preventing a metabolic switch toward glycolysi
5 sk G(D2) or cross-reactive epitopes on nerves, thereby preventing a subsequent dose of unmodified 3F8
6 onents in clearance of free all-trans-retinal, thereby preventing A2E accumulation and photoreceptor
7 of HDL binding to cell-surface proteoglycans, thereby preventing access of HDL to the plasma membran
8 ttached to 13 potential N-glycosylation sites, thereby preventing access to bound peptide and associa
9 creatitis maintains VAMP8-dependent secretion, thereby preventing accumulation of activated trypsin.
10 nt blocks to cell proliferation and apoptosis, thereby preventing accumulation of NO/RNS-generated mu
11 ctively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic i
12 es activity of compartment-resident proteases, thereby preventing activation in other regions of the
13 a situation when energy generation is limited, thereby preventing activation of cell death pathways a
16 ne or cell surface (e.g. flagella) structures, thereby preventing adhesion, disrupting specific virul
18 n distorts the receptor G-protein association, thereby preventing agonist-induced guanine nucleotide
19 motor deficit by removing early dying neurons, thereby preventing amplification of neuronal death fro
20 revent a wasteful drain on cellular resources, thereby preventing an energetic crisis during stress.
24 colon epithelium in an EGFR-dependent manner, thereby preventing and treating DSS-induced intestinal
26 II-induced integrin activation in leukocytes, thereby preventing Ang II-induced recruitment of leuko
31 n of the immune system to be tolerant of self, thereby preventing autoimmunity, is facilitated by the
33 yrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of (2)b
34 Bcl6, inhibits T(FH) differentiation and help, thereby preventing B cell germinal center and antibody
36 the complex of VDAC1 and hexokinase II (HKII), thereby preventing Bax recruitment to VDAC1 and the r
40 ces persistent ssDNA-RPA overhangs in M phase, thereby preventing both classical NHEJ and Rad51-depen
41 ogenitor proliferation after genotoxic injury, thereby preventing both IR- and cyclophosphamide-induc
42 gomeric species and form long-lived complexes, thereby preventing both their further growth into fibr
44 maintain cellular ATP and thus PMCA activity, thereby preventing Ca(2+) overload, even in the face o
47 eferentially binds MurA liganded with UDP-NAG, thereby preventing catalysis by occluding PEP from acc
48 lopment during adolescence or early adulthood, thereby preventing catch-up from earlier acquired defi
49 esponsible for regulating hemichannel opening, thereby preventing cell damage through excessive flux
51 sary and sufficient to confer immunity to CDI, thereby preventing cells expressing the cdiBA genes fr
52 P-1 transcription under unstressed conditions, thereby preventing cells from undergoing stress respon
53 alterations in afferents to dopamine neurons, thereby preventing changes in dopaminergic activity un
55 may effectively modulate several risk factors, thereby preventing chronic disease, and that ADF may m
57 ity for reducing the ClO3- intermediate to Cl-, thereby preventing ClOx- buildup and lowering Re comp
60 lycoprotein VI, integrin alpha2beta1, and vWf, thereby preventing collagen interaction with its three
61 rm a hydrogen bond to the mutant R223 residue, thereby preventing competition between R223 and R152.
62 mplement regulatory protein factor H directly, thereby, preventing complement factor C3 deposition on
63 14-3-3sigma enhanced COP1 self-ubiquitination, thereby preventing COP1-mediated p53 ubiquitination, d
64 ion was inhibited at the membrane fusion step, thereby preventing core entry into the cytoplasm and e
65 main 1 of EspD as a key compound-binding site, thereby preventing correct assembly of the T3SS comple
66 cytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleteriou
70 ponents control TLR3-mediated innate immunity, thereby preventing development of immunodeficiency and
71 d enhanced mitochondrial fatty acid oxidation, thereby preventing diet-induced obesity and insulin re
72 on gene MITF and the proapoptotic factor SOX9, thereby preventing differentiation, inhibiting cell de
73 a encapsulates mycobacterium-containing cells, thereby preventing dissemination and further infection
76 n of IPS-1 and loss of interaction with RIG-I, thereby preventing downstream activation of IRF-3 and
77 bits procaspase-8 activation at the CD95 DISC, thereby preventing downstream activation of the caspas
79 f HER3 heterodimerization and phosphorylation, thereby preventing downstream AKT phosphorylation.
82 ape being destroyed by the host immune system, thereby preventing effective immune control of infecti
83 ctivity of the transcriptional activator ToxT, thereby preventing elaboration of the toxin co-regulat
85 ket encode a catalytically incompetent kinase, thereby preventing emergence of resistant variants.
86 s autophagy and maintains endosomal recycling, thereby preventing endosomes and autophagosomes from r
87 ion of multiple cell cycle-promoting proteins, thereby preventing epithelial cells from exiting the c
88 sitize" aged microglia to an immune challenge, thereby preventing exaggerated behavioral and neuroinf
89 d angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.
91 he oxidized, aggregated material leaves cells, thereby preventing export of apoB-lipoproteins contain
94 s bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress,
96 fering with the binding of Groucho/TLE to TCF, thereby preventing formation of transcription represso
97 PGF2alpha into its central hydrophobic cavity, thereby preventing FP-PGF2alpha interaction and suppre
99 rium in favor of the non-slipped conformation, thereby preventing frameshifting and potentially enhan
100 uestrin depolymerization will limit depletion, thereby preventing full disassembly of the polymeric c
102 apical leaves and, once embolized, were shed, thereby preventing further water loss and protecting t
103 ithin 30 seconds after fusion with a sperm [3], thereby preventing further fertilization events, it i
104 izes GP and triggers premature release of GP2, thereby preventing fusion between the viral and endoso
105 of their cognate G protein-coupled receptors, thereby preventing G protein coupling and often switch
106 as wedges between the transmembrane segments, thereby preventing gating rearrangements that are nece
107 DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of i
109 ll expansion in lymphopenic hosts after aHSCT, thereby preventing GVHD without global immunosuppressi
110 ulted in CD8+ T cell exhaustion and apoptosis, thereby preventing GVHD, whereas PD-L1 interactions wi
112 distant from the dermal papilla are unscathed, thereby preventing hair greying typical of melanocyte
113 ssion of chemoattractant proteins (chemokines), thereby preventing harmful immune cells from penetrat
114 stemic metabolic homeostasis and inflammation, thereby preventing HCC by a non-cell-autonomous mechan
115 ecule drug that inhibits retroviral integrase, thereby preventing HIV DNA from inserting itself into
116 variations that interfere with immunogenicity, thereby preventing HLA-B 57-mediated immune pressure.
119 II-B play an important role in cell adhesion, thereby preventing hydrocephalus during mouse brain de
121 igma, which prevented access of Suv39h1 to H3, thereby preventing hypermethylation of 14-3-3sigma.
122 limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate u
124 electively inhibits allergen-IgE interactions, thereby preventing IgE clustering and mast cell degran
125 ression dampens presentation of self antigens, thereby preventing inappropriate T cell activation tha
129 the virulence of pathogenic bacterial strains, thereby preventing infections caused by Staphylococcus
131 ibits virulence regulation in Vibrio cholerae, thereby preventing intestinal colonization in an infan
132 serted between ARM repeat 10 helices H1-H2-H3, thereby preventing intramolecular helical stacking ess
133 und trp RNA-binding attenuation protein (TRAP), thereby preventing it from binding RNA, and allowing
134 tly binds to the BMP type II receptor (BMPRII), thereby preventing it from interacting with the BMPRI
135 from chromatin in hydroxyurea-arrested cells, thereby preventing it from cleaving stalled replicatio
136 mplexes with and inactivates Sit4 phosphatase, thereby preventing it from dephosphorylating Gln3.
137 lamps encircle DNA and bind to DNA polymerase, thereby preventing it from falling off during DNA repl
138 show that TrkC directly binds to the TbetaRII, thereby preventing it from interacting with the type I
139 ein Axin targets beta-catenin for destruction, thereby preventing it from transducing inappropriate s
140 retains Chs2 at the endoplasmic reticulum (ER), thereby preventing its translocation to the neck.
141 y bind and stabilize a nontoxic form of Abeta, thereby preventing its aggregation into toxic forms.
143 ter RD and associated with phosphorylated Akt, thereby preventing its dephosphorylation and further a
145 (LDL) receptor at the surface of hepatocytes, thereby preventing its recycling and enhancing its deg
146 mpairs the essential GTPase activity of EF-Tu, thereby preventing its release from the ribosome.
148 r, we show that ZCL278 also functions in vivo, thereby preventing Junin virus replication in a mouse
149 pha5 before the C-terminal laminin LG domains, thereby preventing laminin alpha5 from interacting wit
150 e and consequently disrupts LasR dimerization, thereby preventing LasR from binding to its target DNA
154 strains interfere with the activation of RecA, thereby preventing LexA cleavage and SOS induction.
156 pstream hepatocytes to downstream hepatocytes, thereby preventing local saturation of further detoxif
158 ed protein kinase restored sirtuin-3 activity, thereby preventing LPS and ethanol from stimulating th
160 NPXY motif in beta integrin cytoplasmic tails, thereby preventing lysosomal degradation of beta integ
162 n and trapped the receptor in early endosomes, thereby preventing lysosomal trafficking and degradati
163 through binding to Mad1- or Cdc20-bound Mad2, thereby preventing Mad2 activation and promoting the d
165 spermatogonial differentiation factor Sohlh1, thereby preventing meiosis and promoting spermatogonia
167 lization and down-regulate energy expenditure, thereby preventing metabolically beneficial adaptation
168 ART who are at high risk of transmitting HIV, thereby preventing morbidity and onward transmission.
169 ll ribosomal subunit in a single conformation, thereby preventing movement of mRNA and tRNA before mR
171 e progression and promote repair or apoptosis, thereby preventing mutation accumulation and suppressi
172 maintain a stable level of uncomplexed HDAC3, thereby preventing mutual interference in the assembly
173 dation of myocardial Ca(2+)-handling proteins, thereby preventing myocardial apoptosis and necrosis.
175 can potently inhibit Nedd8 activating enzymes, thereby preventing neddylation of Cullin proteins and
176 tinuing or discontinuing exposure to artworks, thereby preventing negative emotions from becoming out
177 epare to respond to public health emergencies, thereby preventing negative impacts through planning a
178 ouples pericytes to the endothelial cell wall, thereby preventing neonatal intraventricular hemorrhag
180 quadrupole bender that deflects the ion beam, thereby preventing neutral contaminants from impinging
182 uclein when the protein concentration is high, thereby preventing non-membrane-bound monomers from ag
183 e signals control the initiation of catalysis, thereby preventing non-productive double-strand breaks
184 d acts as a chaperone of the nucleoprotein (N), thereby preventing nonspecific encapsidation of cellu
185 roduction, and decreased fatty acid synthesis, thereby preventing obesity-induced metabolic complicat
186 d shift of PCCs, are not expressed in the SCN, thereby preventing on RF a shift of the master SCN CC
188 entiated osteoblasts maintains bone formation, thereby preventing osteoporotic bone loss induced by o
189 1 and Aco-2 in preserving AEC mtDNA integrity, thereby preventing oxidant-induced mitochondrial dysfu
190 2alpha degradation and restored SOD2 activity, thereby preventing oxidative stress and hypertension.
191 B1 "desensitized" microglia in the aged brain, thereby preventing pathological infection-elicited neu
192 isk is frequently low and misconceptions high, thereby preventing patients from seeking treatment ear
193 PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and al
194 rt of HLA class I (HLA-I) to the cell surface, thereby preventing peptide presentation to CD8(+) T ce
195 due to ATP elevation by increased glycolysis, thereby preventing phosphorylation and inactivation of
196 tail tip to push against the vertical surface, thereby preventing pitch-back of the head and upper bo
200 as an intracellular inhibitor of PME activity, thereby preventing premature deesterification of pecti
202 rogates injury-induced externalization of TG2, thereby preventing profibrotic crosslinking of extrace
203 cells die as a consequence of Stk2 activation, thereby preventing propagation of the phage to the res
204 Is) interfere with this farnesylation process, thereby preventing proper membrane localization and re
205 cleotide queuosine (Q) at the wobble position, thereby preventing protein synthesis and ultimately re
206 onto the solid surface near the column inlet, thereby preventing QD attachment, whereas in the down-
207 minimize the formation of faulty proteasomes, thereby preventing recognition and inhibition by Ecm29
208 py the reductase-binding site on cyt P450 2B4, thereby preventing reduction of ferric cyt P450 and in
209 f PAR levels in the nucleus and the cytoplasm, thereby preventing release of AIF from mitochondria an
210 translocation stops specifically at XerCD-dif, thereby preventing removal of XerCD from dif and allow
214 ellular pool of deoxynucleoside triphosphates, thereby preventing reverse transcription of retroviral
215 li lactate dehydrogenase as an NADH scavenger, thereby preventing reversible formaldehyde reduction.
216 btype abolishes interaction of RFWD3 with RPA, thereby preventing RFWD3 recruitment to sites of ICL-i
217 -Papas syndrome, inhibits its kinase activity, thereby preventing RIPK4-mediated IRF6 activation and
220 s primarily by inhibiting its ATPase activity, thereby preventing self-conversion into an inactive AD
221 xia telangiectasia mutated in recipient cells, thereby preventing senescence and allowing blood vesse
223 ak2-mediated Hck activation is also inhibited, thereby preventing Stats serine phosphorylation, which
224 ponent YAP negatively regulates Wnt signaling, thereby preventing stem cell overpopulation after a re
225 nd-independent homotypic receptor preassembly, thereby preventing sTNF-induced, but not mTNF-induced,
226 mproving learning about the traumatic context, thereby preventing subsequent development of symptoms
227 effectively sequester the tyrosine kinase Lck, thereby preventing T cell receptor (TCR) signaling by
228 hibitors physically trap the synaptic complex, thereby preventing target DNA binding and thus concert
229 of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic
230 ted amount of material (one to three colonies) thereby preventing the need for subculturing bacterial
231 te of alpha(IIb)/beta(3) integrin (GPIIb/IIIa), thereby preventing the activated integrin from reacti
232 hase-promoting complex/cyclosome (Cdc20-APC/C), thereby preventing the proteolytic destruction of sec
233 membrane (PM) to the trans-Golgi network (TGN), thereby preventing the recruitment of active Lck to t
234 tablishes a strong intramolecular interaction, thereby preventing the access of the cyclophilin domai
235 n altered MHCII-bound self-peptide repertoire, thereby preventing the activation of diabetogenic T ce
236 ient cells ATF3 remains bound to the promoter, thereby preventing the arrival of polymerase II and th
237 ethane to methanol in methanotrophic bacteria, thereby preventing the atmospheric egress of approxima
238 population of inactive junction conformations, thereby preventing the binding of processing enzymes a
240 ofibrils and crosslinks other wall components, thereby preventing the collapse of conductive vessels,
241 asures to modulate the innate immune response, thereby preventing the detrimental effects of sepsis.
242 of B lymphocyte-induced maturation protein-1, thereby preventing the down-regulation of transcriptio
243 -like lesions that later completely regressed, thereby preventing the emergence of mammary tumors in
244 ing: AKT phosphorylates TopBP1 at Serine 1159, thereby preventing the enhanced association of ATR wit
245 s assembled in a modular way via subcomplexes, thereby preventing the formation of a functional H(+)-
246 peroxidation in hypercholesterolaemia rabbit, thereby preventing the formation of atherosclerotic pl
247 s for occupancy of highly regulated promoters, thereby preventing the formation of repressive chromat
248 grees C for 1 hour resulted in E6 degradation, thereby preventing the formation of the E6-p53 complex
249 ir ability to prevent sodium entry into axons, thereby preventing the generation of propagated action
250 C activation while inhibiting TAFI activation, thereby preventing the generation of the antifibrinoly
251 ng germination and early seedling development, thereby preventing the inappropriate activation of tra
252 tion that promotes interaction with arrestins, thereby preventing the interaction of GPCRs with heter
253 ning 3 while enhancing the expression of EZH2, thereby preventing the loss of H3K27Me3 in the irradia
254 ntains fluid-epithelial interface homeostasis, thereby preventing the onset of inflammatory condition
255 creates an iron(III)-hydroperoxo intermediate, thereby preventing the possible thiolate dioxygenation
256 s the probability of Ca(i) sinkhole formation, thereby preventing the post-shock reinitiation of vent
257 ATP binding to TAP and, thus, activity of TAP, thereby preventing the presentation of viral peptides
258 occurs at the ferroxidase site of the protein, thereby preventing the production of hydroxyl radical.
259 up of UDP away from the cleaved GalNAc moiety, thereby preventing the re-formation of the UDP-sugar d
260 inhibit the recruitment of the cyanobacteria, thereby preventing the reoccurrence of cyanobacterial
261 ctional groups allows for copper complexation, thereby preventing the separation of the copper cataly
262 alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is require
264 ing of Smurf1-mediated ubiquitination of RhoA, thereby preventing the targeting of RhoA for proteasom
265 s enclosed by interaction with these proteins, thereby preventing the template bulging responsible fo
266 would disrupt the ECM-integrin signaling axis, thereby preventing the transformation into the insulin
267 ent on the amount of (13)C label accumulation, thereby preventing the use of a common basis set.
268 ry dendritic cells to the adipose compartment, thereby preventing their accumulation in the mesenteri
269 ing their surface and binding phage particles, thereby preventing their attachment to the cell exteri
270 oid volatiles into noncleavable triglycosides, thereby preventing their deglycosylation and release f
272 (AB blastomere) several cell divisions later, thereby preventing their forced reprogramming by an en
274 and efficiently internalizes these chemokines, thereby preventing their interaction with other chemok
275 which HdeA stably binds substrates at low pH, thereby preventing their irreversible aggregation.
276 udding of peroxisomal importomer subcomplexes, thereby preventing their premature assembly at the ER.
277 me slit-dependent shape slivers were shuffled, thereby preventing their spatiotemporal integration, s
278 ty of broken DNA ends in G1-phase lymphocytes, thereby preventing these DNA ends from accessing repai
280 and inhibits its interaction with syntaxin17, thereby preventing these two host SNARE proteins from
282 g rapidly subsides after the onset of hearing, thereby preventing this experience-independent activit
283 6 (P6) and older, outer segments were absent, thereby preventing trafficking of outer segment protei
285 alciparum gametocytes in infected human hosts, thereby preventing transmission of malaria to mosquito
287 to the amino half of spectrin repeats of TRIO, thereby preventing TRIO's amino half of spectrin repea
288 UmodC147W/+ mice by reducing active caspase-3, thereby preventing tubule cell death and loss of epith
291 strain their growth by monitoring IL-2 levels, thereby preventing uncontrolled responses and autoimmu
292 collectively preclude their final maturation, thereby preventing untimely tRNA and mRNA binding and
293 the aggregation in different protein systems, thereby preventing unwanted aggregation and enabling t
294 nding aqueous droplets from entering the trap, thereby preventing unwanted cross contamination by oth
295 by enabling VEC-related phosphatase activity, thereby preventing vascular leak during alveolar hypox
296 same binding site to interact with vIL-6 RNA, thereby preventing vIL-6 RNA from association with the
298 of the viral and cellular endosomal membranes, thereby preventing virus entry into the host cell.
300 L3 Delta403-459 targets KLHL3 for degradation, thereby preventing WNK degradation, whereas general lo
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