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1 and Toll-like receptor (TLR) signals in vitro, thereby promoting a B cell-intrinsic break in toleranc

2 tional activator of UCP1 as well as PGC1alpha, thereby promoting a BAT program.

3 uence of oxidative-induced structural changes, thereby promoting a gain of function in integrin bindi

4 vel to regulate the duration of Shh signaling, thereby promoting a gene expression program that is im

5 mediates repression, specifically of ERalpha, thereby promoting a more migratory phenotype.

6 ances plasmin-mediated activation of TGF-beta, thereby promoting a profibrosing phenotype.

7 o function by limiting translation initiation, thereby promoting a ribosome-free mRNA that is targete

8 increase IL-10 and decrease IL-12 production, thereby promoting a tumor-promoting type 2 response, a

9 roxyvitamin D3 inhibits TCR-driven activation, thereby promoting abatacept sensitivity.

10 he sensitivity to punishment in LgA rats only, thereby promoting abstinence.

11 /-) mice have increased inflammatory activity, thereby promoting acceleration of pulmonary disease.

12 ives mast cells and basophils into exocytosis, thereby promoting allergic and potentially anaphylacti

13 a6beta4 integrins and with other tetraspanins, thereby promoting alpha3beta1 and alpha6beta4 associat

14 myloidogenic conformations of AL light chains, thereby promoting amyloid formation, whereas chondroit

15 ed PPARgamma and enhanced PPARbeta expression, thereby promoting an activated phenotype.

16 from other APCs that cause negative selection, thereby promoting an overall larger number of survivin

17 invasion, in part, by hyperactivation of mTOR, thereby promoting and sustaining protein synthesis und

18 l-associated gammadelta T-cell subpopulations, thereby promoting angiogenesis and cancer development.

19 and MMP release in the tumor microenvironment, thereby promoting angiogenesis and metastasis.

20 nto close proximity the Mdm2 E3 ligase and AR, thereby promoting AR ubiquitylation and degradation.

21 is may target AUF1 destruction by proteasomes, thereby promoting ARE mRNA stabilization.

22 naling cascade in a ligand-independent manner, thereby promoting arteriogenesis in diseased tissues.

23 them from the mRNA cap binding protein eIF4E, thereby promoting assembly of the eIF4E.eIF4G complex.

24 e cooperate to deplete cIAP1, cIAP2, and XIAP, thereby promoting assembly of the ripoptosome, a RIP1/

25 occurrence of EBW during atrial fibrillation, thereby promoting atrial fibrillation persistence.

26 to the C6-hydroxyl of MurNAc in peptidoglycan, thereby promoting attachment of wall teichoic acid (WT

27 at TPL2 mediates TAK1 axis of IL-17 signaling, thereby promoting autoimmune neuroinflammation.

28 of T lymphocytes toward T-helper (Th)17 cells, thereby promoting autoimmunity in systemic lupus eryth

29 on, bioenergetics, and mitochondrial activity, thereby promoting autophagy.

30 e threshold for activation of anergic B cells, thereby promoting autoreactivity.

31 ty of neurotrophic factors in the lesion site, thereby promoting axonal regeneration and locomotor fu

32 tion of RPS3 Ser209 and blocked RPS3 function, thereby promoting bacterial colonization and diarrhea

33 (ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting beta-catenin destabilization.

34 of tightening that is observed in its absence, thereby promoting binding of the second cAMP.

35 stimulation decreases LAMTOR/BORC association, thereby promoting BORC- and Arl8b-dependent lysosomal

36 echanical activation in proprioceptive organs, thereby promoting Ca(2+) influx, which is required for

37 tion of inhibitor of apoptosis proteins (IAPs), thereby promoting cancer cell death.

38 ds to and enhances the kinase activity of Akt, thereby promoting cancer progression.

39 beta-catenin-TCF/LEF-mediated transactivation, thereby promoting cancer stemness.

40 net negative charge of the bacterial surface, thereby promoting cationic antimicrobial peptide resis

41 Unc5A-D) interact with FLRT proteins (FLRT1-3), thereby promoting cell adhesion and repulsion, respec

42 it from cleaving a cell surface-bound adhesin, thereby promoting cell adhesion.

43 f Gbetagamma and GIV from the Gi3-GIV complex, thereby promoting cell migration by enhancing Akt sign

44 thin lipid rafts to prevent Notch1 activation, thereby promoting cell proliferation and tumor formati

45 DLBCL) to drive aberrant NF-kappaB activation, thereby promoting cell survival and propagation.

46 a metabolic advantage to photoreceptor cells, thereby promoting cell survival.

47 ers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.

48 e transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking ski

49 IRK2 Val-13/Leu-14 (VL) internalization motif, thereby promoting channel recycling.

50 y enhancing the interaction of CheY1 and CheA, thereby promoting CheY1-P dephosphorylation, which res

51 base excision repair of endogenous DNA damage, thereby promoting chromosome stability in normal human

52 or macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease dev

53 f hepatic macrophages toward the M1 phenotype, thereby promoting chronic liver injury and fibrosis pr

54 rcadian transcriptional and cytosolic rhythms, thereby promoting circadian oscillations to integral p

55 elical conformations of the bulge nucleotides, thereby promoting coaxial stacking of helices.

56 ng sialic acid from host cell surface glycans, thereby promoting colonization of the upper respirator

57 e Rac and RhoA activation in epithelial cells, thereby promoting complex functions such as sheet migr

58 rosine kinase Fyn and the exchange factor Vav, thereby promoting conjugate formation between NK cells

59 o the plasma membrane by an unknown mechanism, thereby promoting constitutive AKT1 activation and onc

60 k plaques, because low ESS conditions persist, thereby promoting continued local lipid accumulation,

61 by blocking the ubiquitin-proteasome pathway, thereby promoting CRC development.

62 rongly bound states of the cross-bridge cycle, thereby promoting cross-bridge cycling.

63 g via the Notch and Wnt/beta-catenin pathways, thereby promoting crypt regeneration, and also repleni

64 d N-terminal RxxxR motif and the Cupin domain, thereby promoting CuxR dimerization and DNA binding.

65 th the nuclear import receptor importin-alpha, thereby promoting cytoplasmic compartmentalization of

66 7 functions by modulating tubulin acetylation, thereby promoting daughter centriole stability.

67 pineal prevents this Tcf7l2-dependent process, thereby promoting dHbl differentiation.

68 hepsin expression, apoptosis and angiogenesis, thereby promoting diet-induced obesity and glucose int

69 neural progenitor markers Geminin and Foxd4l1, thereby promoting differentiation.

70 balance toward a proinflammatory state in MS, thereby promoting disease activity and progression.

71 noic acid downregulate demethylase components, thereby promoting DNA methylation of key genes and hel

72 and SUV4-20H, to enhance its K20 methylation, thereby promoting DNA synthesis and repair.

73 r minichromosome maintenance complex proteins, thereby promoting DNA synthesis complex assembly and c

74 complex to sites of DNA double-strand breaks, thereby promoting early ATM checkpoint responses and h

75 unodominant HIV epitopes and emergent mutants, thereby promoting efficient control of the virus.

76 istone H3 acetylation and chromatin structure, thereby promoting efficient DNA repair of UV-induced l

77 oordinates resection and nucleotide synthesis, thereby promoting efficient HR repair and genome stabi

78 n together to protect Hrs from ubiquitination, thereby promoting EGFR intraluminal sorting.

79 to one supportive of neurons/oligodendrocytes, thereby promoting endogenous remyelination.

80 othelial growth factor receptor-2 trafficking, thereby promoting endothelial cell migration to VEGF.

81 tions of moderate hypoxia, ROS induce the ISR, thereby promoting energy and redox homeostasis and enh

82 nectin at the arginine-glycine-aspartate site, thereby promoting epithelial adhesion and migration in

83 quired for ER to bind both p38gamma and c-Jun, thereby promoting ER relocation from ERE to AP-1 promo

84 within-population phenotypic differentiation, thereby promoting evolutionary divergence.

85 of the mineralocorticoid receptor by cortisol, thereby promoting excess reabsorption of sodium and wa

86 b of the holoenzyme and weakens its integrity, thereby promoting exchange.

87 ormation competent for 3'-splice site docking, thereby promoting exon ligation.

88 the pre-mRNA might bring exons 6 and 9 closer, thereby promoting exon skipping.

89 eta1 inhibits expression of the miR-29 family, thereby promoting expression of ECM components.

90 active AR for ubiquitin-dependent degradation, thereby promoting expression of select AR target genes

91 lating DNA damage-induced EZH2 downregulation, thereby promoting EZH2-mediated gene silencing and can

92 lates the Ca(2+) affinity depending on the pH, thereby promoting fast ligand release.

93 Bin3's role is to bind and stabilize 7SK RNA, thereby promoting formation of a repressive RNA-protei

94 he enzyme by inducing a conformational change, thereby promoting formation of the persulfide intermed

95 and mechanical properties of actin filaments, thereby promoting fragmentation of partially decorated

96 formation modes and store more elastic energy, thereby promoting fragmentation.

97 excessive consumption of glucose and fructose, thereby promoting further weight gain.

98 nformational changes in their fusion proteins, thereby promoting fusion of the viral envelope with th

99 riving force for long-term silencing of BRCA1, thereby promoting genome instability and tumor progres

100 r destabilization and translational silencing, thereby promoting germ cell development.

101 triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation.

102 ation and Akt substrate AS160 phosphorylation, thereby promoting Glut4 membrane translocation.

103 verinsulinize" the peripheral insulin targets, thereby promoting glycemic volatility.

104 t redirects blood flow away from the aneurysm, thereby promoting growth of a new endothelial lining a

105 to modulate autocrine Hedgehog (Hh) signaling, thereby promoting GSC lineage differentiation.

106 117 accelerates intrinsic nucleotide exchange, thereby promoting GTP loading.

107 teins that repress IMD activity in the midgut, thereby promoting gut hyperplasia.

108 I to resolve a long double-flap intermediate, thereby promoting hairpin removal and preventing TNR e

109 can provide a buffer against this time famine, thereby promoting happiness.

110 te oxidative phosphorylation from respiration, thereby promoting heat production and decreasing oxyra

111 A inhibited the BLM strand-annealing activity, thereby promoting helicase activity and complex dissol

112 evels were also reduced in response to an HED, thereby promoting hepatic beta-oxidation.

113 nfiltration of immune cells upon liver injury, thereby promoting hepatic inflammation and fibrosis.

114 cificity of the second receptor-binding event, thereby promoting heterodimeric versus homodimeric com

115 iquitinates the Fanconi anemia protein FANCD2, thereby promoting homologous recombination and DNA cro

116 ha and ubiquitinates HP1alpha at residue K154, thereby promoting HP1alpha degradation through the aut

117 ly transmit coastally perturbed change inland, thereby promoting ice-sheet instability.

118 ntigens enhance ILC2-derived IL-13 production, thereby promoting IgE-mediated experimental food aller

119 y cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular

120 s directly engage pathways of innate immunity, thereby promoting inflammatory aspects of the metaboli

121 ory and immune responses to pancreatic islets, thereby promoting inflammatory destruction and immune

122 spase-1-dependent interleukin-1beta secretion, thereby promoting interferon-gamma production and T he

123 th neighboring ERGIC membranes upon uncoating, thereby promoting interorganellar cargo transport.

124 te selectivity and enhance nucleotide binding, thereby promoting intersubstrate phosphate transfer.

125 , protects Mcl-1 from proteasomal degradation, thereby promoting its antiapoptotic activity.

126 e propose that DivL recruits CckA to the pole, thereby promoting its autophosphorylation and activity

127 ting dimerization of the oncoprotein survivin, thereby promoting its degradation along with spontaneo

128 s capable of phosphorylating Ser-76 in Cdc25A, thereby promoting its degradation.

129 t sugar moieties on ADAMTS13 interact with MR, thereby promoting its endocytosis by APCs.

130 rrestin2 to serine-phosphorylated VE-cadherin, thereby promoting its internalization into clathrin-co

131 ibitory effect on FoxM1b by SUMO modification, thereby promoting its nuclear translocation and preven

132 nt an ideal niche in which Salmonella resides, thereby promoting its persistence and dissemination.

133 se the translation of the MDA-7/IL-24 protein, thereby promoting its subsequent toxic effects in panc

134 reased activity of the STAT3 and ERK pathways, thereby promoting keratinocyte growth.

135 f mitotic centromere-associated kinesin (MCAK), thereby promoting leading-edge MT growth and cell pol

136 hield FLT3-ITD from external cytokine control, thereby promoting leukemogenesis.

137 gingival endothelial cell expression of Del-1, thereby promoting LFA-1-dependent recruitment of neutr

138 n primary tumors and in draining sentinel LNs, thereby promoting LN metastasis.

139 n and pathogenicity of herpes simplex virus 1, thereby promoting long-term infection.

140 feedback that increases type IV pili activity, thereby promoting long-term surface attachment that ca

141 ocking site for the Crk Src homology 2 domain, thereby promoting LPA-induced morphological changes an

142 of Dvl in turn recruits the axin-Gsk3 complex, thereby promoting Lrp6 phosphorylation to initiate bet

143 molecule 1 (VCAM-1)(+) metastatic tumor cells, thereby promoting lymph node metastasis.

144 tumor-associated lymphatic and blood vessels, thereby promoting lymphatic and hematogenous metastasi

145 stabilize the structure of the mutant protein, thereby promoting lysosomal delivery over retrograde d

146 D ligands MICA and ULBP2 by enhanced shedding, thereby promoting malignant character.

147 ing local monocyte recruitment and activation, thereby promoting MCP-1 secretion, vascular inflammati

148 nAChR/JAK2/STAT3 downstream signaling cascade, thereby promoting metastasis of PC.

149 loid-derived suppressor cells and macrophages, thereby promoting metastatic tumor growth.

150 ls, and which impairs immune cell homeostasis, thereby promoting MIA-CID development.

151 e (2-nt 3' overhang) through mono-uridylation, thereby promoting miRNA biogenesis.

152 reduced ubiquitination of mitofusin via HUWE1, thereby promoting mitochondrial fusion and function.

153 ion of the p55alpha/p50alpha subunits of PI3K, thereby promoting more efficient PI3K signaling during

154 alytic subunit to the ING5 and hEaf6 subunits, thereby promoting MOZ HAT activity.

155 d Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTOR

156 ity of ubiquitin-specific peptidase 48 (USP48), thereby promoting Na(+)-H(+) exchanger (NHE)-3 degrad

157 nd directly phosphorylates PKC zeta at Thr410, thereby promoting Na,K-ATPase endocytosis.

158 ing opposes BMP signaling during gastrulation, thereby promoting neural induction and the development

159 increases beta-catenin levels in the nucleus, thereby promoting neural progenitor proliferation.

160 ween pericytes and NSCs was induced by CORM-3, thereby promoting neurogenesis.

161 either miRNA alone, strongly suppressed Rap2a, thereby promoting neuronal differentiation of neural s

162 o potentiate the action of CXCL5 (ENA-78/ LIX), thereby, promoting neutrophil migration into the peri

163 e TNF receptor complex I in endothelial cells, thereby promoting NF-kappaB activation and maintaining

164 l lines from autologous or allogeneic sources, thereby promoting NK cytotoxic activity against target

165 ulating the bioavailability of growth factors, thereby promoting normal crosstalk between podocytes a

166 at HG negatively regulates sestrin 2 and AMPK, thereby promoting Nox4-mediated eNOS dysfunction and i

167 opeia virus NP to Z and the budding apparatus, thereby promoting NP incorporation into virions.

168 eta-catenin from the Axin destruction complex, thereby promoting nuclear beta-catenin signaling indep

169 the trafficking of viral cores to the nucleus, thereby promoting nuclear entry of the viral genome an

170 effects on endocrine and metabolic functions, thereby promoting obesity and associated metabolic dis

171 e fatty acid release from visceral adipocytes, thereby promoting obesity-induced hepatic insulin resi

172 ks a RANKL-induced, apoptotic JNK-Bid pathway, thereby promoting OC differentiation.

173 f miRNAs are often repressed in human cancers, thereby promoting oncogenesis by derepressing targets

174 ease their ability to migrate into the uterus, thereby promoting one of the earliest and most importa

175 c cells promote both slow and fast myogenesis, thereby promoting overall maturation of muscle fiber t

176 srupting the Smad3-phosphorylated p38 complex, thereby promoting p38 dephosphorylation and inactivati

177 mulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian can

178 at this complex antagonizes the Rrm3 helicase, thereby promoting PFA, by preserving the integrity of

179 es recognition of selected microbes and algae, thereby promoting phagocytosis of both potential infec

180 rs via fast, repetitive synaptic transmission, thereby promoting phase locking between the presynapti

181 gulating phosphatase and tensin homolog (PTEN), thereby promoting phosphorylation of Akt, which leads

182 miR-155 specifically reduced levels of SHIP1, thereby promoting PI3K/Akt activation.

183 of novel concepts, ideas, reagents and probes, thereby promoting positive advances in the field.

184 of novel concepts, ideas, reagents and probes, thereby promoting positive advances in the field.

185 GLP-1 and liraglutide activate the GLP-1R, thereby promoting pre-adipocyte proliferation and inhi

186 dermal collagenous extracellular matrix (ECM), thereby promoting premature skin aging (photoaging).

187 on of epithelial PAGE4 modulates AR signaling, thereby promoting progression to advanced lethal PCa a

188 cell phenotype and induces c-Rel target genes, thereby promoting proliferation, survival, and more in

189 egulated kinase 1/2-dependent mTOR inhibition, thereby promoting pSTAT1 nuclear translocation.

190 in observational studies and clinical trials, thereby promoting public health efforts related to iod

191 differentiation until they reach high density, thereby promoting radial sorting.

192 ing by phosphorylating heptahelical receptors, thereby promoting receptor interaction with beta-arres

193 nuclease activity on the 3'-terminated strand, thereby promoting recombination.

194 IMA kinase Fin1 blocked PP1(Dis2) recruitment, thereby promoting recruitment of Polo to Cut12 and the

195 ensure that sperm move when and where needed, thereby promoting reproductive success.

196 ly active transcription factors in CRPC cells, thereby promoting resistance to AR-targeted therapies.

197 capacity of EPCs and BM stem/progenitor cells, thereby promoting revascularization of ischemic tissue

198 ive stress and improve mitochondrial function, thereby promoting RGC survival.

199 e that NOD1 detects PG within early endosomes, thereby promoting RIP2-dependent autophagy and inflamm

200 itment of MSK1 and Cdk9 to the cox-2 promoter, thereby promoting RNA polymerase II phosphorylation.

201 stabilizes p130, a pRb-related pocket protein, thereby promoting S-phase reentry in postmitotic, diff

202 ducer and activator of transcription 3 (STAT3), thereby promoting self-renewal and tumor progression

203 nition and elicit repulsion between processes, thereby promoting self-avoidance.

204 decreased Hes1 and increased Neurog2 activity, thereby promoting sensory neuron differentiation.

205 (stiff) and decorated (compliant) boundaries, thereby promoting severing.

206 ithin a narrow window of ligand concentration, thereby promoting signaling control.

207 mplex is in kinetic competition with splicing, thereby promoting siRNA production from transposon tra

208 orchestrate higher-order chromosome structure, thereby promoting sister chromatid cohesion, chromosom

209 bly factor to localize at the spindle midzone, thereby promoting spindle midzone dissolution.

210 allergy and affects the epigenome of T cells, thereby promoting stable Treg differentiation and func

211 helps to reduce flaw sensitivity in the glass, thereby promoting structural reliability.

212 facilitates joint formation by evicting Sir3p, thereby promoting subsequent Rad54p-dependent formatio

213 larization and osmotic swelling in precursors, thereby promoting surface expression of the epidermal

214 mulates the translation of G4 harboring mRNAs, thereby promoting survival of leukemic cells.

215 s with FoxO1 in the nucleus of cardiomyocytes, thereby promoting survival.

216 hemokines and produce reactive oxygen species, thereby promoting T cell activation.

217 nt induction of CXCR4 cell surface expression, thereby promoting T cell migration in response to CXCL

218 on and the antigen-presenting capacity of DCs, thereby promoting T cell responses.

219 elieve Foxp3-mediated inhibition of RORgammat, thereby promoting T(H)17 cell differentiation.

220 enitor cells from IL-2-delivered mTOR signals, thereby promoting Tfh differentiation during acute vir

221 lation of cluster of differentiation 36 (CD36), thereby promoting the formation of inflammatory foam

222 of Nek1 leads to underphosphorylation of TAZ, thereby promoting the abnormal accumulation of PC2.

223 ation of TMPs responding to weak TCR agonists, thereby promoting the accumulation of high-affinity T

224 s the expression of VEGF in endothelial cells, thereby promoting the activation of VEGF receptors in

225 ulsion between PV cells and pyramidal neurons, thereby promoting the assembly of perisomatic inhibiti

226 uced phosphorylation of p38, JNK1/2, and BCL2, thereby promoting the autophagic flux.

227 rRNA) and the synthesis of ribosomal proteins, thereby promoting the complex process of ribosome biog

228 phorylation of p27(KIP1) specifically at T157, thereby promoting the cytosolic mislocalization of p27

229 ld ordinarily be perceived as early endosomes, thereby promoting the degradation of selected cargo.

230 ulates the HIF-1alpha pathway in chondrocytes, thereby promoting the demise of these cells.

231 KaiC complex is to inactivate KaiA's activity, thereby promoting the dephosphorylation phase of the r

232 atom away from the stretching-excited CH bond, thereby promoting the DF + CHD(2) product channel of t

233 or bearing mice both systemically and locally, thereby promoting the efficacy of adoptive transfer th

234 ivate host prothrombin and form fibrin cables, thereby promoting the establishment of infectious lesi

235 y protect a subpopulation of cells from death, thereby promoting the establishment of persistent infe

236 t post-TLI/ATG by increasing HSC cell cycling, thereby promoting the exit of host HSC from the marrow

237 irradiation recovery for efficient DSB repair, thereby promoting the extraordinary radioresistance of

238 esterol in chemokine receptor oligomerization, thereby promoting the formation of a signaling hub ena

239 ansfer from the cytochrome b(L) to b(H) hemes, thereby promoting the formation of a ubisemiquinone ra

240 eracts with tubulin in a GTP-dependent manner, thereby promoting the formation of microtubules.

241 is in turn increases sympathetic input to WAT, thereby promoting the formation of rBAT within white f

242 These interactions in turn stabilize TMH 2, thereby promoting the inhibited conformation of DtpA.

243 tant increase in oxidized nitric oxide levels, thereby promoting the inhibition of PTEN by S-nitrosyl

244 ry subunit Bcy1 in low glucose concentrations, thereby promoting the inhibitory function of Bcy1 when

245 at least partially alleviate fitness defects, thereby promoting the initiation of cancers.

246 nd spCSF-1 increases with advancing nephritis, thereby promoting the intrarenal recruitment of monocy

247 vation and inhibition of Maspin transcription, thereby promoting the metastatic phenotype.

248 s pre-organized to bind the first Rev monomer, thereby promoting the overall Rev-RRE assembly process

249 prevents the binding of USP9x deubiquitinase, thereby promoting the proteasomal degradation of FOXO3

250 hosphorylating a PP1-docking site in PP2A-B56, thereby promoting the recruitment of PP1.

251 structural component of the nuclear envelope, thereby promoting the release of DNA in the cytosol.

252 role by enhancing cellular cholesterol efflux, thereby promoting the removal of excess cholesterol fr

253 observed in the structure of the closed state, thereby promoting the resulting conformational switch

254 3 nucleotide cleft and the hydrophobic groove, thereby promoting the short-pitch conformation.

255 ed females increases in the insect population, thereby promoting the spread of the maternally inherit

256 s involved in DNA damage signaling and repair, thereby promoting the stability of these transcripts/p

257 nd localization within the reproductive tract, thereby promoting their access to oocytes.

258 transport espin-1 to the tips of stereocilia, thereby promoting their elongation.

259 invadopodium function in breast cancer cells, thereby promoting their invasiveness.

260 ruiting Dachs to the apical junctional region, thereby promoting tissue growth.

261 unctions as an inhibitory molecule on T cells, thereby promoting tissue tolerance by limiting long-te

262 roduces a unique profile of HIF dysregulation, thereby promoting tissue-specific effects on cell grow

263 e AIP4 with respect to ESCRT-0 ubiquitination, thereby promoting trafficking of CXCR4.

264 er that is dependent on its helicase activity, thereby promoting transcription of its target genes.

265 the ability to traverse the first nucleosome, thereby promoting transcription of most genes.

266 alpha, and its downstream effector kinase MK2, thereby promoting transcription, mRNA stabilization, a

267 acilitates recruitment of CRY1 to CLOCK-BMAL1, thereby promoting transcriptional repression.

268 which turns eIF5 into translational inhibitor, thereby promoting translation of GCN4, the yeast ATF4

269 tophagy as a cytoprotective adaptive response, thereby promoting treatment resistance.

270 h pulls the alpha1-helix out of the interface, thereby promoting trimerization.

271 breaks the interaction between ShcD and Grb2, thereby promoting TrkB-Grb2 association.

272 provide a metabolic advantage to cancer cells, thereby promoting tumor cell proliferation, tumorigene

273 f keratinocytes harboring oncogenic mutations, thereby promoting tumor development.

274 s that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

275 angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread.

276 at NRP-1 activates the tumor microenvironment, thereby promoting tumor growth.

277 tivation alters the tumor inflammatory milieu, thereby promoting tumor growth.

278 rosis factor alpha/nuclear factor kappaB axis, thereby promoting tumor malignancy and subsequent rela

279 TIMP-3 loss might induce chronic inflammation, thereby promoting tumor malignancy as well as poor sur

280 an limit effective antitumor immune responses, thereby promoting tumor progression, it is important t

281 calized MDSC expansion and immune suppression, thereby promoting tumor progression.

282 that impact both tumor and host cell behavior, thereby promoting tumor progression.

283 broblasts (CAFs) in head and neck cancer (HNC), thereby promoting tumorigenesis via modifying the tum

284 econstruction regulates MICA protein shedding, thereby promoting tumour immune evasion, and identify

285 ammatory DCs to produce interleukin-12 (IL-12), thereby promoting type 1 polarized immunity.

286 or the efficient intra-islet survival of CTLs, thereby promoting type 1 diabetes development.

287 14-3-3beta with the ubiquitin ligase Nedd4-2, thereby promoting ubiquitination and degradation of EN

288 e Cdk6 promoter and activated Cdk6 expression, thereby promoting uncontrolled cell proliferation.

289 with activated c-Rel in keratinocytes and SCC, thereby promoting uncontrolled proliferation, a key al

290 consisting of binding sites for SCL and Gata2, thereby promoting V2b-interneuron fate.

291 ides an outlet for lateral compressive forces, thereby promoting vertical mechanical buckling, which

292 TNF)-related apoptosis-inducing ligand (TRAIL), thereby promoting viral persistence.

293 ffer the ability to directly cleave viral DNA, thereby promoting viral clearance.

294 ein down-regulates BST2 from the cell surface, thereby promoting viral release.

295 uld keep infected cells in an activated state, thereby promoting viral replication.

296 extracellular bacterial cyclic dinucleotides, thereby promoting virulence.

297 y Wnt signaling in the lungs of infected mice, thereby promoting virus-associated disease.

298 conformational transition on the beta-switch, thereby promoting VWF binding.

299 tase and stabilizes the AnxA2-S100A10 complex, thereby promoting VWF release.

300 ltransferase MLL1 to promote H3K4 methylation, thereby promoting Wnt target gene transcription.

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