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1 f the tissue directly from biological markers, thus providing 3D cellular scale information and impro
2 -electrode showed good recovery (99.06-100.96%), thus providing a promising tool for analysis of carb
3 apidly (perhaps fewer than ten thousand years), thus providing a high-resolution glimpse into the ini
4 isproportionation to the parent thiol and S(0), thus providing a mechanism for transsulfuration in th
5 e colony-stimulating factor 1 receptor (CSF1R), thus providing a target that may prevent the progress
6 genome does not contain alpha-synuclein (SNCA), thus providing a unique opportunity to study pathogen
9 hat all Artemis DNA substrates have in common, thus providing a basis for understanding how this stru
10 f fluorescently labeled proteins are the same, thus providing a benchmark for ciliary enrichment.
11 entially dispersible nanoparticulate fraction, thus providing a benchmark with which to make quantita
12 e we might be able to turn the switch back on, thus providing a better treatment option for melanoma.
13 control of the second electron transfer step, thus providing a blueprint for the development of a br
14 ically bind and regulate FXR activity in vivo, thus providing a bona fide novel therapeutic agent to
15 annel neuron in the first neuropil, or lamina, thus providing a candidate substrate for the elementar
16 r nucleate to form larger polysulfur aerosols, thus providing a chemical framework for understanding
17 -containing pharmacophores onto oligopeptides, thus providing a chemical tool for the synthesis and m
18 ther levels or other task-related information, thus providing a clear identification of low- and high
19 of dCK inhibition by DI-39 treatment in vivo, thus providing a companion pharmacodynamic biomarker.
20 ncy of charge separation have been determined, thus providing a complete account of the mechanism and
21 d with release studies of those same products, thus providing a consistent analytical platform for in
22 cts with predictable microstructural features, thus providing a controlled microenvironment for in vi
23 tterion and suppresses the fluorine migration, thus providing a convenient and efficient synthesis of
24 isease genes are enriched for essential genes, thus providing a dataset that facilitates the prioriti
25 of the packaging ATPase activity of the motor, thus providing a direct link between structure and fun
26 defined system in a Mediator-dependent manner, thus providing a direct link to the general transcript
27 uccessfully employed as nitrogen nucleophiles, thus providing a direct route to heterocyclic motifs c
28 n accommodate any PTM or unnatural amino acid, thus providing a flexible prediction system for high-t
29 uit's anatomical and physiological properties, thus providing a framework for future experimental and
30 nd in the dynamics of the tropical atmosphere, thus providing a framework for obtaining a better unde
31 of synaptic activity at the single-cell level, thus providing a fuller understanding of how changes a
32 ar processes can result in primary phenotypes, thus providing a fundamentally new molecular approach
33 rved in experiments with binary nanoparticles, thus providing a general framework to understand their
34 ble upstream spiralling motion of sperm cells, thus providing a generic and robust rectification mech
35 re not timed to coordinate sample collections, thus providing a global transcriptomic profile for eac
36 can be applied to a wide range of biomarkers, thus providing a good alternative to standard antibody
37 aben PET data using a dual-window acquisition, thus providing a good compromise between quantificatio
38 y dinitrogen and water, under mild conditions, thus providing a green, mild methodology for removal o
39 excellent agreement with experimental results, thus providing a guide towards engineering epitaxial g
40 two TWIST-E47 dimers on the same face of DNA, thus providing a high-affinity site for a highly stabl
41 eins and phospholipids were the foci of study, thus providing a jumping-off point for advancing our f
42 -expression boundaries in the extended trunks, thus providing a link between activation of these gene
43 tations in covS during invasive GAS infection, thus providing a link between TCS molecular function a
45 olymerized HbS fibers by the mesoscopic model, thus providing a means of bridging the subcellular and
46 ell receptors in which a window has been open, thus providing a means to control guest binding and re
47 ired attention to different stimulus features, thus providing a means to index how representations of
48 n, we identified CCNT2 as a functional target, thus providing a mechanism by which miR-297c-5p impart
49 e excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces coc
50 sion of HBEGF enhanced invadopodium formation, thus providing a mechanism for cell autonomous invasio
51 show that CST unfolds G-quadruplex structures, thus providing a mechanism for CST to facilitate repli
52 n the presence of stalled replicase complexes, thus providing a mechanism for maintaining replication
53 RS system, acts to suppress such development, thus providing a mechanism for protection against phot
54 induce P. aeruginosa lysis and activate PARA, thus providing a mechanism for the enhanced capacity o
55 led to no net evolutionary response over time, thus providing a mechanism for the maintenance of gene
56 conditions with greatest NCC phosphorylation, thus providing a mechanism for the reduced endocytosis
57 of this Efr3 region counteracts Ypp1 binding, thus providing a mechanism through which Stt4/PI4KIIIa
58 lation and PKA-dependent inactivation of RhoA, thus providing a mechanism whereby PKA- and RhoA-depen
59 amma binding interfaces of phosphorylated Pdc, thus providing a mechanistic explanation for the 14-3-
60 koff or kon are involved in hydrogen bonding, thus providing a mechanistic explanation for the obser
61 and regulate the stability of SnRK1 in vitro, thus providing a mechanistic link between SR45 functio
62 and/or phosphatidylinositol-4,5-bisphosphate, thus providing a mechanistic model for the lipid clust
63 cancer progression, from early to late stages, thus providing a model for studying pancreatic cancer
64 han its isogenic PorB3-expressing counterpart, thus providing a molecular basis for increased surviva
65 , distant from the aminopeptidase active site, thus providing a molecular basis for its inhibitory pr
66 to upregulation of the damage receptor Draper, thus providing a molecular memory that allows the cell
67 vival by interfering with tonic BCR signaling, thus providing a molecular rationale for the use of HS
68 ension of adverse effects on living organisms, thus providing a more informed scenario for risk asses
69 uples mutational and environmental robustness, thus providing a necessary step in the evolution of mu
70 give rise to awareness than for averted gaze, thus providing a neural basis for privileged access of
71 tion of hand reach than before its correction, thus providing a neural underpinning to the phenomenon
72 late miRNA biogenesis via distinct mechanisms, thus providing a new foundation to understand the func
73 contains a driving force for ferroelectricity, thus providing a new microscopic mechanism for the coe
74 arise genetically in a combinatorial fashion, thus providing a new paradigm for the complex genetics
75 pi-pi stacking and electrostatic interactions, thus providing a new strategy for designer water remed
76 ression of Hut78 cell tumor formation in skin, thus providing a new therapeutic strategy for CTCL.
77 and mitochondrial function in D. melanogaster, thus providing a new tool that may help clarify the pa
78 e AMPK through increased AMP generated by ASS, thus providing a novel link between protein catabolism
79 expression of key regulators of ESR1 activity, thus providing a novel mechanism by which endocrine re
80 and improves brain function in adult mammals, thus providing a novel nutraceutical approach for the
81 ials using a fungal biomineralization process, thus providing a novel strategy for the preparation of
83 t vascular cells from murine ischemic muscles, thus providing a permissive milieu to transplanted LEP
84 ifferences in cellular differentiation status, thus providing a physiological mechanism for controlli
85 ontent in response to a hypertrophic stimulus, thus providing a physiological model with which to stu
86 tions in the molecular profiles of organelles, thus providing a physiologically relevant set of marke
87 -renew or differentiate to diverse cell types, thus providing a platform for basic and clinical appli
88 nt with alpha2 GlyRS and divergent from AlaRS, thus providing a possible explanation for the puzzling
89 hesis is free of thiol groups and halide ions, thus providing a possible solution to the problem of s
90 s sufficient to restore normal cell migration, thus providing a potential approach for therapeutic st
91 ges enhancing drug transport and cytotoxicity, thus providing a potential baseline for clinically-foc
93 of a system when approaching a tipping point, thus providing a potential early-warning signal suffic
94 inephrine was present in freshly wounded skin, thus providing a potential mechanism for impaired heal
95 ne silencing without appreciable cytotoxicity, thus providing a potential strategy for polypeptide-ba
96 failure within the first two decades of life, thus providing a potential window for therapeutic inte
97 resolution over a broad range of wavelengths, thus providing a powerful tool to rapidly visualise mu
98 hibit excellent rate and cycling performances, thus providing a preview of their practical applicatio
99 deration of spatial or spatiotemporal effects, thus providing a promising option for policy developme
100 disasters and significant climatic variations, thus providing a quasi-experiment to examine the influ
101 ls in controlling viral production during ART, thus providing a rationale for exploring immunotherape
102 terminal oxo complex [UO(OSi(O(t)Bu)3)4K], 3, thus providing a remarkable example of two-electron tr
103 o doxorubicin and reduce the cardiac toxicity, thus providing a remarkable improvement in the drug's
104 n can be triggered by a motivational stimulus, thus providing a richer model of self-control than cla
105 ing the same phenotypic and functional assays, thus providing a robust analysis of their similarities
106 educe oxygen near the film/solution interface, thus providing a self-activated protection from oxygen
107 ch as leaf angle, curvature, and leaf density, thus providing a sensitive method of evaluating the pr
108 ly connecting them with a young healthy mouse, thus providing a shared blood circulation through para
109 educes viral dissemination to internal organs, thus providing a shield for the developing adaptive im
110 riety of shapes in other Brassicaceae species, thus providing a simplified framework for fruit develo
111 s with a limit of detection reaching 10(-8) M, thus providing a solid basis for the construction of s
112 cuss prevention methods to disable the attack, thus providing a solution for enhancing patient privac
114 network extending >40 A from the binding site, thus providing a structural rationale for the observed
115 would have increased potency and selectivity, thus providing a template for further rational drug de
116 the tomato pathogen Pseudocercospora fuligena, thus providing a three-dimensional model of an Avr4 ef
117 c changes from a still-extant recent ancestor, thus providing a tractable case study in pathogen evol
118 tially deficient in miRNAs and/or endo-siRNAs, thus providing a unique opportunity for testing whethe
119 the context of recent synthetic developments, thus providing a unique overview of these complex and
120 distances but are also functionally connected, thus providing a unique paradigm of receptor signaling
121 ht to preserve almost pristine dust particles, thus providing a unique sample of the properties of th
122 livers via subsequent flow cytometric sorting, thus providing a validated method to determine gene ex
123 logical organization of anatomical structures, thus providing a way to compare structural integration
124 ics the structure and reactivity of Co-MFU-4l, thus providing a well-defined platform for studying th
125 tory monitoring of water bodies under the WFD, thus, providing a benchmark for establishing comparabi
126 ithin a few unit cells away from the nanowire; thus providing a mechanism for tuning the carrier dime
127 375 microm and larger hinders SCS advancement, thus providing abilities to engineer closing and noncl
128 nnulation approach also works for an aldehyde, thus providing access to a 2,5-dihydrofuran product in
129 tion of racemic alpha-chiral carboxylic acids, thus providing access to a variety of enantiopure nons
130 with differentially substituted vinylsilanes, thus providing access to amino acid mimics and other v
131 ectivities in the products at the C1 position, thus providing access to both orientations of the THIQ
132 hich can be studied with high time resolution, thus providing access to picosecond dynamics at the at
133 ity of the ferryl oxygen of APO intermediates, thus providing additional driving force for C-H and O-
134 CDC with a very low threshold of MAC binding, thus providing additional insight into their enhanced
135 curately predict toxin-negative stool samples, thus providing additional results in PCR-positive stoo
137 family to readily oxidize cholesteryl esters, thus providing an additional source of carbon for myco
138 ing thymidine analogs and retroviral labeling, thus providing an alternative approach to tackle funda
139 metal amido complex via photoredox catalysis, thus providing an alternative approach to the use of s
140 responders and was non-inferior to telaprevir, thus providing an alternative treatment in areas of th
141 ively in humans than in other primate species, thus providing an anatomical basis for behavioral and
142 d phenotype resembling that described in vivo, thus providing an attractive model to study the origin
143 lectron withdrawing and donating substituents, thus providing an avenue for tuning the driving force
144 growth and viability of squamous lung tumors, thus providing an effective strategy to overcome resis
145 al connectivity to perisylvian language areas, thus providing an efficient circuit for both grapheme-
146 dentification of plastic particles and fibers, thus providing an efficient method to detect and quant
147 ivity is regulated by the RNA exosome complex, thus providing an example of a mechanism that relates
148 ividual differences in insect social behavior, thus providing an example of how comparative genomics
149 at the RRAs act to suppress ARR1 accumulation, thus providing an explanation for their inhibitory act
150 sician when a concerning lesion is identified, thus providing an important adjunct to yearly skin exa
151 energetic costs and permanent somatic damage, thus providing an important mechanism to explain fine-
152 acteria are protected from phagocytic killing, thus providing an intracellular survival niche within
153 e nucleotide, a stable pocket can be produced, thus providing an opportunity for the binding of selec
154 ized with activated AKT on the surface of EAC, thus providing an opportunity for therapeutic targetin
155 f the host-derived R. equi containing vacuole, thus providing an opportunity for VapA to interact wit
156 te understanding of the underlying mechanisms, thus providing an opportunity to devise primary and se
157 mories are susceptible to modifications again, thus providing an opportunity to update seemingly stab
158 stacks that extend along the substrate normal, thus providing an optimal geometry for charge carrier
160 mal degradation and impaired Numb/p53 pathway, thus providing another mechanism how Plk1 antagonizes
161 pes of point vacancies present in the samples, thus providing atomic-level insights into the structur
162 c and have slightly higher LUMO energy levels, thus providing better device performance and higher de
163 NOD2 to stimulate the CD8(+) T cell response, thus providing better protection against influenza A v
164 ivity that the phenolic compounds can display, thus, providing better knowledge of the importance of
165 th in vitro and in patient-derived xenografts, thus providing biologic rationale and functional evide
167 to the thalamus and the dopaminergic midbrain, thus providing both direct and indirect projections, t
168 ecules of CO2 and two low-potential electrons, thus providing both the carbon and reducing equivalent
169 nt environmental and physiological indicators, thus providing broadly generalizable, MRI-compatible,
170 ation in V4 elicited alpha-oscillations in V1, thus providing causal evidence for the opposite propag
172 d death-1 or B7.1 and B7.2 on the T cell side, thus providing clear evidence that B7-H1 modulates T c
173 ther DNA loop, inhibit each other's formation, thus providing clear support for the loop domain model
174 g the influence of sterics on the selectivity, thus providing complementary selectivity to directed C
175 AR function in mitotically active tumor cells, thus providing critical insight into the molecular bas
176 ap, oxide thickness, and detecting wavelength, thus providing design guidelines for constructing 2D n
177 onally, this method operates in confocal mode, thus providing direct 3D spatially resolved chemical s
178 romoted decoupling of neurons from astrocytes, thus providing direct evidence for the role of nanotop
179 d MERS-CoV entry of Calu-3 human airway cells, thus providing direct evidence that virus-Sia interact
180 polar frequency) or in the distribution of it, thus providing direct experimental evidences demonstra
181 a orchestration of histone H2B ubiquitylation, thus providing distinct functional insights of Sus1p i
182 passes a broad range of ene-allene substrates, thus providing efficient access to fused cyclobutanes
183 abilize DnaA filaments on a single DNA strand, thus providing essential precision to this binding mec
184 e into active bone-resorbing osteoclasts (OCs), thus providing evidence that the impact of chronic pe
185 t shifts in peak seedling densities over time, thus providing evidence for the hypothesized spacing m
186 e routinely hospitalized at time of diagnosis, thus providing evidence for the incidence of epilepsy.
187 in the host species they were collected from, thus providing evidence of encounter barriers mediated
188 manner in euthyroid but not hypothyroid mice, thus providing evidence that chondrocyte to osteoblast
189 meostat impaired subsequent short-term memory, thus providing evidence that neural circuits that regu
190 OPRAH exhibited increased biological activity, thus providing evidence that physical formation of the
191 fail to prepare the Y chromosome for meiosis, thus providing evidence that the rapid evolution of ge
192 vasion by being prepackaged within the virion, thus providing evidence, for the first time, of a viri
193 to transfer-hydrogenative C-C bond formation, thus providing examples of reductive heterocyclization
194 owards CD1d-alpha-GalCer and related antigens, thus providing far greater scope for diverse glycolipi
195 ngs; they detect body rotations during flight, thus providing feedback that is essential for controll
197 nuated the insulinotropic activity of TAK-875, thus providing functional validation of the biosensor
198 t a unique locomotor repertoire for H. naledi, thus providing further evidence of locomotor diversity
199 opment of both peripheral and central fatigue, thus providing further evidence that the magnitude of
200 raction between the SAGA DUBm and nucleosomes, thus providing further functional insights into SAGA's
201 ll mutant of the plasma membrane isoform ACA9, thus providing genetic evidence that ACA12 is a functi
202 strand displacement and nucleolytic digestion, thus providing guidance for the design of enzyme-media
203 es are highly evolved for horizontal exchange, thus providing immediate opportunities to test the eff
204 te during the conversion of RC DNA to CCC DNA, thus providing important clues to the pathways of CCC
205 tion of self-DNA-induced autoimmune disorders, thus providing important implications for novel therap
206 dent of the specific nonclassical theory used, thus providing important insight into a large range of
207 population of Rab5-positive sorting endosomes, thus providing important insights into the compartment
208 al coefficients while suppressing decoherence, thus providing improved sensitivity over existing stra
209 n of the E46K mutant compared to WT alpha-syn, thus providing in vivo validation of our findings.
211 el turned out statistically indistinguishable, thus providing independent validation of our model.
212 catalytic acid to give Si(OEt)4 in 60% yield, thus providing inexpensive routes to high-purity preci
213 t cells to move into adjacent cell-free areas, thus providing information on cell culture viability,
214 individual genes or gene combinations in vivo, thus providing information that is conceptually simila
215 using consistent characterization conditions, thus providing insight into the influence of environme
216 lopmental angiogenesis in the pituitary gland, thus providing insight into the long-standing systems
217 play an essential role in blastema formation, thus providing insight into the longstanding question
218 the protection engendered by OMV vaccination, thus providing insight into the mechanism of immune pr
219 uroinflammation, synaptic efficacy and memory, thus providing insight into the pathogenesis of amyloi
220 that control the level of internal motivation, thus providing insights into how internal states affec
221 argets of the two CPEB proteins in Drosophila, thus providing insights into local protein synthesis i
222 n regulates tetherin expression and stability, thus providing insights into the function of SGTA in E
223 tion in heterogeneous co-culture are reported, thus providing insights into the future development of
224 e interaction between SERCA and phospholamban, thus providing insights into the physiological role of
225 -terminal domain of NPM1 and R-motif peptides, thus providing insights into the structural organizati
226 diated degradation and to minimize DNA breaks, thus providing insights into the SUMO and ubiquitin in
227 g mitochondria to host nitrogenase components, thus providing instrumental technology for the grand c
230 vior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social int
231 omal barrier and enable PolII promoter escape, thus providing mechanistic insight into the role of Ch
232 o be responsive to neuronal ovulatory stimuli, thus providing mechanistic insights into steroid signa
233 g different polymers, i.e. F8BT, MDMO-PPV, PS, thus providing micrometric-sized taggants suitable for
234 uring site-specific histone-modifying enzymes, thus providing molecular insight into chromatin signal
237 R originate in the visual and parietal cortex, thus providing neurons in MEC with a subset of cortica
238 h the lipid environment both in wild-type PFO, thus providing new experimental constraints for molecu
239 ynamically and kinetically possible/favorable, thus providing new insight for nanoparticle self-assem
240 lights the HIF1alpha-beta-catenin interaction, thus providing new insights into the impact of hypoxia
241 ew, simple methods to access these parameters, thus providing new tools to study germinal center and
242 ced cMyc-FBW7 binding and cMyc ubiquitination, thus providing novel insight into how EYA1 acts to reg
243 ESCRT-0 component Hrs is an effector of Rab35, thus providing novel mechanistic insight into the coup
244 d cardiovascular outcomes with this condition, thus providing observations and important clinical ins
245 transcription factor for interferon synthesis, thus providing one basis for the observed transiency.
247 due to pleiotropy and shared biological basis, thus providing only a partial, confounded view of gene
248 onals for whom HVC is part of normal practice, thus providing patients with improved clinical outcome
249 ene signature to promote melanoma progression, thus providing potential opportunities for targeted th
250 interfering with its ability to form fibrils, thus providing powerful tools for uncoupling these pro
251 l microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that
252 tent and specific therapeutic activity in CLL, thus providing proof of concept for FcmuR as a valuabl
253 etopiperazines in virtually their final forms, thus providing rapid and highly convergent assembly at
254 and 3.8-fold for pre-organoids, respectively, thus providing rational guidelines towards establishin
255 effect in neutrophils from patients with COPD, thus providing scientific rationale for the combinatio
256 bles its integration into third-party portals, thus providing 'Search as a Service' capabilities, whi
257 orescence intensity of 104-fold upon cleavage, thus providing sensitivity that is unmatched in a cont
258 tases and is expected to impact these lesions, thus providing significant benefits to the patient.
259 routine-only vaccination (AGW = 9.9, CC = 677), thus providing similar levels of efficiency per perso
260 esting state and model 2 a desensitized state, thus providing snapshots of gating transitions in the
261 ylated analogue and 3-hydroxylated metabolite, thus providing strategically placed functional groups
262 zymes share similar active site architectures, thus providing strong evidence for an evolutionary lin
263 y the structure and polarization calculations, thus providing strong support for the local and global
264 ous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci
265 vents accommodation of Lys-tRNA at the A-site, thus providing structural basis for understanding how
266 fraction of protein structural relationships, thus providing structure and function predictions for
267 export of agmatine in exchange of l-arginine, thus providing substrates for further removal of proto
268 able of moving long distances between tissues, thus providing support for operation of a phloem-media
269 ffinity and also affected the gene expression, thus providing support for the function of NreA as a n
270 thways identical to beta-adrenergic receptors, thus providing support that inhibition of this system
271 are considered to be present in equal ratios, thus providing symmetry to the double-capped complex.
272 with a styrax-type resin (Styrax officinalis), thus providing the earliest known evidence of an odor
273 ions were counteracted by antagonism of OX-1R, thus providing the basis for a therapeutic treatment o
274 to be optimal with respect to potency and PK, thus providing the clinical compound 35 which demonstr
275 ive measurements of different ranking results, thus providing the first benchmark platform for integr
276 athogen-specific IgT within the gills of fish, thus providing the first example of locally induced im
277 puting Pareto-optimal sets of reconciliations, thus providing the first systematic method for underst
278 rs of AMH were genetically isolated in Africa, thus providing the first whole genome-level evidence o
279 desalting device that meets both requirements, thus providing the foundational technology piece for t
280 s and glycosidic C-O and cross ring cleavages, thus providing the most comprehensive structural analy
281 ic sites is induced by the chiral environment, thus providing the necessary interactions to be modula
282 n (IgM) and cytokine (IL-10, IL-4) production, thus providing the possibility of the development of u
283 d can tolerate a variety of functional groups, thus providing the potential for further derivatizatio
284 chemosensitivity and blocks metastatic spread, thus providing the rationale for a therapeutic strateg
285 a1 to alpha5 and alpha2 to alpha6 NC1 domains, thus providing the spatial orientation between interac
286 tions between the superficial and deep layers, thus providing the substrate for possible communicatio
287 ime-to-solution and >40 times in problem size, thus providing, to our knowledge, a new platform for p
288 k down one activity, while preserving another, thus providing tools for therapeutics and for understa
289 s the importance of the genes in the pathways, thus providing unique information that may result in t
290 ke perception in response to external stimuli, thus providing unique opportunities for emerging class
291 f stretchable sensors, actuators and circuits, thus providing unique opportunities for emerging class
292 ganism for large-scale in vivo drug screening, thus providing unprecedented opportunities for therape
293 oduce a hierarchy of electronic energy states, thus providing unprecedented opportunities to manipula
294 produced by microalgae directly from seawater, thus providing useful information for monitoring of th
295 emonstrate the neurodegenerative pathogenesis, thus providing useful tools for characterizing the rol
296 ologically monitoring river bedload transport, thus providing valuable additional information for stu
297 tiple views and integrate it with crop growth, thus providing valuable guidance for local drought mit
298 changes across each single chain-Fv fragment, thus providing valuable insight into how sensitive all
299 mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of
300 f the AtHIR1 complex in response to pathogens, thus providing valuable insight into the mechanisms of
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