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1 or 8 weeks induced extensive hepatic fibrosis, whereupon 1D11 dosing was initiated and maintained for
2 adication is frequently not achieved with MTD, whereupon a de facto goal of longer-term tumor control
3 icase E1 to an A/T-rich origin of replication, whereupon a dihexamer forms, resulting in DNA replicat
4 ptors on the cell surface and is internalized, whereupon a pH drop in the endosome (pH approximately
6 KC to relatively common anionic phospholipids, whereupon a two-dimensional search is initiated by the
7 sylceramide in live cells or in mouse tissues, whereupon an HPLC assay enabled detection and quantifi
9 the membrane to the inner part of the cytosol, whereupon another diffusion-trapping mechanism involvi
10 +/-6 days until the development of TIC and MR, whereupon biplane videofluoroscopy and transesophageal
12 Uniform stimuli trigger a symmetric response, whereupon cells stop and round up; then localized patc
13 bjected to non-surgical periodontal treatment, whereupon changes in salivary CSF-1, IL-34, and MMP-8
14 papillomavirus virion uncoats in the endosome, whereupon conformational changes result in a dissociat
15 toxin internalization into acidified vesicles, whereupon cryptic segments from within the 1,050-aa tr
16 P, until replacement of the final alpha-helix, whereupon cyclopropanation and branching activity comp
17 sed of the peptide cation and reagent dianion, whereupon dehydration of the complex via collision-ind
18 lasm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along microtubu
19 d ability of mitotic kinetochores to biorient, whereupon each sister kinetochore forms microtubule (M
20 tural specificity to DNA junctions as a dimer, whereupon each subunit cleaves a phosphodiester bond o
21 n urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversi
22 critical role in bringing Gab2 to FcepsilonRI, whereupon Gab2 becomes tyrosyl-phosphorylated in a Syk
23 habitat lead to extinction of the specialists, whereupon generalists invade from the uniform habitat,
24 ting of the human papillomavirus (HPV) capsid, whereupon host cyclophilins facilitate the release of
25 This run-down was prevented by okadaic acid, whereupon ICl,CaMK remained near its maximum value for
26 osomes of hematopoietic and parenchymal cells, whereupon IgG is diverted from degradation in lysosome
27 S. aureus to facilitate bacterial attachment, whereupon infected or sterile catheters were stereotac
28 g mice unless the mice were stratified by age, whereupon inverse correlations between memory and Abet
29 samine, and N-glycolylglucosamine 6-phosphate, whereupon irreversible de-N-glycolylation of the latte
31 s recruited by DNA-binding activator proteins, whereupon it alters chromatin structure to increase pr
32 ocalize from the nucleolus to the nucleoplasm, whereupon it binds replication protein A and inhibits
33 omes phosphorylated in a lck-dependent manner, whereupon it can directly recruit p85 adaptor subunits
35 ses the star to evolve back into a cool giant, whereupon it experiences renewed mass ejection before
36 ed by increases in the cellular AMP:ATP ratio, whereupon it functions to help preserve cellular energ
37 or after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse gene fa
38 cells and released from apoptotic tumor cells, whereupon it interacts with the complement C5a recepto
39 s, consumption may peak between 2015 and 2020, whereupon it is likely to drop by up to 40% until 2050
41 ates in the nucleus after rapamycin treatment, whereupon it primes the phosphorylation of the RNA pol
42 se DC subsets efficiently internalize CLEC12A, whereupon it quickly translocates to the early endosom
43 elium or H2 as the sample was heated to 523 K, whereupon it reacted with oxygen of the support to giv
45 rod/hook-type proteins before hook completion, whereupon it switches specificity to recognize filamen
46 tion with receptor I, which phosphorylates it, whereupon it translocates into the nucleus presumably
47 to damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to m
48 00) generated an average charge state of 5.88+; whereupon, liquid chromatography/electrospray ionizat
49 the transcription factor IRF3 to the promoter, whereupon MafB acted as a transcriptional antagonist,
50 t-bridges (as many as 18 for specific binding) whereupon many of the unmasked charged groups hydrate
53 loited to separate and purify target analytes, whereupon plutonium and neptunium were simultaneously
54 d by rnc) cleaves the pnp untranslated leader, whereupon PNPase represses its own translation by an u
55 ich MPO and PON1 interact during inflammation, whereupon PON1 binding partially inhibits MPO activity
57 h FcgammaRIIb to promote SHIP phosphorylation, whereupon SHIP binds to Shc and dissociates from Fcgam
58 boxylates, with 3-cyanochromones is described, whereupon spirochromenofuran derivatives 5 or 6 were o
59 MI; n=50) or a severe AMI (anterior AMI; n=50), whereupon surviving animals (n=36 moderate, n=33 seve
60 stumpy forms" until entry into the tsetse fly, whereupon TbPTP1 is inactivated and major changes in p
62 by using the polarizable continuum model (PCM), whereupon the activation of the C-CN bond was found t
63 lt pattern by 96 hours postfertilization (hpf), whereupon the temporal pattern of neuroD expression i
64 nvolved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine
65 ic (TTF*+) or dicationic (TTF2+) counterparts, whereupon the alpha-CD ring, moves along the dumbbell
68 scent network that eventually fills the gland, whereupon the buds shrink in size and become mitotical
69 lysine, is then added to the reaction mixture, whereupon the DNA molecules bind electrostatically to
70 = 0.06), through the spin transition of iron, whereupon the elastic moduli exhibited up to 25% softe
71 ce of an intrahelical, fully base-paired oxoG, whereupon the enzyme promotes extrusion of the target
72 Cdc42 localizes the exocyst to primary cilia, whereupon the exocyst targets and docks vesicles carry
73 2 localizes the exocyst to the primary cilium, whereupon the exocyst then targets and docks vesicles
75 cobalamin-colchicine prodrug by cancer cells, whereupon the hydrazone linker undergoes hydrolysis in
76 ecome fixed when environment variation is low, whereupon the mean fitness in the population is higher
77 re transiently translocated into the ER lumen, whereupon the NST domain is glycosylated to yield an i
78 e host plasma membrane and enters the cytosol, whereupon the P8 shell disassembles and the polymerase
79 olypeptide that is imported into mitochondria, whereupon the pre-sequence is proteolytically removed
80 unaffected until [Zn] increased to 20 microM, whereupon the radius of gyration, RG, values increased
81 ter specifically binds methyl epoxyfarnesoate, whereupon the receptor homodimerizes and changes terti
82 eciably deprotonated at physiological pH also, whereupon the resultant thiolate nucleophile may play
83 with a time constant of approximately 500 fs, whereupon the retinal rapidly twists and encounters a
84 rough the RAC1-NADPH oxidase 1 enzyme complex, whereupon the senescent cells express an antifibrosis
85 he portal that is embedded in the capsid wall, whereupon the structure of the portal and its interact
86 ction by recruiting Csk to active Src kinases, whereupon their activities and consequent c-myc induct
87 required for maintaining the tumor phenotype, whereupon there is a switch from a gene expression pro
88 less activated to differentiate to adipocytes, whereupon these cells reduce expression of several pro
89 on until induced during regeneration or aging, whereupon they become Notch1-dependent and fail to ful
90 me activated by an associated tyrosine kinase, whereupon they dissociate from the receptor and dimeri
91 ced into a mammalian skin by a sandfly vector, whereupon they encounter increased temperature and tox
92 ced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cell
94 il the chromosomes reached the cell periphery, whereupon they often somersaulted and returned to the
95 roken end until they encounter a chi sequence, whereupon they produce a 3' single-stranded DNA tail o
96 cteria until the insect tissues are exhausted, whereupon they reassociate and leave the cadaver in se
97 by activation of endogenous adenylyl cyclase, whereupon they receive stimulation from adjacent PE vi
98 por onto the biomolecule-containing particles, whereupon they were sampled into the inlet of our spec
99 ility to efficiently infect immature human DC, whereupon those DC were observed to undergo rapid acti
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