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1 aid of density functional theory calculations, which account for the observed trends and levels of en
2 determining migraine risk and characteristics, which accounts for sex differences, but there is also
3 oxic transcripts of Alu transposable elements, which activate the NLRP3 inflammasome and additional d
4 ntiferromagnetic corundum derivative Mn2MnWO6, which adopts the Ni3TeO6-type structure with low tempe
5 in leukocyte extravasation and transmigration, which advances our understanding of the complex contri
6 , the C terminus functions as a toggle switch, which affects access of the NADPH substrate to the enz
7 e population of the second bright pipi* state, which affects the dynamics, acting mainly as a "doorwa
8 entified with 70% sensitivity and specificity, which after the incorporation of apolipoprotein epsilo
9 e potent vacuolar-type H(+)-ATPase inhibitors, which all inhibited LGR5 internalization by blocking c
10 1 years of age) showed similar sulci patterns, which allowed us to delineate the mFPC areas in them.
11 iotin-independent malonate decarboxylase (MDC), which allows them to use malonate as the sole carbon
12 ith dimension around 30micromx7micromx5microm, which allows for label-free detection of explosive mol
13 provides the mechanism behind plate tectonics, which allows oceanic lithosphere to be subducted into
14 his includes communication between organelles, which allows them to function and adapt to changing ce
15 d with causative changes in the DNA methylome, which appears relatively impervious to drought stress.
18 oligonucleotides can form G-quadruplexes (G4), which are stabilized by the hydrogen bonding of guani
19 y emerges from interactions between molecules, which are challenging to elucidate with current techni
20 ffective target sites fall within two domains, which are conserved in sequence/structure indicating t
21 ligation, forming RNA-DNA chimeric sequences, which are converted to a sequencing library for paired
22 le in the graphitic regions of graphite oxide, which are dispersed and surrounded by sp(3)-hybridized
23 f the fate and transformation of IAPP in vivo, which are expected to have consequential bearings on I
24 ter-sized synthetic vesicles, or polymersomes, which are internalized by binding to scavenger recepto
25 inhibitors targeting the DUBs USP7 and USP10, which are involved in regulating levels of p53 and MDM
26 are the very early stages of protein folding, which are likely defined by intrinsic local interactio
27 ormation processing, particularly translation, which are maintained by strong selection, the average
29 kaloids, saponins, flavonoids, and terpenoids, which are most likely responsible for their biological
30 tails production of proinflammatory cytokines, which are otherwise detrimental for survival of the pa
31 particularly affected include rice and wheat, which are primary sources of dietary protein for many
32 humans: the classical inflammatory monocytes, which are rapidly mobilized upon inflammation in a CC-
34 cemaker-related issues, and remote monitoring, which are relevant to the practicing cardiologist.
35 ex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryo
36 wn to contain significant amounts of oxalates, which are toxic and, if consumed regularly, can lead t
37 ta from January 1, 1999, to December 31, 2015, which are weighted to be representative of each state
38 open-circuit potential decay transients (OCVD), which attributes to its higher Voc and ff in comparis
39 Anillin contains a RhoA-GTP binding domain, which autoinhibits the NLS and the neighboring microtu
40 functional theory (DFT)-optimized structures, which binds choline in a unique dual-site-binding mode
41 ither of two inhibitory regions, CBD and LAVP, which block substrate access to the substrate-binding
42 inhibitors and decreased p53 protein turnover, which blocked their tumorigenic capacity through cellu
44 lenge in treating cancers with targeted drugs, which by selecting for drug resistance can drive metas
45 -2.2 as a consequence of alternative splicing, which bypasses miRNA-mediated down-regulation under dr
46 llision is described in terms of matter waves, which can also scatter into the region of the geometri
47 vation, cleaves chem163S to generate chem158K, which can be further processed to the most active chem
49 t preferentially by oxidative phosphorylation, which can be maintained by bulk but not local monocarb
50 for a soluble, versatile, HBC-based platform, which can be tailored by incorporation of electroactiv
51 evelop arrays of varying sizes and geometries, which can offer practical solutions for large-scale ti
54 production data and environmental information, which cannot be related to the period in question.
55 and also agree with recent "magic ratio rules", which capture the role of connectivity in determining
58 tients and to identify, with high reliability, which cases should be referred to an ophthalmologist f
59 ment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquit
60 eptor-alpha (PML-RARalpha) oncofusion protein, which causes acute promyelocytic leukemia, inhibits TN
62 lutionary algorithm is proposed to train FCMs, which combines a dynamical multi-agent genetic algorit
64 a platform for perturbation analysis in vivo, which combines live imaging, real-time image analysis,
65 s ability is particularly critical in neurons, which comprise vast, highly differentiated domains suc
66 lair) were rarely detected in the other river, which confirmed that lake sturgeon in the Detroit and
67 in multiple major white matter fiber bundles, which connect the fronto-parietal control network and
68 the proteinaceous polymers are the collagens, which constitute the fibrous matrix outside cells and
69 discovery of the first doubly charmed baryon , which contains two charm quarks (c) and one up quark
70 g, highly tumorigenic glioma stem cells (GSCs), which contributes to tumor initiation and treatment r
71 human 28-day menstrual cycle hormone profile, which controls human female reproductive tract and per
72 Th1-characteristic trafficking receptor CXCR3, which correlated with significant impairment of renal
73 s obtained that binds Shh with a KD of 170 nM, which corresponds to a 120-fold affinity improvement c
74 ncrease requires increased trophic efficiency, which could arise because of ocean warming and DSL sha
75 higher rates of ESRD than HIV-positive whites, which could be attributed to the APOL1 renal risk vari
76 ve tool for investigating brain glycosylation, which could be developed in to brain mapping applicati
78 ns could vary in different signaling pathways, which could be related to conformational selection, si
79 ferase p300 acetylated in its activation loop, which could explain self-acetylation as an important f
81 te can form rapidly under oxidized conditions, which could help explain low concentrations of organic
82 causal chain between these complex phenotypes, which could inform and prevent disordered eating probl
83 ffects by combining daily global weather data, which creates exogenous variation in running among fri
84 electrical, and electromechanical properties, which delineate them from their bulk counterparts and
85 lotron Resonance-Mass Spectrometry (FT-ICR-MS), which delivered the molecular formulae and ion intens
86 nic relationship with instantaneous frequency, which depends on the gating rates of the fast voltage-
87 ith G. vaginalis and other anaerobic bacteria, which depleted tenofovir by metabolism more rapidly th
88 ogy in early-diverging Apicomplexan parasites, which do not divide by canonical binary fission but un
91 etically encoded actin-modifying polypeptides, which effectively induce actin disassembly in eukaryot
92 rates a considerable spontaneous polarization, which effectively tunes the electrical band bending of
93 ced fluorescence fluctuation imaging analysis, which employs statistical resampling to measure the Ep
94 vailable module of the popular PLUMED library, which enables the simultaneous determination of struct
95 CH cases are explained by mutations in TSEN54, which encodes a subunit of the tRNA splicing endonucle
96 ited inactivating mutations of the RASA1 gene, which encodes p120 RasGAP (RASA1), a negative regulato
97 Loss-of-function mutations in the MCOLN1 gene, which encodes TRPML1, cause the neurodegenerative lyso
98 located in one 15.5-Mb locus on chromosome 13, which encompassed the Bhmt gene and defined a potentia
101 ll supernatants produced extracellular matrix, which enhanced subsequent airway smooth muscle growth
103 and potent BTK kinase inhibitor (CHMFL-BTK-11) which exerted its inhibitory efficacy through a covale
105 th E-selectin than do circulating lymphocytes, which exhibit variable E-selectin binding among CD4(+)
107 ically motivated, Bayesian multitask approach, which explicitly models gene-centric dependencies acro
108 on with the adhesive glycoprotein fibronectin, which facilitates bacterial adherence to host cells.
109 pars compacta and the ventral tegmental area, which form the nigrostriatal, mesolimbic, and mesocort
111 ceptor (IR) and mannose receptor C-type 1 (MR), which functions to clear endogenous mannosylated prot
112 2 levels impair interaction of p62 with Keap1, which further decreases Nrf2 function and antioxidativ
114 ver, placebo-controlled oral gluten challenge, which had a fixed sequence, and biopsy cohorts had a g
115 activities were modeled by Bayesian inference, which had a top-down explaining-away effect that enabl
117 neering of herpes simplex virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomic
118 etermined whether a PCSK9 variant (rs11206510), which has been identified for early onset myocardial
119 posal is stratospheric aerosol injection (SAI), which has impacts analogous to those from volcanic er
120 Our data suggest a highly disordered CUB, which has acquired a state similar to that of intrinsi
121 The intermediate filament protein vimentin, which has been previously shown to affect vascular int
122 sequence with independent components analysis, which has been shown to have enhanced signal-to-noise
123 es a unique CPS locus with a mosaic structure, which has been stably maintained in all clone SA isola
124 specially for 20-hydroxyeicosatetraenoic acid, which has both vasoconstrictive and natriuretic action
126 the Asia-Pacific region, including in Vietnam, which has experienced a high burden of disease in rece
127 ssential for the homeostasis of primary cilia, which has important implications for human disorders r
128 ticularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug di
129 obscure class of cyclooctatetraenyl radicals, which have been impossible to access through classical
130 mediates have unique and interesting features, which have been partially revealed through spectroscop
131 ven major reductions in reef growth potential, which have declined from an average 4.2 to -0.4 mm yr(
132 e other 14 known galectins in mammalian cells, which have dimeric or tandem-repeated CRDs enabling mu
133 attentional modulation and mutual inhibition, which have distinct selectivity (feature vs. eye of or
134 sses that of commercial homogeneous catalysts, which have dominated this important industrial process
135 xposure have focused on high-income countries, which have much lower pollutant concentrations than lo
136 [X,Y-substituted 2,6-(pyrazol-1-yl)pyridines], which have produced 16 SCO-active [Fe(II)(bpp(X,Y))2]
138 A repair is a consequence of P62 accumulation, which impairs H2A ubiquitylation and perturbs ATM sign
139 number of fucose substitutions in C. elegans, which in part may be due to different methodological a
140 in part to epigenetic reactivation of ERalpha, which in turn increases TAM-dependent anti-estrogen ch
141 y follows its own specific substrate gradient, which in turn is produced by the preceding enzymatic r
142 ribution that creates large coherency strains, which in turn may promote crack initiation under load.
143 conserved mitochondrial targeting domain (MTD), which, in unstressed conditions, is inhibited by intr
144 plored Wnt-Frizzled and Wnt-SFRP interactions, which, in turn, may reveal further Wnt signaling pathw
146 uitary masses along with clinical correlation, which includes early involvement of ACTH and TSH and a
147 dentified using the National Cancer Data Base, which includes more than 70% of patients newly diagnos
149 it coupling in In0.75 Ga0.25 As quantum wells, which indeed can be tuned by the indium composition, s
150 tions of the two N-oxyl radicals with toluene, which indicate that the HAT process is characterized b
151 sition temperature of 320.16+/-0.35 degrees C, which indicated that there was good thermal stability
152 cross-linking of F57Bpa with KCNQ1 was slowed, which indicates that KCNE1 is displaced within the cha
154 activity of several kinases and phosphatases, which interact in a coordinated fashion to regulate ch
155 n-Seq is for identifying genetic interactions, which involves comparing Tn mutant libraries generated
156 are both accompanied by cell-wall remodeling, which involves the INFLORESCENCE DEFICIENT IN ABSCISSI
157 commonly known as the green peach aphid (GPA), which is an important phloem sap-consuming pest of mo
158 ng to high energies (>10 kilo--electron volts), which is ascribed to an accretion disk corona of ener
159 ta (TGFbeta)-activated kinase 1 (TAK1; MAP3K7), which is associated with poor survival in HCC and int
160 ia, wound infections, and cystic fibrosis (CF), which is caused by mutations of the cystic fibrosis t
162 as equivalent to 6.5 x 10(-11) mol m(-2) s(-1), which is over an order of magnitude greater than the
163 the fibronectin extra domain A isoform (FnEDA), which is relatively restricted in distribution to sit
164 fied in the genome of Pseudomonas sp. BIOMIG1, which is a bacterium present in various environments a
165 ssociated with smaller relative spleen weight, which is a documented consequence of chronic stress in
167 osition-based model, and termed as dMAGA-FCMD, which is able to deal with large-scale FCMs with up to
168 aph, a variant of the classic de Bruijn graph, which is aimed at 'detecting and genotyping simple and
169 spectroscopic imaging (5D EP-JRESI) sequence, which is capable of obtaining two-dimensional (2D) spe
170 represents a different class of 2D materials, which is characterized by low symmetry having 1D metal
171 5 billion of economic productivity every year, which is comparable to recent acute epidemics, includi
172 een shown to reduce cortical dopamine release, which is critically involved in the reinforcing effect
173 ukin (IL)-33 released from breast tumor cells, which is crucial for the induction of IL-13(+) Th2 cel
174 tenin-mediated anti-proliferation of GC cells, which is different from the canonical SOCE/Ca(2+)-indu
175 the need for spatial imaging of the 3D fields, which is difficult in high-energy physics and cosmolog
176 s on macrophages, hepatocytes, and adipocytes, which is distinct from the effect of STING activation
177 etermine that the frequency of the transition, which is driven by two photons from a laser at 243 nan
178 assembling the functional polymerase complex, which is essential for the replication and transcripti
179 cts with amines and ammonia to form particles, which is expected to be particularly important in coas
180 of these synapses leads to initial depression, which is followed by steady-state responses that are f
181 mour suppressor gene loci, most notably SMAD4, which is homozygously deleted in nearly one-third of c
182 n of an ultrathin titanium nitride (TiN) film, which is incorporated in a gated TiN/SiO2/Ag plasmonic
184 lized anaerobically via glycolysis to lactate, which is itself also a potential nutrient for tissues
185 lly precise memory of the location of shelter, which is laid down quickly and updated continuously.
186 ect way on a peculiar measure of tree balance, which is mostly determined by the root balance of the
188 ts C-terminus early in the maturation process, which is progressively removed as maturation proceeds.
189 active gibberellin, GA1, by UV-B in this zone, which is regulated, at least in part, by the expressio
191 EPSP at the soma of CA2 compared with CA1 PNs, which is sufficient to drive action potential output f
192 he effect of the HIV-1 auxiliary protein, Nef, which is suspected of extracellular release by infecte
195 tify the heritability of set-point viral load, which is the fraction of variation in this phenotype a
196 6-EC into cholestane-3beta,5alpha,6beta-triol, which is transformed into the oncometabolite 6-oxo-cho
197 etection for Pam3CSK4 attained was 7.5 mug/mL, which is within the same order of magnitude for that o
199 often require several days of turnaround time, which leads to compromised clinical outcome and promot
200 the crystal packing would improve solubility, which led to a change from N-methylpyridone to a tetra
202 ification of target-specific oligonucleotides, which limits genetics and genomics research on many sp
203 agnosis is time-consuming and labor-intensive, which limits the treatment efficiency especially when
204 number of CCS values are available for drugs, which limits the use of CCS as an identification param
206 o create stretches of phosphorylated residues, which may be a means to amplify signals or stabilize a
207 ression imaging marker of Parkinson's disease, which may be used in clinical trials of disease-modify
208 modulate N2O accumulation in denitrification, which may contribute to further design strategies to c
210 the transition between the two configurations, which may give rise to disease-associated repeat expan
211 udy validates the prognostic power of RETREAT, which may help standardize post-LT surveillance, provi
212 to deregulation of central metabolic pathways, which may identify potential therapeutic targets for t
213 n, in order to influence experimental efforts, which may in turn influence the outcome of cellular di
214 ons generates sparse and orthogonal AP firing, which may support sparse coding during hippocampal inf
215 mediated by an inability to recruit the dlPFC, which mediates the cognitive control needed to overcom
218 onclusion, CMMPs act as 'synthetic stem cells' which mimic the paracrine and biointerfacing activitie
220 ogenic population of human melanopsin-ir RGCs, which most likely are involved in different functions.
222 Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote
223 f the innate immune effector protein kinase R, which phosphorylates the eukaryotic initiation factor
224 es induces changes in the filter conformation, which play a key role in defining both selectivity and
226 TRA had increased intraepithelial neutrophils, which positively correlated with FEV1 %predicted (r =
227 arrangement inspires an attractive hypothesis, which posits that top-down beta-band influences direct
228 r, a higher transporter activity was observed, which possibly acted as a compensatory mechanism in th
230 are consistent with population genetic theory, which predicts that deleterious mito-nuclear interacti
231 ed major differences between the two diseases, which preferentially involve the PrP(Sc) component tha
232 n. nov., from the Early Cretaceous of Alberta, which preserves integumentary structures as organic la
233 G increased the number of circulating B cells, which produced elevated amounts of tumor necrosis fact
234 -derived DNA is sensed in the cytosol by cGAS, which produces the cyclic dinucleotide (CDN) second me
235 releasing neurons of the lateral hypothalamus, which promote the transition to wakefulness from non-r
236 g peripheral T follicular helper (pTfh) cells, which provide help to B cells for developing into Ab-s
237 as for genes SPAD follows a beta distribution, which provides a good description of empirical data an
238 hy of visual areas, dubbed the ventral stream, which rapidly computes object representations that are
240 The use of the licensed antibody palivizumab, which recognizes site II on both the pre-F and post-F
241 kinases, such as the LIM domain kinase (LIMK), which regulates actin activity through phosphorylatio
242 n the Debye screening layer of an electrolyte, which represents a key physicochemical surface propert
243 ons proceed within 10 min at room temperature, which represents among the mildest conditions reported
244 gulator of hermaphroditic cell identity tra-1, which represses the transcription of dmd-3 in hermaphr
245 equipment such as readers and imaging systems, which require intensive and time-consuming procedures.
247 10(9) cfu mL(-1) and 103.97 x 10(7) cfu mL(-1) which resulted in detection limits of 1.99 x 10(4) cfu
248 ement using (13)C-diazomethane" ((13)C-TrEnDi), which results in the methyl esterification of all aci
249 D27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activ
250 SLC45A3 and NDRG1 and other ETS family genes, which retained interstitial TMPRSS2/ERG sequences.
251 ents in La1.6-x Nd0.4Sr x CuO4 under pressure, which reveal a large and unexpected shift of p* with p
252 r transformed alternating current voltammetry, which revealed that the 2-methylimidazolate ligand is
253 encephalitis virus at near-atomic resolution, which reveals an unusual "hole" on the surface, surrou
254 conversion and vector polarization formation, which serve as bridges connecting conventional optical
255 are defective in patient-derived fibroblasts, which, similar to mouse neocortical progenitors, trans
256 ration of a dicentric chromosome intermediate, which subsequently undergoes a series of breakage-fusi
257 retions (commonly referred to as sex hormones), which substantially influence many aspects of metabol
258 -insoluble glucan production were all reduced, which suggested polysaccharide production was decrease
259 d by the most recent whole-genome duplication, which suggests that ancient paralogues can remain in t
260 go senescence in vascular sprouts and vessels, which suggests that pathologic outcomes of centrosome
261 inked in open and closed states, respectively, which suggests that their actions are mediated mainly
263 tionalized with polyclonal anti-M1 antibodies, which then serve to identify the universal biomarker f
265 upon Taxol-mediated microtubule stabilization, which, together with the signaling data, suggests that
266 tudies must therefore rely on patient samples, which typically display a low proportion of parasites
267 s is built upon studies of diatomic molecules, which typically have electronic states that are relati
268 th originates from semi-coherent precipitates, which unavoidably exhibit a heterogeneous distribution
270 A liver disease progression Markov model, which used a lifetime horizon and health care system p
271 resource for Estimates of Model Accuracy (EMA), which uses a pioneering hybrid quasi-single model app
272 previously described hemocompatibility score, which uses 4 escalating tiers of hierarchal severity t
273 ared the method of elastic net regularization, which uses repeated internal cross-validation to selec
274 yrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole a
275 model fits the observed GPP well (R(2) = 0.79), which was confirmed by other model performance checks
278 insulin, and GIP concentrations after surgery, which was accompanied by a marked augmentation of panc
279 s a composite of long-term CV events or death, which was assessed via national health care databases.
280 ents were found to possess an expanded allele, which was associated with a reduction in the quality o
282 XCL10, resulting in target-mediated clearance, which was corroborated using CXCL10-deficient mice.
283 ollowing silver nanoparticle (Ag NP) exposure, which was dependent upon key physicochemical propertie
285 se follicles were strongly positive for IL-15, which was primarily presented in its membrane-bound fo
286 d an increase in luciferase activity under HG, which was reduced after mutation of the Sp-1-binding s
287 ion, respectively, in the extracellular space, which we attributed to a residual calyx attached to th
288 ltiple features arising from the same analyte, which we call "degenerate features", using a context-d
290 , we estimate a common dose-response function, which we use to compute national electricity loads for
291 ed or suppressed oligomerization respectively, which we use to tune the levels of Raf/MEK/ERK signali
292 fied a small number of immunodominant regions, which were in functionally important locations on the
293 autophagy flux in response to hyperammonemia, which were partially reversed following 24-hour and 48
294 ive midzonal hepatocyte death in control mice, which were strongly minimized in HSC-depleted mice.
295 ing of arylenethynylene macrocycles with ODNs, which were used to mediate the assembly of gold nanopa
296 n retrospective measurements of peripouch fat, which will foster future investigation of the role of
297 echanisms of mutation-dependent drug response, which will have a significant impact on cancer precisi
298 ovel community assemblages in future climates, which will require a mechanistic understanding of the
299 NA nanostructures of various shapes and sizes, which would be an important advance for the field.
300 load of MJNV RNA in various tissues of shrews, which would reflect the dynamic infectious status and
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