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1 n activates the nuclear factor-kappaB pathway, which in turn accentuates the priming of Nlrp3, promot
2 ression and secretion of S100A12 by nearly 70%, which in turn activated dermal fibroblasts in vitro.
5 ligand binding to the receptor Patched (Ptch), which in turn activates Gli-mediated transcription th
6 ystem enhances the synthesis of sphingolipids, which in turn activates 3-phosphoinositide dependent p
7 anscription factors is induced by cold stress, which in turn activates downstream cold-responsive (CO
8 uits EspW to the site of bacterial attachment, which in turn activates Rac1, resulting in modificatio
9 aired strands and thus release its complement, which in turn activates the next droplet in the sequen
10 al hormesis by mildly inducing ROS production, which in turn activates the SKN-1/Nrf2 pathway and pos
11 HCV-exo carry miR-19a and target SOCS3 in HSC, which in turn activates the STAT3-mediated transformin
12 or necrosis factor alpha (TNFalpha) by ADAM17, which in turn activates TNF receptors and canonical NF
13 receptor CD36 (cluster of differentiation 36), which, in turn, activates a Nox2-containing NADPH oxi
14 its transcription as well as its translation, which in turn acts as a platform for the stabilization
15 ence adult phenotypes and social interactions, which in turn affect key evolutionary processes such a
16 tients with cancer affect treatment decisions, which in turn affect survival and health-related quali
17 roughness and formation of faulted structure, which in turn affect the mechanical deformation of Mg.
18 ma treatment time and precursor concentration, which in turn affect the nanocomposites electrical con
19 ensory neurons tuned to the expected stimulus, which in turn, affect the processing of subsequent sti
20 dramatically in its bonding to the framework, which in turn affects the crystal structure and electr
22 om temperature magnetic susceptibility tensor, which in turn affects the sign and magnitude of the ps
23 tes miR-17 approximately 92 in cystic kidneys, which in turn aggravates cyst growth by inhibiting oxi
24 individuals with high risks of breast cancer, which in turn aids in the individualization of treatme
25 causes the bacterial cell wall to break down, which, in turn, aids bacterial biofilm development.
26 lower background and much sharper Bragg peaks, which in turn allow more sophisticated analysis of mec
27 ly members with the TORC1 subunit Kog1/Raptor, which in turn allow the TORC1 proximal kinase Sch9/S6K
28 uses abnormal regulation of energy metabolism, which in turn allows cancer cells to survive under low
29 interface independent of the kernel structure, which in turn allows one to map out the respective rol
30 alignment within the composite microstructure, which in turn allows these materials to outperform equ
32 increases the activity of the LPS transporter, which in turn alters the permeability of the outer mem
34 l complications, and congenital malformations, which in turn are associated with increased risks of c
35 ightly controlled networks of gene expression, which in turn are governed by the availability of tran
36 decomposed into all its constituent sub-paths, which in turn are matched with corresponding gene expr
37 o chronic iron crystals within MI territories, which in turn are proinflammatory and favor adverse re
38 very early phase of CNS vascular development, which in turn are recruited from sites of embryonic he
39 tein and transcription factor B, respectively, which in turn are responsible for the loading of RNAP
40 two vacuolar H(+)-pumps, SlAVP1 and SlVHA-A1, which in turn are revealed as potential targets of SlC
41 mary production and are grazed by zooplankton, which in turn are suitably sized food items for predat
42 is important for production of cathelicidins, which in turn, are critical for antibacterial action.
43 an those found in both RASopathies and cancer, which, in turn, are generally more severe than those f
44 orated on the glassy carbon would be hydrated, which in turn assist to adsorb the uranyl sulfates thr
45 average pattern associated with that category, which in turn associated with stronger engagement of t
46 ated with reduced levels of physical activity, which, in turn, associates with the development of num
47 lusion of NDs increased the network stiffness, which in turn augmented the traction forces generated
48 nd methyl palmitate, attracting healthy flies, which in turn become infected and further enhance path
49 nthase (cGAS) binds to DNA and produces cGAMP, which in turn binds to stimulator of interferon genes
50 e-history changes allowed changes in learning, which in turn both allowed and rewarded extended life
51 dentity fusion" - a visceral sense of oneness - which in turn can motivate self-sacrifice, including
52 e triggered by DNA double strand breaks (DSBs), which in turn can be spontaneous or induced by extern
53 phB1) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B
54 stressors to affect immune system development, which in turn can affect brain development and its lon
55 lutants can alter the gut microbiota of hosts, which in turn can affect their health and immune syste
56 vironment suitable for efficient viral growth, which in turn can be a new target for treatment of sap
58 o extract phase information from the specimen, which in turn can be used to measure cell mass, volume
59 ion of a structure and its hydrodynamic ratio, which in turn can be used, for example, to compare a s
60 s food leads to intensification of production, which in turn can have a detrimental effect on quality
61 t mycorrhizal type mediates nutrient dynamics, which in turn can influence forest community structure
62 he quality of published food composition data, which in turn can lead to more accurate nutrient intak
63 corresponding adducts in good to high yields, which, in turn, can be easily converted into a wide ar
64 tive volume fraction of this stabilizer block, which in turn causes a reduction in the packing parame
65 the actin cytoskeleton and membrane dynamics, which in turn causes structural and functional changes
66 eorganize circadian phasing among SCN neurons, which in turn changes the period length of the network
67 f latent pro-matriptase to an active protease, which in turn cleaved the pericellular substrates prot
68 s into the biology of glycan-binding proteins, which in turn complicates the biomedical use of this c
69 atory region and induced Stc2 gene expression, which in turn confers cytoprotection to liver cells ex
71 d temperature variability and autocorrelation, which in turn contributed to persistent droughts in No
72 romotes a metabolic switch towards glycolysis, which in turn contributes to cellular differentiation
73 sults in an exacerbated activation of eNMDARs, which in turn contributes to diminished IA magnitude a
74 xcitatory synaptic strength in VTA DA neurons, which in turn contributes to PE-induced increase in ad
75 determinant of RNA transcription and splicing, which in turn contributes to variation in human traits
76 on of the constricted shape of the spine neck, which in turn controls communication between the synap
78 expression of the transcription factor optix, which in turn controls red pattern variation across He
80 activity in response to persistent DNA damage, which, in turn, controls ATF3 expression in affected c
81 of active TGFbeta by antigen-presenting cells, which in turn converted naive CD4(+) T cells into func
82 anges in the mechanical properties of tumours, which in turn could be related to the stages of tumour
84 ic arbors disrupt proper circuit connectivity, which in turn could contribute to neurodegenerative di
85 l role in setting the basal tonic firing rate, which in turn could control striatal dopaminergic sign
86 ntestinal proteases may enhance NanI activity, which in turn could further potentiate the activity of
87 diabetes mellitus and cardiovascular disease, which in turn could lead to reduced risk of downstream
88 LABA as a consequence of receptor cross-talk, which in turn could modify beta-2 receptor downregulat
89 ors (indels) in the consensus genome sequence, which in turn create significant problems for downstre
90 ads to the generation of beta-mercaptoethanol, which in turn decouples the conjugate acceptor to rele
91 odification in R-2HG-sensitive leukemia cells, which in turn decreases the stability of MYC/CEBPA tra
93 robabilities of conformations in the ensemble, which in turn, depend on the exact amino acid sequence
94 bials against P. aeruginosa biofilm formation, which in turn depends on the presence or absence of FB
95 tor-1alpha stability, and neutrophil survival, which in turn determine further myeloid cell recruitme
96 his variation depends on genetic architecture, which in turn determines responses to natural selectio
98 organization of surrounding solvent molecules, which in turn dictates the helical organization of the
99 s cellular glutamine metabolism and apoptosis, which in turn differentially impact cell proliferation
101 s activate AMP activated protein kinase (AMPK), which in turn directly suppresses sterol regulatory e
102 doping promotes the formation of formal Ni(4+), which in turn directly correlates with an enhanced a
103 Phosphorylated Akt induces let-7e expression, which, in turn, down-regulates TLR4 and further dimini
104 ies result in steep differentials in survival, which in turn drive hybrid zone movement for two woodr
106 resses led to increased secretion of IL-1beta, which in turn drove strong up-regulation of genes asso
107 he protein adsorption from surrounding medium, which in turn efficiently enhanced osteogenic differen
108 inity states of two different beta1 integrins, which in turn elicit distinct effector functions.
110 te synaptosome-associated protein 23 (SNAP-23), which in turn enables the formation of the SNARE comp
111 N deficiency results in stabilization of CHD1, which in turn engages the trimethyl lysine-4 histone H
112 ecules leads to increased spin-orbit coupling, which in turn enhances intersystem crossing rates in t
113 , USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephospho
114 UMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB
115 on, stimulating the transcription factor AP-1, which in turn enhances transcription of amyloid-beta p
116 ), probably present on the efferent terminals, which, in turn, enhances release of acetylcholine and
117 Is induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disea
118 ttern for its 3-5 hydrophobic anchor residues, which in turn explains the large array of peptide sequ
119 laviviruses because it binds Gas6 more avidly, which in turn facilitates its interaction with AXL.
120 vely activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migr
122 ance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional reg
123 rength affects the salt transport by the AMOC, which in turn feeds and sustains the strength of the A
124 endrites, as well as unlabeled axon terminals, which, in turn, form inhibitory-like synapses on audit
125 phocytes display a range of affinity for self, which in turn generates a range of tonic signaling.
127 dback loop maintains cytoplasmic Ca(2+) level, which in turn governs autophagic response through an A
128 ngs demonstrate that PLZF controls ROS levels, which in turn governs the inflammatory function of NKT
129 rder of identical nanostructures is difficult, which in turn has limited experimental verification of
130 targeted gene addition has proven challenging, which in turn has limited the capabilities of the RNP-
131 n oxygen availability and cellular metabolism, which in turn has significant effects on the functiona
133 led to increased reliance on genetic testing, which, in turn, has raised new diagnostic challenges.
134 produce already existing 'experimental models', which in turn, have an unclear accuracy to represent
136 fferent somatic variant calling methodologies, which, in turn, impacted associations with clinical ou
137 at oxytocin provokes the release of serotonin, which in turn impacts on the serotonin 1A receptor sys
138 umed more linear backbones relative to PhF2,3, which in turn impacts self-assembly and polymer chain
139 t help the comprehension of fruit development, which in turn, impacts the quality of the fruits.
141 stable, magnetically regulated accretion mode, which in turn implies the existence of magnetically ga
142 pects of the population correlation structure, which in turn improves population-coding abilities.
143 hich cell density activates the Hippo pathway, which in turn inactivates YAP, leading to changes in t
145 by an increase in temperature from 1970-2014, which in turn increased reference evapotranspiration (
146 s a risk factor for primary MDRO colonization, which in turn increased the likelihood of colonization
147 in part to epigenetic reactivation of ERalpha, which in turn increases TAM-dependent anti-estrogen ch
148 against women and further child maltreatment, which in turn increases the risk of experience or perp
149 but not IgG exposure by upregulating TNFalpha, which in turn induced MCP-1 production by monocytes an
150 through signaling at innate immune receptors, which in turn influence neuronal function not only thr
151 ttoral regions in spring (data from telemetry), which in turn influenced energy acquisition (data fro
154 d the activation of NADPH oxidase NOX2 in DCs, which in turn inhibited phagosomal acidification and r
155 eraction with SUMO-specific protease 1 (SENP1), which in turn inhibits SENP1-mediated de-SUMOylation
156 HIF-1alpha degradation through ubiquitination, which in turn inhibits metastasis of breast cancer cel
157 s to enhance the production of thrombopoietin, which in turn interacts with its cognate receptor c-MP
158 phosphorylated PS1, interacts with Annexin A2, which, in turn, interacts with the lysosomal N-ethylma
159 row and divide to release daughter merozoites, which in turn invade new erythrocytes perpetuating the
160 ive kinetic phenomena at the structural level, which, in turn, invites experimental realization and p
161 he slow suppression of free fatty acids (FFAs), which in turn is responsible for delayed suppression
162 on is a function of the lowest energy pathway, which in turn is a function of structural aspects of t
163 s associated with myenteric neurodegeneration, which in turn is associated with delayed colonic trans
164 ssociated with more selective cortical tuning, which in turn is associated with enhanced perception.
165 is regulated by the metalloprotease ADAMTS13, which in turn is conformationally activated by VWF.
166 te for directional delamination and migration, which in turn is essential for peripheral nervous syst
167 tion depends on the dynamics of crack hopping, which in turn is influenced by the presence of shear b
169 icytes are required for post-SCI angiogenesis, which in turn is needed for fibrotic scar formation.
170 y follows its own specific substrate gradient, which in turn is produced by the preceding enzymatic r
171 mation of a detyrosinated-microtubule network, which in turn is required for localization of APC-depe
172 mplex, the NCD promotes ABL kinase activation, which in turn is required to activate VEGFR2-recruited
173 op-down executive control at rest (left dlPFC), which, in turn, is associated with improvements in a
174 e target cells is dependent on EV composition, which, in turn, is determined by the cell of origin an
175 nique chromatin structure at active enhancers, which, in turn, is required for regulation of target g
176 d or followed by a state of immunosuppression, which in turn jeopardizes the host's ability to combat
177 nd decreased the number of regulatory T cells, which in turn killed a larger number of cancer cells,
178 in microglia and elevated TNFalpha signaling, which in turn lead to hyperexcitability of medium spin
179 ing system and altered cell wall architecture, which in turn lead to increased susceptibility to host
180 specific recognition of target dsDNA (dsDNA-T), which in turn leads to the formation of a high densit
181 of methionine metabolic genes to increase SAM, which in turn leads to an increase in global H3K4me3.
182 nction via mitochondria-nucleus communication, which in turn leads to either a thermogenic or storage
184 n in individuals infected with these subtypes, which in turn leads to greater opportunity for transmi
185 so show that SPRY2 is targeted by microRNA-21, which in turn leads to increased activity of Syk and E
186 s differentially modulate emotional processes, which in turn leads to irrational choice behavior.
187 in alpha-ketoglutarate, a substrate for OGDH, which in turn leads to mTORC1 activation and a subsequ
189 d expression of with-no-lysine kinase 1 (WNK1), which, in turn, leads to increased activity of serum
190 product (ADP + Pi) is followed by ATP uptake, which, in turn, leads to the torque generation step an
192 verexpression led to downregulation of TRIP12, which in turn led to increased RNF168 levels, represse
193 y activating its internal ribosome entry site, which in turn led to increased secretion of laminin-11
194 relations between sickness funds and doctors, which in turn led to the right for insured individuals
195 ding GMP patches forming defined GMP clusters, which, in turn, locally differentiate into granulocyte
196 escape from treatment and to liver metastasis, which in turn makes pancreatic ductal adenocarcinoma (
197 section) is thought to affect gut microbiota, which in turn may affect psychological well-being.
198 ne event causes one or more subsequent events, which in turn may cause further events in a chain reac
199 endothelial cells, astrocytes, and microglia, which in turn may contribute to BBB disruption and enc
200 titutive activation observed in these B cells, which in turn may contribute to the hyporesponsiveness
201 ribution that creates large coherency strains, which in turn may promote crack initiation under load.
202 sed to represent reward signals more strongly, which, in turn, may contribute to unhealthy eating beh
203 plored Wnt-Frizzled and Wnt-SFRP interactions, which, in turn, may reveal further Wnt signaling pathw
204 n functional brain connectivity at school age, which in turn mediates influences on child negative mo
205 ion of the ET-B receptor in endothelial cells, which in turn mediates the decrease in extracellular E
206 responsible for driving the production of TNF, which in turn mediates the development of herpetic neu
207 lycine-aspartic acid (RGD) binding site in FN, which, in turn, mediates cell signaling in physiologic
208 versity contributes to altered brain function, which in turn moderates the emergence of general liabi
209 and cholesterol by influencing gut microbiota, which in turn modulate intestinal gene expression.
210 ecruitment of MSCs to the site of skin injury, which in turn modulates inflammatory responses by dire
211 ese are preferentially active in the germline, which, in turn, mounts defenses that restrain their ac
212 ickly than the paxillin-rich adhesion plaques, which in turn move more quickly than the local matrix,
213 cleaved; CO relocates to a new site near CuB, which, in turn, moves closer to the heme a3 iron by ap
214 d control outperforms variable radius control, which in turn outperforms constant radius removal.
215 (mitogen-activated protein kinase 14 [MAPK14]), which in turn phosphorylates NR4A1, resulting in nuc
216 thern Hemisphere, affecting wildfire activity, which in turn pollutes the air and contributes to huma
217 C activity modified CA1 codes during learning, which in turn predicted how quickly rats adapted to su
218 he slope of sleep slow waves during the night, which in turn predicted reduced daytime learning.
219 tization to several D pteronyssinus molecules, which in turn predicts current mite-related AR and cur
221 ion leads to abnormal repolarization in HFpEF, which in turn predisposes to VA and sudden cardiac dea
222 rge volcanic eruptions produce sulfur dioxide, which in turn produces aerosols; these eruptions thus
223 projects primarily to perirhinal cortex (PRC), which in turn projects to lateral entorhinal cortex (
224 nd secretion of multiple cytokines/chemokines, which in turn promote the differentiation and accumula
225 he accumulation of the polar lipids in leaves, which in turn promoted a higher growth rate compared w
226 ulted in mTORC1-dependent anabolic metabolism, which in turn promoted expression of M-CSF receptor an
227 production of the CXCL13 by TME stromal cells, which in turn promoted ILC3-stromal interactions and p
228 ated macrophages in a TLR7/8-dependent manner, which in turn promoted liposarcoma cell proliferation,
229 l upregulation of the NFkappaB modulator NEMO, which in turn promotes expression of the tumor suppres
230 complex leads to longer and fragile telomeres, which in turn promotes genomic instability and cancer.
231 myosin Dachs at the apical junctional region, which in turn promotes growth by inhibiting Warts.
232 pendent kinase II (CaMKII) phosphorylates OGT, which in turn promotes O-GlcNAc modification and activ
233 on of myogenic genes by directly binding MyoD, which in turn promotes the assembly of the MyoD-Baf60c
235 nillin ANI-2 at the stable cytoplasmic bridge, which in turns promotes the accumulation of the nonmus
236 vator of nuclear factor kappa-B ligand (RANKL), which, in turn, promotes the periodontal bone loss vi
237 s p300 HAT activity on histone H3K18 residues, which, in turn, promotes CARM1 methylation activity on
238 aves CD62L from the surface of CD8(+) T cells, which in turn provide a signal for T cells to leave th
239 ethod on LCO to create more active edge sites, which in turn provides a strong evidence for the theor
240 receives bilateral input from the lateral IP, which in turn receives bilateral input from the dorsal
241 ary response gene 88 (MyD88), to the membrane, which in turn recruit IRAKs via the death domains in t
242 inducing the production of the chemokine CCL2, which in turn recruited circulating CCR2(+) monocytes
244 on of autocrine IL-6 and IL-21 in 2D2 T cells, which in turn reduced their Th17 differentiation.
246 complex dissociation and EZH2 downregulation, which in turn reduces EZH2-mediated H3 trimethylation.
247 d increases PG activity in Arabidopsis leaves, which in turn reduces leaf pectin content and leaf rob
249 are expected to be carriers of this mutation, which in turn reduces the utility of identifying carri
250 or that triggered downstream regulatory genes, which in turn, regulated downstream metabolic pathway
252 r (GR), a ligand-induced transcription factor, which in turn regulates genes that induce leukemic cel
253 and its anchor, Cut8, at the nuclear envelope, which in turn regulates proteostasis of certain inner
254 associates with the Ptpn11 (Shp2) phosphatase, which in turn regulates ShcD tyrosine phosphorylation.
256 and p38 MAPK, and target gene integrin beta8, which in turn regulates vascular TGF-beta signaling.
258 tes a spatially graded centripetal actin flow, which in turn reinforces the contraction via myosin re
259 to be a function of temperature and thickness, which, in turn, relate to ionic mobility and different
260 States primarily relies on wet-cooled plants, which in turn require water below prescribed design te
262 ons requires understanding this heterogeneity, which, in turn, requires characterization of individua
263 e to early deteriorations in hepatic function, which in turn result in metabolic disease such as hepa
264 anied an overactive anterior cingulate cortex, which in turn resulted in a high level of PNS activity
265 neven spherical shapes of the starch granules, which, in turn, resulted in reduced starch susceptibil
266 ds to reduced ferroportin 1 (FPN1) expression, which in turn results in decreased cellular iron expor
267 lization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transc
269 leads to a reduced vascular basement membrane, which in turn results in enhanced dorsal aorta vessel
270 to the frequent abortion of septum synthesis, which in turn results in the production of long spore-
271 tory increase in the use of other antibiotics, which in turn selects for the emergence of different M
272 lex organizes spindle and astral microtubules, which, in turn, separate replicated chromosomes accura
273 are and stabilize with appropriate dispersion, which in turn severely limits their catalytic function
274 al fission regulator and a target gene of p53, which, in turn, severely affected chlamydial growth an
275 n of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity i
276 ch metal ions stabilize the amyloid structure, which in turn shapes the ligand geometry and catalytic
277 s increases so does the positive charge at Lu, which in turns shortens the Lu...Cgamma distance.
278 oderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2.
279 ntrols the expression domains of target genes, which in turn specify the position of wing veins.
281 s responsible for resorbing the necrotic bone, which in turn stimulated the deposition of a new bone
282 okes increases in astrocyte calcium signaling, which in turn stimulates COX-1 activity and generates
283 lphavbeta3, promotes upregulation of survivin, which in turn supports anchorage-independent growth of
284 e-defining transcription factor for Th1 cells, which in turn supports IFN-gamma production in a feed-
285 arbon metabolism to drive trehalose synthesis, which in turn supports survival by providing an energy
286 activates synthesis of JH in the mated female, which in turn suppresses resistance to infection throu
288 f TTF moieties changes the linker flexibility, which in turn switches the breathing behavior of 2.
289 croRNA (miRNA) expression profile of the host, which, in turn, through regulation of the host inflamm
290 n of transgenic alphabeta and gammadelta TCRs, which in turn translated to a stronger, and more polyf
291 tivation and paxillin phosphorylation on S126, which in turn triggers a higher expression of cyclin D
292 ogenetic growth in size and spatial movements, which in turn underpins their relatively low reproduct
294 bit yeast target of rapamycin (TOR) complex 2, which, in turn, upregulates or downregulates the activ
295 mouse cells by promoting TGF-beta activation, which in turn was mediated by upregulation of integrin
296 synthase, NO production, and p38 MAPK pathway, which in turn was responsible for the increased H3K9me
297 in the downregulation of Mmp-2 transcription, which, in turn, was dependent on P53 activity both in
298 likely to cause low level of oxidative stress, which in turn will contribute to, and indeed may be th
299 biome manipulations and management strategies, which, in turn, will pay dividends for both the consum
300 nd heating of the lower tropical stratosphere, which, in turn, would increase water vapor concentrati
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