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1 on impairs ciliary motility, and polycystin-2, whose ablation is associated with hydrocephalus are co
2 e anaphase promoting complex/cyclosome (APC/C), whose action is necessary for anaphase initiation.
3 as a critical regulator of matrix degradation, whose actions converge on the dynamics and degradative
4 scription factor, the vitamin D receptor (VDR), whose activating ligand vitamin D has been proposed a
5 ng (SREBP) transcription factors SREBP1 and 2, whose activation and mRNA expression are stimulated by
6 euronal subset, predominantly in the left dHb, whose activation is correlated with resumption of swim
7 res the engagement of a far-upstream enhancer, whose activation is strongly dependent on the AP1 fact
8 t proteins including the central component C3, whose activation products can mediate tissue inflammat
9 plexes, mTOR complex 1 (mTORC1) and 2 (mTORC2), whose activities and substrate specificities are regu
10 s effectuated by auxin response factors (ARFs) whose activity is repressed by Aux/IAA proteins under
11 acter crescentus identifies a novel NAP (GapR) whose activity over the cell cycle is shaped by DNA re
12 limbic region, the basolateral amygdala (BLA), whose activity fluctuates across the estrous cycle du
13 n neurons of the cerebellar nuclei (CbN cells), whose activity generates movement, are inhibited by P
14 rolled mainly by pectin methylesterases (PMEs), whose activity is posttranscriptionally regulated by
15 novel families of microbial carboxylesterases, whose activity could not have been predicted using bio
16 the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their l
18 ins are ubiquitous pro-inflammatory proteases, whose activity is controlled by calpastatin, their spe
19 ith IPOD sites or with PB/SG requires the PLD, whose activity is differentially regulated by the Ndr/
20 uted to a Deltex2 interacting protein, Jmjd1c, whose activity is directly inhibited by Deltex2 and wh
21 matergic pyramidal neurons located in layer 3, whose activity is modulated by local inhibitory gamma-
22 Thus, the SAC is highly responsive to Mps1, whose activity peaks in early mitosis as a result of i
23 ic impact on gene expression was seen for KMO, whose activity promotes the production of neurotoxic q
24 ioral responses depended on the TRPA1 channel, whose activity responded to the rate of temperature in
25 population of dorsal raphe serotonin neurons, whose activity we could link to normal reversal learni
26 endent inactivation of L-type Ca(2+) channels, whose alteration contributes to the dramatic disease T
27 ize, and protein levels follow a daily rhythm, whose amplitude depends on both feeding-fasting and li
30 otein (CA) assembles into polymorphic capsids, whose architecture, assembly, and stability are still
31 LZ can form micron-scale structures with CM2, whose assembly is stimulated by Plk1 phosphorylation i
32 ins, including Akap450, Pcm1, and Pericentrin, whose association with Nesprin-1alpha is increased in
33 pontine inputs: abducens internuclear neurons, whose axons course through the medial longitudinal fas
34 and neurons in the lateral vestibular nucleus, whose axons project through the ascending tract of Dei
35 ng in part through interaction with arrestins, whose binding promotes receptor internalization and si
36 ubstrate of the RNA pyrophosphohydrolase RppH, whose biological function was previously assumed to be
37 tivated outward rectifying K(+) current, IK,L , whose biophysical properties and molecular identity a
38 axosomatic terminal in the auditory brainstem, whose biophysical properties have been well studied in
39 budding yeast and identify 200-kb scale TADs, whose boundaries are enriched for transcriptional acti
40 s containing chemically different side chains, whose break-down products are involved in stress respo
41 ular neoplasm, found in bones and soft tissue, whose cause is currently unknown, but may involve onco
42 multi-organ system failure, sepsis, or cancer, whose cause of death was consistent with organ donatio
43 rial enzyme, conserved across all vertebrates, whose cellular activity and pathway assignment are unk
44 to measure tumor cellular glutamine pool size, whose change might reveal the pharmacodynamic (PD) eff
45 cial insects, including ants, bees, and wasps, whose chemical communication systems have been well-ch
46 (13)C CPMAS shows two neighboring resonances, whose chemical shifts are consistent with carbamate (a
47 GR preferentially occurs via distal enhancers, whose chromatin accessibility is typically cell type-s
48 rs with positively charged N-terminal anchors, whose cleavage via the prepilin peptidase, essential f
50 f Fusarium graminearum GSK3 homolog gene FGK3, whose coding products also shows the similar cytoplasm
51 Some of the tRNAs represent rare tRNA species, whose codons are overrepresented in the viral genome.
52 ed using a variety of neuroimaging techniques, whose combined use can be particularly useful for unde
53 ontrasts with that of a para-connected parent, whose conductance is unaffected by heteroatom substitu
54 nction are dependent on the bacterial S-layer, whose constituents assemble by binding to the secondar
56 ving learning and data-acquisition mechanisms, whose coordinated action is critical for building an e
58 ce is dependent on the geometry of the embryo, whose curved surface is taken into account in the simu
60 d to rolling contacts that are about to slide, whose density is described by a nontrivial exponent [F
61 nates near and around chevron-shaped features, whose density is greatly increased for higher contents
62 iapoptotic member of the BCL-2 protein family, whose depletion causes apoptosis in rodent beta-cells
64 ween microRNA (miRNA) and messenger RNA (mRNA), whose deregulation may be sensitive to environmental
65 using primers that flanked germline mutations, whose design did not rely on prior knowledge of revers
66 ith a specialized cell called an appressorium, whose development is tightly regulated by MAPK signali
67 ignificant with regard to the corpus callosum, whose development undergoes several dynamic stages inc
68 n Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5(1/2) years
69 en blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood ce
71 ormation of triplet alpha,2- and alpha,4-DHTs, whose diradical reactivity led to both radical and pol
72 ose Children with acute myeloid leukemia (AML) whose disease is refractory to standard induction chem
73 r patients with hepatocellular carcinoma (HCC) whose disease progresses during sorafenib treatment.
74 enance, bioenergetics and cell-cell signaling - whose disrupted expression is linked to human disease
76 limatically determined upper and lower limits) whose distributional shifts are well characterized, th
77 rm generated by alternative 3'-end processing, whose divergent C terminus shares the CBD common to al
78 aired DI splicing affects proliferation genes, whose downregulation coincides with cell cycle defects
79 muscle requires p21-activated kinase-1 (PAK1), whose downstream signaling triggers actin remodeling,
80 key processes (among the 90 modeled processes) whose dysregulation may lead to pathological scarring
82 epressions several tens of centimetres across, whose edges grade into spires up to several metres tal
83 nhanced pain may be reduced not by analgesics, whose effectiveness is reduced, but by increasing aler
85 amine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive re
86 ilayer attached to a viscoelastic gel (lamina) whose elasticity and viscosity primarily depend on the
87 ardia, is caused by the S672R mutation in HCN, whose electrophysiological phenotypes include a negati
88 of endogenous neurotoxin quinolinic acid (QA) whose elevated level in serum is marker of many neurol
91 liferator-activated receptor gamma (PPARgamma), whose endothelial expression and activity are decreas
92 ur-subunit chromosomal passenger complex (CPC), whose enzymatic subunit is Aurora B kinase, promotes
94 's largest continental flood basalt provinces, whose eruption played a role in the Cretaceous-Paleoge
95 ed from the omega-3 docosahexaenoic acid (DHA), whose esterified form is transported by the major fac
97 silent synapses in the nucleus accumbens (NAc), whose eventual unsilencing/maturation by recruitment
98 igh-frequency RF GaN devices are demonstrated, whose exceptional performance is enabled by epitaxial
99 a cellular subdomain within the midhypocotyl, whose expansion drives the final step of this developm
100 ALL SCP1-LIKE PHOSPHATASE14 locus (imRNASSP14 ), whose expression originated from the 5' region of a
101 Moreover, we found that miR-23a and miR-23b - whose expression was increased in the early stage of
102 ting hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume.
103 a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression directly correlates with aggressive
104 lated genes with shared cis promoter elements, whose expression can be controlled positively or negat
105 identify a long noncoding RNA, named Chronos, whose expression in muscle is positively regulated wit
106 pathways, including CADM1, SPHK1, and YAP/TAZ, whose expression independently predicted survival.
107 oniae by expression of the zinc exporter CzcD, whose expression is activated by the novel TetR-family
108 n-enriched, neuron-specific miRNA, miR-124-3p, whose expression is highly dysregulated in stressed ro
109 s to the later myofibril breakdown by enzymes, whose expression is increased by the paired box 4 (PAX
110 show that Syk is a direct target of miR-146a, whose expression is indirectly regulated by Meis1 thro
111 e a family of 18 proteins of unknown function, whose expression is largely restricted to epidermis.
112 eptor that binds human genome-encoded ligands, whose expression is negligible in normal tissues, but
113 vitro Mechanistically, we found that miR-130, whose expression is up-regulated in adipose tissues of
115 We identified an oncogenic mutation, F247L, whose expression robustly activated the MAPK pathway a
116 P. aeruginosa heparinase-encoding gene, hepP, whose expression was significantly enhanced when P. ae
117 variant in a female patient with mild anemia, whose father also carries the trait and is from the Tu
118 rion outer membrane and the parasite pellicle, whose features suggest the presence of membrane contac
119 is the European gypsy moth (L. dispar dispar), whose females are flightless, the two Asian subspecie
120 genes, RPL35a and RPL23, and ferredoxin, FDX1, whose flanking regions including promoters, terminator
121 phoretic force is due to the flexural phonons, whose flow is known to be ballistic and distance-indep
122 proved biofouling resistance in the membranes, whose flux had a decline of 8% after 24 h of operation
124 ion is enaminic 2,3-dehydropipecolic acid (DP), whose formation involves consecutive transamination,
125 taining both a fixing and a non-fixing strain), whose frequency could be predicted using a simple dif
130 , produces a cytotoxic macrolide, mycolactone, whose function(s) in the environment remains elusive.
131 lisation is governed by transcription factors, whose functions and essentiality differ between fungal
132 wo mammalian isozymes, GSK3alpha and GSK3beta, whose functions remain ill-defined because of a lack o
133 rs3740394, rs3740393) were located near AS3MT, whose gene product catalyzes methylation of iAs to MMA
134 the cloning of avirulence genes PWT3 and PWT4, whose gene products elicit defense in wheat cultivars
135 Caribbean and Pacific Coral Sea water samples, whose geographical patterns of diversity and read abun
136 istry have exploited strong directional bonds, whose geometric reliability lends predictability to so
137 urther demonstrate that co-disruption of Apob, whose germline loss is embryonically lethal, completel
138 ogen responsible for dengue hemorrhagic fever, whose global incidence has increased dramatically over
139 ventral tegmental area (VTA) dopamine neurons, whose glutamate afferents react robustly to cocaine.
140 del is that during anaphase, "free" importins, whose gradient inversely correlates with active Ran an
142 ion is caused by the reduction of CO2 into CO, whose high affinity with platinum triggers the formati
143 cesses and facilitates access to GPU clusters, whose high-performance processing power makes simulati
144 ariable temperate phages, like GIL16 or Bam35, whose hosts are Bacillus cereus and related Gram-posit
145 n terms of their dynamic community structures, whose identification however relies on a priori assump
146 rily coordinated by Zn(2+) transporters (ZnTs) whose identity and role in the heart are not well esta
147 sses after eradication of HCV with interferon, whose immunomodulatory activity might contribute to th
149 x is organized into specialized sensory areas, whose initial territory is determined by intracortical
150 uire heterotrimeric Galphai protein signaling, whose intensity and duration are controlled by the reg
151 proximity with subunit gamma residues 104-109, whose interaction may influence the rotation of the ca
152 ur types express extensive repertoires of NRs, whose interactions provide multiple paths for disease
153 S2 ligands and redox-active, nitrosyl ligands, whose interplay guides the H2 production mechanism.
154 ntanglements from newly incorporated monomers, whose key features can be recapitulated with molecular
155 ixed creole-speaking population of Cape Verde, whose Kriolu language traces to West African languages
158 by GSK-3, with approximately 47 proteins (1.4%) whose levels increased and approximately 78 (2.4%) wh
159 okines, growth factors, and apoptosis markers) whose levels were significantly higher in serum before
160 tion transfer, allowing extracellular ligands, whose levels are also subject to noise, to incremental
161 g information about the prospective recipient (whose life was saved by the donation) increased the pa
162 the most extensively studied betaAR, beta2AR, whose ligands are used for asthma and cardiovascular d
163 ing white dwarf in the binary system MV Lyrae, whose light curve displays quasi-periodic bursts of ab
166 e or its connection to fibrillin microfibrils, whose major component, fibrillin-1, is genetically ass
167 nt an opportunity for new therapeutic targets, whose manipulation could be used to mitigate ophthalmi
168 ional subspace of a higher dimensional system, whose manipulation requires precise control over the w
170 sted of 7 participants (5 females and 2 males) whose mean (SD) age at the most recent examination was
171 of the terpenoid synthase superfamily (CL0613) whose members have a characteristic alpha terpene synt
172 equent inactivation of phospholipase A2 (PLA2), whose metabolites are known to modulate ion channels.
173 r can be extended to saprophytic mycobacteria, whose more complex genomes encode more Mce systems, we
175 rs of expansion mutations in the C9orf72 gene, whose motor and cognitive-behavioural symptoms span a
176 ase-2 is a pro-inflammatory and cancer marker, whose mRNA stability and translation is regulated by t
177 pical chemokine receptor 1 [duffy blood group]) whose mRNA transcript levels in plasma exosomes signi
178 ons and verify cell viability in our platform, whose multiplexing and integration of numerous steps a
179 ) are DNA photoproducts linked to skin cancer, whose mutagenicity depends in part on their frequency
180 ZMs involved genes (SCN2A, HNRNPU and SMARCA4) whose mutation is known to cause ASD or other neurodev
181 agent is based on silver nanoparticles (AgNP), whose nanoplasmonic properties and safe use in bioapp
182 Magnificent frigatebirds (Fregata magnificens) whose nestlings have experienced high mortality rates
183 ion changes, revealed an edited mRNA, clec-41, whose neural expression is dependent on deamination.
184 ogically classified by topological invariants, whose non-zero value guarantees the presence of robust
186 d nitrogenous disinfection byproducts (N-DBPs) whose occurrence in drinking waters has recently been
188 genome is made of transposable elements (TEs), whose ongoing activity continues to impact our genome
189 context, ultralow threshold polariton lasers, whose operation relies on Bose-Einstein condensation o
190 l forming tubulin-like dynamic protofilaments, whose organization in the Z-ring is an unresolved prob
191 ity of states (LDOS) near a magnetic impurity, whose orientation may be controlled by an external mag
193 es two main functionally specialized lineages, whose origins and differentiation pathways remain inco
194 s a cell cycle-regulated transcription factor, whose over-expression is a marker for poor outcome in
196 a zinc finger transcription factor, OsGATA12, whose overexpression causes increased leaf greenness,
197 The effector caspase is recruited through PYD, whose overexpression induced pyroptosis but only after
198 are important reactive oxygen species targets, whose oxidation results in rapid, reversible, catalyti
201 a universal approximator of dynamical systems, whose performance often depends on sensitive hyperpara
202 evident from a charge density wave transition, whose periodicity is given by kF/pi, consistent with s
203 ence of cannabinoids, unique natural products, whose pharmacology is going to gain increasing interes
204 agating combustion synthesis (SPCS) technique, whose phase constitutions were identified as Ca9Al6O18
207 a photoluminescent uranium organic framework, whose photoluminescence intensity can be accurately co
209 the groundwork for further studies of CNbeta1, whose physiological substrates are currently unknown.
212 large number of genomic fragments (scaffolds), whose positions and orientations along the genome are
213 at 1- to 2-kb genomic regions termed hotspots, whose positions and activities are determined by PRDM9
214 t promising combinations is sulbactam-ETX2514, whose potent antibacterial activity, in vivo efficacy
215 Lon recognizes HspQ via a C-terminal degron, whose precise presentation, in synergy with multiparti
216 two genes lngR and lngS in the Longus operon, whose predicted products share homology with transcrip
217 he contribution of its Sac phosphatase domain, whose preferred substrate is PI4P, remains unclear.
218 mides as novel reversible inhibitors of KDM1A, whose preliminary exploration resulted in compound 2 w
219 oupling with the antenna via plasmonic states, whose presence increases the local density of states.
220 latter also identified the RNMT cofactor RAM, whose presence is required for cytoplasmic cap methylt
221 family of actin-depolymerizing factors (ADFs), whose primarily function is to regulate the severing
222 ion of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 predisposes to
225 of the adenomatous polyposis coli (APC) gene, whose product is an important component of the destruc
226 fied in Myh9, Ppp1r12a, Ppp1r12b and Trp53bp2, whose products have been implicated in the regulation
227 y give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types.
228 ti-species microbial communities (microbiomes) whose properties may result from inter-species interac
229 ly, membranes can be viewed as complex fluids, whose properties are linked to key biological function
230 In contrast to classical critical systems, whose properties depend only on symmetry and the dimen
231 sibility to create novel functional materials, whose properties transcend those of their constituent
235 eins combine to form anthrax lethal toxin (LT), whose proximal targets are mitogen-activated kinase k
236 iolated aptamer and 6-mercapto-1-hexanol (MCH), whose ratio was optimized by electrochemical impedanc
237 simulating the present-day SPG stratification, whose realistic reproduction appears a necessary condi
238 r proteins to their numerous partner proteins, whose recognition motifs undergo an extensive disorder
239 mosomes, but not for the mitochondrial genome, whose reconstruction still represents a significant ch
241 was also demonstrated for serotypes 8 and 31, whose reducing end sugars are glucose and galactose, r
242 and efficient n-doping of host semiconductors, whose reduction potentials are beyond the thermodynami
243 ancing regeneration of dorsal root (DR) axons, whose regenerative capacity is particularly weak.
244 ependent myeloid system of tissue macrophages, whose regulation by local microenvironments remain und
245 yotic AMPK exists as alphabetagamma complexes, whose regulatory gamma subunit confers energy sensor f
247 a and Rhg4 alleles, and PI 88788-type soybean, whose resistance requires only the rhg1-b allele.
248 a non-conserved motif ((153)ESEEKAWQKLCSL(165)), whose role was recently shown to be critical for its
249 alysed by poly-ADP-ribose polymerase 1 (PARP1), whose role in gene transcription modulation has been
250 , velocities and stresses of dynamic ruptures, whose rupture speed range from sub-Rayleigh to supersh
251 of tocochromanol accumulation in major crops, whose seeds are nonphotosynthetic, remains limited.
252 s as a unique catalyst for dioxygen reduction, whose selectivity can be changed from a preferential 4
253 n early pioneer and codiscoverer of B-1 cells, whose seminal contributions enhanced our understanding
254 small number of primary DCC recruitment sites, whose sequence and genomic context are X-specific.
255 xperiments yielded several novel IAPP analogs, whose sequences are highly similar to that of IAPP but
256 ke, StFAR3, StCYP86A22 and StPOD72-like genes, whose sequences suggest that they may be closely relat
258 in a tube to obtain a total of 370 seedlings, whose shoot and taproot lengths were measured repeated
259 rence to Zta Ser186 (a unique residue for Zta) whose side chain hydroxyl oxygen atom interacts with t
260 ersible temperature-induced volume transition, whose sign depended on the valency of the solvent.
261 umor samples revealed the presence of nucCD24, whose signal intensity correlated positively with the
262 by proteins with an ETS domain, such as ETV6, whose single DNA-binding domain cannot contact both so
263 er particles needed for photonic applications, whose size must be comparable to the wavelength of vis
264 a wide range of jobs, and synergistic workers, whose skills are useful in combination and fill a hole
265 ing from skill diversity: jacks-of-all-trades, whose skills can be applied independently on a wide ra
266 ere found in a centro-parietal scalp location, whose slope depended on change size, consistent with s
270 nd to associate with mild or supportive winds, whose speed and direction may change under global warm
271 DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruple
272 sis factor receptor superfamily molecule GITR, whose stimulation is closely linked to thymic Treg cel
273 nihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million
275 ve antagonists SB269,652 (1) and SB277011A (2) whose structural similarity and pharmacological dispar
276 permeable, low-density (semi-dilute) liquids, whose structural features are likely to strongly impac
278 meshwork at the T cell immunological synapse, whose structure has been shown to be important for T c
279 inal biradicals of TTT-NN, TPT-NN, and PPP-NN, whose structures and molecular packing were examined b
280 es are often described as supercooled liquids, whose structures are topologically disordered like a l
281 cylindrical micelles, and stacks of bilayers, whose structures responded to atmospherically relevant
282 We applied PRT to the Pro/N-end rule pathway, whose substrates include the short-lived Mdh2 malate d
283 tified 5 genes (PIM2, ZAK, TACC1, ZFR, ZNF565) whose suppression induced cell death upon PI3K inhibit
284 in-modified magnetic nanoparticles (MNP@Strep) whose surface is functionalized with suitable biotinyl
286 gional multidisciplinary HCV Innovation Teams, whose system redesign efforts have produced innovative
287 uced a Raman coefficient of freshness (CFresh), whose time course is linearly decreasing, with differ
289 lls represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via
290 ant to current medical and surgical therapies, whose tumor cells characteristically show a high level
291 ucho/TLE as a functionally relevant substrate, whose ubiquitylation by UBR5 is induced by Wnt signali
292 and the translation termination factor GSPT1] whose ubiquitylation is induced by immunomodulatory dr
293 ence, but also for computational neuroscience, whose ultimate goal is to understand how cognition is
294 have been shown to promote cancer progression, whose underlying mechanisms are largely unclear, espec
295 size and stochasticity in irrigation systems, whose understanding is key for devising mitigation and
296 e cyclopentadienyl ligand, the indenyl ligand, whose unique properties have in many cases imparted di
297 y-scale during two crop years from 444 plants, whose variety was genetically ascertained, and on 17 i
298 e passive, elastic and incompressible objects, whose volume depended on the pH and ionic conditions.
299 identifying a strain of HIV-1 group O (RBF206) whose Vpu protein evolved an effective antagonism of h
300 to a single spike we applied a spatial filter, whose weights were adapted to the covariance of ongoin
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