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1 ayer in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular inter
2 successful means of protecting biomass carbon, yet a subset causing a disproportionately high share o
5 ty may be involved in the progression of PTSD, yet also identified candidate MRs driving the disease
6 gressive ratio schedule of food reinforcement, yet an attenuated locomotor response to acute cocaine.
7 ssential monovalent cation at its active site, yet another parallel with B12 enzymes, and we characte
8 s are the toughest known biological materials, yet are lightweight and virtually invisible to the hum
10 f the real connectome as the generative model, yet better explained the connectivity of most regions.
11 gh degree of temporal and spatial specificity, yet biological processes are commonly regulated, in a
12 e glycopeptidolipids or lipopentapeptide (L5P), yet both lipids are present in other M. avium subspec
13 tients with non-small-cell lung cancer (NSCLC), yet cardiac injury after treatment is a significant c
14 es in digestive and immune system functioning, yet cetacean microbiomes remain largely unexplored, in
15 e circuitry that drives addiction and relapse, yet cocaine apparently has no effect on electrically s
16 gth 4 MPa, which is 30% of its original value, yet comparable to the pristine strength of existing se
17 at Tcf1 long and short isoforms have distinct, yet complementary, functions and may represent an evol
18 turation in brain PM) appear to have opposite, yet complementary, influences on many bilayer properti
19 s only model the overall change of a gene set, yet completely overlooked heterogeneous time-dependent
20 of metabolism, and immunodeficiency disorders, yet complications such as graft-vs.-host disease (GvHD
21 Guinea had reasonably high malaria mortality, yet Congo (Brazzaville) ranked 38th and Guinea ranked
24 uire careful monitoring due to their toxicity, yet current methods are too complex or bulky for point
25 enting breast cancer recurrence and mortality, yet data from prospective cohort studies are limited.
27 emoglobin (Hb) multiplicity is common in fish, yet despite its ubiquitous nature, the functional sign
28 l tenascin C, indicative of elevated rigidity; yet despite continued ROCK2 activities/p-Mypt1 inactiv
29 is (a model of enhanced exogenous FA delivery) yet developed steatosis upon induction of hepatic de n
30 y used drug in colorectal cancer chemotherapy, yet development of drug resistance to 5-fluorouracil i
31 Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in lab
32 the landscape of genomic mutations in cancer, yet efforts to correlate somatic mutations found in on
34 est losses (e.g. 0.39% yr(-1) in IUCN cat III), yet even highest status areas lost 0.13% yr(-1) (IUCN
35 ed by scenarios involving stopping or pausing, yet evidence that the STN causally implements stops or
36 enuated L-ala,SP prodrug metabolite formation, yet exacerbated L-ala,SP + amiodarone effects, implica
37 lf-renewing in reaction to persistent antigen; yet, excessive expansion reduces memory potential and
38 a common component of weight loss strategies, yet exercise programs are associated with surprisingly
39 t advantages over current therapeutic options, yet experimental vaccines have not been successful to
40 leading cause of death in the developed world, yet facile preclinical models that mimic the natural s
41 riable component of the human skin microbiome, yet factors that determine their abundance changes are
42 h the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection.
43 loss is critical to restore normal physiology, yet few cases are documented in mammalian postnatal li
44 ested that heavy metals have ototoxic effects, yet few epidemiological studies have investigated the
45 morbidity and mortality in sub-Saharan Africa, yet few facilities are able to maintain long-term surv
46 adult body size has its roots earlier in life, yet few life-course studies have data on siblings with
47 ols has been developed in the past 5-10 years, yet few of these tools are integrated and make use of
48 at the highest risk of death from anaphylaxis, yet few population-based studies have described the fr
49 found in the Amazon and Orinoco river basins, yet few resources for genetic studies and the genetic
50 hangeably to make critical clinical decisions, yet few studies have compared these approaches as appl
51 icrobial stewardship program (ASP) guidelines, yet few studies have systematically evaluated its impa
52 s are available for both these common cancers, yet for so many women access to these is beyond reach.
54 ased dramatically during the past two decades, yet gaps in the quality of care persist and mortality
55 educed expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a
56 nguistically diverse indigenous ethnic groups, yet genetic variation and histories of peoples from th
58 luster from a specific seven-particle cluster, yet giving rise to the catalytic production of a sea o
59 sed proliferation and manage oxidative stress, yet glutamine is often depleted at tumor sites owing t
61 idization, 16-S rRNA gene amplicon sequencing), yet high-throughput methods for assessing community s
63 ets are the sole source of EGF in circulation, yet how EGF is stored or released from stimulated cell
64 cosal TH17 cell responses have been described, yet how these cells are sustained in chronically infla
65 d removal of macroalgae by herbivorous fishes, yet how these findings relate to degraded reef systems
66 entified at the molecular and cellular levels, yet how these phenomena affect cortical circuit activi
67 ntral to adaptive immunity and self-tolerance, yet how this is determined by different antigens is no
68 of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is n
69 disulfide-stabilized C-terminal "index finger," yet how these binding events trigger receptor activat
70 ccumulate in the CNS during neuroinflammation, yet, how these cells contribute to CNS antigen drainag
71 ibed risk factor for adverse metabolic health; yet, how eating at a later circadian time influences b
72 e cycle of HIV-1 has been studied extensively, yet important steps that occur between viral capsid re
74 ns commonly activate cellular gene expression, yet inhibiting their recruitment paradoxically reactiv
75 ly studied as invasions of individual species, yet interactions between plants and symbiotic fungi (m
76 at has transformed the nation's food security, yet irreconcilable differences exist between maize pro
77 nt or oscillatory changes in the ATP fraction, yet is insensitive to constant changes in this fractio
78 om non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strate
79 ragment antigen-binding region of an antibody), yet it maintains functional activity, binding to p40
82 esource is comparable to wind and solar power, yet it does not suffer as much from varying weather co
83 es a field strength of approximately 100 V/cm, yet it efficiently recovers proteins and nucleic acids
84 s at both the macroscopic and cellular levels, yet it has been considerably less observed in artifici
85 nt failure in patients with atopic dermatitis, yet it has been sparsely described in the literature.
86 on of peat ever found in a free-floating mire, yet it has formed during the past seven centuries and
87 s (CSCs), require niches to maintain stemness, yet it is unclear how CSCs maintain stemness in the su
88 ength of stay (LOS) after lung cancer surgery, yet it is unclear if a routine of early discharge is a
89 anding cognitive shifts could recruit the DMN, yet it is unknown whether this holds for nonhuman spec
91 ributes such as orientation and face identity, yet it would be counterproductive to apply it to dynam
92 ant component of the long-term climate system, yet its controlling factors are largely uncertain due
93 widespread clinical and research applications, yet its effect on ongoing neural activity in humans is
94 s disorder (PTSD) in many states of the union, yet its efficacy in treating PTSD symptoms remains unc
95 RH workhorse cluster was commissioned in 2010, yet its eight-core CPUs with only 24GB RAM work well i
96 ys a major role in both evolution and disease, yet its functional impact on transcription factor (TF)
97 accounts for approximately 50% of the protein, yet its functional role, if any, remains a mystery.
98 kine-is upregulated in breast cancer patients, yet its impact on breast cancer behavior remains to be
100 ed as a tumor suppressor in colorectal cancer, yet its potential role in PCa has not been investigate
102 ficant burden associated with pain management, yet its precise underlying mechanism and prevention re
103 neurological disorders of various etiologies, yet its role in altering brain function as a consequen
104 s to gene expression dynamics in many tissues, yet its role in auditory development remains unclear.
105 important disturbance to ecosystems worldwide, yet knowledge about the impacts of invasive species on
106 nerated by NGS, the presence of newly evolved, yet known, strains of both CPV-2a and CPV-2b were iden
107 or symptomatic urinary tract infections (UTIs), yet large-scale evaluations of bacteriuria management
109 e importance of physical activity and fitness, yet limited data exist on the associations between obj
110 scale differences have been known for decades, yet little is known about differences at the fine scal
111 ainst pathogen exposure and epithelial injury, yet little is known about how enteropathogens may circ
112 rized motility and generating traction forces, yet little is known about how tension borne by an indi
113 g disorders that stem from traumatic memories, yet little is known about how this process changes the
114 s in abundant quantities in various organisms, yet little is known about its biosynthesis and physiol
115 is one of the primary drivers of species loss, yet little is known about its effect on other componen
116 r improving catalyst activity and selectivity, yet little is known about the dynamic compositional an
117 plants to light has been studied extensively, yet little is known about the effect of dynamic fluctu
118 pairment in older adults in the United States, yet little is known about whether AMD is appropriately
119 s to inflammatory mechanical hypersensitivity, yet little is known as to the post-translational mecha
120 to contribute to multiple myeloma development; yet, little is known of the role of this pathway in di
121 ural features in different tetraploid species; yet, lncRNAs slightly differ from coding transcripts.
122 S/AMPV-C F&G, was slightly attenuated in vivo, yet maintained similar characteristics in vitro when c
123 l clinical and pathological disease phenotype, yet maintained their structural diversity in the ancho
124 rimarily via direct cell-to-cell transmission, yet many have evolved to counteract an antiviral prote
125 cingulate cortex (ACC) remains controversial, yet many theories suggest a role in behavioral adaptat
127 can influence plant phenotype in diverse ways, yet microbial contribution to plant volatile phenotype
128 ced in response to TAC in cMy-mOVA-OT-II mice, yet more CD3(+) T cells infiltrated their myocardium w
129 as been regarded as one of the most effective, yet most challenging approaches for increasing the pac
131 FASs) are, or have been, on the global market, yet most research and regulation continues to focus on
132 ula genome, and they play seemingly important, yet mostly uncharacterized, physiological functions.
133 ent and nonspecific spontaneous fusion events, yet must be low enough to allow it to be overcome upon
134 mbranes has a fascinatingly complex structure, yet nanoscale nonuniformities inherently present in po
135 s of multiple proteins and other biomolecules, yet network visualizations usually only show proteins
136 Chromatin looping is key to gene regulation, yet no broadly applicable methods to selectively modif
137 dinary threat to the world's aging population, yet no disease-modifying therapies are available.
138 espiratory tract infections in young children, yet no highly effective treatment or vaccine is availa
139 the risk of childhood externalizing disorders, yet no large cohort study has investigated this associ
141 nantly observed within mitochondria, a source, yet not a sink, of AcroB adducts, illustrating that a
142 under all stress conditions, with significant, yet not complete, overlap of readthrough-induced loci
144 sed almost entirely on crystalline structures, yet now a clear trend is emerging, shifting the emphas
145 readout, making indirect readout an important, yet often ignored, contributor to the expression of pa
147 haracteristics of the heart disease condition, yet only aged HCM females displayed anxiety- and depre
149 teins play important roles throughout biology, yet our understanding of the relationship between thei
150 n essential scaffolding for biology education, yet outdated methods for teaching the tree of life (TO
151 dependent on the progression through distinct, yet overlapping phases of wound healing, including hem
154 and molecularly highly heterogeneous disease, yet prognostication relies predominantly on clinical t
156 rges that were not synchronized to CI stimuli, yet reflected changing repetition frequency by increas
157 fically binds to telomerase RNA in a distinct, yet related, manner to how it binds DNA; and (2) Est1
160 ntagonizes TGFbeta-mediated cell cycle arrest, yet remains critical for the pathological, EMT-inducin
162 cells can be propagated indefinitely in vitro, yet retain the capacity to become fully differentiated
163 e dynamics and structure of molecular species, yet revealing these correlations experimentally has pr
164 Mutations are the raw material for evolution, yet robustness to their effects is required for specie
165 use of skin and soft tissue infections (SSTIs), yet sex bias in susceptibility to S. aureus SSTI has
166 ients is now touted as the optimal care model, yet significant barriers often prevent its implementat
168 These results suggest that using a novel, yet simple, paradigm can result in meaningful pupil me
170 l modulatory network has highly heterogeneous, yet stereotyped, pattern of connectivity.SIGNIFICANCE
171 portant as preparation to pursue STEM careers, yet students in the United States lag behind other cou
172 s key for making informed treatment decisions, yet studies suggest an association between prognostic
174 controlling polycation-membrane interactions, yet such information is surprisingly difficult to obta
175 where effectors are secreted during infection, yet such knowledge is essential to understand and comb
177 e forces is a major challenge in cell biology; yet such measurement is essential to the understanding
178 he primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization
179 ified hepatic PERK activation to asparaginase, yet surprisingly, mRNA levels of key ISR gene targets
180 rtunity to target the highest-risk population, yet surveillance rates in the United States and Europe
182 etabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of t
183 rochemically identified zones in the striatum, yet technical hurdles have hampered the study of the f
184 and p21-associated differentiation in wdSCCs; yet tenascin C retention in connective tissue extracel
185 re prophylaxis (PrEP) interventions worldwide, yet tenofovir disoproxil fumarate/emtricitabine (TDF/F
186 ay that culminates in depletion of axonal NAD(+), yet the identity of the underlying NAD(+)-depleting
187 nteractions with GABAergic granule cells (GCs), yet the incidence of MC-GC connections is very low, a
188 cted based on studies in any human population, yet the allelic effects are evaluated in a population-
190 ways were comparable in oxLDL-loaded Mvarphis, yet the binding of p65/RelA (the prototypic NF-kappaB
191 ity during prion infection have been reported, yet the bioenergetic respiratory status of mitochondri
192 Melanoma is one of the deadliest cancers, yet the cells of origin and mechanisms of tumor initia
193 neral density and increased risk for fracture, yet the cellular origin of the bone phenotype remains
194 solved organic carbon (DOC) to the deep ocean, yet the contribution from advective settings has just
195 ment to the differentiation of helper T cells, yet the cues that position cells in this region are la
196 catalysts of enantioselective transformations, yet the discovery of organic catalysts effective at lo
197 otein scaffold that surrounds the active site, yet the exact nature of catalytically relevant protein
198 er alterations (SCNAs) affecting cancer genes, yet the extent to which recurrent SCNAs exert their in
199 of both malignant and nonmalignant disorders, yet the factors affecting their formation are incomple
201 ation far beyond operational lease boundaries, yet the full extent of these impacts is unknown and th
203 y connected with distributed cortical regions, yet the functional significance of this extensive thal
204 ocated between the neocortex and the striatum, yet the functions of corticoclaustral and claustrocort
205 s a major determinant of crop production time, yet the genetic control of this process, including gen
206 jor reduction in periprocedural complications, yet the incidence of conduction disturbances has remai
207 s is pervasive in egress routes of malignancy, yet the intrinsic effects of force on tumour cells rem
208 for measurements of many types of omics data, yet the meaningful integration of several different da
211 mmation is known to affect cancer development, yet the mechanisms by which immune signaling drives tr
212 immune defense at host/environment interfaces, yet the mechanisms by which they interact with CD4(+)
213 te cancer cell invasive growth and metastasis, yet the mechanisms mediating these functions still lar
214 eposition of diet-derived carotenoid pigments, yet the mechanisms of carotenoid uptake and transport
216 mediate both regulatory and pathogenic roles, yet the mechanisms underlying such opposing effects re
217 or of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure
218 recognized by correlative chromatin features, yet the molecular composition of the vast majority of
219 ne-loss and an accumulation of repetitive DNA, yet the nature of the gene repertoire of fly Y-chromos
220 alent interactions than the earlier actinides, yet the origin of this shift in chemistry is not under
221 ost extreme of all neuropsychiatric disorders, yet the origins of the sex difference remain obscure.
222 an important reservoir of influenza A viruses, yet the potential of viruses in this reservoir to tran
223 tion of antibiotics to save lives of patients, yet the present benchtop molecular diagnosis is time-c
225 of animals, healthy volunteers, and patients, yet the relevance of this to pharmacotherapeutic actio
226 ng blocks were identified almost a decade ago, yet the role of repulsive interactions in guiding stru
227 omplement of proteins present in mitochondria, yet the rules that govern this selection are unclear.
229 ortant molecular-level nonequilibrium physics, yet the simple functional form leads to a continuum-le
230 to coat and contain the commensal microbiota, yet the specificity of these antibodies remains elusiv
231 has become a facile genome editing technology, yet the structural and mechanistic features underlying
232 amyloids are often key virulence determinants, yet the structural basis for their activity remains el
233 st catastrophic and hazardous events on Earth, yet the temporal details of post-supereruption activit
234 in samples associated with flooding surfaces, yet the temporal trends of parasite prevalence and hos
235 ganisms ranging from invertebrates to mammals, yet the underlying mechanisms have only recently begun
239 cells and interstitial dermal dendritic cells, yet the virus fully replicates only in the latter.
240 are known to be impaired after extended wake, yet, the underlying neuronal correlates have been diff
241 f rare-earth orthoferrites and orthochromites; yet, the mechanisms behind such effects remain to be u
242 ibutor to children's well-being and sociality; yet, the neural basis of coparenting has not been stud
243 ney diseases in African ancestral populations; yet, the underlying biologic mechanisms remain uncerta
246 to identify potential pharmacological targets, yet their expression patterns and physiological functi
247 failure pathogenesis during viral myocarditis, yet their identities and functions remain poorly defin
249 genitor cells was proposed in several species, yet their origin and characteristics are not very clea
251 g-standing candidates for playing such a role, yet their precise contribution has remained elusive.
253 rolled by capsid-associated tegument proteins, yet their specific roles have not yet been defined.
255 mation transfer within and across brain areas, yet their underlying mechanisms remain hotly debated.
256 n the biosphere is returned to the atmosphere, yet there are limits to our ability to predict respira
257 ese viruses are ongoing in multiple countries, yet there is a dearth of mass rearing infrastructure s
258 tion to traditional alpha1-adrenergic ligands, yet there is little information describing this drug c
259 ility to convert evaporation energy into work, yet there is little understanding about the potential
261 CD57(+) NK cells in cancer immunosurveillance, yet there is scant information about how they mature.
262 ndings that do not meet all of these criteria, yet there may be ethically compelling arguments to off
263 e-mediated control of clade B HIV-1 infection, yet there remains a relative paucity of data regarding
264 e responses were similar for all doses tested, yet there was a dose-dependent increase in insulin sec
265 tone modifiers, which silence gene expression; yet, there exists a subset of PRC-bound genes actively
266 hycardia (VT) is being increasingly performed; yet, there is often confusion regarding indications, o
269 mulated by administration of ovarian steroids, yet they appear with ovarian steroid levels indistingu
271 e and have an unusual open-access copper site, yet they can still react with superoxide at rates limi
272 ted a 90% relative decrease in megakaryocytes, yet they developed more aggressive metastasis than wil
273 ies are currently the key player in the field, yet they fail to meet the commercial demands of scalab
275 Both fern mitogenomes are highly repetitive, yet they show extremely low levels of active recombina
276 lantation into the injured rodent spinal cord, yet they support delayed functional recovery, a findin
278 no apparent macroscale damage can be detected, yet this damage initiates and potentiates in pathologi
280 less than 15% probability of dying at 1 year, yet this lower-risk end of the score range captured ne
282 ive assessment method for neuromotor function, yet this was to our knowledge never done in neonatal l
283 of intracellular GSH and ensuing elevated ROS; yet this treatment results in no apparent toxicities i
284 might be amplifying genetic risk for obesity, yet those at highest risk could mitigate this risk by
285 nvironment plays a major role in human health, yet tools to study the health impacts of complex envir
286 ents can be treated with iron supplementation, yet TT patients have diminished capacity to process ir
287 ngenital cytomegalovirus is the most frequent, yet under-recognised, infectious cause of newborn malf
289 that can elevate arterial blood pressure (ABP) yet understanding of the mechanisms involved remain in
290 ell fates across developmental space and time, yet understanding how complexity and integration emerg
291 ht absorption compared to amorphous CDs (a-CD) yet undoped g-CD display limited photosensitizer abili
292 tory domain (NID) is intrinsically disordered, yet utilizes transient intramolecular interactions wit
293 an that with the parental virus (pH1N1/NS1-wt), yet virus titers were not significantly increased in
294 mage or enzymatic activity within HDM extract, yet was facilitated by applying the allergen under an
295 peutic intervention in serious mental illness, yet we know very little about their distribution or fu
296 mmalian brain contains diverse neuronal types, yet we lack single-cell epigenomic assays that are abl
297 se and inward-opening, and identifies diverse, yet well-defined roles for different Na(+)-coordinatin
299 ns in asthma onset, severity and exacerbation, yet with the exception of antibiotics, few treatments
300 ans in both extended and coiled conformations, yet xyloglucan chains were not directly visible by FES
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