ライフサイエンスコーパス: -activated channel

1 ber increased cytosolic ATP-, lumenal Ca(2+)-activated channel activities to a nearly maximum level.

2 The density of the small-conductance Ca(2+)-activated channel decreased along the apical dendrite, w

3 e voltage-gated channel Kv1.3 and the Ca(2+)-activated channel IKCa1.

4 The Ca(2+)-activated channel of intermediate-conductance (KCa3.1) i

5 This study thus identifies a Ca(2+)-activated channel permeable to Ca(2+) and critical for C

6 2) revealed new proteins, including a Ca(2+)-activated channel TRPM5, for MUC5AC secretion.

7 levels over time, involving extrinsic Ca(2+)-activated channels late during activation.

8 The absence of Zn(2+)-activated channels in rats and mice may explain why this

9 nel recordings show that capsaicin- and acid-activated channels have the same conductance, that the t

10 K 293 cells, which showed pH-dependent (acid-activated) channel activity.

11 ltered the activity of either class of L-Arg-activated channels, which were blocked by micromolar con

12 On the contrary, cytosolic ATP-activated channel activities were decreased as lumenal C

13 oncentration dependent and the Po of the ATP-activated channel was unaffected by membrane voltage, re

14 f either beta- or gamma-ENaC block the basal-activated channel in a concentration-dependent fashion.

15 c side of the bilayer increased lumenal Ca2+-activated channel activities, suggesting that it lowered

16 indicating that calcium channels and calcium-activated channels do not participate in shaping the pre

17 ted channels is lower than that of capsaicin-activated channels.

18 Tg- and CCh-activated channels were permeable to Na(+) and Ba(2+), b

19 factor required for Ca2+ to inhibit the cGMP-activated channel.

20 inked to the control of a G-protein and cGMP-activated channels which functions to generate high syna

21 dephosphorylation of 'on' bipolar cell cGMP-activated channels, resulting in a rise in the sensitivi

22 tion by CaMKII is the 'on' bipolar cell cGMP-activated channels.

23 nsistent with CaMKII phosphorylation of cGMP-activated channels leading to a voltage-dependent reduct

24 ed via a cGMP cascade to the control of cGMP-activated channels.

25 igate the action of cytoplasmic Ca2+ on cGMP-activated channels in the outer segment.

26 has recently been demonstrated for rod cGMP-activated channels.

27 The increased affinity of the cGMP-activated channels in response to a fall in [Ca2+] has t

28 of rhodopsin and to transitions in the cGMP-activated channels.

29 cribe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature co

30 TRPC2,3,6 and 7 are widely accepted as DAG-activated channels, although TRPC3 can also be regulated

31 lcium signals in T cells occur via depletion-activated channels.

32 on 0.5 microM gamma-aminobutyric acid (GABA)-activated channels (10 +/- 1 pS) in inside-out or outsid

33 tches had the same chord conductance as GABA-activated channels and were gabazine-resistant.

34 ately 70 000) did not pass through the gamma-activated channel, indicating an upper limit to the pore

35 Two classes of glutamate-activated channels mediate excitation at central synapse

36 dynamic behaviour of post-synaptic glutamate-activated channels.

37 receptor-mediated currents or forms glycine-activated channels with the NR1 subunit alone.

38 EK293 cells exhibit increased basal and GPCR-activated channel currents, and increased Ca(2+) fluores

39 The calcium permeability of heat-activated channels is lower than that of capsaicin-activ

40 The homogenate-activated channels were Ca2+ sensitive, selective for Ca

41 is a major determinant for hyperpolarization-activated channel gating.

42 molecular determinant for hyperpolarization-activated channel gating.

43 alter gating of the plant hyperpolarization-activated channel, KAT1.

44 r residue conserved in all hyperpolarization-activated channels, by Ala substitution produced a depol

45 tials and distal dendritic hyperpolarization-activated channels that mediated site independence of so

46 InsP3-activated channels invariably inactivated, with average

47 spines through voltage-sensitive and ligand-activated channels, as well as through Ca(2+) release fr

48 ns BKCa channels primarily operate as ligand-activated channels gated by intracellular Ca(2+) and tha

49 Channelrhodopsin-2 (ChR2) is a light-activated channel that can conduct cations of multiple v

50 mediated transmission, and, by using a light-activated channel to excite the network, we demonstrate

51 using Cre-dependent expression of the light-activated channel Channelrhodopsin-2.

52 Like the light-activated channel of the cell, it is non-selective among

53 Light-activated channels exhibited similar unitary currents, r

54 r potassium channels and two different light-activated channels, all of which have an effect on Vmem

55 ion transport as ion pumps or directly light-activated channels.

56 ity using layer-specific expression of light-activated channels and indicator dyes.

57 of a highly Ca(2+)-permeable class of light-activated channels of Drosophila photoreceptors.

58 sembled those ascribed to one class of light-activated channels, TRP.

59 subunit of a class of Ca(2+)-selective light-activated channels that carry the bulk of the phototrans

60 alcium influx through the TRP and TRPL light-activated channels triggers a complex regulatory hierarc

61 Mallotoxin-activated channels remain incrementally sensitive to Ca2

62 lar Mg2+ stabilized the open state of NAD(+)-activated channels.

63 +) on the single N-methyl-D-aspartate (NMDA)-activated channel burst duration and frequency and on th

64 -1592, -1460 and -1754) block the open NMDA-activated channel were studied at membrane voltages (Vm)

65 provides evidence that occupancy of the NMDA-activated channel by Mgi2+ destabilizes the closed state

66 urrent, a four-state model in which the NMDA-activated channel can close while blocked by Mgi2+ is pr

67 ng sites at different depths within the NMDA-activated channel.

68 FA reduces the mean open time of single NMDA-activated channels in a concentration-dependent manner w

69 se presynaptic terminals reveals single NMDA-activated channels, showing multiple conductance levels,

70 of both the Ca(2+)- and the Ca2+/nucleotide-activated channels, suggest a mechanism for channel open

71 ors, hyperpolarization and cyclic nucleotide-activated channels (HCNCs) and a separate target that ha

72 ls with the same property (cyclic nucleotide-activated channels) have been reported that are involved

73 ing able to form homomeric cyclic-nucleotide-activated channels.

74 Oxidant-activated channels were observed to display two gating m

75 cation channel, zTrpa1b, coupled with photo-activated channel ligands, such as optovin and 4g6.

76 The L-Pro-activated channels were not affected by either L- or D-A

77 In heart, G-protein-activated channels are complexes of two homologous prote

78 Acid-sensing ion channels (ASICs) are proton-activated channels expressed in neurons of the central a

79 between 6.0 and 6.5, as expected for proton-activated channels, and current-voltage dependence did n

80 caused by RANTES, indicating that the RANTES-activated channel was the Ca2+ -activated K+ channel.

81 of membrane ionic conductances and receptor-activated channels in CNS neurons and, via these mechani

82 e identified critical functions for receptor-activated channels in the endoplasmic reticulum that all

83 els were blocked by gadolinium; the receptor-activated channels formed upon expression of higher leve

84 ), capacitative Ca2+ entry, and Ca2+ release-activated channel opening (CRAC), and often underlies th

85 tes the cooperation with the calcium release-activated channel Orai1 in directing localized cytoskele

86 lowed by Ca(2+) entry through Ca(2+) release-activated channels (CRACs).

87 ker) and gadolinium(III) chloride (a stretch-activated channel blocker) did not alter the level of ac

88 sis by adding gadolinium chloride (a stretch-activated channel blocker) to the saline (0.008 g.mL-1)

89 ure-dependent gating properties of a stretch-activated channel with a current/voltage plot indicating

90 Moreover, disruption of a stretch-activated channel, Piezo1, in zebrafish prevents extrusi

91 MscL, a stretch-activated channel, saves bacteria experiencing hypo-osmo

92 how that hypotonic shock generates a stretch-activated channel-dependent calcium pulse in yeast.

93 indicates its possible identity as a stretch-activated channel.

94 ctivated K(+) channel that is also a stretch-activated channel.

95 hlin with the cell surface bound and stretch-activated channel TREK-1.

96 nels may contribute to the increased stretch-activated channel activity observed in mdx myofibers.

97 Neither stretch-activated channel was detected in the grain protoplasts

98 describes a physiologically relevant stretch-activated channel, at both the single-channel and whole-

99 anodine receptor (RyR) and (iii) the stretch-activated channel (SAC) in both single myocytes and mult

100 ased proliferation is induced by the stretch-activated channel Piezo1 and involves calcium-triggered

101 ecome too crowded, they activate the stretch-activated channel Piezo1 to trigger extrusion of cells t

102 Stretch-activated channels (SACs) have been found in myocardial

103 Stretch-activated channels (SACs) have been found in smooth musc

104 Stretch-activated channels (SACs) have been shown in other prepa

105 integrated changes in caveolin-3 and stretch-activated channels (SACs).

106 spider venom that is known to block stretch-activated channels in animal cells, but the spontaneous

107 We tested the hypothesis that both stretch-activated channels (SACs) and intracellular calcium ([Ca

108 lipid-mediated modifier of cationic stretch-activated channels, eliminated the voltage and divalent

109 ane, Ca2+-permeable cation channels (stretch-activated channels) opened and a global increase in [Ca2

110 block voltage-gated Ca(2+) channels, stretch-activated channels (SACs), or the Na(+)-Ca(2+) exchanger

111 th TEA, Tris or choline, eliminating stretch-activated channels but suggesting that if transmembrane

112 Unitary ionic currents from stretch-activated channels and [Ca2+]i images were recorded simu

113 ting mechanism and pharmacology from stretch-activated channels described previously.

114 ation of both ERK1/2 and p38 kinase, stretch-activated channels, small GTPase proteins, and extracell

115 ed MSHA, whereas other inhibitors of stretch-activated channels (Gd(3+), ruthenium red, SKF96365) did

116 results suggest that the opening of stretch-activated channels allows ions, including Ca2+, to enter

117 anical distention-induced opening of stretch-activated channels in smooth muscle cells.

118 s not useful in the investigation of stretch-activated channels which may underlie the myogenic respo

119 nium (III) chloride (an inhibitor of stretch-activated channels) only blocked the activation of ERK1/

120 y gadolinium (Gd3+), an inhibitor of stretch-activated channels, but is independent of extracellular

121 Consistent with the presence of stretch-activated channels, we show that Ca2+ influx is triggere

122 iminated by gadolinium, a blocker of stretch-activated channels.

123 ated channels was similar to that of stretch-activated channels.

124 ished by gadolinium, an inhibitor of stretch-activated channels.

125 in creating these signal: Rho/ROCK, stretch-activated channels, and 'Molecular Strain Gauges.' We al

126 at Gd3+-sensitive, poorly selective, stretch-activated channels were not involved.

127 The stretch-activated channels were inhibited by a spider venom that

128 The entry of Ca2+ through stretch-activated channels is also amplified by Ca2+ release fro

129 that inhibiting Ca2+ influx through stretch-activated channels using various compounds, including a

130 distinguished by signalling through stretch-activated channels.

131 s mechanosensitive (ie, swelling- or stretch-activated) channels was tested.

132 ing nor identical to the endogenous swelling-activated channel.

133 m with the properties of endogenous swelling-activated channels.

134 ed channels and inositol 1,4,5-trisphosphate-activated channels.

135 The dendritic arborization and voltage-activated channel complement of rat neocortical pyramida

136 for the pore-forming subunit of low voltage-activated channel proteins has not been unequivocally id

137 l tissues, whereas KCNQ1 function as voltage-activated channels with very slow kinetics in cardiac ti

138 alpha1G and alpha1H and to the high voltage-activated channels formed by alpha1Ebeta3.

139 R-type high voltage-activated channels inactivate fully in a few hundred mil

140 , P/Q- and R-type channels, the high voltage-activated channels most intimately associated with presy

141 be classified as either low or high voltage-activated channels.

142 endent inhibition of non-L-type high-voltage-activated channels of the Ca(v)2 family.

143 of these otherwise long-lasting high-voltage-activated channels.

144 sually permit Ca influx through high-voltage-activated channels.

145 ction with the external potential in voltage-activated channels.

146 lpha1A, alpha1B, and alpha1E) or low voltage-activated channels (alpha1G).

147 d its function to maintain these low voltage-activated channels closed at resting membrane potentials

148 tion of channels did not gate as low voltage-activated channels, requiring stronger depolarizations t

149 Low-voltage-activated channels are called 'T' type because their cur

150 7-P9) type I hair cells acquired low-voltage-activated channels that shortened the rise time of the r

151 chanisms (transducer adaptation, low-voltage-activated channels, nonquantal transmission, and spike t

152 between the N-cadherin JMD and these voltage-activated channels.

153 Ca2+ influx through L-type voltage-activated channels (LTCs) is particularly effective at a

154 c L-type voltage-gated calcium (high voltage-activated) channel with accessory proteins beta and alph