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1 ity, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environme
2 review presents current knowledge for an age-adapted immunosuppression based on both, experimental an
7 his zinc finger is impaired in high-altitude-adapted Tibetans, suggesting that their adaptation to hi
9 rical stimulation that includes an amplitude-adapted pulse train which induces force enhancements wit
14 directed antibodies that recognize the avian-adapted H1 strain in current influenza vaccines but not
15 ere we investigate accessibility of the best-adapted genotype in the general case of K > 2 units.
16 that lead from a given genotype to a better-adapted genotype are important measures of accessibility
17 smissibility with the 2014 initial wild bird-adapted clade 2.3.4.4 virus, with potential acquisition
18 support the hypothesis that PLVA is a bobcat-adapted virus which is less fit in mountain lions and un
21 nd bulk stable carbon isotope values of cave-adapted shrimp suggest that carbon from methanotrophic b
26 insights into the genome evolution of a cold-adapted diatom from the Southern Ocean, Fragilariopsis c
27 Our twin findings-that the sexes of a cold-adapted species respond differently to modern climate fo
28 st clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memo
32 ifreeze proteins (AFPs) protect certain cold-adapted organisms from freezing to death by selectively
33 odelling, to investigate how two common cold-adapted bird species, willow and rock ptarmigan (Lagopus
34 t memory CD4 T cell formation following cold-adapted influenza vaccination is boosted when Ag is admi
35 d use appears to exacerbate declines in cold-adapted bird and butterfly species, and prevent increase
39 l protein-coding gene segments from the cold-adapted temperature-sensitive master donor virus A/Ann A
40 in the common experimental site, where cold-adapted populations produced roots with greater absorpti
41 cool shifts in temperature class where cool-adapted Acer saccharum increased and temperature neutral
42 -genome exon sequence analysis of 31 culture-adapted parasite lines associated amplification of the p
43 hermore, we found that a highly cell culture-adapted HCV strain was able to achieve a complete viral
45 f is present in the majority of cell culture-adapted PEDV strains but is missing in emerging field is
46 kably, reverse-genetics-derived cell culture-adapted PEDVAVCT12 harboring uncleavable N displayed gro
47 rived from naturally occurring, cell culture-adapted, or genetically modified live attenuated ASFV.
48 ne of this virus containing all nine culture-adapted mutations had 10-fold-higher levels of RNA repli
51 ype (WT) PoSaV Cowden strain, tissue culture-adapted (TC) PoSaV has two conserved amino acid substitu
52 t U.S. PEDV strain PC21A, the tissue culture-adapted PC177 (TC-PC177) contains a 197-amino-acid (aa)
54 0(4) to 10(5) free opsin molecules in a dark-adapted rod cell-a number that is three orders of magnit
56 ifference in frequency response between dark-adapted and light-adapted flies, resulting in high-frequ
57 e median junctional conductance between dark-adapted rods is approximately 140 pS, regardless of the
61 ual cycle) was similar to that of cones dark-adapted in the intact eye (with both the RPE and retina
62 nsitivity of salamander and mouse cones dark-adapted in the isolated retina (with only the retina vis
66 analysis, levels of 11-cis-RAL in fully dark-adapted heterozygous KI mice were similar to that in WT
67 solated from Arabidopsis thaliana WT in dark-adapted and high-light-stressed (NPQ) states, we find th
69 cells (ONalphaGCs and sOFFalphaGCs) in dark-adapted mouse retinas with elevated intraocular pressure
71 hat ligand binding of 11-cis-retinal in dark-adapted Rho was essentially irreversible with a half-lif
72 ngle quantal responses displayed normal dark-adapted kinetics, but rods were only half as sensitive a
73 ge-free, room temperature structures of dark-adapted (S1), two-flash illuminated (2F; S3-enriched), a
76 wide range of sensitivities in the same dark-adapted conditions, suggesting a divergence of the rod p
77 d and cone responses (the a-wave of the dark-adapted ERG protocol of 12.0 cd/s/m2) was longer (mean d
78 o -17.9 muV]; P=.003; the a-wave of the dark-adapted ERG protocol of 12.0 cd/s/m2: mean difference, -
79 d and cone responses (the a-wave of the dark-adapted ERG protocol of 3.0 cd/s/m2: mean difference, -4
80 s, taken using a digital camera through dark-adapted pupils using a standard protocol and the same eq
81 a, M-cones and melanopsin contribute to dark-adapted DAC responses with a similar threshold intensity
83 m species in the diversification of long-day-adapted tetraploid potatoes, showing that extant natural
86 on population developed from the wild desert-adapted Solanum pennellii and domesticated tomato (Solan
87 coreference resolution system with a domain-adapted system produced results that are consistent with
88 -measure of 0.14 (B3), while a simple domain-adapted rule-based system achieved an F-measure of 0.42.
90 the pulse-response behaviour of the drought-adapted biota of these systems, a response that is estim
91 xpression divergence between upland (drought-adapted) and lowland (mesic) ecotypes of the perennial C
93 zing antibodies than those produced from egg-adapted viruses, extending the established benefits of c
94 ifferences in glycosylation between H3N2 egg-adapted vaccines and circulating strains likely contribu
95 ted in ferrets and humans exposed to the egg-adapted 2016-2017 H3N2 vaccine strain poorly neutralize
96 idic environment) at higher pHs, but the egg-adapted strains become less acid stable at lower pHs.
97 o decreasing pH, while the fusion of the egg-adapted strains Udorn and X:31 is strongly dependent on
98 a clade 3C.2a H3N2 strain; however, the egg-adapted version of this viral strain lacks the new putat
99 ls, which have developed various environment-adapted structures and materials through natural selecti
100 , cell viability and growth; and (6) ethanol-adapted E. coli cells restore the majority of these redu
101 ic data of both ethanol-stressed and ethanol-adapted E. coli cells with computationally predicated et
105 responses were only elicited by a fibroblast-adapted rhesus CMV vector with limited tissue tropism; a
112 0,000 times the 50% lethal dose (LD50) of gp-adapted EBOV, and naive gps were then introduced as cage
114 of both "healthcare-acquired and healthcare-adapted pathobiota." Under this framework, the criticall
116 Given that EpaX is enriched in hospital-adapted isolates, this study points to the importance of
120 fed larvae, fed nymphs and in mammalian host-adapted organisms cultivated in dialysis membrane chambe
125 bility outside the host, reflecting the host-adapted lifestyle and person-to-person transmission of t
126 mpur, Malaysia, and compared it with a human-adapted laboratory line (A1-H.1) derived from the P. kno
129 lutinin (HA) proteins of seal H3N8 and human-adapted H3N2 viruses to respiratory tissues of humans an
131 sum virus (MCV), the only known extant human-adapted poxvirus, causes a long-duration infection chara
134 s an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi (6,7) , the
136 ctivation, and further clarify how the human-adapted poxvirus MCV can so effectively evade antiviral
137 Motility studies established that the human-adapted typhoidal S. Typhi, S. Paratyphi A, and S. Senda
138 is not known about the biology of this human-adapted bacterial pathogen and the complexity of the dis
139 that Halobacterium salinarum, a hypersaline-adapted archaeal organism, grows exponentially at the si
140 d for ADCC against cells infected with a lab-adapted HIV-1 isolate (HIV-1NL4-3), a primary HIV-1 isol
141 re engineered into Gag from a subtype B, lab-adapted provirus or Gag from a subtype C primary isolate
142 ted vaccines focus on glycoproteins from lab-adapted strains, which may poorly reflect primary viral
143 these mutations, G147R, in the NA of the lab-adapted A/WSN/33 (H1N1) strain while we were passaging a
144 Surprisingly, these two commonly used lab-adapted strains produced drastically different titers in
146 661 against Plasmodium falciparum laboratory-adapted strains (mean IC50 32 nM), Ugandan field isolate
148 P phase variation have focused on laboratory-adapted E coli strains and have been limited in the numb
150 ome sequences of eleven long-term laboratory-adapted parasite strains were examined, revealing four i
153 eviously identified as VFs in the laboratory-adapted reference strain H37Rv and shown to confer lysoz
154 amino-acid difference between the laboratory-adapted ROD10 and ROD14 Envs controlled the enhancement
156 and the generation of high-titer, laboratory-adapted viruses with diminished virulence in animal mode
157 this pathogen are conducted with laboratory-adapted strains which may not be representative of the s
159 that are used for photochemistry for a light-adapted measurement from a pulse amplitude modulation fl
161 ency response between dark-adapted and light-adapted flies, resulting in high-frequency response also
164 tcome measures would include chromatic light-adapted psychophysics, with attention to the photorecept
165 tandard combined, standard flash cone, light-adapted 3.0 Hz flicker and red cone responses were analy
166 tandard combined, standard flash cone, light-adapted 3.0 Hz flicker and red cone responses were up to
167 retinography (ERG) and multifocal ERG, light-adapted achromatic and 2-color dark-adapted perimetry, a
169 ltiple occasions, giving rise to green light-adapted variants from ancestral blue light-adapted ones.
171 atomic-level structural model of a low-light-adapted chromatophore vesicle from Rhodobacter sphaeroid
172 S936D) ) set the frequency response of light-adapted flies to low frequencies typical of dark-adapted
173 of dense cone dysfunction detected on light-adapted perimetry and multifocal ERG but with near-norma
175 teady-state absorption contours of the light-adapted monomeric bR in nanodiscs composed of different
178 little impact on the forward (dark- to light-adapted form) photoreaction was observed, the change in
179 n exposure followed by TGFbeta induces liver-adapted TRM, including their signature high expression o
183 cific genetic changes were discovered in MIL-adapted parasites, including deletions at the LdMT trans
184 achievement, in concert with a mitochondria-adapted CRISPR/Cas9 platform, could prompt a revolution
188 receptor transgenic mouse (2D2) and a mouse-adapted human influenza virus to test the hypothesis tha
194 ssages through the lungs of KI mice, a mouse-adapted virus emerged (MERSMA) that grew in lungs to ove
195 eered mice was then used to generate a mouse-adapted virus that replicated efficiently within the lun
196 ajority of wild-type (strain EGDe) and mouse-adapted (InlA(m)-expressing) L. monocytogenes recovered
197 n of BALB/c mice with a bioluminescent mouse-adapted EV71 construct (mEV71-NLuc) resulted in a lack o
199 of neurotropic disease based on a non-mouse-adapted human isolate, which can be used to investigate
200 gests that murine models utilizing non-mouse-adapted isolates can be obtained for all four DENVs.
201 8 days before a homologous H5N1 and/or mouse-adapted EBOV challenge, as well as a heterologous H5N1 c
204 am/1203/04 (VN1203), and the NA of the mouse-adapted H1N1 influenza virus A/Puerto Rico/8/34 (PR8) in
206 ted mice against lethal challenge with mouse-adapted Ebola virus (ma-EBOV) in a dose-dependent manner
207 minutes after a lethal challenge with mouse-adapted EBOV or selected H5N1 influenza viruses from cla
209 and were sequentially challenged with mouse-adapted influenza virus H1N1/A/Puerto Rico/8/1934 and St
210 rom mouse brains with three different murine-adapted scrapie strains (Chandler, 22L, and Me7) and sys
213 an activate surface mediated immunity in non-adapted hosts and contribute to non-host resistance.
215 ergetic processes are under selection in PAH-adapted fish from the most contaminated ER site and ex v
216 study of positron emission tomography (PET)-adapted salvage therapy with brentuximab vedotin (BV) an
219 assessed the feasibility and activity of PET-adapted salvage therapy with brentuximab vedotin, follow
221 spleens of guinea pigs in vivo, a guinea pig-adapted SUDV variant (SUDV-GA) uniformly lethal to these
222 te that transmission of viruses that are pre-adapted to the HLA molecules expressed in the recipient
224 of habitats in severe disequilibrium by pre-adapted individuals, rather than by gradual adaptation f
227 lysis of DCE MR imaging and DWI, the BI-RADS-adapted reading algorithm, which adapted ADC thresholds
228 produce long-lasting bacteremia in reservoir-adapted (natural host or passive carrier of a microorgan
229 evolutionary information with the resolution-adapted structural recombination approach of Rosetta, ca
230 ata were collected using age- and respondent-adapted versions of the PediQUEST Memorial Symptom Asses
234 cal trial in Hodgkin lymphoma (HL) (Response-Adapted Therapy in Advanced Hodgkin Lymphoma [RATHL]).
235 imaging to determine the utility of response-adapted therapy for stage III to IV classic Hodgkin lymp
237 Particular attention is given to response-adapted therapy, which is emerging as a cornerstone of c
238 dapt treatment in a clinical trial: Response-Adapted Therapy in Advanced Hodgkin Lymphoma (RATHL).
239 Phase 3 Trial of Systematic Versus Response-adapted Timed-Sequential Induction in Patients With Core
246 a multidisciplinary approach, coupling risk-adapted intensive neoadjuvant and adjuvant chemotherapie
248 iPET result may potentially help design risk-adapted therapies in patients with aggressive lymphomas.
249 stic models that can be used to develop risk-adapted treatment approaches for patients with ENKTL bei
251 on has served to identify subgroups for risk-adapted postremission therapy, but the initial treatment
253 n are part of prognostic scores guiding risk-adapted consolidation strategies, HL at initial diagnosi
256 is information should be used to inform risk-adapted therapy and to assist in screening to reduce lon
262 rmore, most data come from studies on rodent-adapted prion strains, making current understanding of t
263 petent rodents, these models rely on "rodent-adapted" viruses that have been passaged several times t
265 knowledge of diversity across other savanna-adapted species, as well as with palaeoclimate and paleo
266 cs in both TLR4-stimulated normal and sepsis-adapted human blood monocytes and mouse splenocytes.
267 oughput genome-wide translocation sequencing-adapted repertoire sequencing (HTGTS-Rep-seq), to quanti
271 e a potential risk to public health if swine-adapted viruses with H1N1pdm09 genes also have an increa
272 a potential risk for public health if swine-adapted viruses with H1N1pdm09 genes have an increased r
274 ispersion energies determined using symmetry-adapted perturbation theory (SAPT), while the induction,
277 Transverse tubules (t-tubules) are uniquely-adapted membrane invaginations in cardiac myocytes that
278 ionary time not to defend against vertebrate-adapted pathogens but instead to counteract infection by
280 e-dependent susceptibility of cold- and warm-adapted amphibian species to the fungal pathogen Batrach
281 he greatest susceptibility of cold- and warm-adapted hosts occurred at relatively warm and cool tempe
282 s between pathogens and their cold- and warm-adapted hosts should occur at relatively warm and cold t
283 l rates (e.g. metabolism) for cool- and warm-adapted species, and independent of latitude or elevatio
284 taxa and a higher proportion of large, warm-adapted species (i.e., snails and predatory dipterans) r
288 n the relative composition of cold- vs. warm-adapted species in a local assemblage [the community tem
290 ersity might be necessary to instruct a well-adapted immune response and regulated inflammatory respo
292 ay explain the difficulty in developing well-adapted lines carrying Wsm1 despite improved tolerance t
296 minated by Warnstorfia fontinaliopsis, a wet-adapted moss commonly found in the Antarctic Peninsula.
298 ns in situ and their controls in two wetland-adapted tree species (Alnus glutinosa and Betula pubesce
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