ライフサイエンスコーパス: -binding site

1 ssion and bound the Fshb promoter at an AP-1-binding site in a complex with c-JUN.

2 nal modeling, identified an allosteric BTB-1-binding site near loop5, where it blocks the ATP-depende

3 which was reduced after mutation of the Sp-1-binding site.

4 tein-1) activity and that the EGR1- and AP-1-binding sites in the CD44v6 promoter account for its res

5 PD-L1 3'-UTR contains two functional miR-155-binding sites.

6 rough an activating and an inhibiting Ca(2+)-binding site located on the cytoplasmic side of the RyR

7 ions that are far from the regulatory Ca(2+)-binding site of cTnC.

8 Allosteric activation of DAT via the Zn(2+)-binding site may be of interest to restore transport in

9 e transporter (DAT) has a tetrahedral Zn(2+)-binding site.

10 Intact Ca(2+)-binding sites on CaM and an intact gating brake sequence

11 hat Ln(3+) acts as an agonist of both Ca(2+)-binding sites.

12 s of E-Syt1, only C2A and C2C contain Ca(2+)-binding sites.

13 Zn(2+)-binding sites are also recognized by other first-row tra

14 The specificity and geometry of the dectin-2-binding site provide the molecular mechanism for binding

15 y elements, including the TTP- and miRNA-223-binding sites.

16 Using an FRS2,3-binding site mutant of Fgfr1, we established that FRS ad

17 sterols, and the two sterol- and fatty acid-binding sites are nonoverlapping.

18 human viruses carry mutated 2nd sialic acid-binding sites.

19 mods have alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2, ABS2), Lmods lack TMB

20 comprise alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2, and ABS2).

21 e anillin ActBD harbors three distinct actin-binding sites (ABS 1-3).

22 9-amino-acid protein containing five F-actin-binding sites and two G-actin-binding sites, and interac

23 ing filament barbed ends while three G-actin-binding sites (GABs) on other arms are available to recr

24 g five F-actin-binding sites and two G-actin-binding sites, and interacts with wheat (Triticum aestiv

25 ed because mutations distant from an agonist-binding site can alter agonist sensitivity.

26 istinct, independently regulated, co-agonist-binding site.

27 e the agonist, suggesting a distinct agonist-binding site from that found in TRPV1, a TRP channel fro

28 und 2 (Ki = 19 nM) binds within the aldehyde-binding site of the free enzyme species of ALDH2.

29 anic framework materials with tertiary amine-binding sites.

30 A resolution, reveal multiple aminoglycoside-binding sites within the large and small subunits, where

31 e point mutations of key residues in the AMP-binding site decrease its inhibitory effect but also cle

32 ing acute glucose starvation, and intact AMP-binding sites on AMPK are not required for AMPK activati

33 Antibodies generated against the ANG-binding site on PLXNB2 restricts ANG activity in vitro a

34 g the CD33 IgV domain, which is the antibody-binding site for GO, as well as diagnostic immunophenoty

35 We show that its antigen-binding site has adopted an architecture that positions

36 ted predominantly to stabilizing the antigen-binding site conformation.

37 ns suggest that the formation of the antigen-binding site is generally a destabilizing process and th

38 fic antibodies combine two different antigen-binding sites in a single molecule, enabling more specif

39 failed to be properly recruited at their AP1-binding site.

40 Can1 mutants altered in the arginine-binding site or a cytosolic tripeptide sequence permanen

41 owed the identification of the enzyme's aryl-binding site location and determination of its unique, c

42 gulated by intracellular pH, in part, at ATP-binding site 1 formed by the nucleotide-binding domains.

43 letion or mutational inactivation of its ATP-binding site, RAD51-interacting domain, or phosphorylati

44 However, our data also suggest that ATP-binding site 1 modulates intraburst gating.

45 loop L7) of the globin domain and in the ATP-binding site (helices H9 and H11) of the kinase domain.

46 n domain-dimerization interface, and the ATP-binding site are important in the signal transduction me

47 that inhibits DNA gyrase by binding the ATP-binding site in the ATPase subunit.

48 Here we present the mutations in the ATP-binding site of PI3Kalpha to progressively transform the

49 -alpha3 loop directly interacts with the ATP-binding site of the CKI1 histidine kinase domain.

50 and two loops, RL1 and RL2, flanking the ATP-binding site playing a significant role.

51 eract with conserved residues within the ATP-binding site.

52 Disease-causing variations in the ATP-binding sites of ABCB4 cause defects in PC secretion, wh

53 ted patients who harbor mutations in the ATP-binding sites of ABCB4.

54 olled by the interaction of ATP with two ATP-binding sites, sites 1 and 2, in CFTR.

55 CLCNKB mutations in barttin-binding sites, dimer interface or selectivity filter oft

56 es (mono-, di-, trivalent in terms of biotin-binding sites) are studied to rationalize the results ob

57 y of TRP channels and a well-defined calcium-binding site within the intracellular side of the S1-S4

58 Furthermore, removal of the calmodulin-binding site from the SPB component Spc110 weakens SPB-m

59 t TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making inte

60 In the two cAMP-binding sites of RIalpha, exocyclic phosphate oxygens of

61 t we hypothesize is a secondary carbohydrate-binding site.

62 In contrast to T1 sigma1, the carbohydrate-binding site of T3 sigma1 is located in the tail domain,

63 inct from previously identified carbohydrate-binding sites.

64 Here, the catechin-binding site of SULT1A3, which sulfonates monoamine neur

65 l interaction with distant TCF4/beta-catenin-binding sites in the intron of Rnf43 This novel activity

66 and deactivates both of the divalent cation-binding sites of the cTnC C-domain.

67 CD4-binding site (CD4BS), glycans in the V1/V2 and V3 region

68 mechanisms that limit the development of CD4-binding site (CD4bs), HCDR3-binder bnAbs via sequential

69 (Env) and its interaction with receptor CD4-binding site neutralizing antibodies as a model system,

70 Introduction of two SIVmac316 CD4-binding site residues (G382R and H442Y) into the SIVmac2

71 d them with 21 MAbs specific for V3, the CD4-binding site (CD4bs), and gp41 derived from chronically

72 hat target either the trimer apex or the CD4-binding site.

73 onoverlapping epitopes, such as the anti-CD4-binding-site antibodies 3BNC117 and VRC01.

74 and or in complex with either CD4 or the CD4-binding-site antibody PGV04 at 5.6 A, 5.2 A and 7.4 A re

75 he complete energetic landscape of the Cdc42-binding site on ACK.

76 We identified a centrin-binding site within H. sapiens Prp40 homolog A (HsPrp40A

77 This centrin-binding site is highly conserved within the first nuclea

78 Cys117 and Cys195 in the high affinity cGMP-binding site.

79 ressing a FRET-biosensor comprising the cGMP-binding sites of PKGIalpha.

80 The presence of these two channel-binding sites on VAMP721, one also required for SNARE co

81 o other LysM proteins and a conserved chitin-binding site.

82 sition 87 with alanine perturbs the chloride-binding site in the proton-exit channel.

83 detailed molecular mapping of a cholesterol-binding site in a protein, including an orientation of t

84 We have now determined the cholesterol-binding site of the M2 protein in phospholipid bilayers

85 Cataloguing cholesterol-binding sites is a vital step in the effort to understan

86 observations have suggested five cholesterol-binding sites in VDAC1, but direct experimental evidence

87 ntify two, to our knowledge, new cholesterol-binding sites on the A2A adenosine receptor, a G-protein

88 ches, we identified two putative cholesterol-binding sites in the transmembrane domain of GIRK2.

89 nd conformational flipping rearranges client-binding sites, providing a paradigm of how energy from A

90 stallographic study that placed the cofactor-binding site in the C-terminal domain rather than the an

91 ining at replication termination and cohesin-binding sites, where intertwines are thought to arise an

92 iled-coil domain 1 of EspD as a key compound-binding site, thereby preventing correct assembly of the

93 amino acid substitution within the compound-binding site in the N-terminal domain of the CA protein.

94 quence variation but conservation of the CR2-binding site.

95 terminal truncations, we show that the CSPG4-binding site on TcdB extends into the CROP domain, requi

96 Consistent with the location of the CSPG4-binding site on TcdB, we show that the anti-TcdB antibod

97 Deletion of the distal CTCF-binding site results in loss of Ramp3 expression in non-

98 is study, we created a mouse model with CTCF-binding site mutations at the Igf2-H19 imprint control r

99 oral lobar degeneration are enriched in CTCF-binding sites found in brain-relevant tissues, implicati

100 used CRISPR/Cas9 gene editing to mutate CTCF-binding sites at the putative start site of TERRA transc

101 re repeats can initiate at subtelomeric CTCF-binding sites to generate telomere repeat-encoding RNA (

102 Spy1 lacks the cyclin-binding site that mediates p27 and substrate affinity, e

103 unnel of RNAP aligns with the Shine-Dalgarno-binding site of the 30S subunit.

104 nse transcript downstream of the sgRNA/dCas9-binding site.

105 We observed two decavanadate-binding sites, one in the C-terminal domain and another

106 ate-dependent reduction of the dicarboxylate-binding site of complex II (site IIf); (b) pore opening

107 no information concerning their natural DNA-binding site.

108 origin sequence known to be a weaker ORC-DNA-binding site.

109 and we identified a specific palindromic DNA-binding site 5'-TTGATN4ATCAA-3' in these target sequence

110 ing studies were performed using the Ros DNA-binding site with the Ml proteins.

111 quentially at a single sequence-specific DNA-binding site to form a 2:1 complex, we have carried out

112 We show that the DNA-binding site specificity of Aiptasia NF-kappaB is simila

113 n for epistasis between mutations across DNA-binding sites.

114 nalysis of enriched transcription factor DNA-binding sites in the promoters of differentially express

115 ess PDC's ability to interact with STAT5 DNA-binding sites.

116 The DNA-binding sites of estrogen receptor alpha (ERalpha) show

117 ppression is dependent on the number of DND1-binding sites.

118 ds to the identification of a potential drug-binding site of ZIKV NS5, which might facilitate the dev

119 ulting in external accessibility of the drug-binding site (outward-facing, closed NBD conformation),

120 se tissues and a genome-wide analysis of Dsx-binding sites.

121 onsistent with the presence of the second E2-binding site.

122 unctional regions such as drug- and effector-binding sites in the human population.

123 Importantly, we show that effector-binding sites on arrestins have distinct conformations i

124 CYP46A1 surface, which differs from the EFV-binding site.

125 d (iii) eIF4G742-1196, which lacks the eIF4E-binding site.

126 The ERalpha-binding sites in tamoxifen-associated endometrial tumors

127 tion directly by binding to a consensus ERK2-binding site in the EpCAM promoter and indirectly throug

128 site-directed mutagenesis of a predicted ETS-binding site within the CDKN2A promoter abolished lucife

129 at potential histone methyltransferase EZH2-binding sites.

130 Finally, analysis of transcription factor-binding site motifs of differentially dysregulated genes

131 s the best predictor of transcription factor-binding sites (TFBS) followed by features employed by DN

132 dicted DH in predicting transcription factor-binding sites (TFBSs), turning publicly available gene e

133 o disrupt consensus ETS transcription factor-binding sites and are correlated with both reduced SDHD

134 oding elements, such as transcription factor-binding sites and non-coding RNAs.

135 s other than changes in transcription factor-binding sites that drive patterning.

136 We also identify transcription factor-binding sites that may drive these effects.

137 al enhancers, validated transcription-factor-binding sites and RNA motifs.

138 and encompasses a Myc-associated zinc finger-binding site that regulates KRAS transcription.

139 is study, we identified three forkhead (Fkh)-binding sites in the 140-bp region of the moricin promot

140 gion of the moricin promoter and several Fkh-binding sites in the lysozyme promoter, and demonstrated

141 lysozyme promoter, and demonstrated that Fkh-binding sites are required for activation of both morici

142 patial proximity, which formed a fluorophore-binding site in situ and turned on fluorescence.

143 EC50 Finally, we altered the number of GABA-binding sites by a mutation and again found that the rel

144 Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encod

145 to a monoglycopeptide shows that the GalNAc-binding site of its lectin domain is rotated relative to

146 with other amino acid residues in the GERAMT-binding site for proper chaperone-dependent regulation o

147 dues, glutamine or asparagine, in the GERAMT-binding site.

148 nalysis, we identified several P. gingivalis-binding sites of ArcA, which led to the discovery of an

149 y effectors in cNCCs, while a functional GLI-binding site was identified downstream of Foxf2 Consiste

150 eceptor (NMDAR) is controlled by a glutamate-binding site and a distinct, independently regulated, co

151 r shows the presence of an additional glycan-binding site, which broadens its binding specificity.

152 The glycan-binding site of T1 sigma1 is located in the head domain

153 -agonist of the NMDA receptor at the glycine-binding site, can be released by astrocytes in a calcium

154 ecific for both the CD4 and coreceptor gp120-binding sites.

155 ZNF764- and GR-binding sites demonstrated similar distribution in vario

156 matin remodeling and robust GR binding at GR-binding sites associated with blocked genes.

157 tivation correlates with the distance of Grh-binding sites to the transcription start sites of its ta

158 site shows structural similarity to the GTP-binding site of MoaA, suggesting that the viperin substr

159 how that hAgo1 and hAgo2 have a single GW182-binding site and that miRNA binding increases hAgo's aff

160 ethylation, is accommodated by BAF45C's H3K4-binding site.

161 the Cys residues at the apocytochrome c heme-binding site (CXXCH).

162 e than one modification, cluster in the heme-binding site, supporting a hierarchy of vulnerable amino

163 ttering (SAXS) data, and location of heparin-binding sites.

164 restingly, all proteins bound at the heparin-binding sites of laminin, including the globular domains

165 The HEXIM-binding site embedded in the 5-hairpin of 7SK (HP1) enco

166 geneous nuclear ribonucleoprotein F (hnRNPF)-binding sites and near hnRNPF-regulated alternatively sp

167 To map the hsp70-binding site in SOD2, we used a series of pulldown assay

168 pulldown experiments revealed multiple Hsp70-binding sites on XIAP, suggesting that it is a direct, p

169 A hitherto unknown IgE-binding site was mapped on the stalk region of CD23, and

170 The E128K mutation in the IL1R-binding site enhanced integrin binding.

171 ed the identification of potential inhibitor-binding sites and optimization of interactions of hits u

172 The integrin-binding sites on iC3b remain incompletely characterized.

173 (+) ions across the cell membrane via an ion-binding site becoming alternatively accessible to the in

174 lation required a highly conserved NF-kappaB-binding site but not a predicted TonE, suggesting cross-

175 Conformational changes near the ketamine-binding site were propagated to the interface between th

176 ts to complementary components of the ligand-binding site is nonequivalent.

177 gene ontology, enzyme commission and ligand-binding sites from various analogous and homologous func

178 uctural studies of the beta1AR define ligand-binding sites in the transmembrane helices and effector

179 o-existent, exo- and endofacial GLUT1 ligand-binding sites.

180 domain that can accommodate multiple ligand-binding sites.

181 The linker-binding site on the SBD is a potential target for small

182 tes but retained a previously suggested LIP5-binding site.

183 ultiple PIP2 lipids bind the canonical lipid-binding site and unique peripheral sites of the PH domai

184 molecules to Rv3802, we identified its lipid-binding site and the structural basis for phosphatidyl-b

185 al for inhibition, whereas functional lysine-binding sites in KIV7 , KIV8 , and KIV10 were not requir

186 isosteres that each interact with the lysine-binding sites in K2hPg Further, the adoption of an alpha

187 tructure of an NSAID allosteric site-the MEF-binding site of SULT1A1-is determined using spin-label t

188 The structure suggests that the menthol-binding site is located within the voltage-sensor-like d

189 e example of PerR lacking a structural metal-binding site.

190 large degree of lateral offset between metal-binding sites.

191 ratomic separation between the N-donor metal-binding sites.

192 sequence comprising two potential HXH metal-binding sites.

193 taining both structural and regulatory metal-binding sites.

194 nds Ni(II) ions at both its transition-metal-binding sites: the His3Asp motif (site 1) and the His6 m

195 ignificant distance from the TCR.peptide.MHC-binding site, remarkably affected ligand binding.

196 shift effects in sites removed from the MHC-binding site.

197 )-variant, a germline mutation in a microRNA-binding site in KRAS, is a predictive biomarker of cetux

198 ype-associated SNPs were present in microRNA-binding sites of genes involved in energy metabolism and

199 essed genes and contained potential microRNA-binding sites, which suggested possible contributions to

200 genes, all of which contain conserved miR159-binding sites of analogous complementarity.

201 r cooperative interactions, microRNA (miRNA)-binding sites are still largely investigated as function

202 o identify canonical and non-canonical miRNA-binding sites from peaks identified by Ago2 Cross-Linked

203 inds and cross-links MTs via a C-terminal MT-binding site.

204 nd the MyoA neck region adjacent to the MTIP-binding site, and both myosin light chains co-located to

205 nzymes, which we find regulated by novel MYC-binding sites, validating an additional transcriptional

206 hibitory residues tethered within the NAD(+)-binding site by an intramolecular disulfide in the oxidi

207 The overall architecture and NADP(+)-binding site of Tfu-FNO were highly similar to those of

208 homologue Smurf2 carry a non-covalent Nedd8-binding site within its catalytic HECT domain.

209 tural analysis reveals that Smurf2 has Nedd8-binding sites within the small sub-domain of N-lobe and

210 having only one functional neurotransmitter-binding site and single-channel electrophysiology to mea

211 f the 13 human SULT isoforms harbor an NSAID-binding site.

212 Using the NSAID-binding site structure of SULT1A1 as a comparative model

213 Finally, the NSAID-binding site structure offers a template for developing

214 Nucleotide-binding site leucine-rich repeat resistance genes (NLRs)

215 ants is mediated by intracellular nucleotide-binding site leucine-rich repeat (NLR) receptor proteins

216 le loop restructuring to form the nucleotide-binding site.

217 tory RCK domains, thus connecting nucleotide-binding sites and ion gates.

218 n further expanding our knowledge of odorant-binding site structures in ORs of disease vector insects

219 tors, to identify a component of the odorant-binding site of an OR from the malaria vector, Anopheles

220 l analyses using agonists to map the odorant-binding sites of these receptors have been limited becau

221 ined positions adjacent to the essential ORC-binding site within Saccharomyces cerevisiae origin DNA.

222 he mammalian genome contains hundreds of p53-binding sites.

223 access of the tethered ligand to the peptide-binding site.

224 graft survival, estimated AA MMs at peptide-binding sites of the HLA-DRB1 molecule account for an im

225 he C-lobe constitutes the inositol phosphate-binding site, which, along with the participation of the

226 the pT1471 phosphate occupies the phosphate-binding site of a canonical pY complex, while Y1473 occu

227 first intron, which carries a conserved PHR1-binding site (P1BS) motif.

228 sPs and PtdInsPs interact with the polyanion-binding site located on an inner chamber wall of the enz

229 PRC2-binding RNA motifs are enriched at PRC2-binding sites on chromatin and H3K27me3-modified nucleos

230 Mammalian PRC2-binding sites are enriched in CG content, which correlat

231 s, CRISPR-Cas9-mediated disruption of PRDM15-binding sites in the Rspo1 and Spry1 promoters recapitul

232 because of the existence of a second product-binding site.

233 the receptor to the intracellular G protein-binding site.

234 n peak calling algorithms that infer protein-binding sites by detecting genomic regions associated wi

235 tion of G4 and the adjacent putative protein-binding sites within the 5' UTR was necessary and suffic

236 GlcPSe, is equipped with a conserved proton-binding site arguing for an electrogenic transport mode.

237 und -260 and -230 mV, respectively, in the Q-binding site, respectively, suggesting that release of t

238 that HOPS-dependent fusion requires both Rab-binding sites, with Vps39 being the stronger Ypt7 intera

239 Several tethers have multiple Rab-binding sites with largely untested function.

240 ly, pathogenic ataxin-3 with a mutated Rad23-binding site at UbS2, despite being present at markedly

241 clude is Avo3, occludes the FKBP12-rapamycin-binding site of Tor2's FRB domain rendering TORC2 rapamy

242 des to enable verification of functional RBP-binding sites within intronic and exonic sequences of re

243 antibody epitope and may comprise a receptor-binding site.

244 pace of bnAb C05, which targets the receptor-binding site (RBS) of influenza haemagglutinin (HA) via

245 Nonetheless, the evolution of the receptor-binding site and the stem region on HA is severely const

246 p beginning at position 150) of the receptor-binding site common to this subgroup and a unique insert

247 nd that antibodies specific for the receptor-binding site located in the head domain of HA therefore

248 nd structural plasticity within the receptor-binding site.

249 or eliminating competent chemokine receptor-binding sites on Env trimers resulted in a loss of syner

250 n (domain II) containing a high-affinity Rev-binding site, and two or three additional domains.

251 al helicase cassettes, while 12 binds an RNA-binding site inside the N-terminal cassette.

252 ed to HeLa cells, RBDmap uncovered 1,174 RNA-binding sites in 529 proteins, many of which were previo

253 ts to efficiently delineate the complete RNA-binding sites.

254 the sequence upstream of lpiA lacks an RpoN-binding site.

255 One monomer provides the SAM-binding site, whereas the conserved C-terminal tail of t

256 substitutions that are found in the 2nd SIA-binding site of NA proteins of avian-derived IAVs that b

257 ulted from substitution T401A in the 2nd SIA-binding site, indicating that substrate binding via this

258 blishing that FD of Fis occurs at the single-binding site level, and we find that the off rate satura

259 Tumors with mutations in the SMAP-binding site of the PP2A A subunit displayed resistance

260 the primary amino acid sequence in the SOD2-binding site in hsp70.

261 ments, mediated by the formation of a sodium-binding site in the apo-structure.

262 PARP-1-dependent Sox2-binding sites reside in euchromatic regions of the genom

263 ses revealed that PDC-E2 is bound to a STAT5-binding site in the promoter of the STAT5 target gene cy

264 Abeta, presumably as both bind at the sterol-binding site on Abcg4.

265 aled selective binding to the NNMT substrate-binding site residues and essential chemical features dr

266 interaction, mutating the putative substrate-binding site in a constitutively active Hsp104 variant i

267 and (S)-17b, which bind within the substrate-binding site of MMP-13 and surround the catalytically ac

268 ellular space and reconfigures the substrate-binding site such that it relinquishes its affinity for

269 nd the alternate exposition of the substrate-binding site to either side of the membrane.

270 demonstrate the plasticity of the substrate-binding site, which confers substrate specificity by con

271 to act at a site separate from the substrate-binding site.

272 st: immobilizing enzymes can block substrate-binding sites or prohibit conformational changes, substr

273 an allosteric network that couples substrate-binding sites.

274 exofacial (e2) and endofacial (e1) substrate-binding sites.

275 group and the architecture of the NLP sugar-binding site.

276 rgoes conformational changes where the sugar-binding site alternatively faces the external and intern

277 us vestibule (600 A(3)) leading to the sugar-binding site.

278 ealed that ciA-C2 partially occupies the SV2-binding site on HCA1, causing direct interference of HCA

279 pled channel of communication between the TA-binding site, ATPase site, and effector interaction surf

280 he identification of LigM's tetrahydrofolate-binding site and protein-folate interactions.

281 s contain multiple transcription factor (TF)-binding sites and integrate the effects of each TF to co

282 represent the first analysis of OCRs and TF-binding sites in distinct populations of postmortem huma

283 S) to identify and map open chromatin and TF-binding sites in plant genomes.

284 nt Ritornello, a new approach for finding TF-binding sites in ChIP-seq, with roots in digital signal

285 By mutating individual TF-binding sites within the TE, we identified a module of T

286 ouse-specific TEs that encode a module of TF-binding sites in mouse embryonic stem cells (ESCs).

287 ChRs having a mutation(s) at the transmitter-binding sites.

288 27 acetylation contained a bona fide TRbeta1-binding site.

289 e tRNA anticodons explore the aminoacyl-tRNA-binding site (A site) of an open 30S subunit, while inac

290 e presence of a low-affinity, noncovalent Ub-binding site within the HECT domain.

291 pecifically the role of RING1 and various Ub-binding sites, brief structural comparisons among member

292 stor, pyruvate oxidase, such as a ubiquinone-binding site and the requirement for FAD as cofactor.

293 e proteasome shuttle Rad23 through ubiquitin-binding site 2 (UbS2).

294 ynamically linked E2 approximately ubiquitin-binding sites analogous to that recently reported for E6

295 tionally distinct E2 approximately ubiquitin-binding sites: a high-affinity Site 1 required for E6AP

296 e expression through interaction with 3' UTR-binding sites.

297 both VEGFR2 and NRP1, including the VEGF164-binding site of NRP1 and the NRP1 cytoplasmic domain (NC

298 -helixes alpha3 and alpha4 represent the Vif-binding site of A3H.

299 a flexible loop near the high-affinity zinc-binding site.

300 These differences include a novel zinc-binding site and regions unique to the mammalian IP5 2-K