ライフサイエンスコーパス: -deficient

1 n and lifespan of wild-type, but not Sir-2.1-deficient, C. elegans.

2 portant target in the mechanism of complex 1-deficient vision loss.

3 mutagenesis and skin carcinogenesis in IGF-1-deficient geriatric skin may be caused by defects in mul

4 The adoptive transfer of HDM-pulsed LRP-1-deficient CD11b(+) DCs into WT mice generated a similar

5 Four weeks after AngII-Ald infusion, PAI-1-deficient (PAI-1(-/-)) mice developed severe cardiac fib

6 experiment, injecting mouse PSCs into Pdx-1-deficient rat blastocysts, we generated rat-sized pancre

7 By using both IL-10-deficient and wild-type mothers, we showed that both ino

8 Here, we have reported that miR-146a-deficient mice developed more severe experimental autoim

9 Moreover, miR-146a-deficient mice do not resolve inflammation after discont

10 R-155 targets in tumor-infiltrating, miR-155-deficient CD8(+) T cells, suggesting that miR-155 and IC

11 AR-dependent LTP was also lacking in the n-3-deficient group.

12 nsoni eggs do not develop in mice with IRF-4-deficient DCs (IRF-4(f/f) CD11c-cre).

13 but this effect was delayed in interleukin 6-deficient mice.

14 A20-deficient thymic Treg cells exhibit reduced dependence o

15 ze and insulin content in pancreata of A2AAR-deficient mice were decreased compared with control mice

16 Notably, A2AR-deficient, terminally mature NK cells retained prolifera

17 The use of A2aR-deficient CD4 T cells established that this CGS effect w

18 osure and the stomatal VPD regulation of ABA-deficient mutants may be conditional on the initial pret

19 ter loss were strongly suppressed in the ABA-deficient mutant sitiens, indicating that these effects

20 Metabolomics analysis of ACC-deficient liver identifies a marked increase in antioxid

21 follicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream.

22 rates however that both ActRIIB- and ActRIIA-deficient mice display a hypertrophic phenotype.

23 erapeutic efficacy from gene therapy for ADA-deficient SCID, with an excellent clinical safety profil

24 by the tmeA strain of Chlamydia, since AHNAK-deficient cells revealed no invasion phenotype.

25 levels were correspondingly reduced in SR-AI-deficient mice.

26 model inflammatory stimuli, and alphaMbeta2-deficient PMN displayed defective inflammatory functions

27 ovary control cells (CHOK1) and alphavbeta3-deficient or transfected HEK293 cells.

28 AMCase-deficient mice exhibit premature morbidity and mortality

29 By longitudinal analysis of AnxA2-deficient muscle we find that poor myofiber repair due t

30 on of DNA in the cytoplasm of AT and Artemis-deficient cells.

31 Mutations in ARTEMIS-deficient patients impaired the interaction with the C t

32 Here we report that Atf3-deficient (Atf3(-/-)) mice developed spontaneous tumors,

33 In marked contrast, Atm-deficient tumors displayed an enhanced response to the t

34 Furthermore, TBC1D5 depletion in autophagy-deficient cells rescues retromer recruitment to endosoma

35 WT and B2-deficient mice were infected with H1N1 PR8 by intranasal

36 Additionally, T-bet-deficient Treg cells lacked expression of the Th1-charac

37 also enhanced transduction of the FX binding-deficient HAdV-5HVR5*HVR7*E451Q (AdT*).

38 mic profiling to identify genes enabling BLM-deficient and/or cytidine deaminase-deficient cells to t

39 forks are the entry point for MRE11 in BRCA-deficient cells.

40 Reducing NAPRT levels in a BRCA2-deficient cancer cell line exacerbated DNA damage in res

41 metastases was both strongly inhibited in C3-deficient mice (C3(-/-) mice), with tumors undetectable

42 s administration of recombinant CCL5 to C3aR-deficient mice rescues the defects in inflammatory cell

43 In contrast to C3(-/-) mice, C5-deficient mice had no apparent defect in platelet activa

44 , prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clea

45 cific Ab responses were dysregulated in CCR7-deficient mice, displaying an unexpected increase in the

46 We report that CCRL2-deficient mice have a defect in neutrophil recruitment a

47 reduced IFN-I responses in WT but not CD11b-deficient mice, and protected lupus-prone MRL/Lpr mice f

48 CD11d-deficient M1 macrophages demonstrated improved migration

49 TCR expression, in a newly identified CD247-deficient patient are described.

50 Moreover, residual CD28-deficient TFR cells showed a diminished suppressive capa

51 /6 donors but not from MHC class II- or CD40-deficient donors.

52 Studies of CD40L-deficient patients reveal the critical role of CD40L-CD4

53 were lower before and after ischemia in CD73-deficient mice.

54 Wild-type (WT) and B cell-deficient mice received ovalbumin (OVA) intranasally bef

55 ethality in infected animals, whereas B cell-deficient mice showed CD4(+) T cell loss but recovered f

56 ity to IgG-mediated arthritis in 2 mast cell-deficient murine lines: KitWsh/Wsh, which develops robus

57 myeloid progenitors from NFI-A myeloid cell-deficient mice impeded myeloid cell maturation and promo

58 gammadelta-T-cell-deficient mice developed profound RPE and retinal damage

59 Adoptive transfer of CerS6-deficient splenocytes, which have significantly decrease

60 Transplantation of infected Cftr-deficient alveolar macrophages into the lungs of noninfe

61 combined immunodeficient common gamma chain-deficient stem cell factor (huNSG) mice exhibited robust

62 the L. donovani-infected livers of chemokine-deficient mice (CXCR6(-/-) mice were used as CXCL16-defi

63 how for 4 weeks or a methionine- and choline-deficient diet for 1, 4, 8, or 12 weeks to induce a cont

64 To address this question, we generated Cic-deficient mice and human oligodendroglioma cell models.

65 CL-deficient cells exhibited decreased GFP-tagged mitochond

66 used gene augmentation therapy in a CNGbeta1-deficient dog model to evaluate potential translation to

67 We found that covR-deficient serotype III S. agalactiae 874391 was signific

68 Mice infected with covR-deficient S. agalactiae produced less proinflammatory cy

69 natures in a muscle- and heart-specific CPT2-deficient mouse (Cpt2(M-/-)) model.

70 In agreement, Cry-deficient mice have reduced body ( approximately 30% red

71 ced in the liver and skeletal muscles of Cry-deficient mice.

72 Here we show, using Cu-deficient mouse models, that steady-state levels of ATP7

73 earance, which was corroborated using CXCL10-deficient mice.

74 nt mice (CXCR6(-/-) mice were used as CXCL16-deficient surrogates) indicated that individual IFN-gamm

75 els of human breast cancer or in a cyclin D1-deficient model, we observed a cyclin D1-mediated reduct

76 enicity was restored in either RIPK3- or DAI-deficient mice.

77 ling BLM-deficient and/or cytidine deaminase-deficient cells to tolerate constitutive DNA damage and

78 DN in wild-type (DGKalpha(+/+)) and DGKalpha-deficient (DGKalpha(-/-)) mice in which diabetes was ind

79 all of which are aberrantly elevated in DND1-deficient PGCs.

80 -specific IgE revealed plasma IgE from DOCK8-deficient patients is directed against staple food antig

81 estigate the phenotype and function of DOCK8-deficient CD4(+) T cells to determine (1) intrinsic and

82 ining the infectious susceptibility of DOCK8-deficient patients.

83 Investigations into the DOCK8-deficient CD4(+) T cells provided an explanation for som

84 of Jagged 1 and Jagged 2 single- and double-deficient DCs to induce AAI.

85 In c-REL/IkappaBNS double-deficient mice, Treg numbers were dramatically reduced,

86 ed by Drp1 deletion, and is observed in Drp1-deficient fibroblasts.

87 effects on atherogenesis in apolipoprotein E-deficient (ApoE(-/-)) mice.

88 [S], were evaluated in the apolipoprotein E-deficient (Apoe(-/-)) mouse model of atherosclerosis.

89 c deficiency of CXCR4 in an apolipoprotein E-deficient mouse model.

90 EGFR-deficient myeloid cells in the colon of DSS-treated LysM

91 tion was diminished in myeloid-specific Egfr-deficient mice, as marked by decreased Arg1 and Il10 mRN

92 ydrogen atom source (PhSiH3 ) or an electron-deficient olefin.

93 l protein, PS1, that binds a highly electron-deficient non-natural porphyrin at temperatures up to 10

94 s for the selective halogenation of electron-deficient and strained aliphatic molecules is rare.

95 port, we present unique examples of electron-deficient arenes instead undergoing preferential substit

96 nt dual-metal catalyzed reaction of electron-deficient o-chlorovinylpyridines with o-aminophenylboron

97 transfer from F(-) anions to the pi-electron-deficient ClBDPPV through anion-pi electronic interactio

98 for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylme

99 initial adsorption of water via the electron-deficient H atom and the subsequent dissociation of the

100 Vinyl boronates react with electron-deficient alkyl iodides in the presence of visible light

101 infection), whereas studies with eosinophil-deficient mice identified this innate immune cell as ess

102 ay exert beneficial effects against estrogen-deficient bone loss.

103 In addition, the AP1 factor-deficient newborn mice display a collodion membrane phen

104 , and Erdr1 fails to induce apoptosis in Fas-deficient cells.

105 ogical function of FDXR, we generated a Fdxr-deficient mouse model and found that loss of Fdxr led to

106 regulate myelin thickness, we examined FGFR2-deficient mice for the expression of key signaling molec

107 The HLCC-to-LCC ratio was rescued in FKBP65-deficient murine embryonic fibroblasts by reconstitution

108 gene 1 (ETS1) is overexpressed in these FLI1-deficient iMegs, suggesting FLI1 negatively regulates ET

109 entirely blocked at an early stage in Flower-deficient CTLs and is rescued to wild-type level by rein

110 aluminum hydroxide can be achieved in Foxp3-deficient mice using nondepleting anti-CD4 Abs.

111 meliorated in PPK (Klkb1)-deficient and FXII-deficient mice and in wild-type (WT) mice pretreated wit

112 Furthermore, using IFN-gamma-deficient Th17 cells, we demonstrate the disease-amplify

113 on is increased in B-lineage cells from Gli3-deficient FL and showed that these cells expressed reduc

114 Glycan-deficient Env derivatives can be used as priming immunog

115 ke receptors (TLRs) and integrins, in a gp96-deficient murine cell line.

116 Studies that used splenocytes from GPR120-deficient mice have confirmed this conclusion.

117 ed with a decreased lipolytic capacity of GR-deficient adipocytes under postabsorptive and fasting co

118 Using a miR-H2-deficient mutant virus, we found no evidence that miR-H2

119 Hdac8-deficient LT-HSCs displayed hyperactivation of p53 and i

120 to potentiate PARP inhibitor treatment of HR-deficient tumours.

121 HS-deficient MM cells exhibited strongly decreased autocrin

122 ws activation of cell signaling events of HS-deficient cells.

123 HuR-deficient PDAC cells lacked the ability to engraft succe

124 As a consequence, HVEM-deficient recipients failed to afford protection against

125 ycline-inducible mutant demonstrated that I2-deficient virions are defective in cell entry.

126 largely compromised, and that permitted ICP0-deficient mutants to replicate.

127 On the other hand, the Igf1r-deficient mice exhibited no AHR, and a selective decreas

128 IgG transfer in IgG-deficient mice implicated IgG as the pathogenetic ligand

129 hy subjects caused insulin resistance in IgG-deficient mice via FcgammaRIIB, indicating that similar

130 In vitro, IL4I1-deficient B cells proliferate more efficiently than thei

131 inflammation was marginally reduced in ILC2-deficient mice that received combined DEP+HDM, it was ab

132 contrast, reduced epithelial damage in M-ILK-deficient mice is correlated with elevated levels of epi

133 ry cytokine production are impaired in M-ILK-deficient mice, and activation of epithelial NF-kappaB a

134 ve characterization of different aged immune-deficient mouse strains revealed that T cells significan

135 e-deficient (gp91(phox) knockout [KO]), iNOS-deficient (iNOS KO), and C57BL/6 wild-type mice were ora

136 We used invasion-deficient S.

137 aily iodine supplementation in mildly iodine-deficient pregnant women had no effect on child neurodev

138 s to R294, which is mutated in the BXH2 IRF8-deficient mouse.

139 utor to excessive inflammation seen in Irgm1-deficient mice in different contexts.

140 d with marked metabolic changes in the Irgm1-deficient macrophages, including increased glycolysis an

141 eported here, we found that uninfected Irgm1-deficient mice displayed high levels of serum cytokines

142 hropoiesis.sTfR may be useful to assess iron-deficient erythropoiesis, but inflammation influences it

143 ntly change the estimated prevalence of iron-deficient erythropoiesis.sTfR may be useful to assess ir

144 rentiation, and reduced splenomegaly of iron-deficient Hri(-/-) and eAA mice.

145 the acquisition of effector function in ITK-deficient CD8(+) T cells.

146 In addition, jagn-deficient embryos display defects in apical-basal spindl

147 Jarid2-deficient pancreases exhibit impaired deposition of RNAP

148 We showed that JNK1-deficient mice had a significantly higher survival rate

149 fects of tPA were ameliorated in PPK (Klkb1)-deficient and FXII-deficient mice and in wild-type (WT)

150 Naive PD-L2-deficient (PD-L2(-/-)) mice produced significantly more

151 Compared with wild-type controls, HAT-L4-deficient newborn mice had greater body fluid loss and h

152 ECs from LAL-deficient (lal(-/-)) mice possess enhanced proliferation

153 r T-cell development, as demonstrated by LAT-deficient mice, which show a complete lack of peripheral

154 and lack of TCR signaling restoration in LAT-deficient cell lines reconstituted with a synthetic LAT

155 Canonical Wnt signaling was impaired in LGR4-deficient breast cancer cells, and LGR4 knockdown result

156 other than Vip, yet activity rhythms in Lhx1-deficient mice are similar to Vip(-/-) mice under light-

157 expression, and cellular desynchrony in Lhx1-deficient SCN largely results from Vip loss [17, 18].

158 he effect of GDH1 on AMPK is evident in LKB1-deficient lung cancer, where AMPK activation predominant

159 ful in gauging the clinical response of LRBA-deficient patients to CTLA4-Ig therapy.

160 Deltalsr2; it does not rescue the maturation-deficient biofilms of a DeltagroEL1 mutant, thereby diff

161 tably maintained after WNV infection in MAVS-deficient mice.

162 wall after DVT induction were reduced in MC-deficient mice.

163 scues the premature differentiation of Mcph1-deficient neuroprogenitors in vivo MCPH1 itself is degra

164 onfirmed diminished neurogenesis in the MCT8-deficient cell population as well as aberrant migration

165 We show that Mecp2-deficient neurons also lack homeostatic synaptic plastic

166 ary schwannoma cells, the most common Merlin-deficient tumour and the hallmark for NF2.

167 Merosin-deficient congenital muscular dystrophy type 1A (MDC1A)

168 specimens from DMD, Ullrich CMD, and merosin-deficient CMD patients, all of which present high levels

169 MET-deficient mice did not have defects in intestinal homeos

170 )/LacZ mice had impaired regeneration of MET-deficient ISCs.

171 s and levels of protein expression in Mettl3-deficient naive T cells.

172 t-7c were introduced into otherwise microRNA-deficient Dgcr8 knockout mouse embryonic stem cells.

173 cumulated over five generations in eight MMR-deficient mutation accumulation (MA) lines of the model

174 cellular mechanism, and selectivity for MMR-deficient cells.

175 Forty-eight patients (10.7%) had MMR-deficient tumors, and 40 patients (83.3%) had at least 1

176 verses p53 stabilization and rescues the Mpi-deficient phenotype.

177 Metabolomic profiling revealed that MS-deficient Mtb cultured on fatty acids accumulated high l

178 TLR2-, TLR4-, MyD88-deficient and WT BALB/c mice were intratracheally challe

179 rotected sarcomeres from degradation in ncx1-deficient hearts.

180 tion or elevated mTORC1 signalling in Ndfip1-deficient Treg cells.

181 omyelin) are significantly elevated in NECL4-deficient Schwann cells, particularly specific subspecie

182 ctopically express wild-type and NEDDylation-deficient HBx and found that NEDDylation-deficient HBx s

183 ion-deficient HBx and found that NEDDylation-deficient HBx showed less chromatin localization and les

184 tion sites and observed that the NEDDylation-deficient HBx has shorter half-life.

185 n of premature cellular senescence in an NF1-deficient background.

186 tro functional study demonstrated that NFAT5-deficient macrophages were more susceptible to apoptotic

187 ty against tumor cells, and mice with NFATc1-deficient T cells are defective in controlling Listeria

188 As a result, NKG2D-deficient mice produce significantly less Ag-specific Ig

189 esults showed protection from death in NLRP3-deficient (Nlrp3(-/-)) and NLRP3 inhibitor-treated wild-

190 e increase in mitochondrial proteins in Nox4-deficient lung fibroblasts is inhibited by silencing of

191 iary proteins are severely disturbed in Npc1-deficient mice.

192 ion-related genes NLRP3 and IL-1beta in Nrf2-deficient kidneys after UUO.

193 g to ligate synthetic elements to a nuclease-deficient Cas9 (dCas9) in vitro and subsequently deliver

194 lls, but only reduced proliferation in Nupr1-deficient cells.

195 ncer cells adopted in response to a nutrient-deficient microenvironment.

196 entiate cocaine-primed reinstatement in OCT3-deficient and wild-type mice.

197 PFC underlies cognitive dysfunction in Ophn1-deficient mice, as assessed using a delayed spatial alte

198 to Wipi2-positive puncta are reduced in Optn-deficient cells.

199 deletion also impaired transmission of ORF7-deficient virus among the neuronal cells.

200 NADPH oxidase-deficient (gp91(phox) knockout [KO]), iNOS-deficient (iN

201 P2X7-competent and P2X7-deficient macrophages were isolated and stimulated with

202 geted therapies is comparable across all p53-deficient genotypes and may explain the high incidence o

203 r loss of p53 and that targeting Mdm2 in p53-deficient cancers has therapeutic potential.

204 ed replication of C. trachomatis even in p53-deficient cells.

205 haperone represents an Achilles' heel in p53-deficient transformed cells.

206 found that cleft palate pathogenesis in Pax9-deficient embryos is accompanied by significantly reduce

207 Paxillin-deficient neurons have shorter leading processes that ex

208 Multiphoton imaging revealed that paxillin-deficient neurons migrate approximately 30% slower than

209 human embryonic 293 cell lines, while the PF-deficient mutants lacked the ability to stimulate, and t

210 Importantly, Pfn2-deficient mice showed iron accumulation in discrete area

211 by autophagy accumulate more rapidly in PGRN-deficient neurons.

212 aracterized the metabolic phenotypes of PHD2-deficient RAW cells and primary PHD2 knockout bone marro

213 iological significance, we generated phospho-deficient [Su(H)(S269A)] and phospho-mimetic [Su(H)(S269

214 in ribonucleic acid or expression of phospho-deficient LDHA Y10F sensitized the cancer cells to anoik

215 2 kinase, however, neither a phosphorylation-deficient nor a phosphomimetic mutant of SNAP23 can medi

216 ncreases in growth and total P content of Pi-deficient wild-type rice (Oryza sativa) seedlings.

217 ection with Listeria monocytogenes, DNA-PKcs-deficient murine macrophages produce reduced levels of I

218 ial expectations, EAE-challenged plasminogen-deficient (Plg(-)) mice developed significantly delayed

219 As a consequence, PNPLA1-deficient mice lacked a functional corneocyte-bound lipi

220 e measurements from the leaves of polyprenol-deficient plants revealed impaired photosystem II operat

221 ur at every level of the spinal cord of PPT1-deficient (Ppt1(-/-) ) mice before the onset of neuropat

222 Protein-deficient mice were infected with Cryptosporidium parvum

223 Wiskott-Aldrich syndrome protein-deficient neutrophils are unable to polymerize actin and

224 Infection with a PT-deficient strain induced severe pulmonary inflammation b

225 kinetic profile and efficacy in a human PTEN-deficient LNCaP prostate carcinoma xenograft tumor model

226 a putative synthetic-essential gene in PTEN-deficient cancers.

227 MRE11 is highly unstable in PTEN-deficient cells but stability can be significantly resto

228 inhibitor AZD5363 induced apoptosis in PTEN-deficient DLBCLs irrespective of their molecular subtype

229 umor growth in a genetic mouse model of Pten-deficient endometrioid endometrial cancer.

230 cytometric analysis of lung tissue from H2 R-deficient animals revealed increased numbers of CD1d(+)

231 We found that RAD51D-deficient cells had a reduced capacity for HR-mediated g

232 In contrast, RBPJkappa-deficient mice did not experience AAI and airway hyperre

233 neural plasticity, we subjected C3a receptor-deficient mice, GFAP-C3a transgenic mice expressing biol

234 ects type I or type I/II interferon receptor-deficient mice against lethal ZIKV challenge.

235 Western diet-fed LDL receptor-deficient (Ldlr-/-) mice with myeloid-specific deletion

236 By contrast, in REDD1-deficient R28 cells, neither hyperglycemic conditions no

237 de in patients with advanced mismatch repair-deficient cancers across 12 different tumor types.

238 ion of mutant neoantigens in mismatch repair-deficient cancers make them sensitive to immune checkpoi

239 utation profiles observed in mismatch repair-deficient colorectal cancers.

240 nalyzing activated murine wild-type and Rheb-deficient CD4(+) T cells, as well as murine CD4(+) T cel

241 e consistently dephosphorylated in both Rheb-deficient CD4(+) T cells and T cells treated with rapamy

242 adoptive T cell therapy for melanoma, Runx3-deficient CD8(+) tumour-infiltrating lymphocytes failed

243 it fails to localize to the midbody in SCCRO-deficient cells during abscission, and its inactivation

244 ding Cul3(KLHL9/KLHL13), was intact in SCCRO-deficient cells, suggesting that SCCRO selectively, rath

245 The P. aeruginosa quorum-sensing-deficient DeltalasR mutant also enhances C. albicans pat

246 espan of ZIKV-infected interferon signalling-deficient AG129 mice.

247 n with wild-type, but not enzyme-active site-deficient DHHC3.

248 found that, unlike wild-type T cells, SMAD4-deficient T cells differentiate into TH17 cells in the a

249 Smurf2-deficient osteoblasts display increased expression of RA

250 viral glycoproteins fail to mature in SPCA1-deficient cells preventing viral spread, which is eviden

251 We analyzed alphaII spectrin-deficient mice of both sexes and found that loss of alph

252 Spi2A-deficient TH2 cells were studied in in vitro culture or

253 cts of antibiotics were phenocopied in Stat1-deficient mice, with no additional suppression by antibi

254 imary mouse B cells from wild-type and STAT6-deficient mice cultured for 4 d in the presence or absen

255 dispensable, with all stress defects of Sty1-deficient cells being suppressed by expression of the At

256 Ear thickness of wild-type (wt) and Sucnr1-deficient (Sucnr1(-/-) ) mice, sensitized and challenged

257 Both SUFC- and SUFD-deficient RNAi lines accumulated the same intermediate,

258 uberculosis H37Rv DeltapapA1 sulfoglycolipid-deficient mutant had significantly diminished Congo Red

259 -zone) were detected in both the SUMOylation-deficient-Sf1(2KR/2KR) and Dax1 knockout mouse lines, wi

260 human cells and cystathionine beta-synthase-deficient mouse brains, we find an acute and chronic inh

261 Leukotriene C4 synthase-deficient eosinophils exhibited impaired chemotaxis to C

262 ing in vivo and in vitro analysis using TC10-deficient mice, we define the poorly studied Rho GTPase

263 and cadC are substantially increased in Tdg-deficient cells, those of both AP- and betaE-sites are u

264 TET2-deficient macrophages exhibited an increase in NLRP3 inf

265 into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcino

266 c cystic areas were decreased by 45% in TGR5-deficient TGR5(-/-) ;Pkhd1(del2/del2) mice.

267 ve in polarization and chemotaxis, and TIPE2-deficient mice were resistant to leukocyte-mediated neur

268 Consequently, TIPE2-deficient leukocytes were defective in polarization and

269 ed disease onset, prolonged life span of Tk2-deficient mice and restored mtDNA copy number as well as

270 After M. tuberculosis infection, TOLLIP-deficient monocytes demonstrated increased IL-6, increas

271 tes proximal TCR signaling, we studied TRAF3-deficient mouse and human T cells, which showed a marked

272 The new Traj18-deficient mouse strain will assist in studies of iNKT ce

273 We showed previously that Trex1-deficient cells have reduced mammalian target of rapamyc

274 ction by naive wild type and tristetraprolin-deficient CD8(+) T-cells is comparable.

275 is accelerated, not only in tristetraprolin-deficient mice after cytotoxic T lymphocyte depletion, b

276 Melanomas in PP;Trp53-deficient mice lacked either Ras or Braf mutations, and

277 ators CamkII and Stat1 was impaired in Trpc3-deficient M1 cells, gathering insight about other molecu

278 TRPC6-deficient mouse hearts 1 week after transverse aortic co

279 s3 encoding galectin-3 was increased in Tsc2-deficient cells and serum of Tsc2cKO(Prrx1)-cre mice.

280 Activated TTP-deficient neutrophils exhibited decreased apoptosis and

281 Here, we report that constitutive Twf2a-deficient mice (Twf2a(-/-)) display mild macrothrombocyt

282 Our data showed that the GluA1 ubiquitin-deficient mutant enhances GluA1 phosphorylation on Ser-8

283 portantly, expression of the GluA1 ubiquitin-deficient mutants inhibited the adverse effects of Abeta

284 However, ULK1-deficient cells responded normally to DMXAA, indicating

285 reatment of wild-type mice with CSP, and uPA-deficient mice were unresponsive.

286 A Us3-deficient virus was hypersensitive to low-energy-induced

287 ric epithelial cells with wild-type and VacA-deficient H. pylori strains, treatment of cells with pur

288 In contrast, versican-deficient (Vcan(-/-)) lungs did not exhibit increases in

289 ors represent potential therapeutics for VHL-deficient CC-RCC.

290 he viral long terminal repeat (LTR) from Vpr-deficient proviruses was significantly reduced.

291 in viral replication upon infection with Vpr-deficient HIV-1.

292 tation of apoptotic cells, DC-specific Vps34-deficient animals developed increased metastases in resp

293 Similar to Vps34-deficient platelets, ex vivo treatment of wild-type mous

294 d properties, in the life cycle of cell wall-deficient L-form bacteria.

295 udies confirmed that the capsule of the WciG-deficient isolate lacked O-acetylation but was otherwise

296 rs from cisplatin mutation signatures in XPF-deficient Caenorhabditis elegans and supports a model in

297 nd antisteatotic effects observed in ZFP36L1-deficient mice were accompanied by impaired lipid absorp

298 e serial transplantation assays using Zfp521-deficient mice revealed that ZFP521 regulates HSC self-r

299 In zinc-deficient cells, RTC4 RNA with longer transcript leaders

300 mutant p53 by restoring zinc binding to zinc-deficient p53 mutants.