ライフサイエンスコーパス: -fold reduction in

1 ubstitution in P2 caused approximately 1,000-fold reduction in CheA-CheY binding affinity, while Ala

2 5 into the Wyeth strain resulted in a >1,000-fold reduction in lethality of vaccinated athymic nude m

3 was prevented, with at least a 500- to 1,000-fold reduction in the efficiency of initiating gene expr

4 IFN induction coincided with a 100- to 1,000-fold reduction in virus titer, supporting the hypothesis

5 llenge gave a protective effect and a 10,000-fold reduction in CFUs in tissues (p < 0.001).

6 this double mutant strain exhibited a 10,000-fold reduction in mouse bladder colonization 24 h after

7 hat this elevated pK(a) results in a >10,000-fold reduction in the rate constant for oxidations of th

8 NA (10 ng/muL), we demonstrated over 100,000-fold reduction in lambda-DNA concentration.

9 Mutations of these residues cause an 18,000-fold reduction in catalytic rate in vitro and large-scal

10 in the expression of mAP and M80 and a 2,000-fold reduction in viral growth were observed in cells ex

11 utant of pol beta was shown to have a 29,000-fold reduction in polymerization rate with no reduction

12 Compared to the C:G pair, a 1.9- and 79,000-fold reduction in Dpo4 efficiency was observed for termi

13 e-molecule force spectroscopy revealed a 2.1-fold reduction in the normalized force required to unfol

14 4, but longer spacers (x >/= 5) lead to a 10-fold reduction in affinity.

15 nserved structure proximal to A1 caused a 10-fold reduction in all transcripts that utilized A1.

16 in raster mode and discuss advantages (a 10-fold reduction in analysis time) and challenges (suitabl

17 crease in deposition rate together with a 10-fold reduction in analyte consumption while ensuring les

18 nificantly reduced T-cell responses and a 10-fold reduction in anti-EcAII IgG titers relative to the

19 and 1-sample MCIFs both showed at least a 10-fold reduction in AUC and Ki errors compared with uncorr

20 the diacylglycerol lactones showed only a 10-fold reduction in binding affinity with the triple argin

21 r numbers are maintained, but there was a 10-fold reduction in committed PreproB-lymphoid progenitors

22 orded in marine sedimentary deposits as a 10-fold reduction in deposition rates of Eel-derived sedime

23 nt communities: a slope of -0.5 depicts a 10-fold reduction in diversity for every 100-fold increase

24 h assay component resulted in more than a 10-fold reduction in fluorescence background and improved t

25 The S225A mutant exhibited a 10-fold reduction in genome replication, whereas the S225D

26 However, there was a 10-fold reduction in hematologic ADRs among variant carrier

27 A 10-fold reduction in IL-6 and a 5-fold decrease in hyaluron

28 The altered gp5/Trx exhibits a 10-fold reduction in its ability to support growth of T7 ph

29 ucity of memory B cells translated into a 10-fold reduction in latent load.

30 cohort study, these changes resulted in a 10-fold reduction in measurements of viral diversity.

31 contractile ring, but is insensitive to a 10-fold reduction in myosin II levels.

32 150-fold improvement in sensitivity and a 10-fold reduction in peak width in the following microchip

33 hoablatant (S225A) mutation resulted in a 10-fold reduction in replication and a perinuclear restrict

34 ts using fluorescence anisotropy showed a 10-fold reduction in RNA binding in the G100E and G104E mut

35 lants overexpressing AOX exhibited over a 10-fold reduction in ROS accumulation compared with wild-ty

36 e preparation of maltenes by exhibiting a 10-fold reduction in sample processing time, compared to th

37 d peak-calling pipelines we demonstrate a 10-fold reduction in signals in regions common to the black

38 Tandem mass spectrometry revealed a 10-fold reduction in the expression of olpB, which may expl

39 the child and both parents resulted in a 10-fold reduction in the number of potential causal variant

40 Actin stabilized Tm, causing a 10-fold reduction in the rate of cleavage at Arg-133.

41 independently associated with more than a 10-fold reduction in the risk of a complicated course (rela

42 Finally, we report that a 10-fold reduction in TRF2 affects the regulation of telomer

43 e 1 Env DNA vaccine in mice and allowed a 10-fold reduction in vaccine dose.

44 mmunized with such conjugates displayed a 10-fold reduction in viral load.

45 ubstantially better outcomes, including a 10-fold reduction in work disability and an approximately 2

46 mice was associated with a approximately 10-fold reduction in lung virus titer and protection agains

47 NR2D subunits results in a approximately 10-fold reduction in Mg(2+) potency.

48 sufficient B cells, there was again a ca. 10-fold reduction in the frequency of MyD88(-/-) B cells ha

49 tution or deletion of Phe 567 leads to a >10-fold reduction in enzymatic activity, underscoring its i

50 ble data, by treatment day 9 there was a >10-fold reduction in viability in 100% (24/24) of cases and

51 n the Mk3(-/-) mice was accompanied by a >10-fold reduction in viral lung titer and an increase in th

52 earing either substitution showed an over 10-fold reduction in aminoacylation activity.

53 rees C day/night cycle had a greater than 10-fold reduction in viral DNA accumulation compared to pla

54 fission intermediates that contributed to 10-fold reduction in bulk rates of membrane fission.

55 ouse neuroblastoma cells results in 4- to 10-fold reduction in proteinase K (PK)-resistant PrP(Sc), i

56 to 100-fold in TALE-R activity and up to 10-fold reduction in TALEN activity compared with target se

57 ibroblasts from either subject, despite a 10-fold-reduction in TRNT1 protein levels in fibroblasts of

58 The CipA deletion mutant exhibited a 100-fold reduction in cellulose solubilization rate, althoug

59 f DENV in vitro and in vivo, marked by a 100-fold reduction in DENV load in murine lymph nodes.

60 hypomorphic mouse strain that displays a 100-fold reduction in epidermal matriptase mRNA levels.

61 St14 hypomorphic mice, which have a 100-fold reduction in intestinal matriptase mRNA levels, dis

62 A 100-fold reduction in neutrophil infiltration was observed i

63 of L. major, and this correlated with a 100-fold reduction in parasite load.

64 ated a 50% reduction in testis weight, a 100-fold reduction in sperm number and the presence of abnor

65 moval of BsCBM66 from SacC results in a ~100-fold reduction in activity against levan.

66 Our simulations predict an ~100-fold reduction in heating compared with previous designs

67 rexpressing hiCE displayed approximately 100-fold reduction in the IC50 for PPD compared to cells lac

68 se with diameters of about 50 nm exhibit 100-fold reduction in thermal conductivity, yielding ZT = 0.

69 of KRIT1(L717,721A), which exhibited a >100-fold reduction in HEG1 affinity.

70 This method, Tn5mC-seq, enables a >100-fold reduction in starting material relative to conventi

71 ss of hydrolase activity, resulted in a >100-fold reduction in the efficiency of UCHL1(GLU7ALA) relat

72 ion of rod CNG channels and a subsequent 100-fold reduction in rod responses, while preserving normal

73 icacy and selectivity, yielding a 20- to 100-fold reduction in population for cells containing a cogn

74 solution of acute infection and a 10- to 100-fold reduction in the number of bacteria and tissue-infi

75 phosphorylation and also caused a 10- to 100-fold reduction in virus production, along with decreased

76 a and bacteremia, as evidenced by a 100-1000-fold reduction in bacterial burden following challenge.

77 The Ab treatment led to a 1000-fold reduction in B cell number that lasted 6 wk.

78 mutation in streptavidin that causes a 1000-fold reduction in biotin binding affinity without disrup

79 onductance by N451S, but with an almost 1000-fold reduction in apparent affinity.

80 f the PERV pol gene and demonstrated a >1000-fold reduction in PERV transmission to human cells, usin

81 imized correctly, result in a more than 1000-fold reduction in biomaterials and cells consumption whe

82 f 1 novel variant, E141G-CaM, revealed an 11-fold reduction in Ca(2+)-binding affinity and a function

83 tic growth factors, resulting in an up to 11-fold reduction in response to a cocktail of stem cell fa

84 A 4- to 11-fold reduction in the rate of ribonucleotide incorporati

85 ain cleavages showed approximately 4- and 11-fold reductions in A2 subunit generation and approximate

86 sed fragility of this locus, with a 2- to 12-fold reduction in metaphase gaps and breaks compared wit

87 10G and 9G variants, the latter having a 13-fold reduction in surface expression of PorA.

88 way offers a 4-fold reduction in time and 13-fold reduction in resource requirement compared to the c

89 variant displayed a approximately 10- to 13-fold reduction in dNTP binding affinity, compared with t

90 he hydroxylated QDs result in a dramatic 140-fold reduction in nonspecific binding relative to that o

91 NA was maintained with a 6-, >143-, and >143-fold reduction in affinity toward single C-C, A-A, and G

92 nal absence of GP Ib-IX correlates with a 15-fold reduction in the number of lung metastatic foci usi

93 ithin the cytoplasmic compartment led to >15-fold reduction in false-positive signals and a significa

94 a homologous R286K substitution causes a 150-fold reduction in k(cat)/K(m).

95 d-type HSV-2 infection and can lead to a 150-fold reduction in wild-type HSV-2 viral replication in c

96 transmembrane 6 also had a major effect (18-fold reduction in salmeterol affinity).

97 tin sulphate or heparan sulphate-PGs and 2.2-fold reduction in neurocan and brevican core proteins in

98 ificant reduction in hepatic I/R injury (4.2-fold reduction in the aminotransferase and a 3.5-fold re

99 y induced the greatest tumor regression (6.2-fold reduction in size compared to PBS-treated controls)

100 of several ISGs (r = -0.68; P = 0.001); a 2-fold reduction in a four-gene ISG signature predicted an

101 st this USA300 strain, resulting in only a 2-fold reduction in bacterial burden.

102 d purified S462A mutant enzyme exhibited a 2-fold reduction in CTP synthetase 1 activity, whereas the

103 uction of F5H expression but only around a 2-fold reduction in expression of other lignin pathway gen

104 nstead, we found that MVT binding caused a 2-fold reduction in F-actin's bending persistence length a

105 ificantly decreased actin turnover, with a 2-fold reduction in filament severing frequency.

106 ciency induces, as previously described, a 2-fold reduction in mature B cells.

107 by gamma-radiation doses >/=2.5kGy, and a 2-fold reduction in OTA cytotoxicity was observed.

108 However, this leads to only a 2-fold reduction in rate of incorporation at a physiologic

109 riants with a 10G repeat tract exhibited a 2-fold reduction in surface expression of PorA protein.

110 e antigen-presenting cells, resulting in a 2-fold reduction in T-cell priming.

111 emsima glycoforms, which translated into a 2-fold reduction in the level of FcgammaIIIa receptor bind

112 xpression pattern, Id1 deficiency led to a 2-fold reduction in the number of LT-HSCs defined as Lin(-

113 ematic use of PET/CT was associated with a 2-fold reduction in the number of relapses (9.6% vs. 4.2%,

114 se PLT remained greater than 100,000 had a 2-fold reduction in the occurrence of GEV (P = 0.0374).

115 in the Pcat promoter mutant resulted in a 2-fold reduction in total amounts of capsule and in avirul

116 in the 280-290 b1-NRP2 loop resulted in a 2-fold reduction in VEGF165 affinity.

117 n of endogenous Mov10 by 80% resulted in a 2-fold reduction in virus production but no discernible im

118 in nuclear import rate and a approximately 2-fold reduction in nuclear residence time compared with t

119 on in work disability and an approximately 2-fold reduction in total joint replacement and mortality.

120 the treated group could have resulted from 2-fold reduction in primary tumor size compared with that

121 n, while on-target knockdown was improved (2-fold reduction in IC50).

122 nted in wavelet domain to achieve at least 2-fold reduction in the number of holographic measurements

123 These mutants showed a modest 2-fold reduction in cell-to-cell infection assays.

124 saccharide IgM mAb ( approximately 1.2- to 2-fold reduction in fluorescence).

125 Compared with 4,4'-o-BBV, 2-fold reductions in lower limits of detection (LOD) and q

126 deficient or CD4-depleted mice demonstrate 2-fold reductions in HIF-1alpha expression as compared to

127 A mutant exhibited a modest (approximately 2-fold) reduction in competitiveness, while the other two

128 the receptor binding site that leads to a 20-fold reduction in binding.

129 ve complex (PRC) targets, together with a 20-fold reduction in expression of fertilization independen

130 Moreover, a 20-fold reduction in Gbeta5 and RGS9-1 expression was also

131 flow over other SPROX protocols include a 20-fold reduction in the amount of total protein needed for

132 eration, which reflected an approximately 20-fold reduction in cleavage rate at Arg372.

133 und that ART was associated with a 10- to 20-fold reduction in risk for sexual transmission of HIV.

134 er to as read clouds This enables a 4- to 20-fold reduction in sequencing requirements and a 5-fold i

135 in unpredictable ways, ranging from 3- to 20-fold reductions in maximal growth rate.

136 n in plasma HIV RNA levels and an almost 200-fold reduction in HIV-infected human cell numbers in mou

137 idge-have major effects, causing 100- to 200-fold reductions in catalytic efficiency (k(cat)/K(m)).

138 ncy, except for Arg173, which displayed a 22-fold reduction in IC(50).

139 We report here that approximately 22-fold reduction in 2D NMR data collection time for the bo

140 cantly (P < 0.001) reduced densities, a 2.25-fold reduction in sinking rates, and a higher propensity

141 etargeting system produced a greater than 25-fold reduction in total body radiation exposure relative

142 total N-nitrosamine concentration, a ~25000-fold reduction in concentration is needed between washwa

143 in mice infected with spores and led to a 26-fold reduction in lung CFU by 6 d postinfection versus n

144 A 1.3-fold reduction in the rate of transducin activation by r

145 on schemes and observe that OSS provides a 3-fold reduction in average seed frequency over the best p

146 Loss of miRNAs resulted in a 3-fold reduction in binucleate hepatocytes, indicating tha

147 e showed a diffuse labeling pattern with a 3-fold reduction in dentin appositional rate compared to c

148 loss of complexity could cause more than a 3-fold reduction in fishery productivity.

149 icant sparing of white matter tracts and a 3-fold reduction in lesion volume, and resulted in marked

150 Additionally, a 3-fold reduction in non-geminate recombination is measured

151 2D-DIGE revealed a 3-fold reduction in optic nerve neurofilaments.

152 red to the wild-type strain, also showed a 3-fold reduction in parasite burden.

153 level of primary expansion, with at most a 3-fold reduction in the case of responses to Listeria.

154 utation of one of the MDRs, MdrM, led to a 3-fold reduction in the IFN-beta response to L. monocytoge

155 nd CD103(+) DCs in the liver, results in a 3-fold reduction in the proliferative response of Ag-speci

156 CD), a sterol-chelating reagent, causing a 3-fold reduction in total cellular sterols as well as enha

157 n the putative C (coupling) motif causes a 3-fold reduction in velocity and a 6-fold reduction in pro

158 ng ability and yet have only approximately 3-fold reduction in ATPase stimulation by nucleosomes.

159 quitinome studies and show a approximately 3-fold reduction in the proportion of miscleaved peptides

160 channel function, such as a approximately 3-fold reduction in the response to cAMP.

161 The microfluidic approach showed a nearly 3-fold reduction in error as compared to previous methods.

162 tance (>/=50%), altered burst proportions (3-fold reduction in the proportion of long bursts), and en

163 versus 18.5+/-3.5%), and oxidative stress (3-fold reduction in tissue malondialdehyde).

164 IL-8-treated LAPC-4 cells exhibit a 2- to 3-fold reduction in PSA and AR levels, when compared with

165 one marrow iNKT numbers, we observed 2- to 3-fold reduction in the numbers of iNKT cells in the splee

166 3 knockdown and CRM-1 overexpression cause 3-fold reductions in PGC-1alpha target gene expression, co

167 row specificity of Apo3A at acid pH, a 13-30-fold reduction in specific activity is accompanied by re

168 and pulling forces that result in up to a 30-fold reduction in the threshold electric field needed to

169 ge phagosomal acidification resulted in a 30-fold reduction in USA300 expression of the staphylococca

170 ence of FliS resulted in an approximately 30-fold reduction in extracellular Hag accumulation in cell

171 We observed a >300-fold reduction in the IFN-stimulated genes (ISGs) MxA an

172 rhesus fibroblasts led to a greater than 300-fold reduction in the viral titer by 48 h but had little

173 dvantage of this assay is the more than 3000-fold reduction in radioactive waste over existing protoc

174 A 33-fold reduction in NA expression is accompanied by only a

175 e R1689H variant showed an approximately 340-fold reduction in the rate of Arg-1689 cleavage, whereas

176 PK17 and -34 results in an approximately 350-fold reduction in pollen transmission efficiency.

177 ure transcriptional termination and up to 39-fold reductions in full-length transcripts in adult mous

178 81% decrease in XT-1 mRNA, an average of 1.4-fold reduction in GAG-side chains of chondroitin sulphat

179 f the reporter genes, as suggested by a 10.4-fold reduction in L-protein RNA transcript.

180 ha-smooth muscle actin expression, and a 2.4-fold reduction in collagen I deposition.

181 ithin bulges and loops and resulted in 0.3-4-fold reduction in the measured binding affinities for di

182 and microtip electrode pairs resulted in a 4-fold reduction in nonspecific adsorption of blood cells

183 Concomitantly, we observed a 4-fold reduction in spontaneous miniature release events f

184 The pathway offers a 4-fold reduction in time and 13-fold reduction in resource

185 UBC promoter intron loss caused a 4-fold reduction in transgene expression.

186 ers were right-side out, and we observed a 4-fold reduction in transport rate.

187 of Cyp24a1 (BVE(Cyp24a1-null)) exhibited a 4-fold reduction in tumor growth.

188 on of arsB in C. jejuni resulted in 8- and 4-fold reduction in the MICs of arsenite and arsenate, res

189 of these residues leads to a approximately 4-fold reduction in k(cat) for Cu(I) oxidation.

190 y precursor population and a corresponding 4-fold reduction in CD4(+) memory cell number.

191 positions relative to the wild type had a >4-fold reduction in HI titers compared to homologous antis

192 oval, however, was significantly impaired (4-fold reduction in rate) compared with MOR1.

193 prophylaxis achieved a highly significant, 4-fold reduction in postoperative endophthalmitis in patie

194 from these viruses exhibited only a 2- to 4-fold reduction in their dNTP utilization efficiency but

195 Classical nicotinic agonists show a 10-40-fold reduction in binding affinity, whereas binding of l

196 R740H by thrombin showed an approximately 40-fold reduction in the rate of A2 subunit generation, whi

197 ver, these virions show an approximately 400-fold reduction in specific infectivity due to an inabili

198 Glu214 to Ala or Asp caused at least a 4000-fold reduction in k(cat), with 10-fold increases in K(m)

199 However, PMCA4a rescue caused a 44-fold reduction in AP-2beta, a known anti-proliferative t

200 n absence of stromal Cav-1 predicted an 11.5-fold reduction in 5-year progression-free survival.

201 duced synergistic effects, including an 11.5-fold reduction in LC50, 43% reduction in LT50 and a 78%

202 ion experiments at 50 degrees C allows a 2.5-fold reduction in cellulase loading compared with using

203 nf6Delta cells there was a approximately 2.5-fold reduction in rRNA synthesis rate compared to WT, bu

204 es exhibited a corresponding approximate 3-5-fold reduction in cytotoxic activity [L1210 IC(50) for (

205 reduction in the aminotransferase and a 3.5-fold reduction in aspartate aminotransferase) compared w

206 d experimental conditions, we achieved a 3.5-fold reduction in nonspecific adsorption of non-target p

207 duced damage, as indicated by a relative 3.5-fold reduction in the number of dying neurons adjacent t

208 utions are proximal to IIIS5, exhibits a 4.5-fold reduction in dihydropyridine binding and is insensi

209 lex mixtures such as urine combined with a 5-fold reduction in analysis time compared with the conven

210 Pretreatment with c-di-GMP resulted in a 5-fold reduction in bacterial CFU in the lung (P < 0.05) a

211 advantages include shortened run times, a 5-fold reduction in formaldehyde concentration, a signific

212 In the model, a 5-fold reduction in infectivity (from 1.6% to 0.3%) occurr

213 in NA expression is accompanied by only a 5-fold reduction in K(b)-SIINFEKL complex cell-surface exp

214 term hematopoietic stem cells (LT-HSCs), a 5-fold reduction in LT-HSCs capable of 24-hour homing, and

215 the Npu DnaE intein to splice with only a 5-fold reduction in rate compared to the wild-type Cys+1 i

216 ast, the revertant genome exhibited only a 5-fold reduction in replication.

217 Instead, the absence of Nlrp3 caused a 5-fold reduction in the number of tumor-associated MDSCs f

218 fect, while dual inactivation results in a 5-fold reduction in thymocyte cellularity, accompanied by

219 nsfection in HEK293 demonstrated a 28- and 5-fold reduction in the expression of tTG(V1) and tTG(V2),

220 in Vero cells and showed an approximately 5-fold reduction in specific infectivity, commensurate wit

221 licing but corresponded to a approximately 5-fold reduction in the accumulation of M1.

222 ground (AdT*RGE) resulted in a significant 5-fold reduction in spleen uptake and attenuated the antiv

223 ylthiobenzothiazole; APB) leads to a 3- to 5-fold reduction in TBSV replication in yeast.

224 and found 15 genes with significant (>or=1.5-fold) reduction in expression in at least one proband.

225 m values, and those scoring higher than a 50-fold reduction in k cat/ K m value were selected for fur

226 This protocol resulted in a 50-fold reduction in material required from previous CEC me

227 ctor, whereas PMCA4b rescue resulted in a 50-fold reduction in p15 (Cyclin D1/Cdk4 inhibitor).

228 RAG1 C325Y demonstrated a 50-fold reduction in recombination activity in cultured pro

229 labeling (TUNEL) revealed a approximately 50-fold reduction in beta-cell apoptosis in streptozotocin-

230 r Ocr monomer results in an approximately 50-fold reduction in binding affinity for a methyltransfera

231 opulations, resulting in an approximately 50-fold reduction in IL-7-dependent B lineage generative ca

232 There is also an approximately 50-fold reduction in the affinity of the R229W variant for

233 we found 39 strong terminators, yielding >50-fold reduction in downstream expression, that have suffi

234 hy caused by viable bacteria, with a peak 50-fold reduction in thymocyte numbers.

235 1c gene from C. jejuni resulted in 10- to 50-fold reductions in the natural transformation frequency.

236 the expression of M80.5/protease and a 2,500-fold reduction in viral growth.

237 ate bacterial cells and their DNA with a 500-fold reduction in sample volume (from 10 to 0.02mL).

238 substrate when the enzyme suffers a 175-550-fold reduction in k(cat).

239 ered lipid homeostasis associated with a 0.6-fold reduction in the expression of the gene elongation

240 tin treatment, which was the result of a 1.6-fold reduction in mitochondrial volume density and alter

241 nd lymph node metastasis, resulting in a 3.6-fold reduction in progression-free survival.

242 in the Reb1p-binding sequence caused an 8.6-fold reduction in beta-galactosidase activity.

243 in H1650 SP cells after 2h resulting in a 6-fold reduction in AnxA2 mRNA expression and 92% decrease

244 auses a 3-fold reduction in velocity and a 6-fold reduction in processivity.

245 e the time-limiting incubation step with a 6-fold reduction in the incubation time.

246 corporation could be partly explained by a 6-fold reduction in the specificity constant of the CMP-Kd

247 ld increase in k(cat) and an approximately 6-fold reduction in the K(m) for ATP and by rendering the

248 iod, S100a9(-/-) mice displayed an average 6-fold reduction in circulating and lung-recruited neutrop

249 ays after injection, there were 3.8- and 2.6-fold reductions in the mRNAs for M-cone and S-cone opsin

250 mples analyzed, with SERS demonstrating a 60-fold reduction in acquisition time compared with HPLC.

251 placental insufficiency/FGR, the observed 60-fold reduction in the choline/lipid ratio by (1)H MRS ma

252 Mutation of fosB or bshA caused a 16- to 60-fold reduction in fosfomycin resistance in these S. aure

253 Finally, there is more than a 600-fold reduction in the HSC pool of mice deficient in both

254 proline causes a massive approximately 6000-fold reduction in catalytic efficiency.

255 by fluorophosphonate derivatives (13- to 63-fold reduction in potency).

256 ering RNAs in INS-1E cells resulted in a 1.7-fold reduction in glucose-stimulated insulin secretion.

257 ion in FABP4 transcription (P=0.049) and 2.7-fold reduction in apoptosis (activated caspase 3; P=0.04

258 from DGK1-overexpressing cells showed a 7.7-fold reduction in DAG kinase activity; the reduced enzym

259 absence of both Itk and Rlk, leading to a 7-fold reduction in invariant NKT cell numbers in the thym

260 alanine produced an at least approximately 7-fold reduction in activity, while a histidine and tyrosi

261 eta immunization resulted in an impressive 7-fold reduction in the number of amyloid core plaques and

262 Accordingly, we find modest 1.5- to 2.7-fold reductions in G.T activity upon altering the CpG co

263 ubunit generation and approximately 3- and 7-fold reductions in A1 subunit generation for the R1689H

264 A significant (2.7-fold) reduction in CD3zeta chain expression on CD3epsilo

265 HIV infection as manifested by a profound 70-fold reduction in plasma HIV RNA levels and an almost 20

266 e interval: 1.6, 10.4), and there was a 2.75-fold reduction in the median time to progression.

267 contrast, L-cIDPR displays a comparative 75-fold reduction in activity, but is only ca 2-fold less p

268 the variant allele was associated with a 3.8-fold reduction in FABP4 transcription (P=0.049) and 2.7-

269 Preliminary data show a 3.8-fold reduction in the rate of preterm delivery, a decrea

270 ed a 25% reduction in homing efficiency, 3.8-fold reduction in transplantable long-term hematopoietic

271 phage lambda gpA packaging motor causes an 8-fold reduction in translocation velocity without substan

272 f protein S, resulting in an approximately 8-fold reduction in Ki compared with TFPI alone.

273 ential impact on SCD risk reduction (up to 8-fold reduction in the number of SCDs in the population)

274 on, the variant integrases displayed up to 8-fold reductions in their catalytic efficiencies for 3'-p

275 Pneumococci lacking RafK showed a 50- to 80-fold reduction in expression of the raf operon genes aga

276 d decreases in affinity for ATP and up to 80-fold reductions in turnover rate.

277 ) of 390 +/- 80 nM) with a 13-, 169-, and 85-fold reduction in affinity toward single C-C, A-A, and G

278 th retapamulin ointment resulted in up to 85-fold reduction in bacterial burden and a 53% decrease in

279 from isolated muscle fibers resulted in a 9-fold reduction in myoblast expansion, caused by delayed

280 However, we observed a 9-fold reduction in number of neutrophils infiltrating isc

281 cells in IRAK-M(-/-) mice resulted in a five-fold reduction in tumor growth as compared with tumors i

282 This allows for a four-fold reduction in contact time compared to conventional

283 lls and tumors to docetaxel, allowing a four-fold reduction in effective dose.

284 This many-fold reduction in measurement time will enable more freq

285 1,000-fold increase in speed and a 1-million-fold reduction in cost.

286 unique cellular barcodes, we achieved a 2(n)-fold reduction in the number of arrays and quantity of r

287 mbinant mutant calmodulins exhibited several-fold reductions in calcium binding affinity.

288 of human and mouse cortical neurons with six-fold reduction in image data requirements and three time

289 f the increase in PEF energy to ensure a ten-fold reduction in De (ze, 63.7 J), activation electric f

290 Thousand-fold reductions in IgG1 titers to both Ags were observed

291 esults in central tumor necrosis and a three-fold reduction in human tumor vascular density.

292 se experiments reveal an approximately three-fold reduction in activation energy for ion transport at

293 Western blotting confirmed a two- to three-fold reduction in renal cortical homogenate insulin rece

294 of catalase in the brain resulting in three-fold reductions in inflammation and complete neuroprotec

295 castrated men and was associated with a two-fold reduction in area under the curve (P = .0001), alth

296 a formation by serum starvation led to a two-fold reduction in ciliogenesis in fibroblasts derived fr

297 c superhydrophobic surface can lead to a two-fold reduction in contact time compared to equivalent ri

298 fly-infested plants exhibited at least a two-fold reduction in gall formation on both stem and crown

299 those with MPO G alleles had more than a two-fold reduction in hazard of recurrence (adjusted hazard

300 There was a two-fold reduction in the amplitudes of the evoked endplate