ライフサイエンスコーパス: -fold

1 2 was significantly decreased by 2.8 +/- 1.0-fold.

2 tein 1c target gene fatty-acid synthase (3.0-fold), early growth response-1 (3.2-fold), and TNFalpha

3 wth response-1 (3.2-fold), and TNFalpha (3.0-fold), whereas the expression of peroxisome proliferator

4 FP group, cells from BMP group showed >1,000-fold higher BMP-2 release, and the majority of them stai

5 utated) immunocytokines that are up to 1,000-fold more potent on target cells, allowing specific sign

6 lysine-PEG copolymer, enabling up to a 1,000-fold protection against digestion by serum nucleases.

7 h SP (1 microM), markedly increase (by 1,000-fold) TNF gene expression in cultured human LAD2 and pri

8 Apelin-36-[L28C(30kDa-PEG)] is 10,000-fold less potent than apelin-36 at activating the APJ re

9 Mutations of these residues cause an 18,000-fold reduction in catalytic rate in vitro and large-scal

10 ture and has a much higher (4,000- to 20,000-fold increased) particle-to-PFU ratio in vitro than herp

11 methylation, which, together, achieve 30,000-fold MECP2 up-regulation from the Xi in cultured cells.

12 t the state level, variation ranged from 2.1-fold (Wisconsin decile range, 1.5%-3.3%) to 9.5-fold (Ne

13 with cancer ( P < .001), with 3.3-fold, 2.1-fold, and 1.8-fold differences shown for lung, colorecta

14 ns in pathogenesis-associated genes were 3.1-fold enriched in infecting but not nose-colonizing bacte

15 d Poly(I:C), respectively, with at least a 1-fold change relative to unexposed thrombocytes.

16 eachates was enhanced as indicated by a 2-10-fold increase in distribution coefficients for individua

17 ood at different larval masses produced a 10-fold difference in mass between smallest and largest adu

18 erial lysis typically requires at least a 10-fold higher electric field ( approximately 10 kV/cm), re

19 meta-analysis of four studies estimated a 10-fold increase (in other words, times 10) in PBDE exposur

20 nserved structure proximal to A1 caused a 10-fold reduction in all transcripts that utilized A1.

21 increase in stiffness correlating with a 10-fold upregulation of lysyl oxidase like-1 gene expressio

22 ion angle and polarization, and achieved 10-fold enhancement in fluorescence intensity compared to a

23 nt reduction in Galphaq binding affinity (10-fold increase in Ki compared with WT RGS2 in a flow cyto

24 th subnanomolar affinity at acidic pH and 10-fold lower affinity at neutral pH.

25 sults show that C152 has an approximately 10-fold greater affinity than C461 for lipid bilayers, desp

26 stasis of breast cancer was approximately 10-fold smaller than glioma vasculature.

27 ome of closely related cyanobacteria, but 10-fold larger than most plastid genomes.

28 the PykF Khalf for phosphoenolpyruvate by 10-fold (from 3.5 to 0.36 mm), thus influencing glycolysis.

29 ed Th17 induction and the correspondingly 10-fold higher CT B subunit-specific serum IgG response in

30 long with an improved limit of detection (10-fold enhancement, 100 picomole) in the detection of angi

31 During 10-fold cross validation, we increased the accuracy of the

32 on is largest in small pores, increasing >10-fold but remaining 30-fold shorter than the DNA contour

33 ss than 0.2 to greater than 0.7 IU/ml had 10-fold higher tuberculosis incidence rates than those who

34 teristic curve) that reaches 0.65 both in 10-fold cross-validation and on an independent test set.

35 ediated intracellular delivery results in 10-fold improvement of its cancer cell-killing efficacy.

36 n by 50%, impedes salivary gland invasion 10-fold, and causes a complete absence of liver invasion as

37 ficant increases in lymphoma in both men (10-fold increase, P < .001) and women (8.34-fold increase,

38 hed at the vegetal pole and six were over 10-fold enriched at the animal pole.

39 143; 95% CI: -0.248, -0.039, p=0.008) per 10-fold increase in the estimated amount of sulfur used wit

40 The improved signal-to-noise ratio (10-fold enhancement) in the detection of angiotensin I is d

41 gA, which reduced channel activity up to 10-fold.

42 ities was assessed and validated by using 10-fold cross-validation to limit the effect of optimistic

43 erformance was internally validated using 10-fold cross-validation.

44 ) family of tyrosine kinase receptors was 10-fold higher in primary tumors of metastatic colorectal t

45 High extraction efficiency (90%), a 100-fold preconcentration factor and a detection limit of 5.

46 utine in tobacco (Nicotiana tabacum) but 100-fold less frequent in Arabidopsis (Arabidopsis thaliana)

47 ators, and not significantly affected by 100-fold excess sulfate, which reduced selenate uptake by 10

48 e that specific DNA molecules can induce 100-fold volumetric hydrogel expansion by successive extensi

49 ibitor, and its affinity for legumain is 100-fold higher than that of cystatin C.

50 retains full metabolic activity, but is 100-fold impaired in its ability to activate APJ.

51 tionary phase and boosts heat resistance 100-fold when expressed in Escherichia coli This qualifies C

52 uce the actin sliding velocity more than 100-fold in the in vitro motility assay.

53 ifferent types of honey varies more than 100-fold, it is a target for fraud.

54 ough the amount of HT in the biscuit was 100-fold lower than the biscuit formulated with HT.

55 ile THC concentrations in the lymph were 100-fold higher than in plasma.

56 typical of type I IFNs, albeit with 100-1000-fold reduced potency compared with rmIFNalpha1 and rmIFN

57 increases its polarity by approximately 1000-fold and reduces the toxicity of Taxol towards cancer ce

58 proved the protective capacity of H2 S >1000-fold compared to similar levels of the nonspecific H2 S

59 ably, concentrations of PARP inhibitor >1000-fold higher than the IC50 were required to ablate both A

60 Because treated patients are at >1000-fold increased risk of meningococcal disease, vaccinatio

61 optimization, wherein >/=10-, 100-, or 1000-fold improvement in a variety of key pharmacological par

62 a further boost in activity, with up to 1000-fold rate enhancement.

63 1beta-HSD1) enzyme (IC50 3.0 nM) with >10000-fold selectivity over human 11beta-hydroxysteroid dehydr

64 101/Ser119/Ser174 but most considerably (106-fold) at Ser169.

65 on-haem metals to demonstrate 30-fold and 11-fold enhancements in the oxidase activity of Cu- and Fe-

66 latitudes (8% vs. 11% of genera), despite 11-fold lower abundance (1.2% vs. 12.7% of basal area).

67 riant and isoform dependent, with a 5- to 11-fold lower sensitivity to Cav1.3 variants during SN DA-l

68 arly 25-fold for DON, 90-fold for ZEA and 12-fold for T-2 toxin assay using Ab2-AuNPs.

69 -mediated inhibition of FXa approximately 12-fold in the presence of protein S.

70 ents were combined, the current increased 12-fold, showing the two effects are due to independent mec

71 h a KD of 170 nM, which corresponds to a 120-fold affinity improvement compared to the parent molecul

72 ITP-based immunoassay and demonstrate a 1300-fold improvement in limit of detection compared to a sta

73 e population varied over an approximately 15-fold range, from 57 for IGF1 to 872 for IGF2R, although

74 of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor sub

75 (8)]-gamma-MSH-NH2 (compound 5), which is 16-fold selective for the hMC1R (EC50 = 4.5 nM) versus othe

76 re found to be highly abundant in leaves (16-fold) as compared to flower tissues.

77 patients had a 25-fold, a 26-fold, and a 18-fold higher risk of dying from myocardial infarction, he

78 carrier in vivo jetPEI, siRNA-L2 achieved 19-fold greater tumor accumulation and 46-fold increase in

79 dicating a stabilization energy at pH 5.0, 2-fold higher than that observed at pH 8.0.

80 in vitro (false discovery rate, </=0.001; 2-fold change) with 557 showing decreased and 329 showing

81 orting (45.9 per 1000 patient-days) were 1.2-fold (95% CI, 1.1-1.2) higher than rates without family

82 the number of perfect assemblies (up to 25.2-fold).

83 ment of PSGL-1 positive and 4.4-fold and 3.2-fold enrichment of PSGL-1 negative Jurkat and HL60 cells

84 e-to-pore time distributions decrease by 3.2-fold when the averages of the seven measurements from 8-

85 ase (3.0-fold), early growth response-1 (3.2-fold), and TNFalpha (3.0-fold), whereas the expression o

86 Risk of IBS was 4.2-fold higher in patients who had infectious enteritis in

87 injected with Diap1 dsRNA have approx. 1.5-2-fold higher levels of caspase activity than controls 24

88 In vivo, Runx2 was induced by 6.2-fold in pulmonary epithelium of house dust mite-challeng

89 otations in 3 are correlated (geared) in a 2-fold cogwheel pathway between the aryl and the pentiptyc

90 lization to internal standards corrected a 2-fold difference in lipids intensity, which allowed a mea

91 We identified 764 genes with at least a 2-fold difference in TL1A-mediated expression between IFNG

92 ce method inherently represents at least a 2-fold difference.

93 k of cardiac or sudden cardiac death and a 2-fold higher risk of any-cause death.

94 both humans and rodents, they experience a 2-fold increase in mood disorder prevalence vs. males.

95 by the use of the coatings, which led to a 2-fold increase in plum storability.

96 ring with PTEN germline mutations confer a 2-fold increased prevalence (OR 2.7) of thyroid cancer com

97 risk-increasing foods is associated with a 2-fold increased risk of all-cause mortality.Selecting spe

98 alysis, black and Asian patients were at a 2-fold risk of SJS/TEN when compared with white patients.

99 cells that expressed MAN2A1-FER were about 2-fold more sensitive to the FER kinase inhibitor crizotin

100 g increases the vibrational lifetime about 2-fold, which results in larger signals at longer time sca

101 10-2 VF univariable model showed an almost 2-fold better fit to the data (R2 = 9.2% vs 4.9%).

102 interval (CI), 1.22-2.00]; P < 0.001) and 2-fold (OR = 2.00 [CI, 1.15-3.49]; P = 0.015), respectivel

103 was also associated with an approximately 2-fold higher risk of below-knee lower extremity amputatio

104 gher than that of Pol mu and approximately 2-fold higher than that of Pol lambda.

105 hemically, Rrh(-/-) mice had approximately 2-fold higher vitamin A (all-trans-retinol (all-trans-ROL)

106 inimally basally activated ( approximately 2-fold) when associated with mutated p85alpha.

107 challenge with lipopolysaccharide (LPS) by 2-fold.

108 efore pregnancy and was associated with a >2-fold increase in the risk of offspring obesity at ages 6

109 M harbored expression changes (<2-fold or >2-fold) in clinically actionable genes including gains of

110 tion, and invasiveness and formed larger (>2-fold) xenograft tumors in mice, with more metastases, th

111 late from the roots constitutively and had 2-fold higher malate concentrations in the xylem sap than

112 Step count was at least 2-fold greater on POD1 [mean difference 843.3 steps (95% C

113 17 of 20 BrM harbored expression changes (<2-fold or >2-fold) in clinically actionable genes includin

114 and total cardiovascular risk were nearly 2-fold in comparison with subjects who remained below CAC5

115 drimer nanoparticle uptake significantly ( 2-fold both 2 and 6h following treatment).

116 as ERBB2/HER2, which showed a greater than 2-fold expression increase in 7 of 20 BrM (35%).

117 substrate, ATM, is upregulated by 1.5- to 2-fold at P0 and 6 months in preCGG brain, as is p-Ser1981

118 tistically significant, rates of BPAR were 2-fold higher in patients administered belatacept every 8

119 ad increased proliferation rates that were 2-fold higher than in Cdc73(+/+) mice (P<0.05).

120 though viruses from the tenofovir arm were 2-fold less infectious, they replicated at rates similar t

121 sition rate can be as high as [{n(n + 1)}/2]-fold over conventional EEM spectrometers.

122 mug/mL) and the sensitivity was increased 20-fold [0.04192 (mug/mL)(-1)] in comparison with undiluted

123 22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia.

124 g E. coli K-12 in pure cultures, PEf1 was 20-fold more effective in suppressing E. coli under simulat

125 us mechanical gradient that spans over a 200-fold difference in stiffness, approaching the mechanical

126 Taxol towards cancer cell lines by over 200-fold.

127 (IN T124N/V165I/T174I) confers marked (>2000-fold) resistance to KF116.

128 meal, which did not reach significance (1.21-fold; 95% CI: 0.92-, 1.61-fold; P = 0.060).

129 a number of compound families by 18- to 210-fold, including the silent virulence factor malleilacton

130 bility, the resolution of which yielded a 25-fold improvement in taxadiene production.

131 Within 30 days, CABG patients had a 25-fold, a 26-fold, and a 18-fold higher risk of dying from

132 Signal was amplified nearly 25-fold for DON, 90-fold for ZEA and 12-fold for T-2 toxin

133 suppressor that is normally upregulated 250-fold in RGC development, promotes long-distance optic ne

134 CBD concentrations in the lymph were 250-fold higher than in plasma, while THC concentrations in

135 n 30 days, CABG patients had a 25-fold, a 26-fold, and a 18-fold higher risk of dying from myocardial

136 We demonstrate 26-fold and 3.8-fold enrichment of PSGL-1 positive and 4.4-

137 We now show that ANI-7 is up to 263-fold more potent at inhibiting the growth of breast canc

138 Posaconazole levels in dHL-60 cells were 265-fold greater than the exposure concentration.

139 pstream and 79 kb downstream) with median 27-fold redundancy per base.

140 ity in plasma (Ki = 1.63 +/- 0.18 nM, >27000-fold selectivity, t1/2(plasma) =16 +/- 4 h).

141 tdischarge VTE, mortality increased about 28-fold (2.60% vs 0.09%; P < 0.001).

142 Optimal constructs conferred 10(3)-fold binding enhancements with only two ligands.

143 in 0.2cm(2) area of nail permitting a 10(3)-fold increase in initial drug uptake.

144 The risk of all second cancers was 1.3-fold higher for HL survivors with a first-degree relativ

145 eased specific activity at 65 degrees C, 1.3-fold improved kcat and a Tm increased by 5 degrees C abo

146 lysine acetylation in Cpt2M(-/-) hearts 2.3-fold compared with littermate control mice fed a ketogen

147 d not (95% CI, 3.1-5.7); risk of IBS was 2.3-fold higher in individuals who had infectious enteritis

148 n-binding affinity, with a approximately 3.3-fold increase after 1 h for the high FcRn-binding albumi

149 e relative with cancer ( P < .001), with 3.3-fold, 2.1-fold, and 1.8-fold differences shown for lung,

150 r expressed in PET false-negative cases (5.3-fold change, P < .001) which provides a mechanistic expl

151 ulted in the best all-round variant with a 3-fold improved half-life at 60 degrees C, 5-fold increase

152 95% confidence interval, 0.26-0.55 IUPM), 3-fold lower than the frequency observed in the Baltimore

153 We observed 3-fold increases in tumor mass and levels of angiogenesis

154 on HCC cell growth, improving IC50 by over 3-fold.

155 tative genital protrusion varied more than 3-fold between species ranging from 0.5% of somatosensory

156 mutant bound to the DNA consensus with a 30-fold increase in affinity (100 nm).

157 Therefore, the new design allows a 30-fold longer reaction time and a 40-fold increase in pres

158 different non-haem metals to demonstrate 30-fold and 11-fold enhancements in the oxidase activity of

159 -maximal ATPase was reduced dramatically (30-fold).

160 pores, increasing >10-fold but remaining 30-fold shorter than the DNA contour length in the locus.

161 ecific IgG and IgA with the IgA responses 30-fold greater than systemic levels.

162 ting galectin-3, which is increased up to 30-fold in cancer patients, promotes blood-borne metastasis

163 stantial basal activation of p110delta (>300-fold) and disrupts inhibitory interactions from the nSH2

164 cific CTLs than soluble vaccines and even 31-fold greater than perhaps the strongest adjuvant in clin

165 A threefold to 32-fold increase occurred within 15 minutes after initiatio

166 (10-fold increase, P < .001) and women (8.34-fold increase, P < .001) with PIDD were observed.

167 es of over 9 mAh cm(-2)areal , which is a 35-fold increase in capacity compared to without phenol.

168 developed massive albuminuria (controls: 35-fold; KO: 5400-fold versus baseline), hypoalbuminemia, r

169 ried significantly among sites, more than 36-fold on a mass basis.

170 from FePP by 2.55-fold (95% CI: 1.48-, 4.37-fold; P = 0.001) but not from FeSO4 There was a trend to

171 8-fold enrichment of PSGL-1 positive and 4.4-fold and 3.2-fold enrichment of PSGL-1 negative Jurkat a

172 reover, serum bile acids were increased 45.4-fold, consistent with blood-to-hepatocyte transporter re

173 Runx2 was up-regulated by 6.4-fold during IL-13-induced goblet cell differentiation of

174 Notably, a 4-fold C-H hydroarylation provided a highly conjugated org

175 entified and 740 proteins that presented a 4-fold change were considered a CRC proteomic signature.

176 ecific tissues for (18)F-4FMFES, notably a 4-fold decrease in blood-pool activity as compared with (1

177 Indeed, Ru-thio-chrysin displayed a 4-fold greater inhibition of platelet function and thrombu

178 ghest quintile for TMAO (>/=135 muM) had a 4-fold higher risk of cardiac or sudden cardiac death and

179 evaluated for seroconversion, defined as a 4-fold increase in immunoglobulin G directed against Crypt

180 A 4-fold modified risk was found with ADRA1A rs17426222 and

181 nd that 9 of 17 (53%) paired sera had a >/=4-fold increase in antibody titer to cluster-related strai

182 in response to IL4 treatment resulting in 4-fold lower PPARgamma expression in knock-out cells than

183 searching ability of Pol beta is at least 4-fold higher than that of Pol mu and approximately 2-fold

184 Ninety were novel mRNAs over 4-fold enriched at the vegetal pole and six were over 10-f

185 rimary teeth from 3 GACI subjects revealed 4-fold increased cervical cementum thickness ( P = 0.00007

186 activity of M2beta-S1 is slowed more than 4-fold in the presence of OM, whereas the actin concentrat

187 zed mouse model, leading to a greater than 4-fold increase in HA-binding IgG responses.

188 : six samples (four to approximately 1- to 4-fold coverage) from a 3,500 year temporal transect ( app

189 optimization led to compound 28, which was 4-fold more potent than its parent 3.

190 lows a 30-fold longer reaction time and a 40-fold increase in pressure compared to standard PTR-TOF-M

191 ed 19-fold greater tumor accumulation and 46-fold increase in per-tumor-cell uptake in a mouse orthot

192 Strikingly, nanodiscs elicited up to 47-fold greater frequencies of neoantigen-specific CTLs tha

193 t quartile of a 127-variant score had a 2.49-fold increased odds of cardioembolic stroke (95% confide

194 m increased the odds of ONHD presence by 1.5-fold (odds ratio [OR] = 1.56 [confidence interval (CI),

195 ubsequent airway smooth muscle growth by 1.5-fold (P < 0.05), which was dependent on MMP-1 activation

196 hese, 176 proteins were altered at least 1.5-fold (p-value < 0.05) in abundance during hypochlorite s

197 e Bmal1(fx/fx);Tek-Cre mice decreased by 1.5-fold and was accompanied by a profound decrease in proli

198 xic solanine and chaconine, exceeding by 2-5-fold the recommended limit, and ranging from 2578+/-86mg

199 n after injection of the tracer showed a 2.5-fold increase in metabolic stability of (18)F-4FMFES ove

200 alpha-tocopherol concentration was over 3.5-fold higher in supplemented samples than in control lamb

201 010 in South Asian forests and increased 3.5-fold relative to 1850.

202 ntervention period was associated with a 4.5-fold greater odds of receiving preferred beta-lactam the

203 ificantly larger (all P < 0.04) by up to 8.5-fold in +DD compared to -DD subjects.

204 d (Wisconsin decile range, 1.5%-3.3%) to 9.5-fold (Nebraska decile range, 1.0%-10.3%).

205 y and systolic dysfunction, evidenced by a 5-fold greater heart mass, 60-90% reduction in blood eject

206 and growth factor treated cartilage gave a 5-fold increase in stiffness correlating with a 10-fold up

207 ardiac arrhythmia and is associated with a 5-fold increase in the risk for stroke.

208 neural retina following a photobleach and 5-fold lower retinyl esters in the RPE.

209 d the performance of our method using both 5-fold cross-validation and independent tests.

210 rimination of positive/negative signals by 5-fold when compared to detection with traditional RGB int

211 3-fold improved half-life at 60 degrees C, 5-fold increased specific activity at 65 degrees C, 1.3-fo

212 Parasite densities decreased 5-fold from 2006 to 2010; 72% of P. falciparum and 87% of

213 well as the AMPA receptor subunit GluA1i (5-fold).

214 luK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fo

215 per gram) and retention and a greater than 5-fold decrease in kidney uptake relative to MIP-1095.

216 s are decorated by large spikes around the 5-fold vertices.

217 mine, whereas one atpE mutant exhibited a 50-fold increase in MIC for BDQ.

218 , URMC-099 activation of autophagy led to 50-fold increases in the plasma drug concentration of the v

219 differ with respect to body size (10- to 50-fold lower fresh weights of E. cyaneus) and cellular str

220 , and nanoparticles, in the range of 200-500-fold within 5 min.

221 so greatly stimulate TNF secretion (by 4,500-fold).

222 d -825 have nanomolar beta1-AR affinity >500-fold beta1-AR vs beta2-AR selectivity and no agonism.

223 tion, the limit of detection was lowered 500-fold (0.22 mug/mL) and the sensitivity was increased 20-

224 reference genome, our assembly features a 52-fold increase in contig length and notable improvements

225 anslation rates were repressed, by up to 530-fold, when mRNA structures overlapped with the ribosome'

226 ive albuminuria (controls: 35-fold; KO: 5400-fold versus baseline), hypoalbuminemia, reduced GFR, and

227 increased iron absorption from FePP by 2.55-fold (95% CI: 1.48-, 4.37-fold; P = 0.001) but not from

228 rived mesenchymal stem cells, displayed a 55-fold increase in the expression of hepatocyte growth fac

229 n applied to the human genome, we achieve 55-fold genome coverage, allowing us to map autonomous prom

230 current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the

231 n PAL-RNAi transgenic plants resulted in 1.6-fold increase in phenylacetaldehyde emission.

232 isone dose is associated with a 1.5- and 2.6-fold increase (P < 0.001 and P < 0.001) in the rate of c

233 inf) varied among these strains by 33.7-56.6-fold.

234 set of repurposable drugs is approximately 6-fold more enriched with drugs having published evidence

235 The diagnosis rate of OUD increased nearly 6-fold from 2001 to 2014 (from 0.26 per 100000 person-year

236 al dendrites, these inputs produce a 5- to 6-fold larger EPSP at the soma of CA2 compared with CA1 PN

237 mples analyzed, with SERS demonstrating a 60-fold reduction in acquisition time compared with HPLC.

238 thermostability and increased affinity by 60-fold.

239 gM with synonymous alternates produced a 600-fold range in FlgM activity.

240 significance (1.21-fold; 95% CI: 0.92-, 1.61-fold; P = 0.060).

241 ourse of the test, NCC levels increased 3.68-fold (P<0.01) and pNCC levels increased 2.73-fold (P<0.0

242 -, approximately 5.1-, and approximately 6.7-fold increases in col Ialpha 1, sox 9, and aggrecan gene

243 sitively related to aqueous zinc, but were 7-fold lower than larvae.

244 vaccination, we observed an approximately 70-fold expansion of the plasmablast population.

245 hr-513 in WT-GC-A increased the Km 23- to 70-fold but the same mutations in GC-A-8E only increased th

246 tion of the second nucleotide (kobs2) is 700-fold faster for tCfTP than tCTP due the increased effect

247 fold (P<0.01) and pNCC levels increased 2.73-fold (P<0.01) relative to baseline.

248 velopment of a small molecule with around 75-fold selectivity towards KDM2A/7A versus other KDMs, as

249 P < .001), with 3.3-fold, 2.1-fold, and 1.8-fold differences shown for lung, colorectal, and breast

250 tOH ingestion for 8 weeks significantly (1.8-fold) up-regulated Pxr mRNA levels in WT mice.

251 We demonstrate 26-fold and 3.8-fold enrichment of PSGL-1 positive and 4.4-fold and 3.2-

252 at decreasing average error rates (up to 5.8-fold relative to the input), whereas MutS is the best fo

253 This corresponds to an unprecedented 7.8-fold increase in crossover frequency.

254 ground, named I-A(12%), with approximately 8-fold reduced I-A expression on the surface of B cells, d

255 mutations in GC-A-8E only increased the Km 8-fold, consistent with one site affecting the phosphoryla

256 mutations are associated with modest 2- to 8-fold increases in MICs for BDQ and clofazimine, whereas

257 ociated with a 1.81-, 2.59-, 6.17-, and 8.80-fold increase, respectively, in the risk of death and my

258 ared to those from IL5tg mice, including 800-fold higher levels of eotaxin-1.

259 versus lowest TMAO quartile had a crude 1.86-fold higher mortality risk (Ptrend < 0.001).

260 ion than their parental AAV vectors (2- to 9-fold over AAV2), with the highest of these being the hap

261 12-oxo phytodienoic acid (OPDA), which was 9-fold higher in VMW than VMG.

262 nal was amplified nearly 25-fold for DON, 90-fold for ZEA and 12-fold for T-2 toxin assay using Ab2-A

263 o-input logic with a dynamic range up to 900-fold and scale them to four-input AND, six-input OR, and

264 ying the interactions between disulfide bond-folded proteins in the bacterial cytoplasm of an Escheri

265 the ADAMTS13 cleavage site through A2-domain-fold thermodynamic destabilization.

266 ed assembly pathway that initiates at a five-fold vertex and continuously proceeds outwards in a spir

267 benchmarking experiments based on both five-fold cross-validation and independent tests indicated th

268 to an additional increase of more than five-fold in imaging contrast in vivo.

269 f the PacBio RSII platform by more than five-fold, while maintaining the ability to correctly call al

270 offers high sensitivities, achieving a four-fold increase in the supported number of subscribers and

271 uction was realized to be approximately four-fold as compared to the corresponding electrode modified

272 rate for S. pinnata (1 h) was three- to four-fold higher than for nonhyperaccumulators, and not signi

273 nected metal helix slat structures with four-fold symmetry, which exhibits nonresonant Drude-like res

274 site(s) existing on the surface of any GLTP-fold and delineate new differences between GLTP superfam

275 the Americas has been accompanied by a multi-fold increase in reported incidence of fetal microcephal

276 orms a bilobal structure consisting of an OB-fold and a holiday junction resolvase domain.

277 CPMG-RD captured a low populated protein-folding conformation triggered by the Glu-145 replacemen

278 d, and oxidative stress, disturb the protein-folding capacity of the endoplasmic reticulum (ER), ther

279 tructural information for this vital protein-folding machine in humans.

280 eaked in the oxic layers and was up to seven-fold higher in smooth than pustular mats.

281 sites, inhibits Angpt1 signalling at seventy-fold lower concentrations.

282 y enhance microtubule growth rate by several-fold in vitro.

283 ischemic strokes and might multiply several-fold during the next decades.

284 contrast, S. melilutra models exhibit a six-fold increase in stiffness from expected stiffness-volum

285 Substrate binding breaks the six-fold symmetry of the complex, allowing five of the six V

286 Several different strand-folding topologies have been reported for Q-quadruplexes

287 sample tubes are filled may result in a ten-fold increase in sample haemolysis, compared to the reco

288 ion with acetonitrile/water/formic acid, ten-fold dilution and analysis by LC-MS/MS using a pH 10 car

289 able to those of known oncogenes and are ten-fold higher than those of random genes.

290 ostaglandin E2 (PGE2) due to their thousands-fold higher cyclooxygenase-2 (COX-2) expression than imm

291 The strategy is based on a three-fold, partially intermolecular [2+2+n] (n = 1 or 2) cycl

292 ae maintained chemical defenses nearly three-fold greater than those of siblings reared in streams.

293 he Janus catalyst exhibits a more than three-fold increase in catalytic efficiency compared to the Pt

294 ination over intramuscular delivery of a two-fold higher vaccine dose.

295 ostsynaptic currents (sEPSCs) three- and two-fold higher, respectively, than those of adapting neuron

296 riflate in facilitating this reaction is two-fold: it enables "ate" complex formation and overcomes c

297 Some varieties had more than two-fold greater RS content than a US long-grain intermediat

298 The 28-day all-cause mortality was two-fold higher when procalcitonin did not show a decrease o

299 This is an example of a well-folded partner of NUPR1, because its other interacting p

300 e is intrinsically disordered, and even well-folded proteins adopt non-native geometries during synth