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1 oducts, chemical waste dumps, and analytical-grade material, covering the production time period from
2 ts, 71% (95% CI, 67% to 75%) experienced any-grade treatment-related AEs (most commonly fatigue [25%]
3 breast and ovarian lesions using a clinical-grade contrast agent (kinase insert domain receptor [KDR
4 therapy of low-dose anti-CD3 with a clinical-grade self-containing L. lactis, appropriate for human a
5 sing, the cost for biomanufacturing clinical-grade patient specific iPSCs and their derivatives are v
7 ort on the feasibility of producing clinical-grade BCR-ABL-specific cytotoxic T lymphocytes (CTLs), e
8 42 patients with CUP using targeted clinical-grade, next-generation sequencing of circulating tumor D
9 ed the therapeutic potential of the clinical-grade alkyl-phospholipid ether analog CLR1404, 18-(p-iod
10 geted ultrasonography (US) by using clinical-grade vascular endothelial growth factor receptor 2 (VEG
12 be carried out on multigram scales in common-grade solvents without the need for reaction mixtures to
13 realized through the use of compositionally-graded alloy libraries, which were photo-thermally heate
15 eliberation, the ECDP writing committee down-graded recommendations regarding bile acid sequestrant u
18 g chlorogenic and rosmarinic acids, and food-grade phenolic apple and rosemary extracts at various do
33 HO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner
35 s were extracted from 40 tumor VOIs (26 high-grade), 36 BPH VOIs, 6 prostatitis VOIs, and 37 healthy-
36 lity colonoscopy, proximal polyps, or a high-grade or large adenoma (>/=20 mm) at baseline (8865 [74%
37 s infection, cytological abnormalities, high-grade lesions, and cervical procedures related to HPV 31
41 cted women have a higher burden of anal high-grade squamous intraepithelial lesions (HSIL) and anal c
42 -grade [moderately differentiated], and high-grade [poorly differentiated], respectively), chromogran
43 g (31 mutations per sample +/- 15), and high-grade cancer (33 mutations per sample +/- 18) (P = .30).
47 ry of pancreatic cancer (P = 0.027) and high-grade dysplasia (HGD) (P = 0.003) were independent risk
49 clear differentiation between low- and high-grade glioma (area under the receiver operating characte
50 boost" trial showed that young age and high-grade invasive carcinoma were the most important risk fa
51 ransformed and neoplastic low-grade and high-grade prostate epithelial tissue from radical prostatect
52 PH, prostatitis, or healthy tissue) and high-grade tumors from other tissue (low-grade tumors or beni
53 rfusion and metabolism between low- and high-grade tumors in the transgenic adenocarcinoma of mouse p
56 cases of high-risk (hr) HPV-associated high-grade lesions and carcinomas in the anogenital region an
57 observed in patients with asymptomatic high-grade carotid disease versus patients with acutely sympt
62 resistance in ovarian and other cancers.High-grade serous ovarian cancers (HGS-OvCa) frequently devel
64 e distal fallopian tube among all cases.High-grade serous carcinomas (HGSCs) are associated with prec
65 n 93.4% of cases, and dedifferentiated (high-grade cancer) in 41.7% of cases at prevalence screening
68 p comprised 27 non-dysplastic and eight high-grade dysplasia cases, whereas the high-risk group (8% o
69 spectively), and patients who had fewer high-grade tumors (13% v 64%, respectively) or right-sided pr
70 s 34.9% (22 of 63); the sensitivity for high-grade DCIS components was 91.8% (45 of 49) versus 36.7%
71 for moderate-grade disease, and 17% for high-grade disease; the corresponding risks of any recurrence
74 formed meta-analysis on the results for high-grade serous ovarian cancer with the results from analys
75 he lack of effective chemotherapies for high-grade serous ovarian cancers (HGS-OvCa) has motivated a
78 inally, liver cancer organoid-generated high-grade tumors exhibited significantly increased extracell
79 ith age-adjusted IPI 2,3) of the German High-Grade Non-Hodgkin Lymphoma Study Group were analyzed wit
84 I 96-100) and the probability of having high-grade dysplasia or intramucosal adenocarcinoma was 0% (0
85 -27), whereas the probability of having high-grade dysplasia or intramucosal adenocarcinoma was 87% (
87 ostate stem-cell antigen could identify high-grade dysplasia/cancer with an accuracy of 96% (95% CI,
89 n (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minima
90 ow-grade glioma (AUC, 0.818) and MTI in high-grade glioma (AUC, 0.854) and for all WHO grades (AUC, 0
92 pharmacologic suppression of MARCKS in high-grade RCC cell lines in vitro led to a decrease in cell
95 (beta) (CaMKK2) is highly expressed in high-grade serous ovarian cancer, and we investigated its rol
96 h the development of drug resistance in high-grade serous ovarian cancer, were examined from patient
97 prBP protein levels were upregulated in high-grade serous ovarian patient tumors, where the FoxM1 sig
98 a significant reduction in perfusion in high-grade tumors that associated with increased hypoxia and
99 and macrophages (GAM), which infiltrate high-grade gilomas, constitute a major cellular component of
102 en loss, with early neoplastic lesions (high-grade prostatic intraepithelial neoplasia) with striking
104 Despite multimodality treatment, most high-grade gliomas eventually recur and are ultimately incura
105 tumor specimens of 213 patients (mostly high-grade gliomas [89%]) included in the Vienna Cancer and T
106 tients with a clinical diagnosis of non-high-grade DCIS that would preclude active surveillance.
107 nical trials randomizing women with non-high-grade DCIS to active surveillance, defined as imaging su
109 enting with a clinical diagnosis of non-high-grade DCIS, 8320 (22.2%) had invasive carcinoma based on
111 HR, 1.14; 95% CI, 1.01 to 1.29) but not high-grade prostate cancer (HR, 0.83; 95% CI, 0.64 to 1.07).
112 The primary outcomes were incidence of high-grade cervical disease (cervical intraepithelial neoplas
113 e is known about the long-term yield of high-grade cervical intraepithelial neoplasia (CIN) and the i
114 rvical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and in
115 r-protocol population, the incidence of high-grade cervical, vulvar and vaginal disease related to HP
116 te persistently high detection rates of high-grade DCIS in two consecutive subsequent screening round
118 methylation can predict the presence of high-grade disease at histology in women testing positive for
120 er, little is known about their risk of high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC)
122 E, 22 samples of LGD, and 34 samples of high-grade dysplasia) were identified, randomly assigned to 7
123 e expression data derived from a set of high-grade human gliomas, shows that high Caspase-8 expressio
125 th significantly increased detection of high-grade precancerous cervical lesions compared to cytology
128 BB is repressed in approximately 30% of high-grade serous ovarian cancer (HGSOC) patients and is a re
129 ted tomography (CT) imaging features of high-grade serous ovarian cancer (HGSOC), to assess their ass
131 se progression [DP], 13%) versus 33% of high-grade tumors (grade 3 or 4) (complete response, 0%; part
132 the presence of unstable bradycardia or high-grade arteriovenous block in the absence of myocardial d
133 the presence of unstable bradycardia or high-grade arteriovenous block without significant alteration
135 ctors for malignancy (adenocarcinoma or high-grade dysplasia) occurring in the setting of an MCN.
136 f premalignant lesions, such as low- or high-grade dysplastic nodules (LGDNs and HGDNs, respectively)
137 or important proportions of low- and/or high-grade lesions, but their contribution dropped in ICCs, w
139 ignificantly increased risk for ovarian high-grade serous carcinoma (HGSC; 3.8% cases vs. 0.2% contro
140 tudy show no elevated risk for overall, high-grade or advanced-stage prostate cancer, or death due to
141 n a substantial proportion of pediatric high-grade gliomas (pHGG), often in association with TP53 los
142 ations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.
143 aluated multi-omics profiles of primary high-grade serous ovarian cancer tumours (N=357) to delineate
145 ict occurrence of residual or recurrent high-grade cervical intraepithelial neoplasia of grade two or
147 de dissection, which disclosed residual high-grade muscle-invasive urothelial cancer extending to the
148 ars or older, had a platinum-sensitive, high-grade serous or endometrioid ovarian, primary peritoneal
149 m diffuse large B-cell lymphoma, termed high-grade B-cell lymphoma with translocations involving myc
152 Barrett's esophagus for progression to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC
153 factors associated with progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC)
154 elodysplasia, whereas transformation to high-grade lymphoma occurred in 3 patients who had received c
159 preselection of urothelial cells, where high-grade urothelial cancer cells are characterized by a lar
161 omas, tubular adenomas >/=10 mm or with high-grade dysplasia, and conventional adenomas with villous
165 vels of SLFN5 expression correlate with high-grade gliomas and shorter overall survival in patients s
166 als and Methods Seventeen patients with high-grade gliomas who had received 10-44 administrations of
169 CA1 or BRCA2 mutations in patients with high-grade serous ovarian cancer (HGSC) are associated with f
171 t an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemo
172 tudy included 90 comatose patients with high-grade spontaneous subarachnoid hemorrhage who underwent
174 num-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma.
175 ant negative correlation may indicate higher-grade elements within the tumor leading to poorer outcom
178 esent and carefully characterize an industry-grade CMOS camera as a cost-efficient alternative to com
179 ow-grade [well differentiated], intermediate-grade [moderately differentiated], and high-grade [poorl
180 (11 of 27); the sensitivity for intermediate-grade DCIS components was 84.1% (53 of 63) versus 34.9%
182 nsecutive patients with low- or intermediate-grade gastroenteropancreatic NETs took part in this pros
188 s neoplasms (IPMN), 2 adenocarcinomas, 1 low-grade intraepithelial pancreatic neoplasia, and 1 case o
198 this proportion increased through ASCUS, low-grade squamous intraepithelial lesions, CIN1, and CIN2 (
199 erson-years among patients with baseline low-grade dysplasia (95% CI 1.5-7.2), and 7.3 per 100 person
200 erson-years among patients with baseline low-grade dysplasia (95% CI, 4.9-14.0), and 13.5 per 100 per
201 sex, smoking, length of BE, and baseline low-grade dysplasia that identified patients with BE at low,
203 WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid
204 ontrast enhancement of vertebral bodies, low-grade destruction of vertebral bodies, hyperintense/homo
205 that DACH1 was higher in normal breast, low-grade and luminal-type cancer in comparison with breast
206 ther TSPO imaging can accurately capture low-grade inflammatory processes such as those present in sc
208 lenge the common assumption that central low-grade inflammation in schizophrenia is mirrored by incre
209 es are associated with increased chronic low-grade inflammation and elevated plasma glucose levels.
210 olic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of
212 glucose metabolism, satiety, and chronic low-grade inflammation to contribute to obesity and type 2 d
215 atypical, metabolically induced, chronic low-grade inflammation, plays an important role in the devel
218 Obesity is characterized by chronic low-grade, systemic inflammation, altered gut microbiota, an
219 ent in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated i
220 ng, length of BE, and baseline-confirmed low-grade dysplasia were significantly associated with progr
221 rit (or ZT), which can directly converts low-grade wasted heat (400 to 500 K) into electricity, has b
223 dren with NF1 are at risk for developing low-grade gliomas of the optic pathway and brainstem, indivi
224 kurtosis imaging (DKI) to differentiate low-grade glioma (LGG) (World Health Organization [WHO] grad
227 as histologic grade (G1, G2, or G3, for low-grade [well differentiated], intermediate-grade [moderat
229 imaging versus conventional imaging for low-grade DCIS components was 74.0% (20 of 27) versus 40.7%
230 ents with T1N0 breast cancer was 10% for low-grade disease, 13% for moderate-grade disease, and 17% f
232 cale TOEC systems to extract energy from low-grade heat and identifies key factors for performance op
233 has the potential to harvest energy from low-grade heat sources by using a temperature difference to
234 rmocells) are of interest for harvesting low-grade waste thermal energy because of their potentially
235 mance for IDH gene mutation detection in low-grade glioma (AUC, 0.818) and MTI in high-grade glioma (
238 on is the earliest genetic alteration in low-grade gliomas (LGGs), but its role in tumor recurrence i
239 Prespecified outcome measures included low-grade CIN (grade 1 [CIN1]) and high-grade CIN (grade 2 [
240 e ovarian tumors (BOT) can progress into low-grade serous carcinomas and have relatively indolent cli
241 A condition more common than IBD is low-grade inflammation, which correlates with altered gut mi
243 Conclusion Women with stage II to IV low-grade serous carcinoma who received HMT after primary tr
244 individuals with NF2 typically manifest low-grade tumors affecting the cranial nerves (vestibular sc
245 red it to non-transformed and neoplastic low-grade and high-grade prostate epithelial tissue from rad
246 syndrome are prone to the development of low-grade brain tumors (gliomas) within the optic pathway (o
248 unexpected genes; permitted detection of low-grade constitutional, somatic, and revertant mosaicism;
249 e prevalence round; conversely, rates of low-grade DCIS and, less markedly, intermediate-grade DCIS d
250 th Barrett's esophagus, the diagnosis of low-grade dysplasia (LGD) is subjective, and reported outcom
251 th the transformation and progression of low-grade fibrillary astrocytoma to high-grade anaplastic gl
252 cally nonsignificantly increased risk of low-grade serous tumors (pOR = 1.48, 95% CI: 0.92, 2.38) was
255 ) with residual or progressive benign or low-grade brain tumors at a single center between April 2001
256 th residual and/or progressive benign or low-grade brain tumors requiring radiotherapy for long-term
257 th residual and/or progressive benign or low-grade brain tumors treated with SCRT and ConvRT techniqu
258 of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL) who were t
263 ltrasound was judged semiquantitatively; low-grade contrast enhancement (CE) suggested its absence, a
266 ls in patients with active FPIES suggest low-grade intestinal mast cell activation or increased mast
267 school-aged children suggesting systemic low-grade inflammation as a phenotypic characteristic of thi
270 derlying cause of catatonic signs is the low-grade inflammation of white matter tracts, which marks a
272 ed IL-6 production in this depot and the low-grade systemic inflammation typically associated with vi
275 Histologic analysis showed absent to low-grade inflammatory infiltrates without cardiomyocyte nec
276 tmosphere at ambient conditions by using low-grade heat from natural sunlight at a flux of less than
277 fy contaminated, acidic wastewater using low-grade heat sources, such as geothermal energy, without c
282 and type 2 diabetes are associated with low-grade inflammation and specific changes in gut microbiot
285 10% for low-grade disease, 13% for moderate-grade disease, and 17% for high-grade disease; the corre
286 apid vortex agitation (>/=3200 rpm) in LC/MS-grade solvents and by exposing them to the DART source j
290 the acceptable purity of 99.996% for polymer-grade C2 H4 ), as demonstrated by experimental breakthro
291 Early cortical infarcts are common in poor-grade patients after aneurysmal subarachnoid haemorrhage
292 ed solution for the analysis and publication-grade graphical presentation of dithionite scramblase as
293 sequencing, which will lead to the reference-grade assembly of allopolyploid cotton and serve as a ge
295 samples (n = 158) were tested with research-grade reagents and 122 independent validation set sample
296 Periodontal Indices, respectively, on sixth-grade school children (n = 1,539) of Medak District in T
297 improve power densities compared to standard-grade CEMs when performing RED using streams containing
299 edure, and categorized into one out of three-grades in the HOUSE classification system, and concomita
300 patient experienced a dose-limiting toxicity-grade 3 transient asymptomatic hyponatremia at the 1.0-m
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