ライフサイエンスコーパス: -guided

1 Here, we performed activity-guided HPLC-fractionation of SBE, identified the active

2 iding weak links in the ablation chain, ALCI-guided ablation is expected to improve success rate of p

3 e 23 kb constructs), from which an algorithm-guided 192-member 4.5 Mb library is built.

4 Multigenome-alignment-guided probe selection led to the development of a set o

5 the IVUS-guided group versus the angiography-guided (6.9% vs. 8.4%, p = 0.22) although the TVR was si

6 ibizumab 0.3 mg with and without angiography-guided macular laser photocoagulation significantly decr

7 By using structure- and antigenicity-guided mutagenesis strategies focused on the V2 and V3 r

8 Individualized autoregulation-guided cerebral perfusion pressure management may be a p

9 search will help define which autoregulation-guided method is beneficial, safe, and most practical.

10 ted for the aqueous leaf extract and its bio-guided separation resulted in the identification of the

11 Bioactivity-guided isolation of 3-(octahydro-9-isopropyl-2H-benzo[h]

12 s for chemical fractionation and bioactivity-guided chemical analysis were used to identify the bio-a

13 Bioassay-guided fractionation identified two oxazole natural prod

14 ction of therapeutics to risk-based, biology-guided treatment of patients with FL.

15 e use of targeted therapeutics and biomarker-guided clinical trials, are fueling further technologica

16 mortality was 12% (n = 53) in the biomarker-guided group and 13% (n = 57) in the usual care group (H

17 urred in 164 patients (37%) in the biomarker-guided group and 164 patients (37%) in the usual care gr

18 ography using (18)F-FDG followed by Cerenkov-guided resection of lymph nodes in healthy mice has prev

19 atrial fibrillation after contact force (CF)-guided pulmonary vein isolation.

20 In CF-guided pulmonary vein isolation, PVR is explained by lac

21 , we describe a structure-based, computation-guided predictive method for reversibly controlling enzy

22 Because contact-guided protein modeling approach is valuable for predict

23 erge as vital facilitators of rapid, contact-guided migration of CSCs in aligned 3D collagen matrices

24 een the POR and PER is necessary for context-guided exploratory behavior but not for associating fear

25 l FC may represent a special case of context-guided behavior.SIGNIFICANCE STATEMENT Representations o

26 ed, unsignaled, and renewal) and two context-guided object recognition tasks (with 3D and 2D objects)

27 own control can be exerted over contextually-guided visual search.

28 atly diminished using evolutionary couplings-guided adaptive sampling.

29 reign nucleic acids using CRISPR RNA (crRNA)-guided nucleases.

30 I-F) relies on a 350 kDa CRISPR RNA (crRNA)-guided surveillance complex (Csy complex) to bind foreig

31 eliminating nucleic acid invaders in a crRNA-guided manner.

32 ic (ENB)-guided and computed tomography (CT)-guided percutaneous tissue sampling of lung nodules.

33 s (ENB-guided sampling, 88.9% [32 of 36]; CT-guided sampling, 82.0% [41 of 50]).

34 i, and complications were reviewed in 431 CT-guided medical renal biopsies performed between July 200

35 enal parameters, abdomino-pelvic CT and a CT-guided biopsy.

36 in whom the diagnosis was confirmed by a CT-guided biopsy.

37 The diagnosis was confirmed by CT-guided biopsy.

38 gard to optimizing nucleic acid yields in CT-guided lung core needle biopsies used for genomic analys

39 thin-suite (89)Zr-labeled radiotracer PET/CT-guided biopsy performed without reinjection.

40 Results CT-guided sampling was more likely to be diagnostic than EN

41 l of dynamical models, mathematics, and data-guided methodologies for improving strategies for contro

42 Our data-guided methodology identifies a number of TFs previously

43 With data-guided frameworks we can develop better predictions abou

44 DNA-guided nanoparticle colloidal crystallization allows for

45 into the molecular mechanisms that drive DNA-guided DNA silencing by an archaeal Ago.

46 ties, a 2,2-diphenyl-1-picrylhydrazyl (DPPH)-guided purification of the aqueous extract of Z. jujuba

47 es of combined stereo-electroencephalography-guided and MRI-guided stereotactic laser interstitial th

48 tromagnetic navigational bronchoscopic (ENB)-guided and computed tomography (CT)-guided percutaneous

49 lyses was noted with the two approaches (ENB-guided sampling, 88.9% [32 of 36]; CT-guided sampling, 8

50 ng was more likely to be diagnostic than ENB-guided biopsy (86.0% [129 of 150] vs 66.0% [99 of 150],

51 A substrate envelope-guided design strategy is reported for improving the res

52 CKGROUND & AIMS: Endoscopic ultrasound (EUS)-guided chemoablation with ethanol lavage followed by inf

53 assigned to 1 of 2 groups that underwent EUS-guided pancreatic cyst lavage with either 80% ethanol (c

54 l, Parhad et al. (2017) harness an evolution-guided approach to define the genetic determinants of ge

55 ith the power and mapping precision of exome-guided GWAS (EG-GWAS) versus cHD-based GWAS.

56 arization strategy was noninferior to an FFR-guided revascularization strategy with respect to the ra

57 infarct-related artery, the addition of FFR-guided complete revascularization of non-infarct-related

58 T (Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease), sharing a common

59 ion, (ii) capturing at the tip and filopodia-guided actin anterograde flow with phagocytic cup format

60 n the Indiana University FIRM registry, FIRM-guided ablation produced high single-procedure success,

61 Fluorescence-guided surgery is an emerging imaging technique that can

62 Intraoperatively, radio- and fluorescence-guided SN detection rates were scored at working distanc

63 ing optical imaging devices for fluorescence-guided surgery.

64 sicians likely to have performed fluoroscopy-guided interventional (FGI) procedures (referred to as F

65 A subsequent fMRI-guided transcranial magnetic stimulation experiment conf

66 ace-detection task and combined it with fMRI-guided pharmacological inactivation of ML to test whethe

67 These findings portend that future genome-guided secondary metabolite discovery and isolation effo

68 total of 87 patients (10.8%) in the genotype-guided group vs 116 patients (14.7%) in the clinically g

69 reated with perioperative warfarin, genotype-guided warfarin dosing, compared with clinically guided

70 To determine whether genotype-guided dosing improves the safety of warfarin initiation

71 HVPG-guided patients had a greater reduction of HVPG and a lo

72 variceal bleeding were randomized to an HVPG-guided therapy group (N = 84) or to a control group (N =

73 In the HVPG-guided group, acute responders were treated with nadolol

74 24 months), mortality was lower in the HVPG-guided therapy group than in the control group (29% vs.

75 he survival probability was higher with HVPG-guided therapy than in controls, both in acute (HR = 0.5

76 angina or an acute coronary syndrome, an iFR-guided revascularization strategy was noninferior to an

77 Image-guided percutaneous thermal ablation has been one of the

78 and optical images were acquired, and image-guided surgery was performed.

79 h widespread use of techniques such as image-guided radiotherapy, volumetric modulated arc therapy, h

80 sments of resection extent and central image-guided review was low, with agreement of 63% (< 90% v >/

81 Conclusion Image-guided transthoracic core needle biopsy is an effective

82 hold promise for metastasis diagnosis, image-guided surgery, and theranostic PEGylated drug therapies

83 ov using search terms "fluorescence," "image-guided surgery," and "near-infrared imaging" to identify

84 tumor and blood-brain barriers with MR image-guided focused ultrasound (MRgFUS), and whether this tre

85 DA, members of the American Society of Image-Guided Surgery, and members of the World Molecular Imagi

86 als of omission of cancer surgery when image-guided biopsy indicates a breast pCR.

87 k breast lesions (HRLs) diagnosed with image-guided needle biopsy that require surgical excision to b

88 We have matched preoperative DTI with image-guided sampling of the brain-tumor interface in 26 patie

89 on for accurate cancer diagnosis and imaging-guided therapy.

90 jection, which ensured its effective imaging-guided PDT.

91 quality of nucleic acid yields from imaging-guided core needle biopsy.

92 Interventions/Intravascular imaging-guided PCI of the proximal right coronary artery and the

93 F) and photoacoustic (PA) dual-modal imaging-guided synergistic chemo-photothermal therapy (PTT).

94 ) imaging examination followed by MR imaging-guided biopsy strategies in the detection of prostate ca

95 The following three MR imaging-guided biopsy strategies were further evaluated in each

96 usion guidance, and (c) in-gantry MR imaging-guided biopsy.

97 recession sequences were used for MR imaging-guided catheterization, balloon dilation, and stent impl

98 A modified clinical MR imaging-guided focused ultrasound brain system was used with a 3

99 are evidence of the potential of MR imaging-guided HIFU to be part of a routine strategy for the tre

100 e clinical efficacy and safety of MR imaging-guided HIFU were demonstrated.

101 e 50 recruited patients underwent MR imaging-guided HIFU.

102 emission tomography (PET) multimodal imaging-guided combination cancer therapy.

103 Multimodal imaging-guided synergistic combination therapy has shown great p

104 se To demonstrate the feasibility of imaging-guided catheter-directed delivery of endothelial cell th

105 or (i) functional magnetic resonance imaging-guided regions; (ii) a region identified from an unguide

106 Here we develop an informatics-guided ab initio approach to accelerate the design and d

107 bility of one of the constituents, the input-guided up-regulation or down-regulation of the CDN's con

108 ndomly assigned to a 6-month interventionist-guided (n = 125) or self-guided (n = 121) weight loss pr

109 ges were also greater in the interventionist-guided group at both time points.

110 ed primary outcome trended lower in the IVUS-guided group versus the angiography-guided (6.9% vs. 8.4

111 Our results suggest that knowledge-guided prioritization of genes using ProGENI gives new i

112 tilized to demonstrate a novel type of leaky-guided acoustic wave that couples simultaneously to two

113 ology may one day be applicable to the light-guided treatment of type 2 diabetes and other metabolic

114 Our new linker-guided strategy can be used to enrich the discovery of s

115 The SHAPE-mapping-guided basepairing probabilities are obtained using the

116 our study highlights the need for mechanism-guided targeting of anti-apoptotic BCL-2 proteins to eff

117 The vision of a precision medicine-guided approach to novel cancer drug development is chal

118 Memory-guided behavior requires maintenance of task-relevant in

119 In this study, we used a memory-guided saccade task to temporally dissociate the visual

120 s support accurate memory storage and memory-guided behavior, whereas sleep SWR reactivation is bette

121 y-guided task, but stimulation during memory-guided saccades, while influencing RTs and errors, did n

122 lexibly configure memory networks for memory-guided behavior and dissolve them equally fast to allow

123 navigation, but also in a variety of memory-guided behaviours.

124 ding predicts the accuracy of working-memory-guided behavior, including memory precision.

125 s via a simple and robust templated meniscus-guided coating method.

126 of a complex between the paRNA and microRNA-guided Argonaute 1 that, together, recruit SUV39H1 and i

127 le facilitating the assembly of the microRNA-guided Argonaute 1 complex and gene silencing.

128 n crystal structure, and by structural model-guided redesign of channelrhodopsins for altered ion sel

129 herefore, TNBC lacks targets for molecularly-guided therapies.

130 MR-guided vacuum biopsy and MR-guided lesion bracketing wer

131 MR-guided vacuum biopsy and MR-guided lesion bracketing were performed for DCIS compone

132 Conclusion MR-guided focused ultrasound is technically feasible for fo

133 The diagnostic yields of MR-guided biopsy per patient and target were analyzed, and

134 bined with MR-guided needle biopsy and/or MR-guided lesion localization or bracketing where appropria

135 Conclusion In-bore 3-T MR-guided biopsy is safe and effective for prostate cancer

136 In-bore 3-T MR-guided prostate biopsy was performed in 134 targets in 1

137 , 3+3; index tumor </=10 mm(3)) underwent MR-guided focused ultrasound between July 2011 and February

138 ent preoperative MR imaging combined with MR-guided needle biopsy and/or MR-guided lesion localizatio

139 MRI-guided pulsed focused ultrasound (pFUS) combined with sy

140 enthusiasm for clinical use of advanced MRI-guided radiotherapy systems.

141 stereo-electroencephalography-guided and MRI-guided stereotactic laser interstitial thermal therapy (

142 pproaches have led to the development of MRI-guided laser interstitial thermal therapy (LITT).

143 In the current study, we used MRI-guided transcranial magnetic stimulation (TMS) to assess

144 nditional needles, diagnostic MR neurography-guided GFN blocks were performed in the retroperitoneum.

145 Here, we present an NMR-guided all-atom discrete molecular dynamics (DMD) platfo

146 magnetic relaxation enhancement- and CSP-NMR-guided HADDOCK modeling of the dimer-dimer interface of

147 ivity, PDZ1i (113B7), identified through NMR-guided fragment-based drug design, inhibited MDA-9/Synte

148 de-dependent endonuclease activity and a non-guided DNA endonuclease activity.

149 Frequency of OCT-guided management decisions, stratified by indication an

150 osphorylation at S289 are defective for odor-guided behavior.

151 principal cells precisely to drive olfactory-guided behavior.

152 diately after formation, mediating olfactory-guided behavior.

153 te their respective contributions to outcome-guided behaviors in rats.

154 PET-guided therapy has improved outcomes in Hodgkin lymphoma

155 reatment, and prospective trials to test PET-guided therapy in this disease are anticipated.

156 , and 3 increasingly complex pharmacogenomic-guided protocols.

157 Clinical trials testing pharmacogenomic-guided warfarin dosing for patients with atrial fibrilla

158 demonstrate that a state-of-the-art physics-guided data mining can provide an efficient pathway for

159 Intracardiac and pulmonary artery pressure-guided management has become a focus of hospitalization

160 s data promise to expand the use of pressure-guided heart failure management.

161 PA pressure-guided HF management reduces morbidity and mortality in

162 am of the Ti2AlC-Cr2AlC via first-principles-guided Bayesian CALPHAD framework that accounts for unce

163 patients were randomized to either NT-proBNP-guided or conventional treatment (1:1).

164 ients were randomized to either an NT-proBNP-guided strategy or usual care.

165 zation or equivalent) to either an NT-proBNP-guided strategy or usual care.

166 Nonetheless, NT-proBNP-guided therapy did not significantly improve the combine

167 The PRIMA II trial (Can NT-ProBNP-Guided Therapy During Hospital Admission for Acute Decom

168 This study aimed to assess whether NT-proBNP-guided therapy of patients with acute decompensated HF u

169 ients (286 [9%] deaths in 3336 procalcitonin-guided patients vs 336 [10%] in 3372 controls; adjusted

170 procalcitonin concentrations (procalcitonin-guided group) or control.

171 ays was significantly lower in procalcitonin-guided patients than in control patients (286 [9%] death

172 as1 complex as a unique example of a protein-guided programmable endoribonuclease.

173 ese modes include surface plasmons and quasi-guided modes, and by tailoring the absorption modes to e

174 that will further guide us toward rationally-guided new therapies: synergistic combination of selecti

175 iven by the introduction of PfHRP2-based RDT-guided treatment.

176 ffolding was achieved by combining reference-guided with de novo assembly followed by extensive impro

177 The benefit from fractional flow reserve-guided complete revascularization in ST-segment-elevatio

178 th 3-vessel disease, fractional flow reserve-guided complete revascularization reduced the primary en

179 sis on the effect of fractional flow reserve-guided complete revascularization.

180 Retroelement-guided diversification is further shown to be active in

181 s of the world used to drive adaptive reward-guided behavior.

182 exposure as rats performed a complex reward-guided decision-making task in which predicted reward va

183 buse, during performance of a complex reward-guided decision-making task.

184 s a choice between two options during reward-guided decision-making.SIGNIFICANCE STATEMENT Current th

185 RNA-guided Cas9 endonucleases protect bacteria from viral in

186 RNA-guided CRISPR-Cas9 endonucleases are widely used for gen

187 RNA-guided endonucleases (RGENs) have invigorated the field

188 tral element of this immune system is an RNA-guided surveillance complex capable of targeting non-sel

189 degrade invasive genetic elements by an RNA-guided, RNA-targeting multisubunit interference complex.

190 he CRISPR-Cas systems in prokaryotes are RNA-guided immune systems that target and deactivate foreign

191 The CRISPR-Cas9 RNA-guided endonuclease system allows precise and efficient

192 , short palindromic repeats and the Cas9 RNA-guided nuclease (CRISPR/Cas9) system provides a new oppo

193 hanism of target search on DNA by CRISPR RNA-guided Cas9 proteins, which is followed by a selective c

194 associated (Cas) systems employ the dual RNA-guided DNA endonuclease Cas9 to defend against invading

195 ed in recent years as a highly efficient RNA-guided gene manipulation platform.

196 onse system, has been widely adopted for RNA-guided genome editing and transcription regulation in ap

197 tructural understanding of Cas9-mediated RNA-guided DNA targeting and cleavage.

198 This is the first demonstration of a non-RNA-guided Cas9 endonuclease and first step towards eliminat

199 These findings suggest the existence of RNA-guided transposition and fit the guns-for-hire concept w

200 The revolutionary RNA-guided endonuclease CRISPR/Cas9 system has proven to be

201 The RNA-guided Cas9 endonuclease can be introduced into cells as

202 e we performed random mutagenesis of the RNA-guided Cas9 nuclease to look for variants that provide e

203 The RNA-guided Cpf1 (also known as Cas12a) nuclease associates w

204 The RNA-guided Cpf1 nuclease cleaves double-stranded DNA targets

205 Whereas the RNA-guided CRISPR interference mechanism varies widely among

206 The RNA-guided CRISPR-Cas9 nuclease from Streptococcus pyogenes

207 The RNA-guided DNA endonuclease Cas9 has emerged as a powerful t

208 Recently, the RNA-guided endonuclease Cas9 from the microbial CRISPR (clus

209 The RNA-guided endonuclease CRISPR-associated protein 9 (Cas9),

210 The RNA-guided, RNA-targeting clustered regularly interspaced sh

211 These RNA-guided nucleases are powerful weapons in the fight again

212 Here we will review this RNA-guided nuclease system for gene editing with respect to

213 ng CRISPR-associated (cas) genes make up RNA-guided, adaptive immune systems in prokaryotes whose eff

214 nerates double strand breaks in DNA upon RNA-guided recognition of a complementary DNA sequence, whic

215 crobes against foreign nucleic acids via RNA-guided endonucleases.

216 s, enabling validation of robust in vivo RNA-guided DNA interference activity in Escherichia coli.

217 standing of the mechanisms involved in rotor-guided ablation.

218 PFC) of male rhesus macaques performing rule-guided prosaccades and antisaccades, a well established

219 embryos before initiation of the CXCL12/SDF1-guided chemotaxis.

220 Self-guided iCBT is effective in treating depressive symptoms

221 Self-guided iCBT was significantly more effective than contro

222 Self-guided internet-based cognitive behavioral therapy (iCBT

223 conveniently and cost-effectively as a self-guided digital audiovisual programme, so might also redu

224 ical and policy decision making because self-guided iCBT can be considered as an evidence-based first

225 nth interventionist-guided (n = 125) or self-guided (n = 121) weight loss program supporting behavior

226 44% in the guided group and 19% in the self-guided group met the 5% goal.

227 loss were greater in the guided versus self-guided group (at 6 months: 3.5 kg v 1.3kg; P < .001; 3.6

228 Randomized clinical trials in which self-guided iCBT was compared with a control (usual care, wai

229 Sensory-guided behaviors require the transformation of sensory i

230 Hedgehog (SHH) and consequently altering SHH-guided neural cell-fate decisions.

231 trates that cell signaling pathway signature-guided treatment for breast cancer is viable.

232 simple interface could supplement spatially-guided motor routines with communicative-ostensive cues.

233 This novel stability-guided classification scheme is delivered in two flavour

234 n that the transcranial magnetic stimulation-guided regions make to language tasks.

235 acy of the transcranial magnetic stimulation-guided regions was validated in a second sample of 108 p

236 to these 'transcranial magnetic stimulation-guided' regions remained highly significant even after c

237 Structure-guided biochemical, mutational, computational, and bindi

238 Structure-guided exploration of commercial chemical space using mo

239 Structure-guided improvements yield superior affinity reagents sui

240 Structure-guided mutagenesis enabled uncoupling of virulence from

241 Structure-guided mutagenesis of residues within the GDP-binding po

242 Structure-guided mutagenesis of the pore residues shows that they

243 Structure-guided mutagenesis revealed four catalytic residues that

244 Structure-guided mutagenesis reveals that His175, Arg186, Thr276 a

245 Structure-guided mutation of a critical residue, F270, to glycine

246 Here, we describe a structure-guided development of a series of covalent and mutant-se

247 st this hypothesis, we developed a structure-guided evolution approach that does not require selectiv

248 A structure-guided hybridization approach using two privileged subst

249 otoxin modification and will aid a structure-guided rational drug design approach to treating multidr

250 By site-directed mutagenesis and structure-guided analyses, we dissected the function of individual

251 We here employ computational and structure-guided design to develop improved native-like trimers th

252 We used computational and structure-guided design to develop two next-generation NNRTI drug

253 coli GUS operon is identified, and structure-guided GusR mutants pinpoint the residues essential for

254 omparative structural analysis and structure-guided molecular design to develop potent and selective

255 t activity against acetyl-CoA, and structure-guided mutagenesis of putative active site residues iden

256 -chosen training sequences made by structure-guided SCHEMA recombination has enabled us to accurately

257 Finally, structure-guided mutational analysis confirms the importance of RN

258 use of protein crystallography in structure-guided drug discovery emerged as enzyme structures allow

259 exemplify current developments in structure-guided target identification and fragment-based lead dis

260 More recently, use of structure-guided design with fragment-based drug discovery, which

261 The structure-guided cell-based inhibition studies further demonstrate

262 We report the structure-guided design and group-based optimization of a series o

263 ompounds and set the stage for the structure-guided design of better translation inhibitors.

264 We report the structure-guided design of HIV-1 cyclically permuted gp120 that fo

265 of the XPA-DNA interaction through structure-guided drug design efforts.

266 We have used structure-guided methods to develop a lead molecule that targets t

267 We have used structure-guided SCHEMA recombination to create a large set of fun

268 In this study, we used structure-guided truncations of the PB2 subunit to show that a PB2

269 Using structure-guided pharmacophore design followed by docking, we foun

270 holderia phytofirmans coupled with structure-guided disulfide cross-linking in P. aeruginosa suggest

271 Structural analysis, combined with structure-guided mutagenesis, leads us to propose a catalytic mech

272 The CBT consisted of weekly therapist-guided sessions, with a maximum duration of 24 weeks.

273 to undergo percutaneous computed tomographic-guided IRE.

274 Computed tomography-guided radiofrequency ablation (CT-RFA) and laparoscopic

275 the context of positron emission tomography-guided response assessment and the evolving cHL treatmen

276 rative analysis to a reference-transcriptome-guided approach on gene ontology and tox-pathways, we co

277 Ultrasound-guided, closed-abdominal injections supported consistent

278 and reliability of a para-aortic, ultrasound-guided technique for injecting quickly-polymerizing coll

279 nt nodal disease on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in p

280 valuate whether a single-operator ultrasound-guided, right-sided, central venous catheter insertion v

281 y serious harms from screening or ultrasound-guided fine-needle aspiration.

282 from 107 patients, who underwent ultrasound-guided prostate biopsy (67 patients had at least one can

283 nd negative transrectal ultrasonography (US)-guided biopsy findings; to determine the significant can

284 Systematic transrectal ultrasonography (US)-guided biopsy is the standard approach for histopatholog

285 nd patient outcomes for ultrasonography (US)-guided percutaneous irrigation of calcific tendinopathy.

286 r double-needle procedure when performing US-guided percutaneous irrigation of calcific tendinopathy

287 ual to 3 ng/mL after negative transrectal US-guided biopsy findings underwent state-of-the-art, full

288 ant prostate cancer missed by transrectal US-guided biopsy.

289 least 2 years, with rebiopsy (transrectal US-guided or transperineal saturation) where appropriate.

290 ated image segmentation, semi-automated user-guided error correction, and data analysis.

291 bnAbs in vivo, to further facilitate vaccine-guided bnAb induction studies.

292 necessary for contingent learning and value-guided decision-making, respectively.SIGNIFICANCE STATEM

293 r rewards to particular choices during value-guided learning, whereas the medial orbitofrontal cortex

294 ERG and retinal morphology, photopic vision-guided behaviour is comparable between normal and cone E

295 fects were largely congruent in the visually-guided task, but stimulation during memory-guided saccad

296 We developed a WAFEX-guided principal analysis and unraveled how phosphorylat

297 Reoperation rate after wire-guided BCS in patients with IBC or DCIS.

298 A lower reoperation rate after wire-guided BCS was found in this study than those shown in p

299 radioactive seed localization (RSL) and wire-guided localization (WGL) after breast conserving surger

300 tologically verified IBC or DCIS having wire-guided BCS performed between January 1, 2010, and Decemb